{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:35:27Z","timestamp":1793133327128,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ26H140001"],"award-info":[{"award-number":["LZ26H140001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270991"],"award-info":[{"award-number":["82270991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571101"],"award-info":[{"award-number":["82571101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bone.2026.118102","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:06:41Z","timestamp":1790435201000},"page":"118102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ricolinostat restrains osteoclastogenesis through HDAC6-associated regulation of p65 stability"],"prefix":"10.1016","volume":"214","author":[{"given":"Jiang","family":"Haofu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wangzhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fangdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Jialiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Qingzhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Suxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yongkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shuomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu","family":"Junhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Mengjia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Xinyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yifan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Yixin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Shufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Shengbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bone.2026.118102_bb0005","doi-asserted-by":"crossref","first-page":"Itc17","DOI":"10.7326\/AITC201708010","article-title":"Osteoporosis","volume":"167","author":"Ensrud","year":"2017","journal-title":"Ann. Intern. Med."},{"issue":"Pt 7","key":"10.1016\/j.bone.2026.118102_bb0010","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1242\/jcs.063032","article-title":"Bone remodelling at a glance","volume":"124","author":"Crockett","year":"2011","journal-title":"J. Cell Sci."},{"issue":"33","key":"10.1016\/j.bone.2026.118102_bb0015","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.bone.2026.118102_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136651","article-title":"Osteoblast differentiation and signaling: established concepts and emerging topics","volume":"22","author":"Ponzetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bone.2026.118102_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.578194","article-title":"Dual effects of lipid metabolism on osteoblast function","volume":"11","author":"Alekos","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bone.2026.118102_bb0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.pathmechdis.3.121806.151431","article-title":"The osteoclast: friend or foe?","volume":"3","author":"Novack","year":"2008","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.bone.2026.118102_bb0035","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1021\/acs.jmedchem.5c03085","article-title":"A novel Nrf2 activator suppresses osteoclastogenesis and ovariectomy-induced bone loss by directly interfering Keap1-Nrf2 protein-protein interaction","volume":"69","author":"Huang","year":"2026","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bone.2026.118102_bb0040","article-title":"Synthetic novel flavonoids SZQ-4 suppress osteoclastogenesis and ameliorate osteoporosis via inhibiting reactive oxygen species and regulating SIRT3","volume":"15","author":"Zhou","year":"2026","journal-title":"Antioxidants (Basel)"},{"issue":"20","key":"10.1016\/j.bone.2026.118102_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207623","article-title":"Molecular mechanisms and emerging therapeutics for osteoporosis","volume":"21","author":"Noh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6937","key":"10.1016\/j.bone.2026.118102_bb0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bone.2026.118102_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/aps.2015.85","article-title":"Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-\u03baB and NFATc1 activation and DC-STAMP expression","volume":"37","author":"Zeng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.bone.2026.118102_bb0060","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202502681RR","article-title":"SZQ-3, a novel synthetic chromone-maleimide hybrid targeting NF-\u03baB, prevents postmenopausal osteoporosis by modulating mitochondrial function in bone cells","volume":"40","author":"Zhang","year":"2026","journal-title":"FASEB J."},{"issue":"10","key":"10.1016\/j.bone.2026.118102_bb0065","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13291","article-title":"Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK\/NF-\u03baB pathway","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"issue":"3","key":"10.1016\/j.bone.2026.118102_bb0070","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13781","article-title":"Ubiquitin-proteasome system in periodontitis: mechanisms and clinical implications","volume":"58","author":"Ma","year":"2025","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-10518-z","article-title":"HDAC6 regulates NF-\u03baB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression","volume":"12","author":"Barter","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bone.2026.118102_bb0080","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/pharmrev.123.001111","article-title":"Posttranslational modifications of \u03b1-synuclein, their therapeutic potential, and crosstalk in health and neurodegenerative diseases","volume":"76","author":"Hassanzadeh","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bone.2026.118102_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103259","article-title":"Protein modification and degradation in ferroptosis","volume":"75","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"issue":"18","key":"10.1016\/j.bone.2026.118102_bb0090","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1080\/07391102.2018.1557560","article-title":"Structural and energetic basis for the inhibitory selectivity of both catalytic domains of dimeric HDAC6","volume":"37","author":"Sixto-L\u00f3pez","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"50","key":"10.1016\/j.bone.2026.118102_bb0095","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1021\/bi101014s","article-title":"HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins","volume":"49","author":"Hard","year":"2010","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12903-018-0624-1","article-title":"HDAC6 regulates dental mesenchymal stem cells and osteoclast differentiation","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Oral Health"},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00262-023-03624-y","article-title":"HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block PD-L1 for colorectal cancer immunotherapy","volume":"73","author":"Wen","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"11","key":"10.1016\/j.bone.2026.118102_bb0110","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S1470-2045(16)30375-8","article-title":"Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial","volume":"17","author":"Yee","year":"2016","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.bone.2026.118102_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bone.2026.118102_bb0120","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.bone.2026.118102_bb0125","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20051150","article-title":"Autoamplification of NFATc1 expression determines its essential role in bone homeostasis","volume":"202","author":"Asagiri","year":"2005","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.bone.2026.118102_bb0130","first-page":"257","article-title":"Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer","volume":"4","author":"Zeleke","year":"2023","journal-title":"Nat. Can."},{"key":"10.1016\/j.bone.2026.118102_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.920683","article-title":"The crosstalk between MYC and mTORC1 during osteoclastogenesis","volume":"10","author":"Bae","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bone.2026.118102_bb0140","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bone.2026.118102_bb0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: a living systematic review and network meta-analysis for the American College of Physicians","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0150","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1038\/s41467-025-58188-5","article-title":"High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bone.2026.118102_bb0155","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tips.2022.03.014","article-title":"3D cell cultures toward quantitative high-throughput drug screening","volume":"43","author":"Wang","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.bone.2026.118102_bb0160","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1172\/JCI89935","article-title":"MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERR\u03b1","volume":"127","author":"Bae","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bone.2026.118102_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.05.014","article-title":"Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-\u03baB\/AP-1 signaling pathways in macrophages","volume":"97","author":"Youn","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0170","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.bone.2026.118102_bb0175","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.bone.2026.118102_bb0180","first-page":"344","article-title":"A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-\u03baB signaling","volume":"4","author":"Altea-Manzano","year":"2023","journal-title":"Nat. Can."},{"key":"10.1016\/j.bone.2026.118102_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101813","article-title":"Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-\u03baB and STAT3","volume":"38","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.bone.2026.118102_bb0190","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.7150\/thno.69444","article-title":"HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer","volume":"12","author":"Zhou","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bone.2026.118102_bb0195","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-018-1193-6","article-title":"Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-\u03baB pathway dependent of HDAC3","volume":"15","author":"Chen","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bone.2026.118102_bb0200","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41418-021-00862-4","article-title":"Ubiquitination of NF-\u03baB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance","volume":"29","author":"Ren","year":"2022","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.bone.2026.118102_bb0205","first-page":"L332","article-title":"Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung","volume":"317","author":"Menden","year":"2019","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"4","key":"10.1016\/j.bone.2026.118102_bb0210","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2567.2008.02806.x","article-title":"MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: involvement of nuclear factor-kappaB and activator protein-1","volume":"124","author":"Ortiz-Lazareno","year":"2008","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.bone.2026.118102_bb0215","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.bone.2026.118102_bb0220","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41419-018-0718-3","article-title":"RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products","volume":"9","author":"Mao","year":"2018","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.bone.2026.118102_bb0225","article-title":"Ferroptosis in osteocytes as a target for protection against postmenopausal osteoporosis","volume":"11","author":"Jiang","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.bone.2026.118102_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109357","article-title":"Ricolinostat (ACY-1215) inhibits VEGF expression via PI3K\/AKT pathway and promotes apoptosis in osteoarthritic osteoblasts","volume":"118","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."}],"container-title":["Bone"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226003285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S8756328226003285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:27:31Z","timestamp":1793132851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S8756328226003285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":46,"alternative-id":["S8756328226003285"],"URL":"https:\/\/doi.org\/10.1016\/j.bone.2026.118102","relation":{},"ISSN":["8756-3282"],"issn-type":[{"value":"8756-3282","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ricolinostat restrains osteoclastogenesis through HDAC6-associated regulation of p65 stability","name":"articletitle","label":"Article Title"},{"value":"Bone","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bone.2026.118102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118102"}}