{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:18:38Z","timestamp":1793067518237,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,15]],"date-time":"2027-06-15T00:00:00Z","timestamp":1813017600000},"content-version":"am","delay-in-days":257,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009666","name":"The Salt Science Research Foundation","doi-asserted-by":"publisher","award":["202525"],"award-info":[{"award-number":["202525"]}],"id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009666","name":"The Salt Science Research Foundation","doi-asserted-by":"publisher","award":["23C1"],"award-info":[{"award-number":["23C1"]}],"id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["23K08642"],"award-info":[{"award-number":["23K08642"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["26K14622"],"award-info":[{"award-number":["26K14622"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012043","name":"Kindai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bone.2026.117975","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:11:47Z","timestamp":1781201507000},"page":"117975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Roles of Del-1 in effects of hyponatremia on muscle and bone in mice"],"prefix":"10.1016","volume":"211","author":[{"given":"Naoyuki","family":"Kawao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kishigami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Muratani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2026.117975_bb0005","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bone.2026.117975_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000493237","article-title":"Hyponatremia is linked to bone loss, osteoporosis, fragility and bone fractures","volume":"52","author":"Barsony","year":"2019","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.bone.2026.117975_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12877-020-01955-4","article-title":"Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly","volume":"21","author":"Fujisawa","year":"2021","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.bone.2026.117975_bb0020","article-title":"Hyponatremia and bone pathophysiology: an integrated preclinical and clinical perspective","volume":"40","author":"Varaldo","year":"2025","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2026.117975_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00774-023-01472-5","article-title":"Crosstalk between muscle and bone","volume":"42","author":"Kaji","year":"2024","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bone.2026.117975_bb0030","doi-asserted-by":"crossref","first-page":"e3818","DOI":"10.1210\/clinem\/dgaf120","article-title":"Serum sodium, potassium, magnesium, calcium, and phosphorus levels and risk of fracture in the community","volume":"110","author":"Uehara","year":"2025","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2026.117975_bb0035","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.1074\/jbc.M110.155002","article-title":"Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss","volume":"286","author":"Barsony","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117975_bb0040","doi-asserted-by":"crossref","first-page":"e1027","DOI":"10.1210\/clinem\/dgad238","article-title":"An increase in plasma sodium levels is associated with an increase in osteoblast function in chronic SIAD","volume":"108","author":"Monnerat","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bone.2026.117975_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-21-0604","article-title":"Effect of hyponatremia normalization on osteoblast function in patients with SIAD","volume":"186","author":"Potasso","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bone.2026.117975_bb0050","article-title":"The association between handgrip strength and predialysis serum sodium level in patients with chronic kidney disease stage 5D","volume":"7","author":"Markaki","year":"2020","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.bone.2026.117975_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00223-025-01369-7","article-title":"Roles of insulin-like growth factor-1 in muscle wasting and osteopenia in mice with hyponatremia","volume":"116","author":"Kawao","year":"2025","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bone.2026.117975_bb0060","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2337\/db21-0573","article-title":"Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage-dependent miR-150-FNDC5\/pyroptosis axis","volume":"71","author":"Behera","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.bone.2026.117975_bb0065","doi-asserted-by":"crossref","first-page":"197","DOI":"10.22203\/eCM.v024a14","article-title":"Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of \u03b2-catenin","volume":"24","author":"J\u00e4hn","year":"2012","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bone.2026.117975_bb0070","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/jcsm.12892","article-title":"Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice","volume":"13","author":"Kawao","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2026.117975_bb0075","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bone.2026.117975_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287541","article-title":"Effects of elastase-induced emphysema on muscle and bone in mice","volume":"18","author":"Matsumura","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.117975_bb0085","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/a-2003-5704","article-title":"Effects of growth hormone on muscle and bone in female mice: role of follistatin","volume":"131","author":"Ohira","year":"2023","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bone.2026.117975_bb0090","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/jcp.30706","article-title":"Role of peripheral myelin protein 22 in chronic exercise-induced interactions of muscle and bone in mice","volume":"237","author":"Kawaguchi","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bone.2026.117975_bb0095","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3389\/fcell.2020.00793","article-title":"A modified pre-plating method for high-yield and high-purity muscle stem cell isolation from human\/mouse skeletal muscle tissues","volume":"8","author":"Yoshioka","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2026.117975_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117040","article-title":"Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice","volume":"181","author":"Kawao","year":"2024","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117975_bb0105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12032-023-02207-2","article-title":"The roles of P-selectin in cancer cachexia","volume":"40","author":"Ling","year":"2023","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bone.2026.117975_bb0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/emmm.201200231","article-title":"P-selectin genotype is associated with the development of cancer cachexia","volume":"4","author":"Tan","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bone.2026.117975_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cells14020105","article-title":"CCL24 and fibrosis: a narrative review of existing evidence and mechanisms","volume":"14","author":"Greenman","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bone.2026.117975_bb0120","first-page":"85","article-title":"Regulation of eosinophil trafficking in asthma and allergy","volume":"45","author":"Pease","year":"2004","journal-title":"Ernst Schering Res. Found. Workshop"},{"key":"10.1016\/j.bone.2026.117975_bb0125","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bone.2012.12.006","article-title":"Chemokine expression is upregulated in chondrocytes in diabetic fracture healing","volume":"53","author":"Alblowi","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.117975_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1347888","article-title":"Developmental endothelial locus 1: the present and future of an endogenous factor in vessels","volume":"15","author":"Jiang","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bone.2026.117975_bb0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1101\/gad.12.1.21","article-title":"Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the \u03b1v\u03b23 integrin receptor","volume":"12","author":"Hidai","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bone.2026.117975_bb0140","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.molmed.2019.02.010","article-title":"DEL-1-regulated immune plasticity and inflammatory disorders","volume":"25","author":"Hajishengallis","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bone.2026.117975_bb0145","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1074\/jbc.RA120.013024","article-title":"The secreted protein DEL-1 activates a \u03b23 integrin-FAK-ERK1\/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration","volume":"295","author":"Yuh","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bone.2026.117975_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac5380","article-title":"DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates","volume":"7","author":"Shin","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bone.2026.117975_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/ph16020303","article-title":"Erythromycin restores osteoblast differentiation and osteogenesis suppressed by porphyromonas gingivalis lipopolysaccharide","volume":"16","author":"Tamura","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bone.2026.117975_bb0160","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/21623945.2020.1823140","article-title":"Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK\/HO-1- pathway","volume":"9","author":"Kwon","year":"2020","journal-title":"Adipocyte"},{"key":"10.1016\/j.bone.2026.117975_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2025.133284","article-title":"DEL-1 promotes macrophage lipid accumulation and inflammation by inhibiting TGF-\u03b2","volume":"432","author":"Wang","year":"2025","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bone.2026.117975_bb0170","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.21037\/tcr-19-2967b","article-title":"EDIL3 regulates gastric cancer cell migration, invasion and epithelial-mesenchymal transition via TGF-\u03b21\/XIST\/miR-137 feedback loop","volume":"9","author":"Zhang","year":"2020","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.bone.2026.117975_bb0175","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41590-018-0249-1","article-title":"DEL-1 promotes macrophage efferocytosis and clearance of inflammation","volume":"20","author":"Kourtzelis","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bone.2026.117975_bb0180","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1302\/2046-3758.1212.BJR-2023-0087.R1","article-title":"The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development","volume":"12","author":"Chen","year":"2023","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.bone.2026.117975_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188749","article-title":"The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin \u03b15\u03b21\/ERK\/Runx2 pathway","volume":"12","author":"Oh","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.117975_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2019.100238","article-title":"Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model","volume":"16","author":"Kun","year":"2019","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.bone.2026.117975_bb0195","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3390\/ijms26062673","article-title":"Developmental endothelial locus-1 promotes osteoclast differentiation and activation","volume":"26","author":"Imamura","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2026.117975_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113730","article-title":"DEL-1 ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle through SIRT1\/SERCA2-mediated ER stress suppression","volume":"171","author":"Sun","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bone.2026.117975_bb0205","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1210\/en.2006-1321","article-title":"Three Na+\/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption","volume":"148","author":"Li","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bone.2026.117975_bb0210","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/jcsm.13213","article-title":"Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway","volume":"14","author":"Deng","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bone.2026.117975_bb0215","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jcsm.12393","article-title":"Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism","volume":"10","author":"Shen","year":"2019","journal-title":"J. Cachexia. Sarcopenia Muscle"}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226002012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226002012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:43:25Z","timestamp":1786117405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226002012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S8756328226002012"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.117975","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of Del-1 in effects of hyponatremia on muscle and bone in mice","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.117975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117975"}}