{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:39:51Z","timestamp":1769877591414,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.bonr.2017.01.001","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T13:16:38Z","timestamp":1483794998000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis"],"prefix":"10.1016","volume":"6","author":[{"given":"Antonio","family":"Cabal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald S.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa Y.","family":"Jayakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swanand","family":"Sardesai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le T.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"43","key":"10.1016\/j.bonr.2017.01.001_bb0005","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1172\/JCI116872","article-title":"The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates","volume":"92","author":"Balena","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bonr.2017.01.001_bb0010","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1172\/JCI116872","article-title":"The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates","volume":"92","author":"Balena","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bonr.2017.01.001_bb0015","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","article-title":"Denosumab and bisphophonates: different mechanisms of action and effects","volume":"48","author":"Baron","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0020","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bone.2008.11.015","article-title":"The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties","volume":"44","author":"Bevill","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0025","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1359\/jbmr.091035","article-title":"Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density","volume":"25","author":"Bone","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bonr.2017.01.001_bb0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00198-014-2944-6","article-title":"Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial","volume":"26","author":"Bone","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2017.01.001_bb0035","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1517\/13543780902832661","article-title":"Cathepsin K inhibitors for osteoporosis and potential off-target effects","volume":"18","author":"Bromme","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"2","key":"10.1016\/j.bonr.2017.01.001_bb0040","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bone.2013.06.011","article-title":"High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate","volume":"56","author":"Cabal","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0045","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1359\/jbmr.2003.18.6.1125","article-title":"The Food and Drug Administration's osteoporosis guidance document: past, present, and future","volume":"18","author":"Colmna","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"1; 21","key":"10.1016\/j.bonr.2017.01.001_bb0050","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/jbmr.1477","article-title":"Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey","volume":"27","author":"Cusick","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/bonekey.2012.67","article-title":"Therapeutic inhibition of cathepsin K reducing bone resorption while maintaining bone formation","volume":"1","author":"Duong","year":"2012","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.bonr.2017.01.001_bb0060","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00223-015-0051-0","article-title":"Cathepsin K inhibition: a new mechanism for the treatment","volume":"98","author":"Duong","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2017.01.001_bb0065","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jbmr.212","article-title":"Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect","volume":"26","author":"Eisman","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0070","series-title":"Guidelines for preclinical and clinical evaluation of agents used in the prevention or treatment of postmenopausal osteoporosis","author":"FDA","year":"1994"},{"issue":"3","key":"10.1016\/j.bonr.2017.01.001_bb0075","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bmcl.2007.12.047","article-title":"The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K","volume":"18","author":"Gauthier","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5279","key":"10.1016\/j.bonr.2017.01.001_bb0080","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.273.5279.1236","article-title":"Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency","volume":"273","author":"Gelb","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bonr.2017.01.001_bb0085","series-title":"Chapter 10, Bone Mechanics Handbook","article-title":"Mechanical properties of cortical bone and cancellous bone tissue","author":"Guo","year":"2001"},{"key":"10.1016\/j.bonr.2017.01.001_bb0090","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.bone.2006.06.001","article-title":"A biomechanical perspective on bone quality","volume":"39","author":"Hernandez","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0095","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S8756-3282(02)00693-2","article-title":"Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level","volume":"30","author":"Homminga","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0100","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0021-9290(98)00110-9","article-title":"Human vertebral body apparent and hard tissue stiffness","volume":"31","author":"Hou","year":"1998","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.bonr.2017.01.001_bb0105","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1007\/s00198-011-1529-x","article-title":"Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys","volume":"22","author":"Jerome","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2017.01.001_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02509543","article-title":"Effects of low-dose long-term sodium fluoride preventive treatment on rat bone mass and biomechanical properties","volume":"58","author":"Jiang","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2017.01.001_bb0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02509543","article-title":"Effects of low-dose long-term sodium fluoride preventive treatment on rat bone mass and biomechanical properties","volume":"58","author":"Jiang","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2017.01.001_bb0120","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0021-9290(94)90053-1","article-title":"Trabecular bone exhibits fully linear elastic behavior and yields at low strains","volume":"27","author":"Keaveny","year":"1994","journal-title":"J. Biomech."},{"key":"10.1016\/j.bonr.2017.01.001_bb0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/jor.1100150115","article-title":"Systematic errors in compression testing of trabecular bone","volume":"15","author":"Keavery","year":"1997","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0130","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jor.1100160516","article-title":"Finite-element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus","volume":"16","author":"Ladd","year":"1998","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0135","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/jbmr.1695","article-title":"Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study","volume":"27","author":"Langdahl","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bonr.2017.01.001_bb0140","article-title":"Effect of odanacatib on bone density and estimated bone strength in postmenopausal women: a CT-based substudy of the phase 3 Long-Term Odanacatib Fracture Trial (LOFT)","volume":"30","author":"Langdahl","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.bonr.2017.01.001_bb0145","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/jbmr.1695","article-title":"Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study","volume":"27","author":"LangdahlB","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"2; 19","key":"10.1016\/j.bonr.2017.01.001_bb0150","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/jbmr.1475","article-title":"Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys","volume":"27","author":"Masarachia","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bonr.2017.01.001_bb0155","article-title":"Odanacatib anti-fracture efficacy and safety in postmenopausal women with osteoporosis. Results from the phase III Long-Term Odanacatib Fracture Trial (LOFT)","volume":"29","author":"McClung","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bonr.2017.01.001_bb0160","article-title":"Odanacatib efficacy and safety in postmenopausal women with osteoporosis: 5-year data from the extension of the phase 3 Long-Term Odanacatib Fracture Trial (LOFT)","volume":"31","author":"McClung","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S8756-3282(01)00491-4","article-title":"Understanding bone strength: size isn't everything","volume":"29","author":"Meulen","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0170","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0021-9290(01)00011-2","article-title":"Dependence of yield strain of human trabecular bone on anatomic site","volume":"34","author":"Morgan","year":"2001","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.bonr.2017.01.001_bb0175","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","author":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy","year":"2001","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.bonr.2017.01.001_bb0180","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.bone.2011.09.041","article-title":"Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism","volume":"49","author":"Ochi","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0185","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bone.2011.04.001","article-title":"Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys","volume":"49","author":"Ominsky","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2008.08.130","article-title":"Bone density, strength, and formation in adult cathepsin K (\u2212\/\u2212) mice","volume":"44","author":"Pennypacker","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0195","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jbmr.223","article-title":"Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits","volume":"26","author":"Pennypacker","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"8","key":"10.1016\/j.bonr.2017.01.001_bb0200","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/jbmr.2211","article-title":"Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys","volume":"29","author":"Pennypacker","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2017.01.001_bb0205","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJM199003223221203","article-title":"Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis","volume":"322","author":"Riggs","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bonr.2017.01.001_bb0210","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJM199003223221203","article-title":"Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis","volume":"322","author":"Riggs","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bonr.2017.01.001_bb0215","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/8756-3282(94)90815-X","article-title":"Marked decrease in trabecular bone quality after five years of sodium fluoride therapy: assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients","volume":"15","author":"Sogaard","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/8756-3282(94)90815-X","article-title":"Marked decrease in trabecular bone quality after five years of sodium fluoride therapy: assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patients","volume":"15","author":"Sogaard","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2017.01.001_bb0225","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2307\/2527654","article-title":"A multiple comparison rank sum test: treatments versus control","volume":"15","author":"Steel","year":"1959","journal-title":"Biometrics"},{"issue":"2","key":"10.1016\/j.bonr.2017.01.001_bb0230","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.bone.2013.06.008","article-title":"Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: a head-to-head comparison with alendronate","volume":"56","author":"Williams","year":"2013","journal-title":"Bone"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187217300013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187217300013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:17:21Z","timestamp":1762445841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187217300013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":46,"alternative-id":["S2352187217300013"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2017.01.001","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2017.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, N.J., U.S.A. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}