{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:06:49Z","timestamp":1790809609826,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bonr.2022.101622","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T04:03:31Z","timestamp":1663646611000},"page":"101622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The extracellular matrix of human bone marrow adipocytes and glucose concentration differentially alter mineralization quality without impairing osteoblastogenesis"],"prefix":"10.1016","volume":"17","author":[{"given":"Laura","family":"Entz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Falgayrac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Chauveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2022.101622_bb0005","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/jbm.a.34994","article-title":"Osteoblast response to nanocrystalline calcium hydroxyapatite depends on carbonate content","volume":"102","author":"Adams","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.bonr.2022.101622_bb0010","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgab322","article-title":"Bone marrow adiposity in premenopausal women with type 2 diabetes with observations on peri-trabecular adipocytes [WWW document]","author":"Andrade","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2022.101622_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S8756-3282(00)00426-9","article-title":"Glucose-induced inhibition of in vitro bone mineralization","volume":"28","author":"Balint","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jcp.25898","article-title":"Comparative proteomic profiling of human osteoblast-derived extracellular matrices identifies proteins involved in mesenchymal stromal cell osteogenic differentiation and mineralization","volume":"233","author":"Baroncelli","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bonr.2022.101622_bb0025","doi-asserted-by":"crossref","DOI":"10.1089\/ten.tea.2017.0448","article-title":"Human osteoblast-derived extracellular matrix with high homology to bone proteome is osteopromotive [WWW document]","author":"Baroncelli","year":"2018","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.bonr.2022.101622_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2362.1992.tb01450.x","article-title":"Compositional analysis of the collagenous bone matrix. A study on adult normal and osteopenic bone tissue [WWW document]","author":"B\u00e4tge","year":"1992","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bonr.2022.101622_bb0035","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jcb.10622","article-title":"Inorganic phosphate as a signaling molecule in osteoblast differentiation","volume":"90","author":"Beck","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101622_bb0040","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1089\/ten.teb.2016.0454","article-title":"Osteoblast differentiation and bone matrix formation in vivo and in vitro","volume":"23","author":"Blair","year":"2017","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bonr.2022.101622_bb0045","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2741\/3918","article-title":"Bone mineralization","volume":"17","author":"Bonucci","year":"2012","journal-title":"Front. Biosci. Landmark Ed."},{"key":"10.1016\/j.bonr.2022.101622_bb0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/nyas.13572","article-title":"Bone quality changes associated with aging and disease: a review","volume":"1410","author":"Boskey","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bonr.2022.101622_bb0055","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/jbmr.2759","article-title":"Examining the relationships between bone tissue composition, compositional heterogeneity, and fragility fracture: a matched case-controlled FTIRI study","volume":"31","author":"Boskey","year":"2016","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/jcb.20842","article-title":"Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways","volume":"99","author":"Botolin","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101622_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00223-004-0285-8","article-title":"Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization","volume":"77","author":"Brandao-Burch","year":"2005","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0070","first-page":"F530","article-title":"Decreased bone carbonate content in response to metabolic, but not respiratory, acidosis","volume":"265","author":"Bushinsky","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bonr.2022.101622_bb0075","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1002\/jcp.26445","article-title":"Chronic high glucose and insulin stimulate bone-marrow stromal cells adipogenic differentiation in young spontaneously hypertensive rats","volume":"233","author":"Chaves Neto","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bonr.2022.101622_bb0080","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1359\/jbmr.070725","article-title":"Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts","volume":"22","author":"Chen","year":"2007","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.760532","article-title":"Proteoglycans and glycosaminoglycans in stem cell homeostasis and bone tissue regeneration","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101622_bb0090","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1210\/en.2007-0179","article-title":"Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1\/2, phosphoinositide 3-kinase\/Akt, and peroxisome proliferator-activated receptor gamma signaling","volume":"148","author":"Chuang","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bonr.2022.101622_bb0095","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2022.11160","article-title":"Docosahexaenoic acid improves altered mineralization proteins, the decreased quality of hydroxyapatite crystals and suppresses oxidative stress induced by high glucose [WWW Document]","author":"Cifuentes-Mendiola","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bonr.2022.101622_bb0100","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.93.19.10139","article-title":"Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin","volume":"93","author":"Civelek","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bonr.2022.101622_bb0105","article-title":"Evolution of the marrow adipose tissue microenvironment","author":"Craft","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00223-016-0149-z","article-title":"Changes in the fracture resistance of bone with the progression of type 2 diabetes in the ZDSD rat","volume":"99","author":"Creecy","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bone.2018.02.005","article-title":"Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age","volume":"110","author":"Creecy","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00441-014-1913-x","article-title":"Effects of high glucose and high insulin concentrations on osteoblast function in vitro","volume":"358","author":"Cunha","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biomaterials.2017.02.029","article-title":"Protein-free formation of bone-like apatite: new insights into the key role of carbonation","volume":"127","author":"Deymier","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101622_bb0130","doi-asserted-by":"crossref","DOI":"10.2337\/db18-0044","article-title":"MCP-1 feedback loop between adipocytes and mesenchymal stromal cells causes fat accumulation and contributes to hematopoietic stem cell rarefaction in the bone marrow of diabetic patients","author":"Ferland-McCollough","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.bonr.2022.101622_bb0135","first-page":"F750","article-title":"In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression","volume":"277","author":"Frick","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bonr.2022.101622_bb0140","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s11914-014-0238-8","article-title":"Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry","volume":"12","author":"Gamsjaeger","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0145","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-016-0232-5","article-title":"Identification of pyridinoline trivalent collagen cross-links by raman microspectroscopy [WWW document]","author":"Gamsjaeger","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0150","doi-asserted-by":"crossref","DOI":"10.3109\/03008207.2015.1088531","article-title":"Evidence of altered matrix composition in iliac crest biopsies from patients with idiopathic juvenile osteoporosis [WWW document]","author":"Garcia","year":"2016","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0155","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.bone.2011.10.032","article-title":"High glucose concentrations alter the biomineralization process in human osteoblastic cells","volume":"50","author":"Garc\u00eda-Hern\u00e1ndez","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0160","article-title":"Osteoblast and osteoclast responses to A\/B type carbonate-substituted hydroxyapatite ceramics for bone regeneration","volume":"12","author":"Germaini","year":"2017","journal-title":"Biomed. Mater. Bristol Engl."},{"key":"10.1016\/j.bonr.2022.101622_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12860-015-0056-6","article-title":"Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation","volume":"16","author":"Ghali","year":"2015","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bonr.2022.101622_bb0170","doi-asserted-by":"crossref","DOI":"10.1359\/jbmr.090414","article-title":"Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture [WWW document]","author":"Gourion-Arsiquaud","year":"2009","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0175","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1039\/C7BM00695K","article-title":"Recellularization of decellularized adipose tissue-derived stem cells: role of the cell-secreted extracellular matrix in cellular differentiation","volume":"6","author":"Guneta","year":"2017","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bonr.2022.101622_bb0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bone.2013.11.015","article-title":"Nanoscale changes in collagen are reflected in physical and mechanical properties of bone at the microscale in diabetic rats","volume":"60","author":"Hammond","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0185","doi-asserted-by":"crossref","first-page":"9674614","DOI":"10.1155\/2016\/9674614","article-title":"The effects of high glucose on adipogenic and osteogenic differentiation of gestational tissue-derived MSCs","volume":"2016","author":"Hankamolsiri","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0190","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fendo.2016.00085","article-title":"Bone marrow adipose tissue: to be or not to be a typical adipose tissue?","volume":"7","author":"Hardouin","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bonr.2022.101622_bb0195","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M109.054676","article-title":"Development of stepwise osteogenesis-mimicking matrices for the regulation of mesenchymal stem cell functions [WWW document]","author":"Hoshiba","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bonr.2022.101622_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201000038","article-title":"Development of extracellular matrices mimicking stepwise adipogenesis of mesenchymal stem cells [WWW document]","author":"Hoshiba","year":"2010","journal-title":"Adv. Mater. Deerfield Beach Fla."},{"key":"10.1016\/j.bonr.2022.101622_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2011.11.061","article-title":"The balance of osteogenic and adipogenic differentiation in human mesenchymal stem cells by matrices that mimic stepwise tissue development [WWW document]","author":"Hoshiba","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101622_bb0210","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6397820","article-title":"Decellularized extracellular matrix as an in vitro model to study the comprehensive roles of the ECM in stem cell differentiation","volume":"2016","author":"Hoshiba","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0215","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/jbmr.3365","article-title":"Bone tissue collagen maturity and mineral content increase with sustained hyperglycemia in the KK-Ay murine model of type 2 diabetes","volume":"33","author":"Hunt","year":"2018","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0220","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/jbmr.4186","article-title":"Bone tissue composition in postmenopausal women varies with glycemic control from normal glucose tolerance to type 2 diabetes mellitus","volume":"36","author":"Hunt","year":"2021","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0225","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bone.2018.05.030","article-title":"Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes","volume":"114","author":"Karim","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11914-019-00526-w","article-title":"The effect of type 2 diabetes on bone biomechanics","volume":"17","author":"Karim","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038752","article-title":"Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose","volume":"7","author":"Keats","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bonr.2022.101622_bb0240","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/stem.1659","article-title":"Switch from canonical to noncanonical wnt signaling mediates high glucose-induced adipogenesis","volume":"32","author":"Keats","year":"2014","journal-title":"Stem Cells Dayt. Ohio"},{"key":"10.1016\/j.bonr.2022.101622_bb0245","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1089\/scd.2009.0217","article-title":"Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells","volume":"19","author":"Lai","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bonr.2022.101622_bb0250","doi-asserted-by":"crossref","DOI":"10.1007\/s11914-019-00538-6","article-title":"Effects of diabetes on bone material properties [WWW document]","author":"Lekkala","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110039","article-title":"ECM coating modification generated by optimized decellularization process improves functional behavior of BMSCs","volume":"105","author":"Li","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bonr.2022.101622_bb0260","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3109\/14653249.2010.510503","article-title":"Improved proliferation and differentiation capacity of human mesenchymal stromal cells cultured with basement-membrane extracellular matrix proteins","volume":"12","author":"Lindner","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101622_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/jps.22288","article-title":"Rapid characterization of glycosaminoglycans using a combined approach by infrared and Raman microspectroscopies [WWW document]","author":"Mainreck","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bonr.2022.101622_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115962","article-title":"Altered collagen chemical compositional structure in osteopenic women with past fractures: a case-control raman spectroscopic study","volume":"148","author":"Mandair","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0275","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1038\/s41598-018-24229-x","article-title":"Unraveling the compromised biomechanical performance of type 2 diabetes- and roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties","volume":"8","author":"Marin","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0280","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1039\/c1an15167c","article-title":"Raman spectroscopic monitoring of the osteogenic differentiation of human mesenchymal stem cells","volume":"136","author":"McManus","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.bonr.2022.101622_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155447","article-title":"Tissue-specific decellularization methods: rationale and strategies to achieve regenerative compounds [WWW document]","author":"Mendibil","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bonr.2022.101622_bb0290","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00223-020-00720-4","article-title":"Dapagliflozin and liraglutide therapies rapidly enhanced bone material properties and matrix biomechanics at bone formation site in a type 2 diabetic mouse model","volume":"107","author":"Mieczkowska","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep28889","article-title":"ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells","volume":"6","author":"Morandi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0300","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/MED.0000000000000641","article-title":"Advanced glycation endproducts and bone quality: practical implications for people with type 2 diabetes","volume":"28","author":"Moseley","year":"2021","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.bonr.2022.101622_bb0305","doi-asserted-by":"crossref","DOI":"10.1359\/jbmr.040820","article-title":"Bone fragility and collagen cross-links [WWW document]","author":"Paschalis","year":"2004","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0310","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s002239900561","article-title":"MicroRaman spectral study of the PO4 and CO3 vibrational modes in synthetic and biological apatites","volume":"63","author":"Penel","year":"1998","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2022.101622_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2016.08.030","article-title":"Raman spectroscopic investigation on the molecular structure of apatite and collagen in osteoporotic cortical bone [WWW document]","author":"Pezzotti","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.bonr.2022.101622_bb0320","doi-asserted-by":"crossref","DOI":"10.1530\/EJE-18-0182","article-title":"MECHANISMS IN ENDOCRINOLOGY: bone marrow adiposity and bone, a bad romance?","author":"Rharass","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bonr.2022.101622_bb0325","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3389\/fendo.2019.00607","article-title":"High glucose level impairs human mature bone marrow adipocyte function through increased ROS production","volume":"10","author":"Rharass","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bonr.2022.101622_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.06.017","article-title":"Organic matrix quality discriminates between age- and BMD-matched fracturing versus non-fracturing post-menopausal women: a pilot study [WWW document]","author":"Rokidi","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0335","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.actbio.2018.04.039","article-title":"Decoration of RGD-mimetic porous scaffolds with engineered and devitalized extracellular matrix for adipose tissue regeneration","volume":"73","author":"Rossi","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bonr.2022.101622_bb0340","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.34037","article-title":"Osteoblast activity on carbonated hydroxyapatite [WWW document]","author":"Rupani","year":"2012","journal-title":"J. Biomed. Mater. Res. A."},{"key":"10.1016\/j.bonr.2022.101622_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep03663","article-title":"Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability","volume":"4","author":"Sabater","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0350","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s00018-012-1211-2","article-title":"The interrelationship between bone and fat: from cellular see-saw to endocrine reciprocity","volume":"70","author":"Sadie-Van Gijsen","year":"2013","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.bonr.2022.101622_bb0355","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1007\/s00198-006-0155-5","article-title":"Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN\/Kob rats","volume":"17","author":"Saito","year":"2006","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"10.1016\/j.bonr.2022.101622_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065943","article-title":"The phosphate source influences gene expression and quality of mineralization during in vitro osteogenic differentiation of human mesenchymal stem cells","volume":"8","author":"Sch\u00e4ck","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.bonr.2022.101622_bb0365","doi-asserted-by":"crossref","first-page":"C111","DOI":"10.1152\/ajpcell.00120.2019","article-title":"Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport","volume":"318","author":"Schlesinger","year":"2019","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.bonr.2022.101622_bb0370","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2015.05.032","article-title":"Epidemiology of fractures in type 2 diabetes","volume":"82","author":"Schwartz","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0375","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/453940","article-title":"Metformin rescues the MG63 osteoblasts against the effect of high glucose on proliferation","volume":"2014","author":"Shao","year":"2014","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bonr.2022.101622_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.116101","article-title":"Continuous subcutaneous insulin infusion ameliorates bone structures and mechanical properties in type 2 diabetic rats by regulating bone remodeling","volume":"153","author":"Shi","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0385","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41467-020-16878-2","article-title":"Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis","volume":"11","author":"Suchacki","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bonr.2022.101622_bb0390","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1096\/fj.10-161497","article-title":"Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix","volume":"25","author":"Sun","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.bonr.2022.101622_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101545","article-title":"Bone marrow adipose tissue: role in bone remodeling and energy metabolism","author":"Tencerova","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bonr.2022.101622_bb0400","article-title":"Non-obese MKR mouse model of type 2 diabetes reveals skeletal alterations in mineralization and material properties [WWW document]","author":"Tice","year":"2021","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bonr.2022.101622_bb0405","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11914-018-0433-0","article-title":"The role of matrix composition in the mechanical behavior of bone","volume":"16","author":"Unal","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2022.101622_bb0410","doi-asserted-by":"crossref","DOI":"10.1007\/s00198-005-2035-9","article-title":"The role of collagen in bone strength [WWW document]","author":"Viguet-Carrin","year":"2006","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"10.1016\/j.bonr.2022.101622_bb0415","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11010-009-0344-6","article-title":"High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP\/protein kinase A\/extracellular signal-regulated kinase pathway","volume":"338","author":"Wang","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101622_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2013.06.035","article-title":"Combining decellularized human adipose tissue extracellular matrix and adipose-derived stem cells for adipose tissue engineering [WWW document]","author":"Wang","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bonr.2022.101622_bb0425","doi-asserted-by":"crossref","first-page":"11410","DOI":"10.1074\/jbc.M113.541458","article-title":"Hyperglycemia diverts dividing osteoblastic precursor cells to an adipogenic pathway and induces synthesis of a hyaluronan matrix that is adhesive for monocytes","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bonr.2022.101622_bb0430","article-title":"Bone marrow adipocytes: a critical player in the bone marrow microenvironment","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101622_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127973","article-title":"Time related changes of mineral and collagen and their roles in cortical bone mechanics of ovariectomized rabbits [WWW document]","author":"Wen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bonr.2022.101622_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2006.06.002","article-title":"The compositional and physicochemical homogeneity of male femoral cortex increases after the sixth decade [WWW document]","author":"Yerramshetty","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0445","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bone.2016.12.018","article-title":"Marrow adipose tissue composition in adults with morbid obesity","volume":"97","author":"Yu","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101622_bb0450","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1002\/jcb.24607","article-title":"Activation of the PI3K\/Akt pathway by oxidative stress mediates high glucose-induced increase of adipogenic differentiation in primary rat osteoblasts","volume":"114","author":"Zhang","year":"2013","journal-title":"J. Cell. Biochem."}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:26:41Z","timestamp":1762446401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187222004569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":90,"alternative-id":["S2352187222004569"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101622","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The extracellular matrix of human bone marrow adipocytes and glucose concentration differentially alter mineralization quality without impairing osteoblastogenesis","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101622"}}