{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:52:20Z","timestamp":1791996740005,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bone.2026.118010","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:50:04Z","timestamp":1783698604000},"page":"118010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pharmacological and surgical predictors of postoperative healing in medication-related osteonecrosis of the jaw: A retrospective multicenter cohort study"],"prefix":"10.1016","volume":"212","author":[{"given":"Min-Ji","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunmi","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-5730","authenticated-orcid":false,"given":"Jin-Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-6135","authenticated-orcid":false,"given":"Jun-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bone.2026.118010_bb0005","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"5","key":"10.1016\/j.bone.2026.118010_bb0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: So many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"6","key":"10.1016\/j.bone.2026.118010_bb0015","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.tripleo.2011.04.020","article-title":"A model for the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw and teriparatide\u2019s potential role in its resolution","volume":"112","author":"Subramanian","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"2","key":"10.1016\/j.bone.2026.118010_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrrheum.2011.181","article-title":"Epidemiology and pathogenesis of osteonecrosis of the jaw","volume":"8","author":"Reid","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"5","key":"10.1016\/j.bone.2026.118010_bb0025","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 position paper on medication-related osteonecrosis of the jaws\u20142022 update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40902-023-00377-7","article-title":"Associated systemic diseases and etiologies of medication-related osteonecrosis of the jaw: A retrospective study of 265 surgical cases","volume":"45","author":"Chang","year":"2023","journal-title":"Maxillofacial Plastic and Reconstructive Surgery"},{"issue":"10","key":"10.1016\/j.bone.2026.118010_bb0035","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41415-023-6447-8","article-title":"Pre-existing medication-related osteonecrosis of the jaw before dental extraction","volume":"235","author":"Al-Sarraj","year":"2023","journal-title":"Br. Dent. J."},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0040","doi-asserted-by":"crossref","first-page":"17226","DOI":"10.1038\/s41598-021-96480-8","article-title":"Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients","volume":"11","author":"Soutome","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bone.2026.118010_bb0045","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/odi.14496","article-title":"Local radiographic risk factors for MRONJ in osteoporotic patients undergoing tooth extraction","volume":"30","author":"Moreno-Rabi\u00e9","year":"2024","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.joms.2014.07.012","article-title":"Temporal correlation between bisphosphonate termination and symptom resolution in osteonecrosis of the jaw: a pooled case report analysis","volume":"73","author":"Hinson","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"36","key":"10.1016\/j.bone.2026.118010_bb0055","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1200\/JCO.2008.16.9300","article-title":"Natural history of osteonecrosis of the jaw in patients with multiple myeloma","volume":"26","author":"Badros","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bone.2026.118010_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"10.1016\/j.bone.2026.118010_bb0065","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1016\/j.joms.2021.07.029","article-title":"Recurrence-Related Factors of Medication-Related Osteonecrosis of the Jaw: A Five-Year Experience","volume":"79","author":"Chen","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bone.2026.118010_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116722","article-title":"Risk of medication-related osteonecrosis of the jaw after dental extractions in patients receiving antiresorptive agents - A retrospective study of 240 patients","volume":"170","author":"Coropciuc","year":"2023","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/cncr.21130","article-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy","volume":"104","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.bone.2026.118010_bb0080","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00784-024-05911-z","article-title":"Medication-related osteonecrosis of the jaw: a retrospective single center study of recurrence-related factors after surgical treatment","volume":"28","author":"Ruan","year":"2024","journal-title":"Clin. Oral Investig."},{"issue":"5s1","key":"10.1016\/j.bone.2026.118010_bb0085","article-title":"Epidemiology, etiopathogenesis, and management of MRONJ: a European multicenter study","volume":"125","author":"Boffano","year":"2024","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0090","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1038\/s41598-022-11615-9","article-title":"A 5-year retrospective cohort study of denosumab induced medication related osteonecrosis of the jaw in osteoporosis patients","volume":"12","author":"Jung","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bone.2026.118010_bb0095","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.joms.2022.01.012","article-title":"Surgical Therapy in Patients With Medication-Related Osteonecrosis of the Jaw Is Associated With Disease Resolution and Improved Quality of Life: A Prospective Cohort Study","volume":"80","author":"El-Rabbany","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"7","key":"10.1016\/j.bone.2026.118010_bb0100","first-page":"968","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid","volume":"91","author":"Dimopoulos","year":"2006","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.bone.2026.118010_bb0105","first-page":"3527","article-title":"Quality of life in breast cancer patients with bisphosphonate-related osteonecrosis of the jaws and patients with head and neck cancer: a comparative study using the EORTC QLQ-C30 and QLQ-HN35 questionnaires","volume":"32","author":"Kyrgidis","year":"2012","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.bone.2026.118010_bb0110","first-page":"4505","article-title":"Prognosis by cancer type and incidence of zoledronic acid-related osteonecrosis of the jaw: a single-center retrospective study","volume":"30","author":"Hata","year":"2022","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0115","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1038\/s41467-025-59718-x","article-title":"Time since last intravenous bisphosphonate and risk of osteonecrosis of the jaw in osteoporotic patients","volume":"16","author":"Park","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bone.2026.118010_bb0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcms.2020.02.017","article-title":"Medication-related osteonecrosis of the jaw (MRONJ) stage III: Conservative and conservative surgical approaches versus an aggressive surgical intervention: A systematic review","volume":"48","author":"Vanpoecke","year":"2020","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"19","key":"10.1016\/j.bone.2026.118010_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197028","article-title":"BMP-2\/\u03b2-TCP local delivery for bone regeneration in MRONJ-like mouse model","volume":"21","author":"Mikai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40902-024-00431-y","article-title":"Potentiating effect of AMD3100 on bone morphogenetic protein-2 induced bone regeneration","volume":"46","author":"Shim","year":"2024","journal-title":"Maxillofacial Plastic and Reconstructive Surgery"},{"issue":"1","key":"10.1016\/j.bone.2026.118010_bb0135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40902-023-00405-6","article-title":"Effects of rhBMP-2 with various carriers on maxillofacial bone regeneration through computed tomography evaluation","volume":"45","author":"Seo","year":"2023","journal-title":"Maxillofacial Plastic and Reconstructive Surgery"},{"key":"10.1016\/j.bone.2026.118010_bb0140","series-title":"Short-term teriparatide and recombinant human bone morphogenetic protein-2 for regenerative approach to medication-related osteonecrosis of the jaw: a preliminary study","author":"Jung","year":"2017"},{"issue":"11","key":"10.1016\/j.bone.2026.118010_bb0145","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.joms.2020.05.037","article-title":"Can surgical management improve resolution of medication-related osteonecrosis of the jaw at early stages? A prospective cohort study","volume":"78","author":"Giudice","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"10","key":"10.1016\/j.bone.2026.118010_bb0150","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jbmr.3191","article-title":"Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis","volume":"32","author":"Hayashida","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"1\u20132","key":"10.1016\/j.bone.2026.118010_bb0155","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/odi.12764","article-title":"Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment?","volume":"24","author":"Favia","year":"2018","journal-title":"Oral Dis."},{"issue":"3","key":"10.1016\/j.bone.2026.118010_bb0160","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jcms.2018.12.014","article-title":"Is the conservative non-surgical management of medication-related osteonecrosis of the jaw an appropriate treatment option for early stages? A long-term single-center cohort study","volume":"47","author":"Ristow","year":"2019","journal-title":"J. Craniomaxillofac. Surg."},{"issue":"3","key":"10.1016\/j.bone.2026.118010_bb0165","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jds.2023.10.007","article-title":"Bone resection methods in medication-related osteonecrosis of the jaw in the mandible: An investigation of 206 patients undergoing surgical treatment","volume":"19","author":"Suyama","year":"2024","journal-title":"J Dent Sci"},{"issue":"10","key":"10.1016\/j.bone.2026.118010_bb0170","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00198-023-06818-3","article-title":"Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: A multi-institutional retrospective cohort study in Taiwan","volume":"34","author":"Liu","year":"2023","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2026.118010_bb0175","doi-asserted-by":"crossref","first-page":"S239","DOI":"10.1016\/j.identj.2024.07.112","article-title":"MRONJ Risks in Bisphosphonate-Treated Dental Patients: A Population-Based Study","volume":"74","author":"Yoon","year":"2024","journal-title":"Int. Dent. J."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822600236X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S875632822600236X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:40:05Z","timestamp":1791996005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S875632822600236X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S875632822600236X"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.118010","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological and surgical predictors of postoperative healing in medication-related osteonecrosis of the jaw: A retrospective multicenter cohort study","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.118010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118010"}}