{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:32:11Z","timestamp":1762446731425,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bonr.2022.101600","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T03:41:14Z","timestamp":1656646874000},"page":"101600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Identification of bone metabolism disorders in patients with Alstr\u00f6m and Bardet-Biedl syndromes based on markers of bone turnover and mandibular atrophy"],"prefix":"10.1016","volume":"17","author":[{"given":"Krzysztof","family":"Jeziorny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Zmyslowska-Polakowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Wyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Pyziak-Skupie\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Borowiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Szadkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-4469","authenticated-orcid":false,"given":"Agnieszka","family":"Zmys\u0142owska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2022.101600_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2017.00055","article-title":"Bardet-biedl syndrome as a chaperonopathy: dissecting the major role of chaperonin-like BBS proteins (BBS6-BBS10-BBS12)","volume":"4","author":"\u00c1lvarez-Satta","year":"2017","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bonr.2022.101600_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2010.10.001","article-title":"Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects","author":"Ashley","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.bonr.2022.101600_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2015.09.009","article-title":"Serum osteocalcin in subjects with metabolic syndrome and central obesity","author":"Bador","year":"2016","journal-title":"Diabetes metab. Syndr. ClinRes. Rev."},{"key":"10.1016\/j.bonr.2022.101600_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2018.04.013","article-title":"BBS9 gene in nonsyndromic craniosynostosis: role of the primary cilium in the aberrant ossification of the suture osteogenic niche","author":"Barba","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101600_bb0025","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/jmg.36.6.437","article-title":"New criteria for improved diagnosis of bardet-biedl syndrome: results of a population survey","volume":"36","author":"Beales","year":"1999","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bonr.2022.101600_bb0030","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar2165","article-title":"Biology of RANK, RANKL, and osteoprotegerin","volume":"9","author":"Boyce","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2022.101600_bb0035","doi-asserted-by":"crossref","DOI":"10.1259\/dmfr\/79749065","article-title":"Osteoporosis and mandibles","author":"Bo\u017ei\u010d","year":"2006","journal-title":"Dentomaxillofac. Radiol."},{"key":"10.1016\/j.bonr.2022.101600_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/S0168-8227(98)00025-4","article-title":"Changes in bone turnover on deoxypyridinoline levels in diabetic patients","author":"\u00c7akatay","year":"1998","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bonr.2022.101600_bb0045","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"Cole","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.bonr.2022.101600_bb0050","article-title":"Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis","author":"Delmas","year":"1991","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101600_bb0055","doi-asserted-by":"crossref","DOI":"10.3889\/oamjms.2015.092","article-title":"Bone density, osteocalcin and deoxypyridinoline for early detection of osteoporosis in obese children","author":"El-Dorry","year":"2015","journal-title":"Maced. J. Med. Sci."},{"key":"10.1016\/j.bonr.2022.101600_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00200","article-title":"The bones of children with obesity","author":"Fintini","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bonr.2022.101600_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ejhg.2012.115","article-title":"Bardet-biedl syndrome","volume":"21","author":"Forsythe","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.bonr.2022.101600_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2018.00023","article-title":"Managing Bardet-Biedl syndrome\u2014now and in the future","volume":"6","author":"Forsythe","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bonr.2022.101600_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2265.2006.02522.x","article-title":"Circulating osteoprotegerin is correlated with lipid profile, insulin sensitivity, adiponectin and sex steroids in an ageing male population","author":"Gannag\u00e9-Yared","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.bonr.2022.101600_bb0080","doi-asserted-by":"crossref","DOI":"10.1530\/EJE-07-0797","article-title":"Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study","author":"Gannag\u00e9-Yared","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bonr.2022.101600_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2010.09.014","article-title":"Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice","author":"Halade","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bonr.2022.101600_bb0090","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1210\/jc.2018-00496","article-title":"Comprehensive endocrine-metabolic evaluation of patients with Alstr\u00f6m syndrome compared with BMI-matched controls","volume":"103","author":"Han","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2022.101600_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/oby.2007.229","article-title":"The influence of weight loss on serum osteoprotegerin concentration in obese perimenopausal women","author":"Holecki","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.bonr.2022.101600_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.600181","article-title":"Obesity and bone health: a complex link","author":"Hou","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101600_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/genes11111283","article-title":"Next-generation sequencing in the diagnosis of patients with Bardet\u2013Biedl syndrome\u2014new variants and relationship with hyperglycemia and insulin resistance","author":"Jeziorny","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bonr.2022.101600_bb0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11914-017-0351-6","article-title":"Functional diversity of ciliary proteins in bone development and disease","volume":"15","author":"Kaku","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2022.101600_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2006.07.025","article-title":"Accuracy in osteoporosis diagnosis of a combination of mandibular cortical width measurement on dental panoramic radiographs and a clinical risk index (OSIRIS): the OSTEODENT project","author":"Karayianni","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101600_bb0120","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1126\/science.1063525","article-title":"Triallelic inheritance in Bardet-Biedl Syndrome, a Mendelian recessive disorder","volume":"293","author":"Katsanis","year":"2001","journal-title":"Science (80-. )"},{"key":"10.1016\/j.bonr.2022.101600_bb0125","article-title":"Reduced serum total osteocalcin is associated with central obesity in Korean children","author":"Kim","year":"2014","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.bonr.2022.101600_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/sj.dmfr.4600203","article-title":"Morphology of the mandibular cortex on panoramic radiographs as an indicator of bone quality","author":"Klemetti","year":"1997","journal-title":"Dentomaxillofacial Radiol."},{"key":"10.1016\/j.bonr.2022.101600_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/sj\/dmfr\/4600435","article-title":"Radiomorphometric indices of the mandible in a british female population","author":"Ledgerton","year":"1999","journal-title":"Dentomaxillofacial Radiol."},{"key":"10.1016\/j.bonr.2022.101600_bb0140","doi-asserted-by":"crossref","DOI":"10.1515\/cclm-2015-0953","article-title":"Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases","author":"Magni","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bonr.2022.101600_bb0145","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.12.2011.5320","article-title":"Oro-dental findings in bardet-biedl syndrome","author":"Majumdar","year":"2012","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bonr.2022.101600_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/138920211795677912","article-title":"Alstrom syndrome: genetics and clinical overview","volume":"12","author":"Marshall","year":"2011","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.bonr.2022.101600_bb0155","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/humu.22796","article-title":"Alstr\u00f6m syndrome: mutation spectrum of ALMS1","volume":"36","author":"Marshall","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bonr.2022.101600_bb0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jnutbio.2018.06.006","article-title":"High-fat diet disrupts bone remodeling by inducing local and systemic alterations","volume":"59","author":"Montalvany-Antonucci","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bonr.2022.101600_bb0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.archoralbio.2017.11.013","article-title":"High-refined carbohydrate diet promotes detrimental effects on alveolar bone and femur microarchitecture","volume":"86","author":"Montalvany-Antonucci","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bonr.2022.101600_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/0022-3913(89)90137-6","article-title":"Skeletal osteopenia and residual ridge resorption","author":"Ortman","year":"1989","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.bonr.2022.101600_bb0175","first-page":"177","article-title":"Assessment of bone metabolism in obese women","volume":"32","author":"Ostrowska","year":"1998","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.bonr.2022.101600_bb0180","doi-asserted-by":"crossref","first-page":"438","DOI":"10.5603\/EP.2014.0061","article-title":"Selected adipose tissue hormones, bone metabolism, osteoprotegerin and receptor activator of nuclear factor-kB ligand in postmenopausal obese women","volume":"65","author":"Ostrowska","year":"2015","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.bonr.2022.101600_bb0185","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1177\/0022034517716913","article-title":"Oral and craniofacial anomalies of Bardet-Biedl syndrome: dental management in the context of a rare disease","volume":"96","author":"Panny","year":"2017","journal-title":"J. Dent. Res."},{"author":"Prevalence and incidence of rare diseases: Bibliographic data","key":"10.1016\/j.bonr.2022.101600_bb0190"},{"key":"10.1016\/j.bonr.2022.101600_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/ijo.2009.282","article-title":"A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss","author":"Reinehr","year":"2010","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bonr.2022.101600_bb0200","first-page":"97","article-title":"Biochemical markers of bone turnover: part I: biochemistry and variability","volume":"26","author":"Seibel","year":"2005","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.bonr.2022.101600_bb0205","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-015-9954-z","article-title":"High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment","author":"Shu","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101600_bb0210","doi-asserted-by":"crossref","DOI":"10.1007\/s00198-014-2676-7","article-title":"Biochemical markers of bone turnover in diabetes patients - a meta-analysis, and a methodological study on the effects of glucose on bone markers","author":"Starup-Linde","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2022.101600_bb0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13023-020-01468-8","article-title":"Consensus clinical management guidelines for Alstr\u00f6m syndrome","volume":"15","author":"Tahani","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.bonr.2022.101600_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115756","article-title":"Very high bone mineral density in a monogenic form of obesity-associated insulin resistance","volume":"143","author":"Tahani","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101600_bb0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.22540\/JFSF-02-021","article-title":"Diagnosis of osteoporosis in dental patients","volume":"2","author":"Tounta","year":"2017","journal-title":"J. Frailty Sarcopenia Falls"},{"key":"10.1016\/j.bonr.2022.101600_bb0230","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.diabres.2004.10.011","article-title":"The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity","volume":"68","author":"Ugur-Altun","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bonr.2022.101600_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.numecd.2019.08.018","article-title":"Osteoprotegerin in diabetic osteopathy","author":"Valentini","year":"2020","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.bonr.2022.101600_bb0240","doi-asserted-by":"crossref","DOI":"10.1097\/MPG.0000000000000243","article-title":"Relation between serum osteocalcin levels and body composition in obese children","author":"Wang","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.bonr.2022.101600_bb0245","doi-asserted-by":"crossref","DOI":"10.1007\/s00198-004-1692-4","article-title":"Clinical and panoramic predictors of femur bone mineral density","author":"White","year":"2005","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2022.101600_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/0022-3913(74)90093-6","article-title":"Studies of residual ridge resorption. Part I. Use of panoramic radiographs for evaluation and classification of mandibular resorption","author":"Wical","year":"1974","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.bonr.2022.101600_bb0255","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/cge.12656","article-title":"Genetic evaluation of patients with Alstr\u00f6m syndrome in the polish population","volume":"89","author":"Zmyslowska","year":"2016","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bonr.2022.101600_bb0260","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bone.2015.05.046","article-title":"New insights into the biology of osteocalcin","volume":"82","author":"Zoch","year":"2016","journal-title":"Bone"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235218722200434X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235218722200434X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:28:56Z","timestamp":1762446536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235218722200434X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":52,"alternative-id":["S235218722200434X"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101600","relation":{},"ISSN":["2352-1872"],"issn-type":[{"type":"print","value":"2352-1872"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of bone metabolism disorders in patients with Alstr\u00f6m and Bardet-Biedl syndromes based on markers of bone turnover and mandibular atrophy","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101600"}}