{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:01:48Z","timestamp":1790740908442,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bone.2026.118048","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:35:34Z","timestamp":1786577734000},"page":"118048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Longitudinal whole-spine CT mapping of ossification of spinal ligaments: Distribution, progression, and blood biomarkers"],"prefix":"10.1016","volume":"213","author":[{"given":"Masaki","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bungo","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bone.2026.118048_bb0005","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1097\/BRS.0000000000001643","article-title":"Prevalence, concomitance, and distribution of ossification of the spinal ligaments: results of whole spine CT scans in 1500 Japanese patients","volume":"41","author":"Fujimori","year":"2016","journal-title":"Spine"},{"key":"10.1016\/j.bone.2026.118048_bb0010","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s11547-022-01545-x","article-title":"Prevalence and characteristics of diffuse idiopathic skeletal hyperostosis (DISH) in Italy","volume":"127","author":"Ciaffi","year":"2022","journal-title":"Radiol. Med."},{"key":"10.1016\/j.bone.2026.118048_bb0015","doi-asserted-by":"crossref","first-page":"318","DOI":"10.22603\/ssrr.2021-0096","article-title":"The essence of clinical practice guidelines for ossification of spinal ligaments, 2019: 1. Epidemiology of OPLL","volume":"5","author":"Hasegawa","year":"2021","journal-title":"Spine Surg. Relat. Res."},{"key":"10.1016\/j.bone.2026.118048_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9010208","article-title":"A comparison of cervical and thoracolumbar fractures associated with diffuse idiopathic skeletal hyperostosis\u2014a nationwide multicenter study","volume":"9","author":"Katoh","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bone.2026.118048_bb0025","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/s41598-023-29877-2","article-title":"Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament","volume":"13","author":"Okuwaki","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.118048_bb0030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.22603\/ssrr.2021-0229","article-title":"Biomarker research approach to the pathogenesis of ossification of the spinal ligament: a review","volume":"6","author":"Kawaguchi","year":"2022","journal-title":"Spine Surgery and Related Research"},{"key":"10.1016\/j.bone.2026.118048_bb0035","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1148\/radiol.2019181695","article-title":"Criteria for early-phase diffuse idiopathic skeletal hyperostosis: development and validation","volume":"291","author":"Kuperus","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2026.118048_bb0040","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00198-013-2489-0","article-title":"Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study","volume":"25","author":"Yoshimura","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bone.2026.118048_bb0045","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bone.2026.118048_bb0050","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bone.2026.118048_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-38279-x","article-title":"Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis","volume":"14","author":"Sethi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bone.2026.118048_bb0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/BRS.0000000000005208","article-title":"Investigation of the association between hyperlipidemia and ossification of the posterior longitudinal ligament through two-sample mendelian randomization analysis","volume":"50","author":"Zhang","year":"2025","journal-title":"Spine"},{"key":"10.1016\/j.bone.2026.118048_bb0065","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1038\/s41598-020-60248-3","article-title":"Association between ossification of the longitudinal ligament of the cervical spine and arteriosclerosis in the carotid artery","volume":"10","author":"Oshima","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.118048_bb0070","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3171\/2020.3.SPINE2082","article-title":"Risk factors for progression of ossification of the posterior longitudinal ligament in asymptomatic subjects","volume":"33","author":"Doi","year":"2020","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.bone.2026.118048_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174881","article-title":"Serum biomarkers in patients with ossification of the posterior longitudinal ligament (OPLL): Inflammation in OPLL","volume":"12","author":"Kawaguchi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.118048_bb0080","doi-asserted-by":"crossref","DOI":"10.1097\/00007632-200405010-00011","article-title":"High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case-control study in multiple hospitals","volume":"29","author":"Kobashi","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.bone.2026.118048_bb0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1148\/119.3.559","article-title":"Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH)","volume":"119","author":"Resnick","year":"1976","journal-title":"Radiology"},{"key":"10.1016\/j.bone.2026.118048_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2020.101527","article-title":"Diffuse idiopathic skeletal hyperostosis: etiology and clinical relevance","volume":"34","author":"Kuperus","year":"2020","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bone.2026.118048_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113775","article-title":"Human dental pulp stem cell-derived exosomes decorated titanium scaffolds for promoting bone regeneration","volume":"235","author":"Zhang","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bone.2026.118048_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76136-z","article-title":"Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation","volume":"14","author":"Su","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bone.2026.118048_bb0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13018-024-04727-7","article-title":"CircPRKD3\/miR-6783-3p responds to mechanical force to facilitate the osteogenesis of stretched periodontal ligament stem cells","volume":"19","author":"Liu","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bone.2026.118048_bb0110","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3892\/ijmm.2015.2446","article-title":"hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes","volume":"37","author":"Lu","year":"2016","journal-title":"Int. J. Mol. Med."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226002747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226002747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:48Z","timestamp":1790739588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226002747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":22,"alternative-id":["S8756328226002747"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.118048","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal whole-spine CT mapping of ossification of spinal ligaments: Distribution, progression, and blood biomarkers","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.118048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118048"}}