{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:34:14Z","timestamp":1791920054128,"version":"4.3.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bonr.2022.101635","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T13:22:16Z","timestamp":1667827336000},"page":"101635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Impact of romosozumab on serum calcium concentration and factors predicting the fluctuations in calcium concentration upon romosozumab administration: A multicenter retrospective study"],"prefix":"10.1016","volume":"17","author":[{"given":"Hiroyuki","family":"Inose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Tomizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Ariga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Motoyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Okawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2022.101635_bb0005","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"issue":"16","key":"10.1016\/j.bonr.2022.101635_bb0010","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bonr.2022.101635_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2021.105219","article-title":"Effects of prior osteoporosis treatment on 12-month treatment response of romosozumab in patients with postmenopausal osteoporosis","volume":"88","author":"Ebina","year":"2021","journal-title":"Joint Bone Spine"},{"issue":"2","key":"10.1016\/j.bonr.2022.101635_bb0020","first-page":"158","article-title":"Hypocalcemia: updates in diagnosis and management for primary care","volume":"58","author":"Fong","year":"2012","journal-title":"Can. Fam. Phys."},{"issue":"8","key":"10.1016\/j.bonr.2022.101635_bb0025","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1681\/ASN.2007040449","article-title":"Pitfalls of measuring total blood calcium in patients with CKD","volume":"19","author":"Gauci","year":"2008","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"10.1016\/j.bonr.2022.101635_bb0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/ejcts\/ezy403","article-title":"Statistical primer: multivariable regression considerations and pitfalls","volume":"55","author":"Grant","year":"2019","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"9\u201310","key":"10.1016\/j.bonr.2022.101635_bb0035","first-page":"499","article-title":"Tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of bone resorption","volume":"52","author":"Halleen","year":"2006","journal-title":"Clin. Lab."},{"issue":"4","key":"10.1016\/j.bonr.2022.101635_bb0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"key":"10.1016\/j.bonr.2022.101635_bb0045","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2013"},{"issue":"1","key":"10.1016\/j.bonr.2022.101635_bb0055","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1097\/BRS.0000000000001995","article-title":"Bone turnover markers as a new predicting factor for nonunion after spinal fusion surgery","volume":"43","author":"Inose","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"issue":"7","key":"10.1016\/j.bonr.2022.101635_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10637","article-title":"The real-world effect of 12 months of romosozumab treatment on patients with osteoporosis with a high risk of fracture and factors predicting the rate of bone mass increase: A multicenter retrospective study","volume":"6","author":"Inose","year":"2022","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bonr.2022.101635_bb0060","article-title":"Real-world effects and adverse events of romosozumab in japanese osteoporotic patients: a prospective cohort study","volume":"14","author":"Kobayakawa","year":"2021","journal-title":"Bone Rep."},{"issue":"5","key":"10.1016\/j.bonr.2022.101635_bb0065","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bonr.2022.101635_bb0070","article-title":"Efficacy and safety of romosozumab among postmenopausal women with osteoporosis and mild-to-moderate chronic kidney disease","author":"Miller","year":"2022","journal-title":"J. Bone Miner. Res."},{"issue":"5893","key":"10.1016\/j.bonr.2022.101635_bb0075","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/bmj.4.5893.643","article-title":"Interpretation of serum calcium in patients with abnormal serum proteins","volume":"4","author":"Payne","year":"1973","journal-title":"Br. Med. J."},{"issue":"12","key":"10.1016\/j.bonr.2022.101635_bb0080","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0895-4356(95)00048-8","article-title":"Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates","volume":"48","author":"Peduzzi","year":"1995","journal-title":"J. Clin. Epidemiol."},{"issue":"4","key":"10.1016\/j.bonr.2022.101635_bb0085","first-page":"173","article-title":"Hypocalcemic myopathy secondary to hypoparathyroidism","volume":"111","author":"Policepatil","year":"2012","journal-title":"WMJ"},{"issue":"3","key":"10.1016\/j.bonr.2022.101635_bb0090","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00774-013-0447-8","article-title":"Diagnostic criteria for primary osteoporosis: year 2012 revision","volume":"31","author":"Soen","year":"2013","journal-title":"J. Bone Miner. Metab."},{"issue":"1","key":"10.1016\/j.bonr.2022.101635_bb0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/21556660.2012.668504","article-title":"Severe hypocalcemia following a single injection of denosumab in a patient with renal impairment","volume":"1","author":"Talreja","year":"2012","journal-title":"J. Drug Assess."},{"issue":"4","key":"10.1016\/j.bonr.2022.101635_bb0100","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00198-019-05261-7","article-title":"Denosumab-induced hypocalcemia in patients with osteoporosis: can you know who will get low?","volume":"31","author":"Tsvetov","year":"2020","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2022.101635_bb0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/CIA.S4965","article-title":"Diagnosis and management of osteoporosis in the older senior","volume":"4","author":"Vondracek","year":"2009","journal-title":"Clin. Interv. Aging"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:29:47Z","timestamp":1762446587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187222004697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":21,"alternative-id":["S2352187222004697"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101635","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of romosozumab on serum calcium concentration and factors predicting the fluctuations in calcium concentration upon romosozumab administration: A multicenter retrospective study","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101635"}}