{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:06:42Z","timestamp":1791065202543,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Chemistry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bpc.2013.04.002","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T01:54:09Z","timestamp":1367978049000},"page":"12-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Heat-induced fibrillation of BclXL apoptotic repressor"],"prefix":"10.1016","volume":"179","author":[{"given":"Vikas","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max B.","family":"Olenick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett J.","family":"Schuchardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Mikles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Deegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb B.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"Seldeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Kurouski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Hafeez","family":"Faridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor K.","family":"Lednev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpc.2013.04.002_bb0005","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0010","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes & Development"},{"key":"10.1016\/j.bpc.2013.04.002_bb0015","first-page":"1693s","article-title":"BCL-2 gene family and the regulation of programmed cell death","volume":"59","author":"Korsmeyer","year":"1999","journal-title":"Cancer Research"},{"key":"10.1016\/j.bpc.2013.04.002_bb0020","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ceb.2003.10.004","article-title":"Bcl-2-family proteins and the role of mitochondria in apoptosis","volume":"15","author":"Kuwana","year":"2003","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0030","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1242\/jcs.038166","article-title":"Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis","volume":"122","author":"Dewson","year":"2009","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.molcel.2010.01.025","article-title":"The BCL-2 family reunion","volume":"37","author":"Chipuk","year":"2010","journal-title":"Molecular Cell"},{"key":"10.1016\/j.bpc.2013.04.002_bb0040","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbabio.2010.01.007","article-title":"MAC and Bcl-2 family proteins conspire in a deadly plot","volume":"1797","author":"Dejean","year":"2010","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bpc.2013.04.002_bb0045","doi-asserted-by":"crossref","first-page":"20327","DOI":"10.1073\/pnas.0808036105","article-title":"Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins","volume":"105","author":"Chipuk","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bpc.2013.04.002_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.tcb.2008.01.007","article-title":"How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?","volume":"18","author":"Chipuk","year":"2008","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0055","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/354408a0","article-title":"A \u2018molten-globule\u2019 membrane-insertion intermediate of the pore-forming domain of colicin A","volume":"354","author":"van der Goot","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0304-4157(92)90033-7","article-title":"Diphtheria toxin: membrane interaction and membrane translocation","volume":"1113","author":"London","year":"1992","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bpc.2013.04.002_bb0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0300-483X(94)90156-2","article-title":"All in the family: the toxic activity of pore-forming colicins","volume":"87","author":"Lakey","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0070","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.cdd.4400365","article-title":"Bcl-2 family proteins as ion-channels","volume":"5","author":"Schendel","year":"1998","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.bpc.2013.04.002_bb0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0005-2736(02)00579-5","article-title":"Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes","volume":"1565","author":"Zakharov","year":"2002","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bpc.2013.04.002_bb0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.abb.2012.08.009","article-title":"Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor","volume":"528","author":"Bhat","year":"2012","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.bpc.2013.04.002_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jmb.2011.12.015","article-title":"Ligand Binding and Membrane Insertion Compete with Oligomerization of the BclXL Apoptotic Repressor","volume":"416","author":"Bhat","year":"2012","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0090","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jmb.2011.11.024","article-title":"Amyloid fibrils formed by the programmed cell death regulator Bcl-xL","volume":"415","author":"Chenal","year":"2012","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0095","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein Identification and Analysis Tools on the ExPASy Server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.bpc.2013.04.002_bb0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0263-7855(96)00009-4","article-title":"MOLMOL: a program for display and analysis of macromolecular structures","volume":"14","author":"Koradi","year":"1996","journal-title":"Journal of Molecular Graphics"},{"key":"10.1016\/j.bpc.2013.04.002_bb0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","article-title":"Comparative Protein Structure Modeling of Genes and Genomes","volume":"29","author":"Marti-Renom","year":"2000","journal-title":"Annual Review of Biophysics and Biomolecular Structure"},{"key":"10.1016\/j.bpc.2013.04.002_bb0110","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1107\/S0021889891007240","article-title":"Ribbons 2.0","volume":"24","author":"Carson","year":"1991","journal-title":"Journal of Applied Crystallography"},{"key":"10.1016\/j.bpc.2013.04.002_bb0115","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"Journal of Computational Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0120","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"Journal of Chemical Theory and Computation"},{"key":"10.1016\/j.bpc.2013.04.002_bb0125","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/ja00214a001","article-title":"The OPLS force field for proteins: energy minimizations for crystals of cyclic peptides and crambin","volume":"110","author":"Jorgensen","year":"1988","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.bpc.2013.04.002_bb0130","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1021\/jp003919d","article-title":"Evaluation and reparametrization of the OPLS-AA force field for proteins via comparison with accurate quantum chemical calculations on peptides","volume":"105","author":"Kaminski","year":"2001","journal-title":"The Journal of Physical Chemistry B"},{"key":"10.1016\/j.bpc.2013.04.002_bb0135","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1103\/PhysRevB.31.2643","article-title":"Molecular-dynamics study of atomic motions in water","volume":"31","author":"Toukan","year":"1985","journal-title":"Physical Review B"},{"key":"10.1016\/j.bpc.2013.04.002_bb0140","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1021\/j100308a038","article-title":"The Missing Term in Effective Pair Potentials","volume":"91","author":"Berendsen","year":"1987","journal-title":"Journal of Physical Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0145","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: An N.log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"Journal of Chemical Physics"},{"key":"10.1016\/j.bpc.2013.04.002_bb0150","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: A linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"Journal of Computational Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(89)90213-3","article-title":"Rapid measurement of binding constants and heats of binding using a new titration calorimeter","volume":"179","author":"Wiseman","year":"1989","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0160","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.275.5302.983","article-title":"Structure of Bcl-xL\u2013Bak peptide complex: recognition between regulators of apoptosis","volume":"275","author":"Sattler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbamcr.2003.08.012","article-title":"Structural biology of the Bcl-2 family of proteins","volume":"1644","author":"Petros","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.bpc.2013.04.002_bb0170","first-page":"4701","article-title":"Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes","volume":"53","author":"Krajewski","year":"1993","journal-title":"Cancer Research"},{"key":"10.1016\/j.bpc.2013.04.002_bb0175","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1242\/dev.120.10.3033","article-title":"Bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria","volume":"120","author":"Gonzalez-Garcia","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.bpc.2013.04.002_bb0180","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1128\/MCB.16.11.6494","article-title":"Structure\u2013function comparisons of the proapoptotic protein Bax in yeast and mammalian cells","volume":"16","author":"Zha","year":"1996","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0185","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nature02261","article-title":"Protein folding and misfolding","volume":"426","author":"Dobson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0190","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00109-003-0464-5","article-title":"Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution","volume":"81","author":"Stefani","year":"2003","journal-title":"Journal of Molecular Medicine (Berlin)"},{"key":"10.1016\/j.bpc.2013.04.002_bb0195","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1098\/rsta.2003.1194","article-title":"Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems","volume":"361","author":"Vendruscolo","year":"2003","journal-title":"Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences"},{"key":"10.1016\/j.bpc.2013.04.002_bb0200","doi-asserted-by":"crossref","first-page":"31374","DOI":"10.1074\/jbc.M400348200","article-title":"Prefibrillar amyloid protein aggregates share common features of cytotoxicity","volume":"279","author":"Bucciantini","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1472-6807-9-44","article-title":"Amyloidogenic determinants are usually not buried","volume":"9","author":"Frousios","year":"2009","journal-title":"BMC Structural Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-2105-8-65","article-title":"AGGRESCAN: a server for the prediction and evaluation of \u201chot spots\u201d of aggregation in polypeptides","volume":"8","author":"Conchillo-Sole","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bpc.2013.04.002_bb0215","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/emboj\/16.5.968","article-title":"Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2","volume":"16","author":"Chang","year":"1997","journal-title":"EMBO Journal"},{"key":"10.1016\/j.bpc.2013.04.002_bb0220","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1110\/ps.9.10.1960","article-title":"Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy","volume":"9","author":"Bouchard","year":"2000","journal-title":"Protein Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0225","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1110\/ps.04823504","article-title":"Insulin amyloid fibrillation at above 100 degrees C: new insights into protein folding under extreme temperatures","volume":"13","author":"Arora","year":"2004","journal-title":"Protein Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.18388\/abp.2005_3455","article-title":"Circular dichroism and aggregation studies of amyloid beta (11-8) fragment and its variants","volume":"52","author":"Juszczyk","year":"2005","journal-title":"Acta Biochimica Polonica"},{"key":"10.1016\/j.bpc.2013.04.002_bb0235","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jmb.2008.07.052","article-title":"Evidence for stepwise formation of amyloid fibrils by the mouse prion protein","volume":"382","author":"Jain","year":"2008","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0240","doi-asserted-by":"crossref","first-page":"22827","DOI":"10.1074\/jbc.M111.333310","article-title":"Polymorphism of beta2-microglobulin amyloid fibrils manifested by ultrasonication-enhanced fibril formation in trifluoroethanol","volume":"287","author":"Chatani","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/bip.360310111","article-title":"Study of the \u201cmolten globule\u201d intermediate state in protein folding by a hydrophobic fluorescent probe","volume":"31","author":"Semisotnov","year":"1991","journal-title":"Biopolymers"},{"key":"10.1016\/j.bpc.2013.04.002_bb0250","doi-asserted-by":"crossref","first-page":"16462","DOI":"10.1074\/jbc.C300049200","article-title":"Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence","volume":"278","author":"Ban","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0255","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ymeth.2004.03.002","article-title":"Experimental investigation of protein folding and misfolding","volume":"34","author":"Dobson","year":"2004","journal-title":"Methods"},{"key":"10.1016\/j.bpc.2013.04.002_bb0260","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1111\/j.1742-4658.2009.07307.x","article-title":"The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds","volume":"276","author":"Hudson","year":"2009","journal-title":"FEBS Journal"},{"key":"10.1016\/j.bpc.2013.04.002_bb0265","doi-asserted-by":"crossref","first-page":"11519","DOI":"10.1021\/jp207118x","article-title":"Interaction of thioflavin T with amyloid fibrils: stoichiometry and affinity of dye binding, absorption spectra of bound dye","volume":"115","author":"Sulatskaya","year":"2011","journal-title":"The Journal of Physical Chemistry B"},{"key":"10.1016\/j.bpc.2013.04.002_bb0270","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2003.01976.x","article-title":"Potent anti\u2013amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease","volume":"87","author":"Ono","year":"2003","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0275","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1006\/jmbi.2000.3862","article-title":"Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the beta-domain","volume":"300","author":"Krebs","year":"2000","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0280","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/jsbi.2000.4264","article-title":"Amyloid fibril formation and seeding by wild-type human lysozyme and its disease-related mutational variants","volume":"130","author":"Morozova-Roche","year":"2000","journal-title":"Journal of Structural Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0285","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1096\/fj.03-1072fje","article-title":"Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure","volume":"18","author":"De Felice","year":"2004","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.bpc.2013.04.002_bb0290","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00926750","article-title":"beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease","volume":"140","author":"Arispe","year":"1994","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0295","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1006\/bbrc.1994.2047","article-title":"Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide","volume":"202","author":"Mirzabekov","year":"1994","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.bpc.2013.04.002_bb0300","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/(SICI)1097-4547(20000515)60:4<490::AID-JNR7>3.0.CO;2-9","article-title":"Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases","volume":"60","author":"Hirakura","year":"2000","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.bpc.2013.04.002_bb0305","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3109\/13506120009146834","article-title":"Amyloid peptide channels: blockade by zinc and inhibition by Congo red","volume":"7","author":"Hirakura","year":"2000","journal-title":"Amyloid"},{"key":"10.1016\/j.bpc.2013.04.002_bb0310","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/418291a","article-title":"Neurodegenerative disease: amyloid pores from pathogenic mutations","volume":"418","author":"Lashuel","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0315","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/385353a0","article-title":"Bcl-x(L) forms an ion channel in synthetic lipid membranes","volume":"385","author":"Minn","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0320","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1083\/jcb.200210084","article-title":"Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane","volume":"160","author":"Kaufmann","year":"2003","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0325","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jmb.2006.03.052","article-title":"Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism","volume":"359","author":"Thuduppathy","year":"2006","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0330","doi-asserted-by":"crossref","first-page":"31083","DOI":"10.1074\/jbc.M103879200","article-title":"Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes","volume":"276","author":"Basanez","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0335","doi-asserted-by":"crossref","first-page":"49360","DOI":"10.1074\/jbc.M206069200","article-title":"Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature","volume":"277","author":"Basanez","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0340","doi-asserted-by":"crossref","first-page":"13590","DOI":"10.1073\/pnas.0401372101","article-title":"Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals","volume":"101","author":"Jonas","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bpc.2013.04.002_bb0345","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nsb1195-990","article-title":"Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide","volume":"2","author":"Lansbury","year":"1995","journal-title":"Nature Structural Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0350","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0959-440X(96)80089-3","article-title":"Alternative conformations of amyloidogenic proteins govern their behavior","volume":"6","author":"Kelly","year":"1996","journal-title":"Current Opinion in Structural Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0355","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1021\/ja9937831","article-title":"Protofilaments, filaments, ribbons, and fibrils from peptidomimetic self-assembly: implications for amyloid fibril formation and materials science","volume":"122","author":"Lashuel","year":"2000","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.bpc.2013.04.002_bb0360","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature03680","article-title":"Structure of the cross-beta spine of amyloid-like fibrils","volume":"435","author":"Nelson","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0365","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.3874430","article-title":"Involvement of the bcl-2 gene in human follicular lymphoma","volume":"228","author":"Tsujimoto","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.bpc.2013.04.002_bb0370","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1073\/pnas.83.14.5214","article-title":"Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma","volume":"83","author":"Tsujimoto","year":"1986","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bpc.2013.04.002_bb0375","first-page":"7399","article-title":"Role of bcl-2 in growth factor triggered signal transduction","volume":"50","author":"Haldar","year":"1990","journal-title":"Cancer Research"},{"key":"10.1016\/j.bpc.2013.04.002_bb0380","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/348334a0","article-title":"Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death","volume":"348","author":"Hockenbery","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0385","first-page":"203","article-title":"Bcl-2: B cell life, death and neoplasia","volume":"166","author":"Korsmeyer","year":"1990","journal-title":"Current Topics in Microbiology and Immunology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0390","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1021\/bi973052i","article-title":"Acidic pH promotes dimerization of Bcl-2 family proteins","volume":"37","author":"Xie","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpc.2013.04.002_bb0395","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jmb.2005.11.032","article-title":"BCL-XL dimerization by three-dimensional domain swapping","volume":"356","author":"O'Neill","year":"2006","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0400","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/sj.emboj.7600225","article-title":"Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers","volume":"23","author":"Jeong","year":"2004","journal-title":"EMBO Journal"},{"key":"10.1016\/j.bpc.2013.04.002_bb0405","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.febslet.2011.08.012","article-title":"Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL","volume":"585","author":"Ospina","year":"2011","journal-title":"FEBS Letters"},{"key":"10.1016\/j.bpc.2013.04.002_bb0410","first-page":"432","article-title":"Consequences of the molecular mechanism of amyloid formation for the understanding of the pathogenesis of Alzheimer's disease and the development of therapeutic strategies","volume":"45","author":"Lansbury","year":"1995","journal-title":"Arzneimittel-Forschung"},{"key":"10.1016\/j.bpc.2013.04.002_bb0415","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S0166-2236(00)01998-6","article-title":"The role of the ubiquitin\u2013proteasomal pathway in Parkinson's disease and other neurodegenerative disorders","volume":"24","author":"Chung","year":"2001","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.bpc.2013.04.002_bb0420","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02264","article-title":"Folding proteins in fatal ways","volume":"426","author":"Selkoe","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bpc.2013.04.002_bb0425","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nature Medicine"},{"key":"10.1016\/j.bpc.2013.04.002_bb0430","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2009.06.001","article-title":"Tropoelastin as a thermodynamically unfolded premolten globule protein: The effect of trimethylamine N-oxide on structure and coacervation","volume":"487","author":"Dyksterhuis","year":"2009","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.bpc.2013.04.002_bb0435","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.jmb.2006.10.101","article-title":"Lysozyme amyloid oligomers and fibrils induce cellular death via different apoptotic\/necrotic pathways","volume":"365","author":"Gharibyan","year":"2007","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.bpc.2013.04.002_bb0440","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.95.2.554","article-title":"Modulation of cell death by Bcl-XL through caspase interaction","volume":"95","author":"Clem","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Biophysical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462213000835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462213000835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T11:44:34Z","timestamp":1645011874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301462213000835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":88,"alternative-id":["S0301462213000835"],"URL":"https:\/\/doi.org\/10.1016\/j.bpc.2013.04.002","relation":{},"ISSN":["0301-4622"],"issn-type":[{"value":"0301-4622","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat-induced fibrillation of BclXL apoptotic repressor","name":"articletitle","label":"Article Title"},{"value":"Biophysical Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpc.2013.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}