{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:41:33Z","timestamp":1777614093789,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17H04409"],"award-info":[{"award-number":["17H04409"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bonr.2020.100713","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T01:44:46Z","timestamp":1598751886000},"page":"100713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Bone phenotype in melanocortin 2 receptor-deficient mice"],"prefix":"10.1016","volume":"13","author":[{"given":"Tsuyoshi","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiko","family":"Usui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Kokabu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Sugamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Chida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0005","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1742-1241.2006.01276.x","article-title":"Relation of cortisol levels and bone mineral density among premenopausal women with major depression","volume":"61","author":"Altindag","year":"2007","journal-title":"Int. J. Clin. Pract."},{"issue":"5","key":"10.1016\/j.bonr.2020.100713_bb0010","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1210\/endo.137.5.8612546","article-title":"Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line","volume":"137","author":"Boston","year":"1996","journal-title":"Endocrinology."},{"issue":"5","key":"10.1016\/j.bonr.2020.100713_bb0015","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2174\/1389203717666160226145330","article-title":"The melanocortin receptor system: a target for multiple degenerative diseases","volume":"17","author":"Cai","year":"2016","journal-title":"Curr. Protein Pept. Sci."},{"issue":"46","key":"10.1016\/j.bonr.2020.100713_bb0020","doi-asserted-by":"crossref","first-page":"18205","DOI":"10.1073\/pnas.0706953104","article-title":"Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis","volume":"104","author":"Chida","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u20132","key":"10.1016\/j.bonr.2020.100713_bb0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2008.10.027","article-title":"Characterization of mice deficient in melanocortin 2 receptor on a B6\/Balbc mix background","volume":"300","author":"Chida","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.bonr.2020.100713_bb0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.tem.2009.05.003","article-title":"Depression as a risk factor for osteoporosis","volume":"20","author":"Cizza","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2020.100713_bb0035","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1749-6632.1993.tb19694.x","article-title":"Cloning and functional characterization of a family of receptors for the melanotropic peptides","volume":"680","author":"Cone","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.bonr.2020.100713_bb0040","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF02555891","article-title":"Progressive cancellous bone loss in rats after adrenalectomy and oophorectomy","volume":"47","author":"Durbridge","year":"1990","journal-title":"Calcif. Tissue Int."},{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0045","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/me.2004-0212","article-title":"11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation","volume":"19","author":"Eijken","year":"2005","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bonr.2020.100713_bb0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2265.2000.01122.x","article-title":"Tall stature in familial glucocorticoid deficiency","volume":"53","author":"Elias","year":"2000","journal-title":"Clin. Endocrinol."},{"issue":"21","key":"10.1016\/j.bonr.2020.100713_bb0055","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/archinte.167.21.2329","article-title":"Low bone mass in premenopausal women with depression","volume":"167","author":"Eskandari","year":"2007","journal-title":"Arch. Intern. Med."},{"issue":"1","key":"10.1016\/j.bonr.2020.100713_bb0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/0300060517725660","article-title":"Effect of hypercortisolism on bone mineral density and bone metabolism: a potential protective effect of adrenocorticotropic hormone in patients with Cushing\u2019s disease","volume":"46","author":"Guo","year":"2018","journal-title":"J Int Med Res."},{"issue":"10","key":"10.1016\/j.bonr.2020.100713_bb0065","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1210\/me.2009-0069","article-title":"Minireview: live and let die: molecular effects of glucocorticoids on bone cells","volume":"23","author":"Hofbauer","year":"2009","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.bonr.2020.100713_bb0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1620\/tjem.205.123","article-title":"Possible relationship between elevated plasma ACTH and tall stature in familial glucocorticoid deficiency","volume":"205","author":"Imamine","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bonr.2020.100713_bb0075","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1210\/en.2003-1427","article-title":"Mice deficient in 11beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation","volume":"145","author":"Justesen","year":"2004","journal-title":"Endocrinology."},{"issue":"5","key":"10.1016\/j.bonr.2020.100713_bb0080","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/01.psy.0000237858.76880.3d","article-title":"Bone mineral density, bone turnover, and osteoprotegerin in depressed women with and without borderline personality disorder","volume":"68","author":"Kahl","year":"2006","journal-title":"Psychosom. Med."},{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030217","article-title":"Cytoplasmic interactions between the glucocorticoid receptor and HDAC2 regulate osteocalcin expression in VPA-treated MSCs","volume":"8","author":"La Noce","year":"2019","journal-title":"Cells."},{"issue":"2","key":"10.1016\/j.bonr.2020.100713_bb0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/8756-3282(96)00170-6","article-title":"Skeletal response to corticosteroid deficiency and excess in growing male rats","volume":"19","author":"Li","year":"1996","journal-title":"Bone."},{"issue":"6","key":"10.1016\/j.bonr.2020.100713_bb0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tcb.2006.04.005","article-title":"Glucocorticoid receptor isoforms generate transcription specificity","volume":"16","author":"Lu","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bonr.2020.100713_bb0100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jsbmb.2019.02.012","article-title":"Isolated glucocorticoid deficiency: genetic causes and animal models","volume":"189","author":"Maharaj","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.bonr.2020.100713_bb0105","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2003-0990","article-title":"Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength","volume":"145","author":"O'Brien","year":"2004","journal-title":"Endocrinology."},{"issue":"5 Pt 2","key":"10.1016\/j.bonr.2020.100713_bb0110","first-page":"R828","article-title":"Circulating osteocalcin in rats is inversely responsive to changes in corticosterone","volume":"254","author":"Patterson-Buckendahl","year":"1988","journal-title":"Am. J. Phys."},{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0115","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bone.2007.11.010","article-title":"Low bone mineral density and high bone metabolism turnover in premenopausal women with unipolar depression","volume":"42","author":"Petronijevi\u0107","year":"2008","journal-title":"Bone."},{"issue":"6","key":"10.1016\/j.bonr.2020.100713_bb0120","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2010.05.005","article-title":"Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor","volume":"11","author":"Rauch","year":"2010","journal-title":"Cell Metab."},{"issue":"22","key":"10.1016\/j.bonr.2020.100713_bb0125","doi-asserted-by":"crossref","first-page":"21369","DOI":"10.1074\/jbc.M500346200","article-title":"Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone","volume":"280","author":"Sakamoto","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bonr.2020.100713_bb0130","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1172\/JCI110570","article-title":"Differential effects of endocrine dysfunction on the axial and the appendicular skeleton","volume":"69","author":"Seeman","year":"1982","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bonr.2020.100713_bb0135","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1210\/en.2003-0655","article-title":"Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone","volume":"145","author":"Sher","year":"2004","journal-title":"Endocrinology."},{"issue":"2","key":"10.1016\/j.bonr.2020.100713_bb0140","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00223-005-0297-z","article-title":"Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling","volume":"79","author":"Sher","year":"2006","journal-title":"Calcif. Tissue Int."},{"issue":"1\u20136","key":"10.1016\/j.bonr.2020.100713_bb0145","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0960-0760(99)00072-2","article-title":"Cortisol as a mineralocorticoid in human disease","volume":"69","author":"Stewart","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"9","key":"10.1016\/j.bonr.2020.100713_bb0150","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/labinvest.2017.62","article-title":"Adrenocorticotropic hormone and 1,25-dihydroxyvitamin D(3) enhance human osteogenesis in vitro by synergistically accelerating the expression of bone-specific genes","volume":"97","author":"Tourkova","year":"2017","journal-title":"Lab. Investig."},{"issue":"6","key":"10.1016\/j.bonr.2020.100713_bb0155","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00198-018-4420-1","article-title":"Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies","volume":"29","author":"Wu","year":"2018","journal-title":"Osteoporos. Int."},{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0160","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bone.2010.06.002","article-title":"Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation","volume":"47","author":"Yang","year":"2010","journal-title":"Bone."},{"issue":"3","key":"10.1016\/j.bonr.2020.100713_bb0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0165-1781(03)00017-9","article-title":"Bone mineral density in premenopausal women with major depressive disorder","volume":"117","author":"Yazici","year":"2003","journal-title":"Psychiatry Res."},{"issue":"19","key":"10.1016\/j.bonr.2020.100713_bb0170","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1073\/pnas.0912176107","article-title":"ACTH protects against glucocorticoid-induced osteonecrosis of bone","volume":"107","author":"Zaidi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bonr.2020.100713_bb0175","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bone.2005.01.020","article-title":"Multiple melanocortin receptors are expressed in bone cells","volume":"36","author":"Zhong","year":"2005","journal-title":"Bone."}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187220304733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187220304733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:21:12Z","timestamp":1762446072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187220304733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":35,"alternative-id":["S2352187220304733"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2020.100713","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone phenotype in melanocortin 2 receptor-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2020.100713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100713"}}