{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:31:18Z","timestamp":1785177078595,"version":"3.55.0"},"reference-count":204,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR077654"],"award-info":[{"award-number":["R21AR077654"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bonr.2022.101636","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T03:05:33Z","timestamp":1667963133000},"page":"101636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["MSC-EV therapy for bone\/cartilage diseases"],"prefix":"10.1016","volume":"17","author":[{"given":"Joe","family":"Kodama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Otsuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2022.101636_bb0005","article-title":"Strategies for scalable manufacturing and translation of MSC-derived extracellular vesicles","volume":"9","author":"Adlerz","year":"2020","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0010","doi-asserted-by":"crossref","DOI":"10.5812\/atr.37976","article-title":"The current perspectives of stem cell therapy in orthopedic surgery","volume":"5","author":"Akpancar","year":"2016","journal-title":"Arch. Trauma Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009951","article-title":"MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells","volume":"17","author":"Albanese","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bonr.2022.101636_bb0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ijc.22718","article-title":"Multiple myeloma: a review of the epidemiologic literature","volume":"120","author":"Alexander","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bonr.2022.101636_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.553444","article-title":"Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-\/Xeno-free conditions in a microcarrier-based bioreactor culture system","volume":"8","author":"de Almeida Fuzeta","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/6633386","article-title":"Molecular insights into the potential of extracellular vesicles released from mesenchymal stem cells and other cells in the therapy of hematologic malignancies","volume":"2021","author":"Alsagaby","year":"2021","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0035","series-title":"Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine","first-page":"83","article-title":"Different gene expression profile of mesenchymal stem cells from various sources","author":"Arjmand","year":"2019"},{"key":"10.1016\/j.bonr.2022.101636_bb0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13287-015-0116-z","article-title":"Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species","volume":"6","author":"Baglio","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0045","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/stem.1118","article-title":"Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation","volume":"30","author":"von Bahr","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800163","article-title":"Proteomic signature of mesenchymal stromal cell-derived small extracellular vesicles","volume":"19","author":"van Balkom","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.bonr.2022.101636_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/srep21507","article-title":"Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers","volume":"6","author":"Billing","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0060","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/ejh.12765","article-title":"Immunomodulatory effects of bone marrow versus adipose tissue-derived mesenchymal stromal cells on NK cells: implications in the transplantation setting","volume":"97","author":"Blanco","year":"2016","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bonr.2022.101636_bb0065","first-page":"5","article-title":"Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells","author":"Blazquez","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0070","doi-asserted-by":"crossref","first-page":"36162","DOI":"10.1038\/srep36162","article-title":"Trehalose prevents aggregation of exosomes and cryodamage","volume":"6","author":"Bosch","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2016.00083","article-title":"Stem cell-derived extracellular vesicles and immune-modulation","volume":"4","author":"Burrello","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0080","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/cells7120273","article-title":"Tangential flow filtration for highly efficient concentration of extracellular vesicles from large volumes of fluid","volume":"7","author":"Busatto","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0085","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13287-020-01719-2","article-title":"Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury","volume":"11","author":"Cao","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0090","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/sctm.17-0051","article-title":"Mesenchymal stem cells: time to change the Name!","volume":"6","author":"Caplan","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2017.00039","article-title":"Mesenchymal stem cell-derived exosomes: immunomodulatory evaluation in an antigen-induced synovitis porcine model","volume":"4","author":"Casado","year":"2017","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0100","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1097\/TA.0000000000002225","article-title":"The effects of cell type and culture condition on the procoagulant activity of human mesenchymal stromal cell-derived extracellular vesicles","volume":"87","author":"Chance","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.bonr.2022.101636_bb0105","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.2147\/JIR.S336099","article-title":"Mesenchymal stem cell&ndash;originated exosomal circular RNA circFBXW7 attenuates cell proliferation, migration and inflammation of fibroblast-like synoviocytes by targeting miR-216a-3p\/HDAC4 in rheumatoid arthritis","volume":"14","author":"Chang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0110","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s12026-016-8798-6","article-title":"Immunomodulatory effects of mesenchymal stromal cells-derived exosome","volume":"64","author":"Chen","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0115","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.7150\/thno.31017","article-title":"Desktop-stereolithography 3D printing of a radially oriented extracellular matrix\/mesenchymal stem cell exosome bioink for osteochondral defect regeneration","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bonr.2022.101636_bb0120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13075-020-02325-6","article-title":"Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3","volume":"22","author":"Chen","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0125","doi-asserted-by":"crossref","first-page":"14888","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0130","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tcb.2015.01.004","article-title":"Ectosomes and exosomes: shedding the confusion between extracellular vesicles","volume":"25","author":"Cocucci","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.molmed.2018.01.006","article-title":"Manufacturing exosomes: a promising therapeutic platform","volume":"24","author":"Colao","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0140","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.3390\/cells8101160","article-title":"Thrombogenic risk induced by intravascular mesenchymal stem cell therapy: current status and future perspectives","volume":"8","author":"Coppin","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0145","doi-asserted-by":"crossref","first-page":"11561","DOI":"10.1038\/s41598-017-10646-x","article-title":"Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography","volume":"7","author":"Corso","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0150","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0155","first-page":"1399","article-title":"Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis","volume":"8","author":"Cosenza","year":"2018"},{"key":"10.1016\/j.bonr.2022.101636_bb0160","first-page":"207","article-title":"A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis","volume":"10","author":"Cui","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bonr.2022.101636_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/7218067","article-title":"Exosomes derived from M2 macrophages exert a therapeutic effect via inhibition of the PI3K\/AKT\/mTOR pathway in rats with knee osteoarthritic","volume":"2021","author":"Da-wa","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0170","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P","article-title":"Multipotent mesenchymal stem cells from adult human synovial membrane","volume":"44","author":"De Bari","year":"2001","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bonr.2022.101636_bb0175","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1517\/14712598.2015.997706","article-title":"Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells","volume":"15","author":"Del Fattore","year":"2015","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0180","doi-asserted-by":"crossref","first-page":"24120","DOI":"10.1038\/srep24120","article-title":"Differential and transferable modulatory effects of mesenchymal stromal cell-derived extracellular vesicles on T, B and NK cell functions","volume":"6","author":"Di Trapani","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0185","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13075-020-02290-0","article-title":"Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment","volume":"22","author":"Duan","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0190","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13287-021-02507-2","article-title":"Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model","volume":"12","author":"Duan","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0195","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1089\/ten.teb.2013.0664","article-title":"Umbilical cord mesenchymal stem cells: the new gold standard for mesenchymal stem cell-based therapies?","volume":"20","author":"El Omar","year":"2014","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bonr.2022.101636_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5646384","article-title":"Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns","volume":"2016","author":"Elahi","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13287-022-02806-2","article-title":"Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context","volume":"13","author":"Esmaeili","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0210","doi-asserted-by":"crossref","first-page":"9688138","DOI":"10.1155\/2021\/9688138","article-title":"A comparative study on the effect of exosomes secreted by mesenchymal stem cells derived from adipose and bone marrow tissues in the treatment of osteoarthritis-induced mouse model","volume":"2021","author":"Fazaeli","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0215","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00774-010-0215-y","article-title":"Human mesenchymal stem cell proliferation and osteogenic differentiation during long-term ex vivo cultivation is not age dependent","volume":"29","author":"Fickert","year":"2011","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bonr.2022.101636_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201800035","article-title":"Indocyanine green labeling for optical and photoacoustic imaging of mesenchymal stem cells after in vivo transplantation","volume":"12","author":"Filippi","year":"2019","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.bonr.2022.101636_bb0225","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bonr.2022.101636_bb0230","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/14653249.2011.623691","article-title":"Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-\u03b3 licensing","volume":"14","author":"Fran\u00e7ois","year":"2012","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101636_bb0235","doi-asserted-by":"crossref","first-page":"32945","DOI":"10.3402\/jev.v5.32945","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0240","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3390\/molecules19021568","article-title":"miRNA in plasma exosome is stable under different storage conditions","volume":"19","author":"Ge","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.bonr.2022.101636_bb0245","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-021-01126-6","article-title":"Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612","volume":"19","author":"Ge","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bonr.2022.101636_bb0250","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcyt.2021.01.001","article-title":"Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles","volume":"23","author":"Gimona","year":"2021","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101636_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02663","article-title":"Therapeutic application of mesenchymal stem cells derived extracellular vesicles for immunomodulation","volume":"10","author":"Gomzikova","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0260","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/ar2758","article-title":"Developments in the scientific understanding of rheumatoid arthritis","volume":"11","author":"Goronzy","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0265","doi-asserted-by":"crossref","first-page":"20389","DOI":"10.3402\/jev.v2i0.20389","article-title":"As we wait: coping with an imperfect nomenclature for extracellular vesicles","volume":"2","author":"Gould","year":"2013","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-021-00881-9","article-title":"Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice","volume":"116","author":"Gregorius","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bonr.2022.101636_bb0275","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10616-015-9913-6","article-title":"Systematic review of factors influencing extracellular vesicle yield from cell cultures","volume":"68","author":"Gudbergsson","year":"2016","journal-title":"Cytotechnology"},{"key":"10.1016\/j.bonr.2022.101636_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00702-009-0288-8","article-title":"Astrocytes and Glioblastoma cells release exosomes carrying mtDNA","volume":"117","author":"Guescini","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.bonr.2022.101636_bb0285","doi-asserted-by":"crossref","first-page":"32570","DOI":"10.3402\/jev.v5.32570","article-title":"High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources","volume":"5","author":"Haraszti","year":"2016","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0290","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.ymthe.2018.09.015","article-title":"Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity","volume":"26","author":"Haraszti","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0295","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.isci.2019.05.029","article-title":"Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition","volume":"16","author":"Haraszti","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.bonr.2022.101636_bb0300","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0305","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac5608","article-title":"Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis","volume":"7","author":"Headland","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0310","first-page":"8","article-title":"Mesenchymal stromal cell-derived microvesicles regulate an internal pro-inflammatory program in activated macrophages","author":"Henao Agudelo","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/9011548","article-title":"Higher chondrogenic potential of extracellular vesicles derived from mesenchymal stem cells compared to chondrocytes-EVs in vitro","volume":"2021","author":"Hosseinzadeh","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0320","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1778883","article-title":"miR-23a-3p-abundant small extracellular vesicles released from Gelma\/nanoclay hydrogel for cartilage regeneration","volume":"9","author":"Hu","year":"2020","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0325","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.7150\/thno.39238","article-title":"Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism","volume":"10","author":"Hu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bonr.2022.101636_bb0330","doi-asserted-by":"crossref","DOI":"10.1002\/term.3304","article-title":"Exosomes derived from microRNA-21 overexpressed adipose tissue-derived mesenchymal stem cells alleviate spine osteoporosis in ankylosing spondylitis mice","author":"Hu","year":"2022","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0335","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1111\/jcmm.16654","article-title":"Bone marrow mesenchymal stem cell\u2013derived exosomal miR-206 promotes osteoblast proliferation and differentiation in osteoarthritis by reducing Elf3","volume":"25","author":"Huang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0340","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s10020-022-00451-2","article-title":"Exosomal microRNA-140-3p from human umbilical cord mesenchymal stem cells attenuates joint injury of rats with rheumatoid arthritis by silencing SGK1","volume":"28","author":"Huang","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0345","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molimm.2022.01.002","article-title":"miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages","volume":"143","author":"Huang","year":"2022","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0350","doi-asserted-by":"crossref","DOI":"10.1186\/ar2459","article-title":"Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells","volume":"10","author":"Janjanin","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0355","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/jcb.25395","article-title":"Comparative analysis of human mesenchymal stem cells derived from bone marrow, placenta, and adipose tissue as sources of cell therapy: proteomic validation of mesenchymal stem cells","volume":"117","author":"Jeon","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101636_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12248-017-0160-y","article-title":"Preservation and storage stability of extracellular vesicles for therapeutic applications","volume":"20","author":"Jeyaram","year":"2018","journal-title":"AAPS J."},{"key":"10.1016\/j.bonr.2022.101636_bb0365","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12026-019-09088-6","article-title":"Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells","volume":"67","author":"Ji","year":"2019","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/2979124","article-title":"Mesenchymal stem cell-derived exosomes modulate chondrocyte glutamine metabolism to alleviate osteoarthritis progression","volume":"2021","author":"Jiang","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bonr.2022.101636_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105946","article-title":"Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2","volume":"78","author":"Jin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bonr.2022.101636_bb0380","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1111\/jcmm.16860","article-title":"Therapeutic effects of bone marrow mesenchymal stem cells-derived exosomes on osteoarthritis","volume":"25","author":"Jin","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0385","article-title":"From","volume":"9","author":"Johnson","year":"2021"},{"key":"10.1016\/j.bonr.2022.101636_bb0390","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1074\/jbc.C113.532267","article-title":"Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer","volume":"289","author":"Kahlert","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bonr.2022.101636_bb0395","article-title":"Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing: fate of adipose-derived mesenchymal stromal cells","author":"Kallmeyer","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0400","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/pmic.201200373","article-title":"The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles","volume":"13","author":"Katsuda","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.bonr.2022.101636_bb0405","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.bonr.2022.101636_bb0410","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3390\/ijms20071642","article-title":"Individual immune-modulatory capabilities of MSC-derived extracellular vesicle (EV) preparations and recipient-dependent responsiveness","volume":"20","author":"Kordelas","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0415","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4252\/wjsc.v11.i6.347","article-title":"Similarities and differences between mesenchymal stem\/progenitor cells derived from various human tissues","volume":"11","author":"Kozlowska","year":"2019","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0420","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1182\/blood-2003-05-1670","article-title":"Isolation of multipotent mesenchymal stem cells from umbilical cord blood","volume":"103","author":"Lee","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bonr.2022.101636_bb0425","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.actbio.2021.04.026","article-title":"Reactive oxygen species-responsive dendritic cell-derived exosomes for rheumatoid arthritis","volume":"128","author":"Lee","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bonr.2022.101636_bb0430","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s13238-021-00860-9","article-title":"Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis","volume":"13","author":"Lei","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.bonr.2022.101636_bb0435","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials \u2013 an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0440","doi-asserted-by":"crossref","first-page":"26883","DOI":"10.3402\/jev.v4.26883","article-title":"Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles","volume":"4","author":"Li","year":"2015","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0445","doi-asserted-by":"crossref","first-page":"10872","DOI":"10.1038\/ncomms10872","article-title":"Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bonr.2022.101636_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112784","article-title":"Exosomes from different cells: characteristics, modifications, and therapeutic applications","volume":"207","author":"Li","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bonr.2022.101636_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20406223211007369","article-title":"MicroRNA-21 from bone marrow mesenchymal stem cell-derived extracellular vesicles targets TET1 to suppress KLF4 and alleviate rheumatoid arthritis","volume":"12","author":"Li","year":"2021","journal-title":"Ther. Adv. Chronic Dis."},{"key":"10.1016\/j.bonr.2022.101636_bb0460","doi-asserted-by":"crossref","DOI":"10.2174\/1381612828666220128104206","article-title":"Potential effects of exosomes and their MicroRNA carrier on osteoporosis","author":"Li","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bonr.2022.101636_bb0465","article-title":"Chondrocyte-targeted MicroRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy","volume":"10","author":"Liang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bonr.2022.101636_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107824","article-title":"Low-intensity pulsed ultrasound promotes osteoarthritic cartilage regeneration by BMSC-derived exosomes via modulating the NF-\u03baB signaling pathway","volume":"97","author":"Liao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bonr.2022.101636_bb0475","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/03635465221073991","article-title":"Exosomes derived from human urine-derived stem cells overexpressing miR-140-5p alleviate knee osteoarthritis through downregulation of VEGFA in a rat model","volume":"50","author":"Liu","year":"2022","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0480","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/sctm.16-0363","article-title":"Mesenchymal stem cell-derived extracellular vesicles as mediators of anti-inflammatory effects: endorsement of macrophage polarization","volume":"6","author":"Lo Sicco","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0485","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2016.01.061","article-title":"Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth","volume":"320","author":"Lopez-Verrilli","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.bonr.2022.101636_bb0490","doi-asserted-by":"crossref","first-page":"25465","DOI":"10.3402\/jev.v3.25465","article-title":"Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes","volume":"3","author":"L\u0151rincz","year":"2014","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0495","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3379","article-title":"Synovial mesenchymal stem cell-derived extracellular vesicles containing microRN555A-26a-5p ameliorate cartilage damage of osteoarthritis","volume":"23","author":"Lu","year":"2021","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9628536","article-title":"Challenges and controversies in human mesenchymal stem cell therapy","volume":"2019","author":"Lukomska","year":"2019","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0505","first-page":"132","article-title":"miR-205-5p in exosomes divided from chondrogenic mesenchymal stem cells alleviated rheumatoid arthritis via regulating MDM2 in fibroblast-like synoviocytes","volume":"22","author":"Ma","year":"2022","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.bonr.2022.101636_bb0510","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118002","article-title":"Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine","volume":"256","author":"Maqsood","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0520","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/jcb.20681","article-title":"Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow","volume":"97","author":"Mareschi","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101636_bb0525","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3727\/096368911X582769","article-title":"Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility","volume":"21","author":"Mart\u00ednez","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bonr.2022.101636_bb0530","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2021.03.028","article-title":"Importance of stem cell culture conditions for their derived extracellular vesicles therapeutic effect","volume":"168","author":"Mas-Bargues","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0535","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0540","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13287-021-02405-7","article-title":"Proteomic analysis of bone marrow-derived mesenchymal stem cell extracellular vesicles from healthy donors: implications for proliferation, angiogenesis, Wnt signaling, and the basement membrane","volume":"12","author":"McBride","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0545","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/stem.1729","article-title":"Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?","volume":"32","author":"Moll","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0550","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.molmed.2018.12.006","article-title":"Intravascular mesenchymal stromal\/stem cell therapy product diversification: time for new clinical guidelines","volume":"25","author":"Moll","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0555","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bonr.2022.101636_bb0560","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3390\/biom10091353","article-title":"MiRNA profiles of extracellular vesicles secreted by mesenchymal stromal cells\u2014can they predict potential off-target effects?","volume":"10","author":"Nazari-Shafti","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.bonr.2022.101636_bb0565","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2022.151226","article-title":"Reproducibility of extracellular vesicle research","volume":"101","author":"Nieuwland","year":"2022","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0575","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5966\/sctm.2015-0427","article-title":"Concise review: mesenchymal stem cell therapy for pediatric disease: perspectives on success and potential improvements: cell-based therapies for pediatric diseases","volume":"6","author":"Nitkin","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0580","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcyt.2012.10.012","article-title":"Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device","volume":"15","author":"Otsuru","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101636_bb0585","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcyt.2014.10.013","article-title":"Genomic and functional comparison of mesenchymal stromal cells prepared using two isolation methods","volume":"17","author":"Otsuru","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101636_bb0590","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/btm2.10065","article-title":"Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles","volume":"2","author":"Patel","year":"2017","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0595","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.biotechadv.2018.09.001","article-title":"Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment","volume":"36","author":"Patel","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bonr.2022.101636_bb0600","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1002\/jcb.24166","article-title":"Functional heterogeneity of mesenchymal stem cells: implications for cell therapy","volume":"113","author":"Phinney","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101636_bb0605","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise review: MSC-derived exosomes for cell-free therapy","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0610","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1097-4644(19991201)75:3<424::AID-JCB8>3.0.CO;2-8","article-title":"Donor variation in the growth properties and osteogenic potential of human marrow stromal cells","volume":"75","author":"Phinney","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bonr.2022.101636_bb0615","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1517\/14712598.2013.823153","article-title":"Adipose tissue-derived stem cells in clinical applications","volume":"13","author":"Piku\u0142a","year":"2013","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bonr.2022.101636_bb0620","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1089\/scd.2016.0048","article-title":"Unveiling the differences of secretome of human bone marrow mesenchymal stem cells, adipose tissue-derived stem cells, and human umbilical cord perivascular cells: a proteomic analysis","volume":"25","author":"Pires","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bonr.2022.101636_bb0625","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"npj Regen. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0630","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s13287-019-1484-6","article-title":"Functional proteins of mesenchymal stem cell-derived extracellular vesicles","volume":"10","author":"Qiu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0635","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/cells8040369","article-title":"Insights into inflammatory priming of adipose-derived mesenchymal stem cells: validation of extracellular vesicles-embedded miRNA reference genes as a crucial step for donor selection","volume":"8","author":"Ragni","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0640","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0645","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101106RR","article-title":"Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix","volume":"36","author":"Ren","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.bonr.2022.101636_bb0650","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri3622","article-title":"Regulation of immune responses by extracellular vesicles","volume":"14","author":"Robbins","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0655","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1186\/1471-2164-15-910","article-title":"Transcriptomic portrait of human Mesenchymal Stromal\/Stem cells isolated from bone marrow and placenta","volume":"15","author":"Roson-Burgo","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bonr.2022.101636_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119544","article-title":"TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles","volume":"226","author":"Ruiz","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0665","first-page":"6175","article-title":"Efficacy of autologous bone marrow derived Mesenchymal stem cells (MSCs), osteoblasts and osteoblasts derived exosome in the reversal of ovariectomy (OVX) induced osteoporosis in rabbit model","volume":"13","author":"Sadat-Ali","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0670","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3390\/ijms23031017","article-title":"Culture condition of bone marrow stromal cells affects quantity and quality of the extracellular vesicles","volume":"23","author":"Scheiber","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0675","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s12015-009-9098-5","article-title":"Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood","volume":"5","author":"Secco","year":"2009","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.bonr.2022.101636_bb0680","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/jor.20402","article-title":"Donor variation and loss of multipotency during in vitro expansion of human mesenchymal stem cells for bone tissue engineering","volume":"25","author":"Siddappa","year":"2007","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0685","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-11-146","article-title":"Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells","volume":"11","author":"Siegel","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0690","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cytogfr.2009.10.002","article-title":"Mechanisms involved in the therapeutic properties of mesenchymal stem cells","volume":"20","author":"da Silva Meirelles","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bonr.2022.101636_bb0695","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0700","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.plipres.2017.03.001","article-title":"Lipids in exosomes: current knowledge and the way forward","volume":"66","author":"Skotland","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0705","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.colsurfb.2011.05.013","article-title":"Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy","volume":"87","author":"Sokolova","year":"2011","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.bonr.2022.101636_bb0710","first-page":"10","article-title":"Mesenchymal stem cells in knee osteoarthritis treatment: a systematic review and meta-analysis","author":"Song","year":"2020","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bonr.2022.101636_bb0715","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bone.2003.07.005","article-title":"Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells","volume":"33","author":"Stenderup","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2022.101636_bb0720","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1089\/scd.2008.0012","article-title":"Human dental pulp stem cells differentiate into neural crest-derived melanocytes and have label-retaining and sphere-forming abilities","volume":"17","author":"Stevens","year":"2008","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bonr.2022.101636_bb0725","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1089\/scd.2011.0722","article-title":"Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells","volume":"21","author":"Strioga","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bonr.2022.101636_bb0730","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13287-021-02138-7","article-title":"Advances in mesenchymal stem cell exosomes: a review","volume":"12","author":"Tang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0735","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.bonr.2022.101636_bb0740","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/cr.2014.44","article-title":"Double-stranded DNA in exosomes: a novel biomarker in cancer detection","volume":"24","author":"Thakur","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.bonr.2022.101636_bb0745","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","author":"Th\u00e9ry","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0750","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0755","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0760","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/jcmm.17086","article-title":"Gingival mesenchymal stem cell-derived exosomes are immunosuppressive in preventing collagen-induced arthritis","volume":"26","author":"Tian","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0765","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bonr.2022.101636_bb0770","article-title":"MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment","volume":"9","author":"Toh","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0775","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/BST20180079","article-title":"MSC exosome works through a protein-based mechanism of action","volume":"46","author":"Toh","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bonr.2022.101636_bb0780","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jpedsurg.2018.10.020","article-title":"A comparison of clinically relevant sources of mesenchymal stem cell-derived exosomes: bone marrow and amniotic fluid","volume":"54","author":"Tracy","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.bonr.2022.101636_bb0785","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41467-022-28673-2","article-title":"Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo","volume":"13","author":"Uenaka","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bonr.2022.101636_bb0790","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.3390\/ijms20102557","article-title":"Molecular-based treatment strategies for osteoporosis: a literature review","volume":"20","author":"Ukon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb0795","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/bloodadvances.2016003251","article-title":"Replenishing exosomes from older bone marrow stromal cells with miR-340 inhibits myeloma-related angiogenesis","volume":"1","author":"Umezu","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.bonr.2022.101636_bb0800","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bonr.2022.101636_bb0805","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.clim.2014.01.005","article-title":"Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis","volume":"151","author":"Vanniasinghe","year":"2014","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bonr.2022.101636_bb0810","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","article-title":"Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0815","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1080\/15384101.2018.1556063","article-title":"TGF-\u03b21 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b","volume":"17","author":"Wang","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bonr.2022.101636_bb0820","article-title":"Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bonr.2022.101636_bb0825","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.omtn.2020.09.014","article-title":"Synovial mesenchymal stem cell-derived EV-packaged miR-31 downregulates histone demethylase KDM2A to prevent knee osteoarthritis","volume":"22","author":"Wang","year":"2020","journal-title":"Mol. Ther.\u2013Nucleic Acids"},{"key":"10.1016\/j.bonr.2022.101636_bb0830","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s13287-020-02032-8","article-title":"Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0835","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/7625134","article-title":"lncRNA-KCNQ1OT1: a potential target in exosomes derived from adipose-derived stem cells for the treatment of osteoporosis","volume":"2021","author":"Wang","year":"2021","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0840","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biomaterials.2016.07.003","article-title":"Efficient production and enhanced tumor delivery of engineered extracellular vesicles","volume":"105","author":"Watson","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0845","doi-asserted-by":"crossref","first-page":"19861","DOI":"10.3402\/jev.v2i0.19861","article-title":"How pure are your vesicles?","volume":"2","author":"Webber","year":"2013","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0850","doi-asserted-by":"crossref","first-page":"17190","DOI":"10.18632\/aging.203169","article-title":"miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt\/\u03b2-catenin axis","volume":"13","author":"Wei","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.bonr.2022.101636_bb0855","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-5116","article-title":"Which is the most effective one in knee osteoarthritis treatment from mesenchymal stem cells obtained from different sources? \u2014A systematic review with conventional and network meta-analyses of randomized controlled trials","volume":"9","author":"Wei","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0860","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15384101.2021.2019411","article-title":"Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis","volume":"21","author":"Wen","year":"2022","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bonr.2022.101636_bb0865","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav8521","article-title":"Advances in therapeutic applications of extracellular vesicles","volume":"11","author":"Wiklander","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bonr.2022.101636_bb0870","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2019.1609206","article-title":"Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications","volume":"8","author":"Witwer","year":"2019","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0875","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12182","article-title":"Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles","volume":"10","author":"Witwer","year":"2021","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0880","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1735249","article-title":"Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration","volume":"9","author":"Woo","year":"2020","journal-title":"J. Extracellular Vesicles"},{"key":"10.1016\/j.bonr.2022.101636_bb0885","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","article-title":"miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0890","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1080\/21655979.2021.1995580","article-title":"miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis","volume":"12","author":"Xia","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.bonr.2022.101636_bb0895","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/9972805","article-title":"BMSC-derived exosomes ameliorate osteoarthritis by inhibiting pyroptosis of cartilage via delivering miR-326 targeting HDAC3 and STAT1\/\/NF-\u03baB p65 to chondrocytes","volume":"2021","author":"Xu","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bonr.2022.101636_bb0900","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s13287-021-02449-9","article-title":"Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo","volume":"12","author":"Xun","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb0905","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211057465","article-title":"The role and mechanism of exosomes from umbilical cord mesenchymal stem cells in inducing osteogenesis and preventing osteoporosis","volume":"30","author":"Yahao","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bonr.2022.101636_bb0910","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10565-019-09504-5","article-title":"Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity","volume":"36","author":"Yan","year":"2020","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bonr.2022.101636_bb0915","first-page":"111","article-title":"Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19","volume":"26","author":"Yan","year":"2021","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bonr.2022.101636_bb0920","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.18632\/aging.102264","article-title":"LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis","volume":"11","author":"Yang","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.bonr.2022.101636_bb0925","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbrc.2020.02.001","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263\/Mob1\/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis","volume":"524","author":"Yang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bonr.2022.101636_bb0930","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/stemcells.2004-0098","article-title":"Isolation of multipotent cells from human term placenta","volume":"23","author":"Yen","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.bonr.2022.101636_bb0935","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/cbin.11690","article-title":"M1 macrophage-derived exosomes aggravate bone loss in postmenopausal osteoporosis via a microRNA-98\/DUSP1\/JNK axis","volume":"45","author":"Yu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bonr.2022.101636_bb0940","article-title":"Current status and development trend of miRNAs in osteoporosis-related research: a bibliometric analysis","volume":"9","author":"Yun","year":"2021","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.bonr.2022.101636_bb0945","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/biof.1576","article-title":"Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis","volume":"46","author":"Zavatti","year":"2020","journal-title":"Biofactors"},{"key":"10.1016\/j.bonr.2022.101636_bb0950","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1089\/scd.2012.0095","article-title":"Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo","volume":"21","author":"Zhang","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bonr.2022.101636_bb0955","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.joca.2016.06.022","article-title":"Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bonr.2022.101636_bb0960","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jcyt.2018.02.372","article-title":"Mesenchymal stromal cell exosome\u2013enhanced regulatory T-cell production through an antigen-presenting cell\u2013mediated pathway","volume":"20","author":"Zhang","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bonr.2022.101636_bb0965","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.biomaterials.2017.11.028","article-title":"MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity","volume":"156","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0970","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0975","doi-asserted-by":"crossref","first-page":"25138","DOI":"10.18632\/aging.104110","article-title":"Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.bonr.2022.101636_bb0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121169","article-title":"Injectable Mussel-Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration","volume":"278","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bonr.2022.101636_bb0985","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.2147\/IJN.S333465","article-title":"Therapeutic potential of exosomal circRNA derived from synovial mesenchymal cells via targeting circEDIL3\/miR-485-3p\/PIAS3\/STAT3\/VEGF functional module in rheumatoid arthritis","volume":"16","author":"Zhang","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bonr.2022.101636_bb0990","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jbiosc.2021.02.007","article-title":"Exosomes from adipose derived mesenchymal stem cells alleviate diabetic osteoporosis in rats through suppressing NLRP3 inflammasome activation in osteoclasts","volume":"131","author":"Zhang","year":"2021","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.bonr.2022.101636_bb0995","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119204","article-title":"microRNA-935-modified bone marrow mesenchymal stem cells-derived exosomes enhance osteoblast proliferation and differentiation in osteoporotic rats","volume":"272","author":"Zhang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bonr.2022.101636_bb1000","first-page":"1","article-title":"Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment","volume":"18","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bonr.2022.101636_bb1005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1474-9726.2008.00377.x","article-title":"Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts","volume":"7","author":"Zhou","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.bonr.2022.101636_bb1010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41420-020-00374-z","article-title":"BMSC-derived exosomes from congenital polydactyly tissue alleviate osteoarthritis by promoting chondrocyte proliferation","volume":"6","author":"Zhou","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bonr.2022.101636_bb1015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bonr.2022.101636_bb1020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cyto.2010.01.004","article-title":"Secretion profile of human bone marrow stromal cells: donor variability and response to inflammatory stimuli","volume":"50","author":"Zhukareva","year":"2010","journal-title":"Cytokine"}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187222004703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:26:12Z","timestamp":1762446372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187222004703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":204,"alternative-id":["S2352187222004703"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101636","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MSC-EV therapy for bone\/cartilage diseases","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2022.101636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101636"}}