{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:10:06Z","timestamp":1777950606576,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018634","name":"Oregon State University Carlson College of Veterinary Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009612","name":"Oregon State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bonr.2023.101653","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:18:37Z","timestamp":1672877917000},"page":"101653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Role of cartilage and bone matrix regulation in early equine osteochondrosis"],"prefix":"10.1016","volume":"18","author":[{"given":"S.K.","family":"Grissom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Semevolos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Duesterdieck-Zellmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2023.101653_bb0005","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3892\/or.2011.1608","article-title":"Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advance epithelial ovarian cancer","volume":"27","author":"Brun","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bonr.2023.101653_bb0010","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/030098589503200605","article-title":"Osteochondrosis of the articular-epiphyseal cartilage complex in young horses: evidence for a defect in cartilage canal blood supply","volume":"32","author":"Carlson","year":"1995","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.bonr.2023.101653_bb0015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2746\/042516408X273657","article-title":"Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse","volume":"40","author":"Donabedian","year":"2008","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bonr.2023.101653_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.2042-3306.1999.tb05312.x","article-title":"Changes in proteoglycan metabolism in osteochondrotic articular cartilage of growing foals","volume":"31","author":"Hoogen","year":"1999","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bonr.2023.101653_bb0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00774-005-0610-y","article-title":"Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation","volume":"23","author":"Ikeda","year":"2005","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.bonr.2023.101653_bb0030","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/jor.22846","article-title":"Wnt\/\u03b2-catenin signaling of cartilage canal and osteochondral junction chondrocytes and full thickness cartilage in early equine osteochondrosis","volume":"33","author":"Kinsley","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bonr.2023.101653_bb0035","first-page":"3","article-title":"Pathogenesis of epiphyseal osteochondrosis","volume":"197","author":"Laverty","year":"2013","journal-title":"Vet. J. Lond. Engl."},{"key":"10.1016\/j.bonr.2023.101653_bb0040","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/S0736-0266(02)00053-0","article-title":"Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis","volume":"20","author":"Laverty","year":"2002","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bonr.2023.101653_bb0045","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1053\/joca.2001.0447","article-title":"L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway","volume":"9","author":"Lefebvre","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bonr.2023.101653_bb0050","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2746\/042516408X300269","article-title":"Epiphyseal cartilage canal blood supply to the distal femur of foals","volume":"40","author":"Olstad","year":"2008","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bonr.2023.101653_bb0055","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/0300985811398250","article-title":"Early lesions of articular osteochondrosis in the distal femur of foals","volume":"48","author":"Olstad","year":"2011","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.bonr.2023.101653_bb0060","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.joca.2013.02.005","article-title":"Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans","volume":"21","author":"Olstad","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bonr.2023.101653_bb0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.2042-3306.1993.tb04847.x","article-title":"Difficulties in definition of equine osteochondrosis; differentiation of developmental and acquired lesions","volume":"25","author":"Pool","year":"1993","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.bonr.2023.101653_bb0070","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.joca.2016.07.021","article-title":"Lubricin\/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis","volume":"25","author":"Reesink","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bonr.2023.101653_bb0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tvjl.2012.04.023","article-title":"Gene and protein expression of cartilage canal and osteochondral junction chondrocytes and full-thickness cartilage in early equine osteochondrosis","volume":"194","author":"Riddick","year":"2012","journal-title":"Vet. J."},{"key":"10.1016\/j.bonr.2023.101653_bb0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-0897.2012.01148.x","article-title":"Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy","volume":"68","author":"Schatz","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bonr.2023.101653_bb0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cveq.2017.03.009","article-title":"Osteochondritis dissecans development","volume":"33","author":"Semevolos","year":"2017","journal-title":"Vet. Clin. North Am. Equine Pract."},{"key":"10.1016\/j.bonr.2023.101653_bb0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bonr.2018.06.003","article-title":"Expression of pro-apoptotic markers is increased along the osteochondral junction in naturally occurring osteochondrosis","volume":"9","author":"Semevolos","year":"2018","journal-title":"Bone Rep."},{"key":"10.1016\/j.bonr.2023.101653_bb0095","article-title":"Reproducing the biomechanical environment of the chondrocyte for cartilage tissue engineering","author":"Statham","year":"2021","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.bonr.2023.101653_bb0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0363546510378088","article-title":"Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee","volume":"39","author":"Teeple","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bonr.2023.101653_bb0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbadis.2004.05.002","article-title":"Exracellular matrix changes in early osteochondrotic defects in foals: a key role for collagen?","volume":"2690","author":"van de Lest","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bonr.2023.101653_bb0110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.2042-3306.1999.tb05309.x","article-title":"The effect of exercise on the distribution and manifestation of osteochondrotic lesions in the warmblood foal","volume":"31","author":"van Weeren","year":"1999","journal-title":"Equine Vet. J. Suppl."},{"key":"10.1016\/j.bonr.2023.101653_bb0115","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1177\/0363546516686965","article-title":"Intra-articular recombinant human proteoglycan 4 mitigates cartilage damage after destabilization of the medial meniscus in the Yucatan minipig","volume":"45","author":"Waller","year":"2017","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bonr.2023.101653_bb0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/jcs.107.1.47","article-title":"Characterization of articular and growth-plate cartilage collagens in porcine osteochondrosis","volume":"107","author":"Wardale","year":"1994","journal-title":"J. Cell Sci."}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187223000013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187223000013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:26:07Z","timestamp":1762446367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187223000013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":24,"alternative-id":["S2352187223000013"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2023.101653","relation":{},"ISSN":["2352-1872"],"issn-type":[{"value":"2352-1872","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of cartilage and bone matrix regulation in early equine osteochondrosis","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2023.101653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101653"}}