{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:08:42Z","timestamp":1776449322212,"version":"3.51.2"},"reference-count":98,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Anaesthesiology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.bpa.2007.02.001","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T01:04:48Z","timestamp":1181783088000},"page":"257-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Use of blood and blood products in trauma"],"prefix":"10.1016","volume":"21","author":[{"given":"Oliver","family":"Grottke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietrich","family":"Henzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Rossaint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpa.2007.02.001_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/milmed\/162.1.24","article-title":"The trimodal death distribution of trauma victims: military experience from the Lebanon War","volume":"162","author":"Gofrit","year":"1997","journal-title":"Military Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00005373-199502000-00006","article-title":"Epidemiology of trauma deaths: a reassessment","volume":"38","author":"Sauaia","year":"1995","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.TA.0000075338.21177.EF","article-title":"Early coagulopathy predicts mortality in trauma","volume":"55","author":"MacLeod","year":"2003","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"Brohi","year":"2003","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9610(05)81018-9","article-title":"Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion","volume":"160","author":"Ferrara","year":"1990","journal-title":"American Journal of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib6","first-page":"826","article-title":"Physiological predictors of death in exsanguinating trauma patients undergoing conventional trauma surgery","volume":"68","author":"Krishna","year":"1998","journal-title":"The Australian and New Zealand Journal of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0049-3848(85)90096-9","article-title":"Changes in coagulation and fibrinolysis occurring in dogs during hypothermia","volume":"37","author":"Yoshihara","year":"1985","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.bpa.2007.02.001_bib8","first-page":"608","article-title":"Temperature corrected thrombelastography in hypothermic patients","volume":"81","author":"Douning","year":"1995","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.TA.0000066184.20808.A5","article-title":"The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients","volume":"55","author":"Meng","year":"2003","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/01.shk.0000225403.15722.e9","article-title":"Key issues in advanced bleeding care in trauma","volume":"26","author":"Rossaint","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.bpa.2007.02.001_bib11","series-title":"Advanced Trauma Life Support (ATLS) for Doctors","author":"American College of Surgeons","year":"2004"},{"key":"10.1016\/j.bpa.2007.02.001_bib12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00005373-199310000-00014","article-title":"Lactate clearance and survival following injury","volume":"35","author":"Abramson","year":"1993","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00005373-199611000-00001","article-title":"Admission base deficit predicts transfusion requirements and risk of complications","volume":"41","author":"Davis","year":"1996","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1473-0502(02)00029-0","article-title":"Massive blood transfusion in the elective surgical setting","volume":"27","author":"Erber","year":"2002","journal-title":"Transfusion and Apheresis Science"},{"key":"10.1016\/j.bpa.2007.02.001_bib15","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5694\/j.1326-5377.1995.tb124628.x","article-title":"Massive blood transfusion in a tertiary referral hospital. Clinical outcomes and haemostatic complications","volume":"163","author":"Harvey","year":"1995","journal-title":"The Medical journal of Australia"},{"key":"10.1016\/j.bpa.2007.02.001_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/bja\/aei169","article-title":"Coagulopathy and blood component transfusion in trauma","volume":"95","author":"Spahn","year":"2005","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000658-196904000-00001","article-title":"Coagulation disorders in combat casualties. I. Acute changes after wounding. II. Effects of massive transfusion. 3. Post-resuscitative changes","volume":"169","author":"Simmons","year":"1969","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005373-199304000-00002","article-title":"Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients","volume":"34","author":"Faringer","year":"1993","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib19","first-page":"59","article-title":"The use of fresh whole blood in massive transfusion","volume":"60","author":"Repine","year":"2006","journal-title":"Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00005373-200009000-00021","article-title":"United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield","volume":"49","author":"Mabry","year":"2000","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0002-9343(94)90138-4","article-title":"Hemostasis in renal disease: pathophysiology and management","volume":"96","author":"Eberst","year":"1994","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib22","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.1537-2995.2001.41080977.x","article-title":"Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss","volume":"41","author":"Valeri","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.bpa.2007.02.001_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/bja\/aeh174","article-title":"Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage","volume":"93","author":"Bombeli","year":"2004","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-0037-1614486","article-title":"Contribution of erythrocytes to thrombin generation in whole blood","volume":"81","author":"Peyrou","year":"1999","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.bpa.2007.02.001_bib25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1001\/archsurg.1997.01430300062013","article-title":"An independent risk factor for postinjury multiple organ failure","volume":"132","author":"Moore","year":"1997","journal-title":"Archives of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00005373-199808000-00014","article-title":"Multiple organ failure can be predicted as early as 12 hours after injury","volume":"45","author":"Sauaia","year":"1998","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/000313480206800702","article-title":"Blood transfusions correlate with infections in trauma patients in a dose-dependent manner","volume":"68","author":"Claridge","year":"2002","journal-title":"The American Surgeon"},{"key":"10.1016\/j.bpa.2007.02.001_bib28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00005373-199211000-00010","article-title":"Association between blood transfusion and infection in injured patients","volume":"33","author":"Edna","year":"1992","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM199902113400601","article-title":"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group","volume":"340","author":"Hebert","year":"1999","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/01.TA.0000136158.93864.54","article-title":"Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?","volume":"57","author":"McIntyre","year":"2004","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib31","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/01.TA.0000060261.10597.5C","article-title":"Blood transfusion, independent of shock severity, is associated with worse outcome in trauma","volume":"54","author":"Malone","year":"2003","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.TA.0000171459.21450.DC","article-title":"Transfusions result in pulmonary morbidity and death after a moderate degree of injury","volume":"59","author":"Croce","year":"2005","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1423-0410.1998.tb05449.x","article-title":"Replacement of massive blood","volume":"74","author":"Hiippala","year":"1998","journal-title":"Vox Sanguinis"},{"key":"10.1016\/j.bpa.2007.02.001_bib34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000542-199603000-00032","article-title":"Practice guidelines for blood component therapy","volume":"84","author":"American Society of Anesthesiologists Task Force on Blood Component Therapy","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bpa.2007.02.001_bib35","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/jama.1994.03510340067036","article-title":"Practice parameters for the use of fresh frozen plasma, cryoprecipitate and platelets","volume":"271","author":"College of American Pathologists","year":"1994","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.bpa.2007.02.001_bib36","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1537-2995.2001.41070857.x","article-title":"Single-donor platelets reduce the risk of septic platelet transfusion reactions","volume":"41","author":"Ness","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.bpa.2007.02.001_bib37","first-page":"336","article-title":"Packed red cells in acute blood loss: dilutional coagulopathy as a cause of surgical bleeding","volume":"80","author":"Murray","year":"1995","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tmrv.2004.03.003","article-title":"Relationship between platelet count and bleeding risk in thrombocytopenic patients","volume":"18","author":"Slichter","year":"2004","journal-title":"Transfusion Medicine Reviews"},{"key":"10.1016\/j.bpa.2007.02.001_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1365-2141.2003.04468.x","article-title":"Guidelines for the use of platelet transfusions","volume":"122","author":"British Committee for Standards in Haematology Blood Transfusion Task Force","year":"2003","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V88.1.3.3","article-title":"Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology","volume":"1","author":"George","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bpa.2007.02.001_bib41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jtcvs.2004.02.019","article-title":"Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting","volume":"128","author":"Chen","year":"2004","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF03022251","article-title":"Massive transfusion and coagulopathy: pathophysiology and implications for clinical management","volume":"53","author":"Hardy","year":"2006","journal-title":"Canadian Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib43","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/tmrv.2003.50009","article-title":"Risks associated with transfusion of cellular blood components in Canada","volume":"17","author":"Kleinman","year":"2003","journal-title":"Transfusion Medicine Reviews"},{"key":"10.1016\/j.bpa.2007.02.001_bib44","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000658-198510000-00010","article-title":"Fresh frozen plasma supplement to massive red blood cell transfusion","volume":"202","author":"Martin","year":"1985","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib45","series-title":"Transfusion Reactions","article-title":"Transfusion-related acute lung injury","author":"Popovsky","year":"2001"},{"key":"10.1016\/j.bpa.2007.02.001_bib46","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00005373-198708000-00010","article-title":"Outcome of massive transfusion exceeding two blood volumes in trauma and emergency surgery","volume":"27","author":"Phillips","year":"1987","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib47","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1537-2995.2003.00371.x","article-title":"Monitoring the nation's blood supply","volume":"43","author":"Wallace","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.bpa.2007.02.001_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2141.2004.04973.x","article-title":"Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials","volume":"126","author":"Stanworth","year":"2004","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib49","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1055\/s-0038-1655992","article-title":"Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy","volume":"77","author":"Makris","year":"1997","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.bpa.2007.02.001_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2257.1998.00161.x","article-title":"Clinical experience with the use of clotting factor concentrates in oral anticoagulation reversal","volume":"20","author":"Nitu","year":"1998","journal-title":"Clinical and Laboratory Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2141.2004.04972.x","article-title":"British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant","volume":"126","author":"O'Shaughnessy","year":"2004","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib52","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/00003643-200310000-00002","article-title":"Strategies to reduce perioperative blood loss related to non-surgical bleeding","volume":"20","author":"Menzebach","year":"2003","journal-title":"European Journal of Anaesthesiology"},{"key":"10.1016\/j.bpa.2007.02.001_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2141.2001.02908.x","article-title":"The management of coumarin-induced over-anticoagulation","volume":"114","author":"Makris","year":"2001","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib54","first-page":"152","article-title":"Ionized hypocalcemia after fresh frozen plasma administration to thermally injured children: effects of infusion rate, duration, and treatment with calcium chloride","volume":"67","author":"Cote","year":"1988","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-2006-939557","article-title":"Mechanism of action of factor VIIa in the treatment of coagulopathies","volume":"32","author":"Hedner","year":"2006","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"10.1016\/j.bpa.2007.02.001_bib56","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1538-7836.2003.00242.x","article-title":"The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII\/FIX","volume":"1","author":"He","year":"2003","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.bpa.2007.02.001_bib57","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00005373-200104000-00021","article-title":"Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine with grade V liver injuries","volume":"50","author":"Martinowitz","year":"2001","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib58","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0140-6736(99)05155-7","article-title":"Treatment of traumatic bleeding with recombinant factor VIIa","volume":"354","author":"Kenet","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bpa.2007.02.001_bib59","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jama.295.3.293","article-title":"Thromboembolic adverse events after use of recombinant human coagulation factor VIIa","volume":"18","author":"O'Connell","year":"2006","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/j.bpa.2007.02.001_bib60","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/01.TA.0000093395.34097.56","article-title":"Daily multidisciplinary rounds shorten length of stay for trauma patients","volume":"55","author":"Dutton","year":"2003","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib61","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1538-7836.2005.01203.x","article-title":"The Israeli Multidisciplinary rFVIIa Task Force Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force","volume":"3","author":"Martinowitz","year":"2005","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.bpa.2007.02.001_bib62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.TA.0000171453.37949.B7","article-title":"NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials","volume":"5","author":"Boffard","year":"2005","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib63","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/cc5026","article-title":"Recommandations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding - a European perspective","volume":"10","author":"Vincent","year":"2006","journal-title":"Critical Care"},{"key":"10.1016\/j.bpa.2007.02.001_bib64","first-page":"360","article-title":"Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates","volume":"81","author":"Hiippala","year":"1995","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib65","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/bja\/aef574","article-title":"In vivo effect of haemodilution with saline on coagulation","volume":"89","author":"Innerhofer","year":"2002","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib66","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1213\/01.ane.0000194359.06286.d4","article-title":"The effect of fibrinogen substitution on reversal of dilutional coagulopathy: an in vitro model","volume":"102","author":"Fries","year":"2006","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib67","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/bja\/aei160","article-title":"Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model","volume":"95","author":"Fries","year":"2005","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib68","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/jcp.2003.008904","article-title":"Warfarin reversal","volume":"57","author":"Hanley","year":"2004","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.bpa.2007.02.001_bib69","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.0007-1048.2001.03295.x","article-title":"Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients","volume":"116","author":"Preston","year":"2002","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib70","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1046\/j.1365-2141.2001.03214.x","article-title":"Beriplex P\/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding","volume":"115","author":"Evans","year":"2001","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.beha.2005.01.026","article-title":"Plasma and plasma products in the treatment of massive haemorrhage","volume":"19","author":"Erber","year":"2006","journal-title":"Best Practice & Research. Clinical Haematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib72","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0049-3848(99)00079-1","article-title":"Thrombogenicity of prothrombin complex concentrates","volume":"95","author":"Kohler","year":"1999","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.bpa.2007.02.001_bib73","first-page":"3","article-title":"Thrombogenicity associated with factor IX complex concentrates","volume":"28","author":"Lusher","year":"1991","journal-title":"Seminars in Hematology"},{"key":"10.1016\/j.bpa.2007.02.001_bib74","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/00005373-199109000-00007","article-title":"Fibrinolysis in multisystem trauma patients","volume":"31","author":"Enderson","year":"1991","journal-title":"The Journal of Trauma"},{"key":"10.1016\/j.bpa.2007.02.001_bib75","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s002689900001","article-title":"Hypercoagulability following multiple trauma","volume":"20","author":"Engelman","year":"1996","journal-title":"World Journal of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib76","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/00003246-198611000-00001","article-title":"Early activation of humoral proteolytic systems in patients with multiple trauma","volume":"14","author":"Risberg","year":"1986","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib77","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1067\/mtc.2002.120717","article-title":"Hemostatic effects of tranexamic acid in elective thoracic aortic surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"123","author":"Casati","year":"2002","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib78","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0003-4975(02)04412-0","article-title":"High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery","volume":"75","author":"Mossinger","year":"2003","journal-title":"The Annals of Thoracic Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib79","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/bja\/aeh227","article-title":"Perioperative systemic haemostatic agents","volume":"93","author":"Mahdy","year":"2004","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib80","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0889-8537(05)70134-6","article-title":"Drugs to prevent and reverse anticoagulation","volume":"17","author":"Franck","year":"1999","journal-title":"Anesthesiology Clinics of North America"},{"key":"10.1016\/j.bpa.2007.02.001_bib81","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4615-9546-5_6","article-title":"Aprotinin concentrations effective for the inhibition of tissue kallikrein and plasma kallikrein in vitro and in vivo","volume":"247","author":"Hoffmann","year":"1989","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.bpa.2007.02.001_bib82","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(87)91190-1","article-title":"Effect of aprotinin on need for blood transfusion after repeat open-heart surgery","volume":"2","author":"Royston","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.bpa.2007.02.001_bib83","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2165\/00003495-200262150-00003","article-title":"Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery","volume":"62","author":"Porte","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.bpa.2007.02.001_bib84","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0022-5223(97)70415-X","article-title":"Prevalence of anaphylactic reactions to aprotinin: analysis of two hundred forty-eight reexposures to aprotinin in heart opera-tions","volume":"113","author":"Dietrich","year":"1997","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib85","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMoa051379","article-title":"The risk associated with aprotinin in cardiac surgery","volume":"354","author":"Mangano","year":"2006","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib86","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1537-2995.2006.00724.x","article-title":"A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery","volume":"46","author":"Karkouti","year":"2006","journal-title":"Transfusion"},{"key":"10.1016\/j.bpa.2007.02.001_bib87","unstructured":"http:\/\/www.fda.gov\/cder\/drug\/infosheets\/hcp\/aprotininhcp.htm [accessed October 2006]."},{"key":"10.1016\/j.bpa.2007.02.001_bib88","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2165\/00003495-198529030-00003","article-title":"Clinical application of inhibitors of fibrinolysis","volume":"29","author":"Verstraete","year":"1985","journal-title":"Drugs"},{"key":"10.1016\/j.bpa.2007.02.001_bib89","article-title":"Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion","volume":"1","author":"Henry","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.bpa.2007.02.001_bib90","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004896.pub2","article-title":"Antifibrinolytic drugs for acute traumatic injury","author":"Coats","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.bpa.2007.02.001_bib91","unstructured":"www.crash2.LSHTM.ac.uk [accessed October 2006]."},{"key":"10.1016\/j.bpa.2007.02.001_bib92","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0140-6736(99)01264-7","article-title":"Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints","volume":"354","author":"Levi","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bpa.2007.02.001_bib93","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1056\/NEJMra040403","article-title":"Treatment of von Willebrand's Disease","volume":"351","author":"Mannucci","year":"2004","journal-title":"The New England Journal of Medicine"},{"issue":"339","key":"10.1016\/j.bpa.2007.02.001_bib94","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJM199807233390407","article-title":"Hemostatic drugs","volume":"23","author":"Mannucci","year":"1998","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.bpa.2007.02.001_bib95","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0022-5223(19)34638-0","article-title":"The effect of desmopressin acetate on postoperative hemorrhage in patients receiving aspirin therapy before coronary artery bypass operations","volume":"104","author":"Gratz","year":"1992","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib96","first-page":"33","article-title":"Use of desmopressin acetate to reduce blood transfusion requirements during cardiac surgery in patients with acetylsalicylic-acid-induced platelet dysfunction","volume":"37","author":"Sheridan","year":"1994","journal-title":"Canadian Journal of Surgery"},{"key":"10.1016\/j.bpa.2007.02.001_bib97","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1213\/01.ANE.0000100682.84799.E8","article-title":"Prophylactic treatment with desmopressin does not reduce postoperative bleeding after coronary surgery in patients treated with aspirin before surgery","volume":"98","author":"Pleym","year":"2004","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/j.bpa.2007.02.001_bib98","article-title":"Desmopressin for minimising perioperative allogeneic blood transfusion","volume":"1","author":"Carless","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"}],"container-title":["Best Practice & Research Clinical Anaesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521689607000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521689607000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:27:42Z","timestamp":1776425262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521689607000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":98,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S1521689607000171"],"URL":"https:\/\/doi.org\/10.1016\/j.bpa.2007.02.001","relation":{},"ISSN":["1753-3740"],"issn-type":[{"value":"1753-3740","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of blood and blood products in trauma","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Anaesthesiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpa.2007.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}