{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:13:38Z","timestamp":1784607218014,"version":"3.55.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Anaesthesiology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bpa.2016.10.003","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T03:15:14Z","timestamp":1478488514000},"page":"479-489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of vasodilators on haemodynamic coherence"],"prefix":"10.1016","volume":"30","author":[{"given":"Christian","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ertmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rehberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40635-015-0049-y","article-title":"Effects of early hemodynamic resuscitation on left ventricular performance and microcirculatory function during endotoxic shock","volume":"3","author":"Lopez","year":"2015","journal-title":"Intensive Care Med Exp"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib2","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/cc7922","article-title":"Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study","volume":"13","author":"Dubin","year":"2009","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib3","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1186\/cc13932","article-title":"Nitroglycerin reverts clinical manifestations of poor peripheral perfusion in patients with circulatory shock","volume":"18","author":"Lima","year":"2014","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib4","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/CCM.0000000000000223","article-title":"Microcirculatory alterations in traumatic hemorrhagic shock","volume":"42","author":"Tachon","year":"2014","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib5","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1097\/CCM.0b013e31823dae59","article-title":"Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock","volume":"40","author":"Edul","year":"2012","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib6","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1097\/CCM.0b013e3182a63fbf","article-title":"Microvascular perfusion as a target for fluid resuscitation in experimental circulatory shock","volume":"42","author":"van Genderen","year":"2014","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/01.CCM.0000300083.74726.43","article-title":"Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia","volume":"36","author":"Dubin","year":"2008","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.bpa.2016.10.003_bib8","doi-asserted-by":"crossref","first-page":"e103978","DOI":"10.1371\/journal.pone.0103978","article-title":"Conventional hemodynamic resuscitation may fail to optimize tissue perfusion: an observational study on the effects of dobutamine, enoximone, and norepinephrine in patients with acute myocardial infarction complicated by cardiogenic shock","volume":"9","author":"den Uil","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib9","first-page":"250","article-title":"Coupling microcirculation to systemic hemodynamics","volume":"16","author":"de Backer","year":"2010","journal-title":"Curr Opin Crit Care"},{"issue":"Suppl. 5","key":"10.1016\/j.bpa.2016.10.003_bib10","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/cc8011","article-title":"Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients","volume":"13","author":"Lima","year":"2009","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/CCM.0000000000000553","article-title":"International study on microcirculatory shock occurrence in acutely ill patients","volume":"43","author":"Vellinga","year":"2015","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.bpa.2016.10.003_bib12","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.CCM.0000138558.16257.3F","article-title":"Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock","volume":"32","author":"Sakr","year":"2004","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ahj.2003.07.006","article-title":"Microvascular alterations in patients with acute severe heart failure and cardiogenic shock","volume":"147","author":"de Backer","year":"2004","journal-title":"Am Heart J"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/CCM.0b013e3182742e8b","article-title":"Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome","volume":"41","author":"de Backer","year":"2013","journal-title":"Crit Care Med"},{"issue":"12","key":"10.1016\/j.bpa.2016.10.003_bib15","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1007\/s00134-008-1193-6","article-title":"Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24\u00a0h in patients with sepsis","volume":"34","author":"Trzeciak","year":"2008","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200912-1918OC","article-title":"Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial","volume":"182","author":"Jansen","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib17","first-page":"381","article-title":"New insights into the pathophysiology of cardiogenic shock: the role of the microcirculation","volume":"19","author":"Ashruf","year":"2013","journal-title":"Curr Opin Crit Care"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3233\/CH-2009-1194","article-title":"Evaluation of the sublingual microcirculation in cardiogenic shock","volume":"42","author":"Jung","year":"2009","journal-title":"Clin Hemorheol Microcirc"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00134-008-1325-z","article-title":"Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications","volume":"35","author":"Jhanji","year":"2009","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib20","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/cc13905","article-title":"Clinical assessment of peripheral perfusion to predict postoperative complications after major abdominal surgery early: a prospective observational study in adults","volume":"18","author":"van Genderen","year":"2014","journal-title":"Crit Care"},{"issue":"11","key":"10.1016\/j.bpa.2016.10.003_bib21","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00134-010-2005-3","article-title":"Monitoring the microcirculation in the critically ill patient: current methods and future approaches","volume":"36","author":"de Backer","year":"2010","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3233\/CH-151994","article-title":"Evaluation of the microcirculation in critically ill patients","volume":"61","author":"Jung","year":"2015","journal-title":"Clin Hemorheol Microcirc"},{"issue":"10","key":"10.1016\/j.bpa.2016.10.003_bib23","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/aas.12780","article-title":"Scandinavian SSAI clinical practice guideline on choice of first-line vasopressor for patients with acute circulatory failure","volume":"60","author":"Moller","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"issue":"11","key":"10.1016\/j.bpa.2016.10.003_bib24","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.ajem.2016.07.058","article-title":"Positive fluid balance as a major predictor of clinical outcome of patients with sepsis\/septic shock after discharge from intensive care unit","volume":"34","author":"Brotfain","year":"2016","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.hrtlng.2010.04.007","article-title":"Characteristics of patients receiving vasopressors","volume":"40","author":"Benbenishty","year":"2011","journal-title":"Heart Lung"},{"issue":"Suppl. 3","key":"10.1016\/j.bpa.2016.10.003_bib26","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/cc14726","article-title":"Hemodynamic coherence and the rationale for monitoring the microcirculation","volume":"19","author":"Ince","year":"2015","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/rccm.200109-016OC","article-title":"Microvascular blood flow is altered in patients with sepsis","volume":"166","author":"de Backer","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/EJA.0000000000000126","article-title":"Testing a conceptual model on early opening of the microcirculation in severe sepsis and septic shock: a randomised controlled pilot study","volume":"32","author":"van der Voort","year":"2015","journal-title":"Eur J Anaesthesiol"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/CCM.0b013e3181b02fc1","article-title":"Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis\/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial","volume":"38","author":"Boerma","year":"2010","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/107424840400900403","article-title":"Intravenous nitroglycerin in the treatment of decompensated heart failure: potential benefits and limitations","volume":"9","author":"Elkayam","year":"2004","journal-title":"J\u00a0Cardiovasc Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11897-014-0230-8","article-title":"Impact of intravenous nitroglycerin in the management of acute decompensated heart failure","volume":"12","author":"den Uil","year":"2015","journal-title":"Curr Heart Fail Rep"},{"issue":"9","key":"10.1016\/j.bpa.2016.10.003_bib33","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1007\/s00134-002-1407-2","article-title":"Opening the microcirculation: can vasodilators be useful in sepsis?","volume":"28","author":"Buwalda","year":"2002","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.bpa.2016.10.003_bib34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12967-014-0232-z","article-title":"Fluid resuscitation therapy in endotoxemic hamsters improves survival and attenuates capillary perfusion deficits and inflammatory responses by a mechanism related to nitric oxide","volume":"12","author":"Villela","year":"2014","journal-title":"J\u00a0Transl Med"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib35","first-page":"252","article-title":"Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep","volume":"13","author":"Edul","year":"2011","journal-title":"Crit Care Resusc"},{"issue":"9343","key":"10.1016\/j.bpa.2016.10.003_bib36","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(02)11393-6","article-title":"Nitroglycerin in septic shock after intravascular volume resuscitation","volume":"360","author":"Spronk","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/eurjhf\/hfp021","article-title":"Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure","volume":"11","author":"den Uil","year":"2009","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib38","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1164\/ajrccm.161.6.9812004","article-title":"Effects of nitric oxide in septic shock","volume":"161","author":"Vincent","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"9360","key":"10.1016\/j.bpa.2016.10.003_bib39","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(03)12691-8","article-title":"Nitroglycerin for septic shock","volume":"361","author":"Preiser","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/2110-5820-1-27","article-title":"Microcirculatory alterations: potential mechanisms and implications for therapy","volume":"1","author":"de Backer","year":"2011","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.bpa.2016.10.003_bib41","first-page":"15","article-title":"Calcium entry blockers: potential applications in shock","volume":"10","author":"Hess","year":"1983","journal-title":"Adv Shock Res"},{"issue":"1\u20132","key":"10.1016\/j.bpa.2016.10.003_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-2999(84)90510-7","article-title":"Salutary effects of nitrendipine, a new calcium entry blocker, in hemorrhagic shock","volume":"97","author":"Hock","year":"1984","journal-title":"Eur J Pharmacol"},{"issue":"5 Pt 2","key":"10.1016\/j.bpa.2016.10.003_bib43","first-page":"9","article-title":"Calcium-channel blockade in canine hemorrhagic shock","volume":"257","author":"Horton","year":"1989","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF01851204","article-title":"Effects of a calcium antagonist (nifedipine) on cats in live E. coli bacteriemic shock","volume":"188","author":"Bosson","year":"1988","journal-title":"Res Exp Med Berl"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib45","first-page":"135","article-title":"Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion","volume":"33","author":"Karasawa","year":"1991","journal-title":"Circ Shock"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib46","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/0002-8703(84)90693-8","article-title":"Nifedipine in congestive heart failure: effects on resting and exercise hemodynamics and regional blood flow","volume":"108","author":"Leier","year":"1984","journal-title":"Am Heart J"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000178972","article-title":"Effects of iloprost, a stable prostacyclin analog, and its combination with NW-nitro-L-arginine on early events following lipopolysaccharide injection: observations in the hamster cheek pouch microcirculation","volume":"15","author":"Bouskela","year":"1995","journal-title":"Int J Microcirc Clin Exp"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib48","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1378\/chest.98.6.1467","article-title":"Prostacyclin but not phentolamine increases oxygen consumption and skin microvascular blood flow in patients with sepsis and respiratory failure","volume":"98","author":"Pittet","year":"1990","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.bpa.2016.10.003_bib49","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1097\/00003246-199311000-00014","article-title":"Relationship between oxygen uptake and oxygen delivery in septic patients: effects of prostacyclin versus dobutamine","volume":"21","author":"deBacker","year":"1993","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib50","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/00000658-197912000-00011","article-title":"Comparison of corticosteroids and prostaglandins in treatment of hemorrhagic shock","volume":"190","author":"Machiedo","year":"1979","journal-title":"Ann Surg"},{"issue":"8","key":"10.1016\/j.bpa.2016.10.003_bib51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0011-393X(01)80063-1","article-title":"Efficacy of prostaglandin E1 in combination with volume replacement therapy in the treatment of hemorrhagic shock in dogs","volume":"62","author":"Kobori","year":"2001","journal-title":"Curr Ther Res"},{"issue":"20","key":"10.1016\/j.bpa.2016.10.003_bib52","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Steg","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bpa.2016.10.003_bib53","article-title":"Inotropic agents and vasodilator strategies for acute myocardial infarction complicated by cardiogenic shock or low cardiac output syndrome","volume":"1","author":"Unverzagt","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpa.2016.10.003_bib54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcrc.2016.08.010","article-title":"The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials","volume":"37","author":"Belletti","year":"2016","journal-title":"J\u00a0Crit Care"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2110-5820-3-1","article-title":"Resuscitative strategies in traumatic hemorrhagic shock","volume":"3","author":"Bougle","year":"2013","journal-title":"Ann Intensive Care"},{"issue":"10","key":"10.1016\/j.bpa.2016.10.003_bib56","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1097\/00003246-200010000-00020","article-title":"Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion","volume":"28","author":"Heino","year":"2000","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/jsre.1996.0349","article-title":"Regional effects of dobutamine in endotoxic shock","volume":"65","author":"de Backer","year":"1996","journal-title":"J\u00a0Surg Res"},{"issue":"8","key":"10.1016\/j.bpa.2016.10.003_bib58","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1097\/00003246-199708000-00026","article-title":"Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock","volume":"25","author":"Neviere","year":"1997","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib59","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00003246-200002000-00030","article-title":"Dobutamine restores intestinal mucosal blood flow in a porcine model of intra-abdominal hyperpressure","volume":"28","author":"Agusti","year":"2000","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.bpa.2016.10.003_bib60","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/00003246-199707000-00022","article-title":"Inotropic treatment and intestinal mucosal tissue oxygenation in a model of porcine endotoxemia","volume":"25","author":"Germann","year":"1997","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib61","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00024382-200115030-00008","article-title":"Effects of dobutamine on hepato-splanchnic hemodynamics in an experimental model of hyperdynamic endotoxic shock","volume":"15","author":"de Backer","year":"2001","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib62","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.CCM.0000198107.61493.5A","article-title":"The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects","volume":"34","author":"de Backer","year":"2006","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.bpa.2016.10.003_bib63","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/00003246-199710000-00013","article-title":"Dobutamine improves the adequacy of gastric mucosal perfusion in epinephrine-treated septic shock","volume":"25","author":"Levy","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bpa.2016.10.003_bib64","article-title":"Comparative effectiveness of second vasoactive agents in septic shock refractory to norepinephrine","author":"Nguyen","year":"2016","journal-title":"J\u00a0Intensive Care Med"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib65","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jcrc.2012.08.002","article-title":"Systemic and microcirculatory effects of dobutamine in patients with septic shock","volume":"27","author":"Enrico","year":"2012","journal-title":"J\u00a0Crit Care"},{"issue":"8","key":"10.1016\/j.bpa.2016.10.003_bib66","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00134-013-2982-0","article-title":"Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study","volume":"39","author":"Hernandez","year":"2013","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib67","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00000542-200603000-00024","article-title":"Levosimendan, a new inotropic and vasodilator agent","volume":"104","author":"Toller","year":"2006","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib68","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/CCM.0b013e318232962a","article-title":"Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies","volume":"40","author":"Landoni","year":"2012","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.bpa.2016.10.003_bib69","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ejheart.2006.01.007","article-title":"Cardiogenic shock after primary percutaneous coronary intervention: effects of levosimendan compared with dobutamine on haemodynamics","volume":"8","author":"Garcia-Gonzalez","year":"2006","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib70","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijcard.2007.04.143","article-title":"Effects of levosimendan versus dobutamine on long-term survival of patients with cardiogenic shock after primary coronary angioplasty","volume":"127","author":"Samimi-Fard","year":"2008","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.bpa.2016.10.003_bib71","first-page":"276","article-title":"Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies","volume":"76","author":"Landoni","year":"2010","journal-title":"Minerva Anestesiol"},{"issue":"11","key":"10.1016\/j.bpa.2016.10.003_bib72","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1097\/00003246-200111000-00022","article-title":"Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock","volume":"29","author":"Oldner","year":"2001","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib73","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.resuscitation.2005.08.002","article-title":"Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study","volume":"69","author":"Dubin","year":"2006","journal-title":"Resuscitation"},{"issue":"3","key":"10.1016\/j.bpa.2016.10.003_bib74","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00134-006-0519-5","article-title":"Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study","volume":"33","author":"Dubin","year":"2007","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.bpa.2016.10.003_bib75","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/CCM.0b013e3181ef4694","article-title":"Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock","volume":"38","author":"Rehberg","year":"2010","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib76","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1213\/ane.0b013e3181af3fe3","article-title":"Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion","volume":"109","author":"Cunha-Goncalves","year":"2009","journal-title":"Anesth Analg"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib77","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1213\/ane.0b013e3181af40e0","article-title":"Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine","volume":"109","author":"Cunha-Goncalves","year":"2009","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.bpa.2016.10.003_bib78","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/shk.0b013e31804d18f6","article-title":"Cardiovascular effects of levosimendan in the early stages of endotoxemia","volume":"28","author":"Cunha-Goncalves","year":"2007","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib79","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s00134-005-2619-z","article-title":"Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression","volume":"31","author":"Morelli","year":"2005","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib80","doi-asserted-by":"crossref","first-page":"R232","DOI":"10.1186\/cc9387","article-title":"Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study","volume":"14","author":"Morelli","year":"2010","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.bpa.2016.10.003_bib81","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jcrc.2015.05.017","article-title":"Levosimendan reduces mortality in patients with severe sepsis and septic shock: a meta-analysis of randomized trials","volume":"30","author":"Zangrillo","year":"2015","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.bpa.2016.10.003_bib82","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1609409","article-title":"Levosimendan for the prevention of acute organ dysfunction in sepsis","author":"Gordon","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.bpa.2016.10.003_bib83","doi-asserted-by":"crossref","first-page":"e0117004","DOI":"10.1371\/journal.pone.0117004","article-title":"Milrinone attenuates arteriolar vasoconstriction and capillary perfusion deficits on endotoxemic hamsters","volume":"10","author":"Miranda de","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bpa.2016.10.003_bib84","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/SHK.0000000000000152","article-title":"Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis","volume":"41","author":"Flemming","year":"2014","journal-title":"Shock"},{"issue":"11","key":"10.1016\/j.bpa.2016.10.003_bib85","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1113\/jphysiol.2012.232116","article-title":"Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation","volume":"590","author":"Schick","year":"2012","journal-title":"J\u00a0Physiol"},{"issue":"9","key":"10.1016\/j.bpa.2016.10.003_bib86","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s00134-016-4449-6","article-title":"Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis","volume":"42","author":"Koster","year":"2016","journal-title":"Intensive Care Med"}],"container-title":["Best Practice & Research Clinical Anaesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521689616300647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521689616300647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:16:27Z","timestamp":1776410187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521689616300647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1521689616300647"],"URL":"https:\/\/doi.org\/10.1016\/j.bpa.2016.10.003","relation":{},"ISSN":["1753-3740"],"issn-type":[{"value":"1753-3740","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of vasodilators on haemodynamic coherence","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Anaesthesiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpa.2016.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}