{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:42:23Z","timestamp":1790401343880,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bonr.2019.100215","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T02:27:39Z","timestamp":1563330459000},"page":"100215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Aging-associated microstructural deterioration of vertebra in zebrafish"],"prefix":"10.1016","volume":"11","author":[{"given":"Yasuyuki","family":"Monma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-8262","authenticated-orcid":false,"given":"Yasuhito","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bonr.2019.100215_bb0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/dvdy.10387","article-title":"Developmental morphology of the axial skeleton of the zebrafish, Danio rerio (Ostariophysi: Cyprinidae)","volume":"228","author":"Bird","year":"2003","journal-title":"Dev. Dyn."},{"issue":"11","key":"10.1016\/j.bonr.2019.100215_bb0010","first-page":"1201","article-title":"Measurement of bone mineral content in vivo using photon absorptiometry","volume":"111","author":"Boyd","year":"1974","journal-title":"Can. Med. Assoc. J."},{"issue":"2","key":"10.1016\/j.bonr.2019.100215_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000048929","article-title":"Age-related bone loss: old bone, new facts","volume":"48","author":"Chan","year":"2002","journal-title":"Gerontology"},{"issue":"2013","key":"10.1016\/j.bonr.2019.100215_bb0020","article-title":"Age-related changes in trabecular and cortical bone microstructure","author":"Chen","year":"2013","journal-title":"Int. J. Endocrinol."},{"issue":"11","key":"10.1016\/j.bonr.2019.100215_bb0025","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00198-008-0601-7","article-title":"Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae","volume":"19","author":"Cui","year":"2008","journal-title":"Osteoporos. Int."},{"issue":"8\u20139","key":"10.1016\/j.bonr.2019.100215_bb0030","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0531-5565(02)00088-8","article-title":"Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio)","volume":"37","author":"Gerhard","year":"2002","journal-title":"Exp. Gerontol."},{"issue":"4","key":"10.1016\/j.bonr.2019.100215_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0021-9290(94)90014-0","article-title":"The relationship between the structural and orthogonal compressive properties of trabecular bone","volume":"27","author":"Goulet","year":"1994","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1743-7075-9-73","article-title":"Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish","volume":"9","author":"Hasumura","year":"2012","journal-title":"Nutr. Metab. (Lond.)"},{"issue":"9","key":"10.1016\/j.bonr.2019.100215_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075787","article-title":"Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis","volume":"8","author":"Hayes","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","article-title":"A new method for the model-independent assessment of thickness in three-dimensional images","volume":"185","author":"Hildebrand","year":"1997","journal-title":"J. Microsc."},{"key":"10.1016\/j.bonr.2019.100215_bb0055","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0091-679X(04)76018-5","article-title":"Development of cartilage and bone","volume":"76","author":"Javidan","year":"2004","journal-title":"Methods Cell Biol."},{"issue":"4","key":"10.1016\/j.bonr.2019.100215_bb0060","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S8756-3282(03)00212-6","article-title":"Effects of endurance exercise on three-dimensional trabecular bone microarchitecture in young growing rats","volume":"33","author":"Joo","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2019.100215_bb0065","first-page":"29","article-title":"Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities","volume":"13","author":"Laiz\u00e9","year":"2014","journal-title":"Drug Discov. Today"},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/ndt\/gfs333","article-title":"High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease","volume":"28","author":"Lau","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1359\/jbmr.2000.15.1.13","article-title":"Trabecular bone microarchitecture, bone mineral density, and vertebral fractures in male osteoporosis","volume":"15","author":"Legrand","year":"2000","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bonr.2019.100215_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2007080854","article-title":"Mechanisms of vascular calcification in chronic kidney disease","volume":"19","author":"Moe","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.bonr.2019.100215_bb0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00223-005-0043-6","article-title":"Differences in osteocyte density and bone histomorphometry between men and women and between healthy and osteoporotic subjects","volume":"77","author":"Mullender","year":"2005","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2485\/jhtb.23.1","article-title":"A new osteoporosis prevention supplements-diet improve bone mineral density in ovariectomized rats on micro-CT","volume":"23","author":"Nakada","year":"2014","journal-title":"J. Hard Tissue Biol."},{"issue":"11","key":"10.1016\/j.bonr.2019.100215_bb0095","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1371\/journal.pgen.0030199","article-title":"Lessons from \u201clower\u201d organisms: what worms, flies, and zebrafish can teach us about human energy metabolism","volume":"3","author":"Schlegel","year":"2007","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.bonr.2019.100215_bb0100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00004424-200005000-00007","article-title":"A physical model for dual-energy X-ray absorptiometry\u2013derived bone mineral density","volume":"35","author":"Sievanen","year":"2000","journal-title":"Investig. Radiol."},{"issue":"2","key":"10.1016\/j.bonr.2019.100215_bb0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1439-0426.2010.01409.x","article-title":"Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging","volume":"26","author":"Spoorendonk","year":"2010","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.bonr.2019.100215_bb0110","first-page":"45","article-title":"The zebrafish operculum: a powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance","volume":"197","author":"Tarasco","year":"2017","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S8756-3282(02)00801-3","article-title":"Age-related differences between thinning of horizontal and vertical trabeculae in human lumbar bone as assessed by a new computerized method","volume":"31","author":"Thomsen","year":"2002","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.bonr.2019.100215_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/8756-3282(90)90208-G","article-title":"Star volume of marrow space and trabeculae in iliac crest: sampling procedure and correlation to star volume of first lumbar vertebra","volume":"11","author":"Vesterby","year":"1990","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.bonr.2019.100215_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/8756-3282(89)90140-3","article-title":"Star volume of marrow space and trabeculae of the first lumbar vertebra: sampling efficiency and biological variation","volume":"10","author":"Vesterby","year":"1989","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.bonr.2019.100215_bb0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/zeb.2011.0726","article-title":"A novel protocol for the oral administration of test chemicals to adult zebrafish","volume":"8","author":"Zang","year":"2011","journal-title":"Zebrafish"},{"issue":"9727","key":"10.1016\/j.bonr.2019.100215_bb0135","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","article-title":"Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study","volume":"375","author":"Zebaze","year":"2010","journal-title":"Lancet"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235218721930021X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235218721930021X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:19:43Z","timestamp":1762445983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235218721930021X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":27,"alternative-id":["S235218721930021X"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2019.100215","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging-associated microstructural deterioration of vertebra in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2019.100215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100215"}}