{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:35:21Z","timestamp":1793133321141,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017821","name":"University of Connecticut School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017834","name":"UConn John Dempsey Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005622","name":"Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007710","name":"University of Connecticut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bone.2026.118098","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:08:38Z","timestamp":1789603718000},"page":"118098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Alendronate alters mineral composition and has potential to restore enthesis strength without preventing trabecular bone loss during unloading of the supraspinatus enthesis"],"prefix":"10.1016","volume":"214","author":[{"given":"Sydney","family":"Whittaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"De Bruyker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Hemanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix C.","family":"Deymier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0005","first-page":"e6","article-title":"Heart disease and stroke statistics\u20142013 update","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.bone.2026.118098_bb0010","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1302\/2058-5241.5.200006","article-title":"Shoulder biomechanics in normal and selected pathological conditions","volume":"5","author":"Goetti","year":"2020","journal-title":"EFORT Open Rev."},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0015","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jocd.2008.05.097","article-title":"Bone mineral density alterations in upper and lower extremities 12Months after stroke measured by peripheral quantitative computed tomography and DXA","volume":"11","author":"Lazoura","year":"2008","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.bone.2026.118098_bb0020","first-page":"93","article-title":"Irreparable rotator cuff tears: challenges and solutions","volume":"10","author":"Novi","year":"2018","journal-title":"Orthop. Res. Rev."},{"issue":"3","key":"10.1016\/j.bone.2026.118098_bb0025","doi-asserted-by":"crossref","first-page":"333","DOI":"10.32098\/mltj.03.2014.12","article-title":"The enthesis: a review of the tendon-to-bone insertion","volume":"4","author":"Apostolakos","year":"2014","journal-title":"Muscles Ligaments Tendons J."},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/oti.220","article-title":"Systematic literature review of treatment interventions for upper extremity hemiparesis following stroke","volume":"14","author":"Urton","year":"2007","journal-title":"Occup. Ther. Int."},{"issue":"14","key":"10.1016\/j.bone.2026.118098_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17144962","article-title":"Incidence, prevalence, and risk factors of hemiplegic shoulder pain: a systematic review","volume":"17","author":"Anwer","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0040","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S1095-6433(02)00138-1","article-title":"The skeletal attachment of tendons--tendon \u201centheses\u201d","volume":"133","author":"Benjamin","year":"2002","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1115\/1.1536660","article-title":"Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels","volume":"125","author":"Thomopoulos","year":"2003","journal-title":"J. Biomech. Eng."},{"issue":"10","key":"10.1016\/j.bone.2026.118098_bb0050","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.jbiomech.2005.05.021","article-title":"Collagen fiber orientation at the tendon to bone insertion and its influence on stress concentrations","volume":"39","author":"Thomopoulos","year":"2006","journal-title":"J. Biomech."},{"issue":"11","key":"10.1016\/j.bone.2026.118098_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048630","article-title":"Mineral distributions at the developing tendon enthesis","volume":"7","author":"Schwartz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.118098_bb0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.actbio.2018.10.024","article-title":"The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis","volume":"83","author":"Deymier","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bone.2026.118098_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2020.101079","article-title":"Rodent model of disuse-induced bone loss by hind limb injection with botulinum toxin a","volume":"7","author":"Brent","year":"2020","journal-title":"MethodsX"},{"issue":"22","key":"10.1016\/j.bone.2026.118098_bb0070","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJM199511303332201","article-title":"Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis","volume":"333","author":"Liberman Uri","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.bone.2026.118098_bb0075","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3345\/kjp.2017.60.12.403","article-title":"The effect of low-dose intravenous bisphosphonate treatment on osteoporosis in children with quadriplegic cerebral palsy","volume":"60","author":"Moon","year":"2017","journal-title":"Korean J. Pediatr."},{"issue":"7","key":"10.1016\/j.bone.2026.118098_bb0080","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s00198-012-2243-z","article-title":"Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight","volume":"24","author":"Leblanc","year":"2013","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bone.2026.118098_bb0085","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/10790268.2009.11760776","article-title":"Bisphosphonate use in acute and chronic spinal cord injury: a systematic review","volume":"32","author":"Bryson","year":"2009","journal-title":"J. Spinal Cord Med."},{"issue":"2","key":"10.1016\/j.bone.2026.118098_bb0090","article-title":"Long-term use of oral bisphosphonates and fracture risk in men with traumatic spinal cord injury","volume":"2","author":"Carbone","year":"2020","journal-title":"J. Phys. Med. Rehabil."},{"key":"10.1016\/j.bone.2026.118098_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116919","article-title":"Bisphosphonates-related tendinopathies and ligament disorders: cases analysis from the U.S. Food and Drug Administration adverse event reporting system","volume":"177","author":"Ji","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.bone.2026.118098_bb0100","article-title":"High-throughput, multi-image cryohistology of mineralized tissues","volume":"115","author":"Dyment","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bone.2026.118098_bb0105","article-title":"Biomechanical testing of murine tendons","volume":"152","author":"Kurtaliaj","year":"2019","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2013 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinformatics"},{"issue":"16","key":"10.1016\/j.bone.2026.118098_bb0115","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.18.00200","article-title":"Enthesis repair: challenges and opportunities for effective tendon-to-bone healing","volume":"100","author":"Derwin","year":"2018","journal-title":"J. Bone Joint Surg. Am."},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0120","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2106\/JBJS.H.00088","article-title":"Recovery potential after postnatal shoulder paralysis: an animal model of neonatal brachial plexus palsy","volume":"91","author":"Kim","year":"2009","journal-title":"JBJS"},{"issue":"9","key":"10.1016\/j.bone.2026.118098_bb0125","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1359\/jbmr.1999.14.9.1596","article-title":"Trabecular bone turnover and bone marrow cell development in tail-suspended mice","volume":"14","author":"Sakata","year":"1999","journal-title":"J. Bone Miner. Res."},{"issue":"10","key":"10.1016\/j.bone.2026.118098_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164599","article-title":"Cellular and matrix response of the mandibular condylar cartilage to botulinum toxin","volume":"11","author":"Dutra","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bone.2026.118098_bb0135","article-title":"Cortical and trabecular bone modeling and implications for bone functional adaptation in the mammalian tibia","volume":"11","author":"Barak","year":"2024","journal-title":"Bioengineering (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0140","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jbmr.5650060405","article-title":"The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats","volume":"6","author":"Seedor","year":"1991","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0145","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1210\/en.2013-1993","article-title":"Effect of bisphosphonates on the rapidly growing male murine skeleton","volume":"155","author":"Zhu","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/nyas.13572","article-title":"Bone quality changes associated with aging and disease: a review","volume":"1410","author":"Boskey","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bone.2026.118098_bb0155","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: relating their ages","volume":"152","author":"Dutta","year":"2016","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.bone.2026.118098_bb0160","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/jbmr.4643","article-title":"Similarities between disuse and age-induced bone loss","volume":"37","author":"Buettmann","year":"2022","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1359\/JBMR.041010","article-title":"Long-term disuse osteoporosis seems less sensitive to bisphosphonate treatment than other osteoporosis","volume":"20","author":"Li","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.bone.2026.118098_bb0170","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00774-015-0714-y","article-title":"Alendronate does not prevent long bone fragility in an inactive rat model","volume":"34","author":"Naruse","year":"2016","journal-title":"J. Bone Miner. Metab."},{"issue":"10","key":"10.1016\/j.bone.2026.118098_bb0175","first-page":"568","article-title":"Effects of alendronate on bone turnover markers in early postmenopausal women","volume":"61","author":"Yang","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joen.2014.07.010","article-title":"Effects of alendronate on osteoclast formation and activity in vitro","volume":"41","author":"Martins","year":"2015","journal-title":"J Endodont"},{"key":"10.1016\/j.bone.2026.118098_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115850","article-title":"Bisphosphonates impair the onset of bone formation at remodeling sites","volume":"145","author":"Jensen","year":"2021","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.bone.2026.118098_bb0190","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200713R","article-title":"Effects of hindlimb unloading and subsequent reloading on the structure and mechanical properties of Achilles tendon-to-bone attachment","volume":"36","author":"Camy","year":"2022","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bone.2026.118098_bb0195","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.knee.2015.03.004","article-title":"Influence of mechanical unloading on histological changes of the patellar tendon insertion in rabbits","volume":"22","author":"Mutsuzaki","year":"2015","journal-title":"Knee"},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0200","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/19476035221109229","article-title":"Anabolic response of intermittent parathyroid hormone and alendronate on the osteochondral tissue of TMJ","volume":"13","author":"Chen","year":"2022","journal-title":"Cartilage"},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0205","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1152\/japplphysiol.90699.2008","article-title":"Effect of chronic unloading and rehabilitation on human Achilles tendon properties: a velocity-encoded phase-contrast MRI study","volume":"105","author":"Shin","year":"2008","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.bone.2026.118098_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12891-019-3014-1","article-title":"In vitro effects of alendronate on fibroblasts of the human rotator cuff tendon","volume":"21","author":"Sung","year":"2020","journal-title":"BMC Musculoskelet. Disord."},{"issue":"48","key":"10.1016\/j.bone.2026.118098_bb0215","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi5584","article-title":"Toughening mechanisms for the attachment of architectured materials: the mechanics of the tendon enthesis","volume":"7","author":"Golman","year":"2021","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.bone.2026.118098_bb0220","doi-asserted-by":"crossref","first-page":"e777","DOI":"10.1016\/j.eats.2017.02.006","article-title":"Arthroscopic treatment of greater tuberosity avulsion fractures","volume":"6","author":"Godin","year":"2017","journal-title":"Arthrosc. Tech."},{"key":"10.1016\/j.bone.2026.118098_bb0225","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.actbio.2021.01.002","article-title":"Carbonate substitution significantly affects the structure and mechanics of carbonated apatites","volume":"122","author":"Wingender","year":"2021","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.bone.2026.118098_bb0230","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1177\/0022034510377791","article-title":"Aging and bone","volume":"89","author":"Boskey","year":"2010","journal-title":"J. Dent. Res."},{"issue":"73","key":"10.1016\/j.bone.2026.118098_bb0235","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1098\/rsif.2011.0880","article-title":"The nanometre-scale physiology of bone: steric modelling and scanning transmission electron microscopy of collagen-mineral structure","volume":"9","author":"Alexander","year":"2012","journal-title":"J. R. Soc. Interface"},{"issue":"6","key":"10.1016\/j.bone.2026.118098_bb0240","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/8756-3282(95)00370-3","article-title":"Aging and matrix microdamage accumulation in human compact bone","volume":"17","author":"Schaffler","year":"1995","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bone.2026.118098_bb0245","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1615\/CritRevBiomedEng.v34.i3.20","article-title":"Microdamage in bone: implications for fracture, repair, remodeling, and adaptation","volume":"34","author":"Donahue","year":"2006","journal-title":"Crit. Rev. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.bone.2026.118098_bb0250","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.nurpra.2015.01.011","article-title":"Bisphosphonates and atypical femoral fractures","volume":"11","author":"Corrarino","year":"2015","journal-title":"J. Nurse Pract."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226003248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226003248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:26:54Z","timestamp":1793132814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226003248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":50,"alternative-id":["S8756328226003248"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.118098","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alendronate alters mineral composition and has potential to restore enthesis strength without preventing trabecular bone loss during unloading of the supraspinatus enthesis","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.118098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118098"}}