{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:25:50Z","timestamp":1767065150867,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702180"],"award-info":[{"award-number":["81702180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bone Reports"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bonr.2024.101744","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T05:09:34Z","timestamp":1707973774000},"page":"101744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Strontium ranelate retards disc degradation and improves endplate and bone micro-architecture in ovariectomized rats with lumbar fusion induced \u2013 Adjacent segment disc degeneration"],"prefix":"10.1016","volume":"20","author":[{"given":"Qi","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiakang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangqiang","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Nan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Ming","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianwen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bonr.2024.101744_bb0005","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bone.2007.06.025","article-title":"Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1-34) in a rat spinal arthrodesis model","volume":"41-5","author":"Abe","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2024.101744_bb0010","unstructured":"(accessed 4 November \/2013)."},{"key":"10.1016\/j.bonr.2024.101744_bb0015","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.spinee.2010.09.014","article-title":"Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model","volume":"10-12","author":"Allon","year":"2010","journal-title":"Spine J."},{"issue":"30\u20132","key":"10.1016\/j.bonr.2024.101744_bb0020","first-page":"167","article-title":"Young investigator award winner: vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration","volume":"2005","author":"Benneker","year":"2004","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/ard.2007.075572","article-title":"Effects of strontium ranelate on spinal osteoarthritis progression","volume":"67-3","author":"Bruyere","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bonr.2024.101744_bb0030","first-page":"9","article-title":"Incidence and risk factors of reoperation in patients with adjacent segment disease: a meta-analysis","volume":"11-1","author":"Burch","year":"2020","journal-title":"J. Craniovertebr. Junction Spine"},{"key":"10.1016\/j.bonr.2024.101744_bb0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bpobgyn.2008.10.003","article-title":"Effects of hormone replacement therapy on connective tissue: why is this important?","volume":"23-1","author":"Calleja-Agius","year":"2009","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.bonr.2024.101744_bb0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.joca.2006.06.006","article-title":"Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits","volume":"15-1","author":"Calvo","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bonr.2024.101744_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/213234","article-title":"Age-related changes in trabecular and cortical bone microstructure","volume":"2013","author":"Chen","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bonr.2024.101744_bb0050","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393-10169","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bonr.2024.101744_bb0055","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00003086-196807000-00007","article-title":"The nature of pseudarthrosis","volume":"59","author":"DePalma","year":"1968","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bonr.2024.101744_bb0060","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1097\/00007632-199608150-00006","article-title":"The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat","volume":"21\u201316","author":"Dimar","year":"1996","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.592118","article-title":"Intervertebral disk degeneration: the microenvironment and tissue engineering strategies","volume":"9","author":"Dou","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bonr.2024.101744_bb0070","doi-asserted-by":"crossref","first-page":"17892","DOI":"10.1038\/s41598-021-97288-2","article-title":"Biomechanical effects of lumbar fusion surgery on adjacent segments using musculoskeletal models of the intact, degenerated and fused spine","volume":"11-1","author":"Ebrahimkhani","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bonr.2024.101744_bb0075","doi-asserted-by":"crossref","unstructured":"Ensrud KE, Crandall CJ. Osteoporosis. Ann. Intern. Med. 2017;167-3:Itc17-itc32.","DOI":"10.7326\/AITC201708010"},{"issue":"Suppl","key":"10.1016\/j.bonr.2024.101744_bb0080","first-page":"163","article-title":"Risk factors for adjacent-segment failure following lumbar fixation with rigid instrumentation for degenerative instability","volume":"90-2","author":"Etebar","year":"1999","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bonr.2024.101744_bb0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s40610-018-0105-y","article-title":"Contribution of the endplates to disc degeneration","volume":"4-4","author":"Fields","year":"2018","journal-title":"Curr. Mol. Biol. Rep."},{"key":"10.1016\/j.bonr.2024.101744_bb0090","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bone.2017.11.005","article-title":"Non traumatic osteonecrosis of the femoral head is associated with low bone mass","volume":"107","author":"Gangji","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2024.101744_bb0095","first-page":"24","article-title":"The use of medical ozone in chronic intervertebral disc degeneration can be an etiological and conservative treatment","author":"Grangeat","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bonr.2024.101744_bb0100","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1097\/BRS.0b013e318158cd69","article-title":"Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population","volume":"32\u201323","author":"Gruber","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/1529-0131(200201)46:1<92::AID-ART10057>3.0.CO;2-#","article-title":"The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford study","volume":"46-1","author":"Hart","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bonr.2024.101744_bb0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1359\/jbmr.2001.16.2.299","article-title":"Strontium ranelate increases cartilage matrix formation","volume":"16-2","author":"Henrotin","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bonr.2024.101744_bb0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00002517-200104000-00001","article-title":"Minimum 10-year follow-up study of anterior lumbar interbody fusion for isthmic spondylolisthesis","volume":"14-2","author":"Ishihara","year":"2001","journal-title":"J. Spinal Disord."},{"key":"10.1016\/j.bonr.2024.101744_bb0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7150\/thno.48987","article-title":"Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions","volume":"11-1","author":"Kamali","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bonr.2024.101744_bb0125","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1007\/s00198-010-1474-0","article-title":"A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX(\u00ae)","volume":"22-8","author":"Kanis","year":"2011","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bonr.2024.101744_bb0130","series-title":"Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy","first-page":"131","volume":"14-1","author":"Li","year":"2019"},{"key":"10.1016\/j.bonr.2024.101744_bb0135","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12891-015-0788-7","article-title":"Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat","volume":"16","author":"Liu","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bonr.2024.101744_bb0140","article-title":"Estrogen deficiency exacerbates intervertebral disc degeneration induced by spinal instability in rats","volume":"44\u20139","author":"Liu","year":"2019","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jot.2019.10.005","article-title":"Cervical spinal instability causes vertebral microarchitecture change and vertebral endplate lesion in rats","volume":"24","author":"Liu","year":"2020","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bonr.2024.101744_bb0150","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/GME.0000000000000902","article-title":"Association between menopause and lumbar disc degeneration: an MRI study of 1,566 women and 1,382 men","volume":"24-10","author":"Lou","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.bonr.2024.101744_bb0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bone.2013.03.002","article-title":"Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats","volume":"55-2","author":"Luo","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2024.101744_bb0160","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00256-008-0632-3","article-title":"The broadening spectrum of osteoporotic vertebral fracture","volume":"38-4","author":"McKiernan","year":"2009","journal-title":"Skeletal Radiol."},{"key":"10.1016\/j.bonr.2024.101744_bb0165","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1097\/00007632-199310001-00028","article-title":"Finite-element stress analysis of the normal and osteoporotic lumbar vertebral body","volume":"18\u201314","author":"Mizrahi","year":"1993","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/17453677008991550","article-title":"In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs","volume":"41-6","author":"Nachemson","year":"1970","journal-title":"Acta Orthop. Scand."},{"key":"10.1016\/j.bonr.2024.101744_bb0175","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/BRS.0b013e318191e687","article-title":"Parathyroid hormone (1-34) augments spinal fusion, fusion mass volume, and fusion mass quality in a rabbit spinal fusion model","volume":"34\u20132","author":"O\u2019Loughlin","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0180","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/annrheumdis-2012-201710","article-title":"Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1\u03b2 in the synovium","volume":"72-2","author":"Pelletier","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bonr.2024.101744_bb0185","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/annrheumdis-2013-203989","article-title":"Disease-modifying effect of strontium ranelate in a subset of patients from the phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss","volume":"74-2","author":"Pelletier","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bonr.2024.101744_bb0190","series-title":"Biomechanical and clinical studies on lumbar spine fusion surgery: a review","first-page":"617","volume":"61-3","author":"Pradeep","year":"2023"},{"key":"10.1016\/j.bonr.2024.101744_bb0195","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11914-005-0025-7","article-title":"Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action","volume":"3-1","author":"Reginster","year":"2005","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bonr.2024.101744_bb0200","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.bone.2011.06.005","article-title":"Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts","volume":"49-3","author":"Tat","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bonr.2024.101744_bb0205","first-page":"363","article-title":"Osteoporosis and the Management of Spinal Degenerative Disease (II)","volume":"5-6","author":"Tom\u00e9-Bermejo","year":"2017","journal-title":"Arch. Bone Jt. Surg."},{"key":"10.1016\/j.bonr.2024.101744_bb0210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.12998\/wjcc.v11.i1.17","article-title":"Endplate role in the degenerative disc disease: a brief review","volume":"11-1","author":"Velnar","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.bonr.2024.101744_bb0215","doi-asserted-by":"crossref","first-page":"551","DOI":"10.21037\/qims.2018.07.04","article-title":"Senile osteoporosis is associated with disc degeneration","volume":"8-6","author":"W\u00e1ng","year":"2018","journal-title":"Quant. Imaging Med. Surg."},{"key":"10.1016\/j.bonr.2024.101744_bb0220","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00223-004-0240-8","article-title":"Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats","volume":"75-3","author":"Wang","year":"2004","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bonr.2024.101744_bb0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13075-018-1701-1","article-title":"Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice","volume":"20-1","author":"Xiao","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bonr.2024.101744_bb0230","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3892\/etm.2022.11131","article-title":"The anti-inflammation effect of strontium ranelate on rat chondrocytes with or without IL-1\u03b2 in vitro","volume":"23-3","author":"Yu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bonr.2024.101744_bb0235","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1186\/s12891-022-05905-6","article-title":"Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors","volume":"23-1","author":"Yuan","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bonr.2024.101744_bb0240","article-title":"Increased cortical porosity and reduced trabecular density are not necessarily synonymous with bone loss and microstructural deterioration","volume":"3-4","author":"Zebaze","year":"2019","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bonr.2024.101744_bb0245","first-page":"1032","article-title":"Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham study","volume":"27-4","author":"Zhang","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bonr.2024.101744_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2020.11.005","article-title":"Does osteoporosis affect the adjacent segments following anterior lumbar interbody fusion? A finite element study","volume":"146","author":"Zhang","year":"2021","journal-title":"World Neurosurg."},{"key":"10.1016\/j.bonr.2024.101744_bb0255","article-title":"Alendronate prevents intervertebral disc degeneration adjacent to a lumbar fusion in ovariectomized rats","volume":"40\u201320","author":"Zhou","year":"2015","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.bonr.2024.101744_bb0260","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/jbmr.2736","article-title":"Enhancement of lumbar fusion and alleviation of adjacent segment disc degeneration by intermittent PTH(1-34) in ovariectomized rats","volume":"31-4","author":"Zhou","year":"2016","journal-title":"J. Bone Miner. Res."}],"container-title":["Bone Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187224000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352187224000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T16:26:57Z","timestamp":1762446417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352187224000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":52,"alternative-id":["S2352187224000111"],"URL":"https:\/\/doi.org\/10.1016\/j.bonr.2024.101744","relation":{},"ISSN":["2352-1872"],"issn-type":[{"type":"print","value":"2352-1872"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strontium ranelate retards disc degradation and improves endplate and bone micro-architecture in ovariectomized rats with lumbar fusion induced \u2013 Adjacent segment disc degeneration","name":"articletitle","label":"Article Title"},{"value":"Bone Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bonr.2024.101744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101744"}}