{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:04:11Z","timestamp":1784649851242,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX006479"],"award-info":[{"award-number":["BX006479"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bone.2026.117934","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:54:10Z","timestamp":1778770450000},"page":"117934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Age-related differences in the skeletal phenotype of Brown Norway rats induced to develop chronic kidney disease"],"prefix":"10.1016","volume":"210","author":[{"given":"Corinne E.","family":"Metzger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon Y.","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Scorziello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia A.","family":"Back","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Matter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Jaymie","family":"Connerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalisha D.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany D.","family":"Needham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2011","journal-title":"Kidney Int. Suppl."},{"issue":"10","key":"10.1016\/j.bone.2026.117934_bb0010","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/ndt\/gfz259","article-title":"Incidence of fractures in middle-aged individuals with early chronic kidney disease: a population-based analysis of CARTaGENE","volume":"35","author":"Desbiens","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"issue":"10","key":"10.1016\/j.bone.2026.117934_bb0015","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/jbmr.2862","article-title":"Hip fracture in patients with non-dialysis-requiring chronic kidney disease","volume":"31","author":"Kim","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bone.2026.117934_bb0020","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1002\/jbmr.4141","article-title":"Incidence of fractures before and after dialysis initiation","volume":"35","author":"Iseri","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0025","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00198-013-2435-1","article-title":"Incidence and risk factors for hip fractures in dialysis patients","volume":"25","author":"Maravic","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"8","key":"10.1016\/j.bone.2026.117934_bb0035","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s00198-020-05351-x","article-title":"The risk of new fragility fractures in patients with chronic kidney disease and hip fracture\u2014a population-based cohort study in the UK","volume":"31","author":"de Bruin","year":"2020","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.bone.2026.117934_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0121705","article-title":"Increased risks of mortality and atherosclerotic complications in incident hemodialysis patients subsequently with bone fractures: a nationwide case-matched cohort study","volume":"10","author":"Kuo","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0045","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ki.2013.279","article-title":"High rates of death and hospitalization follow bone fracture among hemodialysis patients","volume":"85","author":"Tentori","year":"2014","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.bone.2026.117934_bb0050","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/ndt\/gfz142","article-title":"Fractures and their sequelae in non-dialysis-dependent chronic kidney disease: the Stockholm CREAtinine measurement project","volume":"35","author":"Runesson","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bone.2026.117934_bb0055","series-title":"Chronic kidney disease in the United States, 2021","first-page":"1","volume":"1","author":"Centers for Disease Control and Prevention","year":"2021"},{"issue":"4","key":"10.1016\/j.bone.2026.117934_bb0060","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ki.2013.547","article-title":"The three-year incidence of fracture in chronic kidney disease","volume":"86","author":"Naylor","year":"2014","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.bone.2026.117934_bb0065","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/sj.ki.5001754","article-title":"Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study","volume":"70","author":"Jadoul","year":"2006","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.bone.2026.117934_bb0070","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"4 April","key":"10.1016\/j.bone.2026.117934_bb0075","first-page":"1","article-title":"Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL\/6 mice with more severe deficits in cortical bone properties of male mice","volume":"16","author":"Metzger","year":"2021","journal-title":"PLoS One."},{"issue":"April","key":"10.1016\/j.bone.2026.117934_bb0080","article-title":"Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels","volume":"148","author":"Metzger","year":"2021","journal-title":"Bone"},{"issue":"July 2020","key":"10.1016\/j.bone.2026.117934_bb0085","article-title":"Reversing cortical porosity: cortical pore infilling in preclinical models of chronic kidney disease","volume":"143","author":"Metzger","year":"2020","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.bone.2026.117934_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbm4.10837","article-title":"The dietary fiber inulin slows progression of chronic kidney disease\u2013mineral bone disorder (CKD-MBD) in a rat model of CKD","volume":"7","author":"Biruete","year":"2023","journal-title":"JBMR Plus."},{"issue":"April","key":"10.1016\/j.bone.2026.117934_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2019.05.002","article-title":"Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u03bc CT in a rat model of CKD","volume":"125","author":"Mcnerny","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117934_bb0100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bone.2015.02.006","article-title":"Spatial distribution of intracortical porosity varies across age and sex","volume":"75","author":"Nirody","year":"2015","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2026.117934_bb0105","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1359\/jbmr.091104","article-title":"Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia","volume":"25","author":"Burghardt","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.bone.2026.117934_bb0110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S8756-3282(03)00199-6","article-title":"Bone development and age-related bone loss in male C57BL\/6J mice","volume":"33","author":"Ferguson","year":"2003","journal-title":"Bone"},{"issue":"17","key":"10.1016\/j.bone.2026.117934_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.93771","article-title":"Old age causes de novo intracortical bone remodeling and porosity in mice","volume":"2","author":"Piemontese","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0120","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117934_bb0125","series-title":"Proceedings of the ACM Conference on Human Factors in Computing Systems (CHI \u201911)","first-page":"143","article-title":"The aligned rank transform for nonparametric factorial analyses using only ANOVA procedures","author":"Wobbrock","year":"2011"},{"key":"10.1016\/j.bone.2026.117934_bb0130","series-title":"UIST 2021 - Proceedings of the 34th Annual ACM Symposium on User Interface Software and Technology","first-page":"754","article-title":"An aligned rank transform procedure for multifactor contrast tests","author":"Elkin","year":"2021"},{"key":"10.1016\/j.bone.2026.117934_bb0135","series-title":"Using Cliff\u2019s Delta as a Non-Parametric Effect Size Measure: An Accessible Web App and R Tutorial","first-page":"29","volume":"Vol. 29","author":"Meissel","year":"2024"},{"issue":"March","key":"10.1016\/j.bone.2026.117934_bb0140","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bone.2019.04.019","article-title":"Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl\/6 mice","volume":"127","author":"Heveran","year":"2019","journal-title":"Bone"},{"issue":"August 2021","key":"10.1016\/j.bone.2026.117934_bb0145","article-title":"The combination of aging and chronic kidney disease leads to an exacerbated cortical porosity phenotype","volume":"154","author":"Tippen","year":"2022","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.bone.2026.117934_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13070479","article-title":"Circulating p-cresyl sulfate, non-hepatic alkaline phosphatase and risk of bone fracture events in chronic kidney disease-mineral bone disease","volume":"13","author":"Chang","year":"2021","journal-title":"Toxins (Basel)."},{"issue":"10","key":"10.1016\/j.bone.2026.117934_bb0155","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/ndt\/gfl311","article-title":"Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats","volume":"21","author":"Iwasaki","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.bone.2026.117934_bb0160","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bone.2013.07.037","article-title":"Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease","volume":"57","author":"Iwasaki","year":"2013","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.bone.2026.117934_bb0165","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/jbmrpl\/ziae136","article-title":"The uremic toxin indoxyl sulfate decreases osteocyte RANKL\/OPG and increases Wnt inhibitor RNA expression that is reversed by PTH","volume":"9","author":"Chen","year":"2025","journal-title":"JBMR Plus"},{"issue":"8","key":"10.1016\/j.bone.2026.117934_bb0175","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/sj.ki.5002097","article-title":"Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells","volume":"71","author":"Nii-Kono","year":"2007","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.bone.2026.117934_bb0180","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1523-1755.2004.00472.x","article-title":"Regulation of PTH1 receptor expression by uremic ultrafiltrate in UMR 106-01 osteoblast-like cells","volume":"65","author":"Disthabanchong","year":"2004","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bone.2026.117934_bb0185","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1681\/ASN.2014040414","article-title":"Effects of cinacalcet on fracture events in patients receiving hemodialysis: the EVOLVE trial","volume":"26","author":"Moe","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.bone.2026.117934_bb0190","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ki.2013.547","article-title":"The three-year incidence of fracture in chronic kidney disease","volume":"86","author":"Naylor","year":"2014","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.bone.2026.117934_bb0195","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/sj.ki.5001754","article-title":"Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study","volume":"70","author":"Jadoul","year":"2006","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.bone.2026.117934_bb0200","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.bone.2006.11.011","article-title":"Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft","volume":"40","author":"Cooper","year":"2007","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2026.117934_bb0205","doi-asserted-by":"crossref","first-page":"008","DOI":"10.29328\/journal.aceo.1001006","article-title":"Evaluating cortical bone porosity using Hr-Pqct","volume":"3","author":"Rique","year":"2019","journal-title":"Arch. Clin. Exp. Orthop."},{"issue":"February","key":"10.1016\/j.bone.2026.117934_bb0210","article-title":"Age and sex effects on FGF23-mediated response to mild phosphate challenge","volume":"146","author":"Tippen","year":"2021","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.bone.2026.117934_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0324628","article-title":"Prolonged secondary hyperparathyroidism in adenine-induced CKD leads to skeletal changes consistent with skeletal hyporesponsiveness to PTH","volume":"20","author":"Metzger","year":"2025","journal-title":"PLoS One."},{"issue":"April","key":"10.1016\/j.bone.2026.117934_bb0220","article-title":"Cortical porosity occurs at varying degrees throughout the skeleton in rats with chronic kidney disease","volume":"17","author":"Metzger","year":"2022","journal-title":"Bone Rep."},{"issue":"November 2021","key":"10.1016\/j.bone.2026.117934_bb0225","article-title":"Cortical porosity development and progression is mitigated after etelcalcetide treatment in an animal model of chronic kidney disease","volume":"157","author":"Swallow","year":"2022","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bone.2026.117934_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jbmrpl\/ziae004","article-title":"Inhibition of RANKL improves the skeletal phenotype of adenine-induced chronic kidney disease in mice","volume":"8","author":"Metzger","year":"2024","journal-title":"JBMR Plus."},{"issue":"19","key":"10.1016\/j.bone.2026.117934_bb0235","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138815","article-title":"Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence","volume":"5","author":"Kim","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bone.2026.117934_bb0240","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/MNH.0000000000000782","article-title":"Ageing, cellular senescence and chronic kidney disease: experimental evidence","author":"Tan","year":"2022","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"11","key":"10.1016\/j.bone.2026.117934_bb0245","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of senescent cells in the bone microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226001602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226001602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:27:29Z","timestamp":1784647649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226001602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S8756328226001602"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.117934","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-related differences in the skeletal phenotype of Brown Norway rats induced to develop chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.117934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117934"}}