{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:19:32Z","timestamp":1768450772153,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bonr.2020.100299","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T19:19:16Z","timestamp":1595099956000},"page":"100299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["GNAS mutated thyroid carcinoma in a patient with Mc Cune Albright syndrome"],"prefix":"10.1016","volume":"13","author":[{"given":"M.A.","family":"Legrand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Raverot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nicolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chapurlat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2020.100299_bb0005","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1210\/jc.2001-012022","article-title":"Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome","volume":"87","author":"Akintoye","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0010","doi-asserted-by":"crossref","first-page":"E314","DOI":"10.1210\/jc.2012-3551","article-title":"Virilizing sclerosing-stromal tumor of the ovary in a young woman with McCune Albright syndrome: clinical, pathological, and immunohistochemical studies","volume":"98","author":"Boussa\u00efd","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0015","doi-asserted-by":"crossref","first-page":"E1782","DOI":"10.1210\/jc.2012-1791","article-title":"Characterization and management of testicular pathology in McCune-Albright syndrome","volume":"97","author":"Boyce","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0020","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/jc.2009-2321","article-title":"Cushing syndrome in the McCune-Albright syndrome","volume":"95","author":"Brown","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0025","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1210\/jc.2007-2237","article-title":"The role of type 1 and type 2 5\u2032-deiodinase in the pathophysiology of the 3,5,3\u2032-triiodothyronine toxicosis of McCune-Albright syndrome","volume":"93","author":"Celi","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0030","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1016\/j.jpag.2015.04.001","article-title":"Postpubertal persistent hyperestrogenemia in McCune-Albright syndrome: unilateral oophorectomy improved fertility but detected an unexpected borderline epithelial ovarian tumor","volume":"28","author":"Chevalier","year":"2015","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"10.1016\/j.bonr.2020.100299_bb0035","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1210\/jc.2002-021642","article-title":"Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations","volume":"88","author":"Collins","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 1","key":"10.1016\/j.bonr.2020.100299_bb0040","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1750-1172-7-S1-S4","article-title":"McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia","volume":"7","author":"Collins","year":"2012","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.bonr.2020.100299_bb0045","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0026-895X(25)14307-1","article-title":"Alteration in cyclic AMP-dependent protein kinases and polyamine biosynthetic enzymes during hypertrophy and hyperplasia of the thyroid in the rat","volume":"23","author":"Combest","year":"1983","journal-title":"Mol. Pharmacol."},{"issue":"Suppl. 4","key":"10.1016\/j.bonr.2020.100299_bb0050","first-page":"429","article-title":"Thyroid disease in patients with McCune-Albright syndrome","volume":"4","author":"Congedo","year":"2007","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.bonr.2020.100299_bb0055","first-page":"1166","article-title":"Atypical McCune-Albright syndrome associated with growth hormone-prolactin pituitary adenoma: natural history, long-term follow-up, and SMS 201-995\u2013bromocriptine combined treatment results","volume":"75","author":"Cremonini","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0060","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1210\/jcem-71-6-1596","article-title":"Thyroid abnormalities in the McCune-Albright syndrome: ultrasonography and hormonal studies","volume":"71","author":"Feuillan","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0065","first-page":"2074","article-title":"Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors","volume":"83","author":"Fragoso","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11102-007-0058-2","article-title":"Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-I criteria for remission","volume":"10","author":"Freda","year":"2007","journal-title":"Pituitary."},{"key":"10.1016\/j.bonr.2020.100299_bb0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/srep00161","article-title":"Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2020.100299_bb0080","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1210\/jc.2013-1823","article-title":"Hepatobiliary and pancreatic neoplasms in patients with McCune-Albright syndrome","volume":"99","author":"Gaujoux","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0085","doi-asserted-by":"crossref","first-page":"e18102","DOI":"10.1097\/MD.0000000000018102","article-title":"McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation - a case report","volume":"98","author":"Gaujoux","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bonr.2020.100299_bb0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1055\/s-2003-40597","article-title":"Osteosarcoma of the skull base after radiation therapy in a patient with McCune-Albright syndrome: case report","volume":"13","author":"Hansen","year":"2003","journal-title":"Skull Base."},{"key":"10.1016\/j.bonr.2020.100299_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13023-019-1102-9","article-title":"Best practice management guidelines for fibrous dysplasia\/McCune-Albright syndrome: a consensus statement from the FD\/MAS international consortium","volume":"14","author":"Javaid","year":"2019","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.bonr.2020.100299_bb0100","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2012-302823","article-title":"Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts","volume":"62","author":"Kanda","year":"2013","journal-title":"Gut."},{"key":"10.1016\/j.bonr.2020.100299_bb0105","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Endocrine Society, acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0110","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/340692a0","article-title":"GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours","volume":"340","author":"Landis","year":"1989","journal-title":"Nature."},{"key":"10.1016\/j.bonr.2020.100299_bb0115","article-title":"Follicular thyroid carcinoma with NRAS Q61K and GNAS R201H mutations that had a good 131I treatment response","volume":"2016","author":"Lu","year":"2016","journal-title":"Endocrinol Diabetes Metab Case Rep."},{"key":"10.1016\/j.bonr.2020.100299_bb0120","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.2116665","article-title":"Two G protein oncogenes in human endocrine tumors","volume":"249","author":"Lyons","year":"1990","journal-title":"Science."},{"key":"10.1016\/j.bonr.2020.100299_bb0125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jbmr.3286","article-title":"Increased risk of breast cancer at a young age in women with fibrous dysplasia","volume":"33","author":"Majoor","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2020.100299_bb0130","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/thy.1997.7.433","article-title":"Hyperthyroidism in McCune-Albright syndrome with a review of thyroid abnormalities sixty years after the first report","volume":"7","author":"Mastorakos","year":"1997","journal-title":"Thyroid."},{"key":"10.1016\/j.bonr.2020.100299_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.1986.tb00555.x","article-title":"Osteosarcoma in irradiated fibrous dysplasia","volume":"15","author":"Mock","year":"1986","journal-title":"J. Oral Pathol."},{"key":"10.1016\/j.bonr.2020.100299_bb0140","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jhep.2011.07.018","article-title":"GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation","volume":"56","author":"Nault","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bonr.2020.100299_bb0145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/mc.2940040503","article-title":"Activating point mutations of the gsp oncogene in human thyroid adenomas","volume":"4","author":"O\u2019Sullivan","year":"1991","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bonr.2020.100299_bb0150","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/EJE-08-0313","article-title":"Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain","volume":"159","author":"Palos-Paz","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bonr.2020.100299_bb0155","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jamasurg.2014.535","article-title":"Lessons from McCune-Albright syndrome-associated intraductal papillary mucinous neoplasms: : GNAS-activating mutations in pancreatic carcinogenesis","volume":"149","author":"Parvanescu","year":"2014","journal-title":"JAMA Surg."},{"key":"10.1016\/j.bonr.2020.100299_bb0160","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/mp.55.1.58","article-title":"An R201H activating mutation of the GNAS1 (Gsalpha) gene in a corticotroph pituitary adenoma, MP","volume":"55","author":"Riminucci","year":"2002","journal-title":"Mol. Pathol."},{"key":"10.1016\/j.bonr.2020.100299_bb0165","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1210\/jc.2018-01022","article-title":"Clinical and radiographic gastrointestinal abnormalities in McCune-Albright syndrome","volume":"103","author":"Robinson","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0170","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/1097-0142(19940301)73:5<1411::AID-CNCR2820730516>3.0.CO;2-T","article-title":"Malignancies in fibrous dysplasia","volume":"73","author":"Ruggieri","year":"1994","journal-title":"Cancer."},{"key":"10.1016\/j.bonr.2020.100299_bb0175","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1590\/S0004-27302008000300017","article-title":"Hyperthyroidism related to McCune-Albright syndrome: report of two cases and review of the literature","volume":"52","author":"Sallum","year":"2008","journal-title":"Arq Bras Endocrinol Metabol."},{"key":"10.1016\/j.bonr.2020.100299_bb0180","first-page":"6","article-title":"Breast carcinoma in a 11-year-old girl with Albright\u2019s syndrome","volume":"6","author":"Scanlon","year":"1980","journal-title":"Breast."},{"key":"10.1016\/j.bonr.2020.100299_bb0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF02966691","article-title":"Breast cancer in a patient with McCune-Albright syndrome","volume":"5","author":"Tanabeu","year":"1998","journal-title":"Breast Cancer"},{"key":"10.1016\/j.bonr.2020.100299_bb0190","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000342641","article-title":"Thyroid abnormalities in children and adolescents with McCune-Albright syndrome","volume":"78","author":"Tessaris","year":"2012","journal-title":"Horm Res Paediatr."},{"key":"10.1016\/j.bonr.2020.100299_bb0195","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1210\/jc.2012-1274","article-title":"Somatic GNAS mutation causes widespread and diffuse pituitary disease in acromegalic patients with McCune-Albright syndrome","volume":"97","author":"Vortmeyer","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100299_bb0200","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM199112123252403","article-title":"Activating mutations of the stimulatory G protein in the McCune-Albright syndrome","volume":"325","author":"Weinstein","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bonr.2020.100299_bb0205","doi-asserted-by":"crossref","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","volume":"3","author":"Wu","year":"2011","journal-title":"Sci Transl Med."},{"key":"10.1016\/j.bonr.2020.100299_bb0210","first-page":"969","article-title":"Lipid-rich follicular carcinoma of the thyroid in a patient with McCune-Albright syndrome","volume":"12","author":"Yang","year":"1999","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bonr.2020.100299_bb0215","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/1097-0142(19930815)72:4<1386::AID-CNCR2820720439>3.0.CO;2-J","article-title":"Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis","volume":"72","author":"Yoshimoto","year":"1993","journal-title":"Cancer"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187220300590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187220300590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:21:38Z","timestamp":1762446098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187220300590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":43,"alternative-id":["S2352187220300590"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2020.100299","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GNAS mutated thyroid carcinoma in a patient with Mc Cune Albright syndrome","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2020.100299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100299"}}