{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:22:39Z","timestamp":1780514559359,"version":"3.54.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001502","name":"DAE","doi-asserted-by":"publisher","award":["RTI 4007"],"award-info":[{"award-number":["RTI 4007"]}],"id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/INF\/22\/SP42684\/2021"],"award-info":[{"award-number":["BT\/INF\/22\/SP42684\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030310","name":"Going Merry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023984","name":"Raja Ramanna Centre for Advanced Technology, Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020871","name":"Abu Dhabi University","doi-asserted-by":"publisher","award":["CG008"],"award-info":[{"award-number":["CG008"]}],"id":[{"id":"10.13039\/100020871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Chemistry"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bpc.2024.107303","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:03:45Z","timestamp":1722355425000},"page":"107303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Tailoring solid-state DNP methods to the study of <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" altimg=\"si11.svg\"><mml:mi>\u03b1<\/mml:mi><\/mml:math>-synuclein LLPS"],"prefix":"10.1016","volume":"313","author":[{"given":"Ribal","family":"Jabbour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreejith","family":"Raran-Kurussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Equbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpc.2024.107303_bb0005","doi-asserted-by":"crossref","first-page":"9643","DOI":"10.1021\/acs.chemrev.1c00852","article-title":"Solid-state NMR: methods for biological solids","volume":"122","author":"Ahlawat","year":"2022","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.bpc.2024.107303_bb0010","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1021\/acs.chemrev.2c00197","article-title":"Ultrafast magic angle spinning solid-state nmr spectroscopy: advances in methodology and applications","volume":"123","author":"Nishiyama","year":"2022","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.bpc.2024.107303_bb0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1103\/PhysRev.92.411","article-title":"Polarization of nuclei in metals","volume":"92","author":"Overhauser","year":"1953","journal-title":"Phys. Rev."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1103\/PhysRev.92.212.2","article-title":"Polarization of nuclear spins in metals","volume":"92","author":"Carver","year":"1953","journal-title":"Phys. Rev."},{"key":"10.1016\/j.bpc.2024.107303_bb0025","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-biochem-060614-034206","article-title":"Magic angle spinning nmr of proteins: high-frequency dynamic nuclear polarization and 1h detection","volume":"84","author":"Su","year":"2015","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.bpc.2024.107303_bb0030","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1021\/ja005659j","article-title":"Sensitivity-enhanced nmr of biological solids: dynamic nuclear polarization of y21m fd bacteriophage and purple membrane","volume":"123","author":"Rosay","year":"2001","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"10.1016\/j.bpc.2024.107303_bb0035","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.1021\/acs.chemrev.1c00776","article-title":"Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state nmr","volume":"122","author":"Biedenb\u00e4nder","year":"2022","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jsb.2018.09.011","article-title":"Dnp nmr of biomolecular assemblies","volume":"206","author":"Jaudzems","year":"2019","journal-title":"J. Struct. Biol."},{"issue":"10","key":"10.1016\/j.bpc.2024.107303_bb0045","doi-asserted-by":"crossref","first-page":"9795","DOI":"10.1021\/acs.chemrev.1c01043","article-title":"Biomolecular and biological applications of solid-state nmr with dynamic nuclear polarization enhancement","volume":"122","author":"Chow","year":"2022","journal-title":"Chem. Rev."},{"issue":"8","key":"10.1016\/j.bpc.2024.107303_bb0050","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301053120","article-title":"Contribution of protein conformational heterogeneity to nmr lineshapes at cryogenic temperatures","volume":"121","author":"Yi","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bpc.2024.107303_bb0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuint.2022.105345","article-title":"Evolution of a-synuclein conformation ensemble toward amyloid fibril via liquid-liquid phase separation (llps) as investigated by dynamic nuclear polarization-enhanced solid-state mas NMR","volume":"157","author":"Takamuku","year":"2022","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bpc.2024.107303_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ssnmr.2018.12.003","article-title":"Hyperpolarized mas nmr of unfolded and misfolded proteins","volume":"98","author":"K\u00f6nig","year":"2019","journal-title":"Solid State Nucl. Magn. Reson."},{"issue":"7","key":"10.1016\/j.bpc.2024.107303_bb0065","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.bpj.2018.02.011","article-title":"Dnp-enhanced mas nmr: a tool to snapshot conformational ensembles of a-synuclein in different states","volume":"114","author":"Uluca","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpc.2024.107303_bb0070","series-title":"Successive Stages of Amyloid-\u03b2Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization","author":"Alexey","year":"2015"},{"issue":"6357","key":"10.1016\/j.bpc.2024.107303_bb0075","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.bpc.2024.107303_bb0080","doi-asserted-by":"crossref","first-page":"R1097","DOI":"10.1016\/j.cub.2017.08.069","article-title":"Phase separation in biology","volume":"27","author":"Alberti","year":"2017","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.bpc.2024.107303_bb0085","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41580-020-00303-z","article-title":"A framework for understanding the functions of biomolecular condensates across scales","volume":"22","author":"Lyon","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0090","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1038\/s41467-023-41864-9","article-title":"Intermolecular interactions underlie protein\/peptide phase separation irrespective of sequence and structure at crowded milieu","volume":"14","author":"Poudyal","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpc.2024.107303_bb0095","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1039\/D3CS01065A","article-title":"Protein misfolding and amyloid nucleation through liquid\u2013liquid phase separation","volume":"53","author":"Mukherjee","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"10.1016\/j.bpc.2024.107303_bb0100","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1021\/jp065608u","article-title":"Comparison between protein-polyethylene glycol (peg) interactions and the effect of peg on protein- protein interactions using the liquid- liquid phase transition","volume":"111","author":"Wang","year":"2007","journal-title":"J. Phys. Chem. B"},{"issue":"21","key":"10.1016\/j.bpc.2024.107303_bb0105","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1021\/acs.jpcb.9b01239","article-title":"Impact of molecular crowding on translational mobility and conformational properties of biological macromolecules","volume":"123","author":"Junker","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bpc.2024.107303_bb0110","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3389\/fmolb.2021.744707","article-title":"Structural characterization of the RNA-binding protein serbp1 reveals intrinsic disorder and atypical rna binding modes","volume":"8","author":"Baudin","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bpc.2024.107303_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1024600","article-title":"Targeting phase separation on enhancers induced by transcription factor complex formations as a new strategy for treating drug-resistant cancers","volume":"12","author":"Takayama","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bpc.2024.107303_bb0120","doi-asserted-by":"crossref","first-page":"27,089","DOI":"10.1021\/acs.jpcc.7b07967","article-title":"Comparative study of the magnetic field dependent signal enhancement in solid-state dynamic nuclear polarization experiments","volume":"121","author":"Sarah","year":"2017","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.bpc.2024.107303_bb0125","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1021\/acs.jpcc.6b13087","article-title":"Directly vs indirectly enhanced 13c in dynamic nuclear polarization magic angle spinning nmr experiments of nonionic surfactant systems","volume":"121","author":"Sarah","year":"2017","journal-title":"J. Phys. Chem. C"},{"issue":"5","key":"10.1016\/j.bpc.2024.107303_bb0130","doi-asserted-by":"crossref","DOI":"10.1063\/1.2833582","article-title":"Dynamic nuclear polarization at high magnetic fields","volume":"128","author":"Maly","year":"2008","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bpc.2024.107303_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmr.2012.09.008","article-title":"Helium-cooling and-spinning dynamic nuclear polarization for sensitivity-enhanced solid-state nmr at 14 t and 30 k","volume":"225","author":"Matsuki","year":"2012","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.bpc.2024.107303_bb0140","first-page":"100","article-title":"A primer to polarizing agent design: quantum mechanical understanding of cross effect magic-angle spinning dynamic nuclear polarization","volume":"16","author":"Gkoura","year":"2023","journal-title":"J. Magn. Reson. Open"},{"key":"10.1016\/j.bpc.2024.107303_bb0145","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1039\/D3SC01079A","article-title":"Polarizing agents for efficient high field dnp solid-state nmr spectroscopy under magic-angle spinning: from design principles to formulation strategies","volume":"14","author":"Menzildjian","year":"2023","journal-title":"Chem. Sci."},{"issue":"2","key":"10.1016\/j.bpc.2024.107303_bb0150","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jmr.2010.10.016","article-title":"Theoretical aspects of dynamic nuclear polarization in the solid state\u2013the solid effect","volume":"207","author":"Hovav","year":"2010","journal-title":"J. Magn. Reson."},{"issue":"35","key":"10.1016\/j.bpc.2024.107303_bb0155","doi-asserted-by":"crossref","first-page":"14,287","DOI":"10.1021\/ja304918g","article-title":"Water-soluble narrow-line radicals for dynamic nuclear polarization","volume":"134","author":"Haze","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bpc.2024.107303_bb0160","first-page":"107","article-title":"Dynamic nuclear polarization with trityl radicals","volume":"349","author":"Palani","year":"2023","journal-title":"J. Magn. Reson."},{"issue":"5","key":"10.1016\/j.bpc.2024.107303_bb0165","doi-asserted-by":"crossref","DOI":"10.1063\/1.4738761","article-title":"Solid effect in magic angle spinning dynamic nuclear polarization","volume":"137","author":"Corzilius","year":"2012","journal-title":"J. Chem. Phys."},{"issue":"41","key":"10.1016\/j.bpc.2024.107303_bb0170","doi-asserted-by":"crossref","first-page":"10,858","DOI":"10.1002\/anie.201304657","article-title":"Highly efficient, water-soluble polarizing agents for dynamic nuclear polarization at high frequency","volume":"52","author":"Sauv\u00e9e","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"issue":"35","key":"10.1016\/j.bpc.2024.107303_bb0175","doi-asserted-by":"crossref","first-page":"11,013","DOI":"10.1021\/jacs.8b04911","article-title":"Computationally assisted design of polarizing agents for dynamic nuclear polarization enhanced NMR: the asympol family","volume":"140","author":"Mentink-Vigier","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bpc.2024.107303_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmr.2021.107026","article-title":"The distance between g-tensors of nitroxide biradicals governs mas-dnp performance: the case of the bturea family","volume":"329","author":"Mentink-Vigier","year":"2021","journal-title":"J. Magn. Reson."},{"issue":"8","key":"10.1016\/j.bpc.2024.107303_bb0185","doi-asserted-by":"crossref","DOI":"10.1063\/1.4747449","article-title":"Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings","volume":"137","author":"Thurber","year":"2012","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bpc.2024.107303_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jmr.2012.08.013","article-title":"Fast passage dynamic nuclear polarization on rotating solids","volume":"224","author":"Mentink-Vigier","year":"2012","journal-title":"J. Magn. Reson."},{"issue":"9","key":"10.1016\/j.bpc.2024.107303_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/ange.202317337","article-title":"Rational design of dinitroxide polarizing agents for dynamic nuclear polarization to enhance overall nmr sensitivity","volume":"136","author":"Venkatesh","year":"2024","journal-title":"Angew. Chem."},{"key":"10.1016\/j.bpc.2024.107303_bb0200","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ssnmr.2019.04.002","article-title":"Biradical rotamer states tune electron j coupling and mas dynamic nuclear polarization enhancement","volume":"101","author":"Tagami","year":"2019","journal-title":"Solid State Nucl. Magn. Reson."},{"issue":"24","key":"10.1016\/j.bpc.2024.107303_bb0205","doi-asserted-by":"crossref","first-page":"13,569","DOI":"10.1039\/D0CP02051F","article-title":"Balancing dipolar and exchange coupling in biradicals to maximize cross effect dynamic nuclear polarization","volume":"22","author":"Equbal","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"7","key":"10.1016\/j.bpc.2024.107303_bb0210","doi-asserted-by":"crossref","DOI":"10.1063\/1.3526486","article-title":"Dynamic nuclear polarization assisted spin diffusion for the solid effect case","volume":"134","author":"Hovav","year":"2011","journal-title":"J. Chem. Phys."},{"issue":"5","key":"10.1016\/j.bpc.2024.107303_bb0215","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1039\/C6CP07881H","article-title":"Fast and accurate mas\u2013dnp simulations of large spin ensembles","volume":"19","author":"Mentink-Vigier","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"23","key":"10.1016\/j.bpc.2024.107303_bb0220","doi-asserted-by":"crossref","DOI":"10.1063\/1.4922219","article-title":"The magnetic field dependence of cross-effect dynamic nuclear polarization under magic angle spinning","volume":"142","author":"Mance","year":"2015","journal-title":"J. Chem. Phys."},{"issue":"14","key":"10.1016\/j.bpc.2024.107303_bb0225","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1021\/acs.jpclett.0c00955","article-title":"Full-scale ab initio simulation of magic-angle-spinning dynamic nuclear polarization","volume":"11","author":"Perras","year":"2020","journal-title":"J. Phys. Chem. Lett."},{"issue":"15","key":"10.1016\/j.bpc.2024.107303_bb0230","doi-asserted-by":"crossref","DOI":"10.1063\/1.5042651","article-title":"Large-scale ab initio simulations of mas dnp enhancements using a Monte Carlo optimization strategy","volume":"149","author":"Perras","year":"2018","journal-title":"J. Chem. Phys."},{"issue":"18","key":"10.1016\/j.bpc.2024.107303_bb0235","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1039\/D0SC06959K","article-title":"Targeted dnp for biomolecular solid-state nmr","volume":"12","author":"Gauto","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bpc.2024.107303_bb0240","series-title":"Spin Diffusion in Dynamic Nuclear Polarization Nuclear Magnetic Resonance. EPFL, Tech. Rep","author":"Pinon","year":"2018"},{"key":"10.1016\/j.bpc.2024.107303_bb0245","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00723-008-0129-1","article-title":"High-field dynamic nuclear polarization for solid and solution biological NMR","volume":"34","author":"Barnes","year":"2008","journal-title":"Appl. Magn. Reson."},{"issue":"35","key":"10.1016\/j.bpc.2024.107303_bb0250","doi-asserted-by":"crossref","first-page":"11,385","DOI":"10.1021\/ja061284b","article-title":"Totapol: a biradical polarizing agent for dynamic nuclear polarization experiments in aqueous media","volume":"128","author":"Song","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"50\u201351","key":"10.1016\/j.bpc.2024.107303_bb0255","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/j.jnoncrysol.2009.08.045","article-title":"Vitrification, relaxation and free volume in glycerol\u2013water binary liquid mixture: spin probe esr studies","volume":"355","author":"Banerjee","year":"2009","journal-title":"J. Non-Cryst. Solids"},{"issue":"24","key":"10.1016\/j.bpc.2024.107303_bb0260","doi-asserted-by":"crossref","first-page":"12,465","DOI":"10.1063\/1.1822913","article-title":"Orientational motion of nitroxides in molecular glasses: dependence on the chemical structure, on the molecular size of the probe, and on the type of the matrix","volume":"121","author":"Kirilina","year":"2004","journal-title":"J. Chem. Phys."},{"issue":"12","key":"10.1016\/j.bpc.2024.107303_bb0265","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1002\/chem.201404588","article-title":"Matrix-free dnp-enhanced nmr spectroscopy of liposomes using a lipid-anchored biradical","volume":"21","author":"Fern\u00e1ndez-de-Alba","year":"2015","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bpc.2024.107303_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.789478","article-title":"In-cell nmr of intact mammalian cells preserved with the cryoprotectants dmso and glycerol have similar dnp performance","volume":"8","author":"Xiao","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bpc.2024.107303_bb0275","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jmr.2013.12.005","article-title":"Optimization of an absolute sensitivity in a glassy matrix during dnp-enhanced multidimensional solid-state nmr experiments","volume":"239","author":"Takahashi","year":"2014","journal-title":"J. Magn. Reson."},{"issue":"15","key":"10.1016\/j.bpc.2024.107303_bb0280","doi-asserted-by":"crossref","first-page":"9897","DOI":"10.1039\/C8CP00358K","article-title":"Effect of water\/glycerol polymorphism on dynamic nuclear polarization","volume":"20","author":"Leavesley","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bpc.2024.107303_bb0285","first-page":"1","article-title":"Dnp-assisted solid-state nmr enables detection of proteins at nanomolar concentrations in fully protonated cellular milieu","author":"Costello","year":"2024","journal-title":"J. Biomol. NMR"},{"issue":"2","key":"10.1016\/j.bpc.2024.107303_bb0290","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109235119","article-title":"Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase a-aminoacrylate intermediate","volume":"119","author":"Holmes","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bpc.2024.107303_bb0295","article-title":"Solid-state NMR analysis of unlabeled fungal cell walls from aspergillus and candida species","volume":"6","author":"Fernando","year":"2022","journal-title":"J. Struct. Biol. X"},{"issue":"43","key":"10.1016\/j.bpc.2024.107303_bb0300","doi-asserted-by":"crossref","first-page":"9619","DOI":"10.1021\/acs.jpclett.3c02455","article-title":"Polarization amplification in dynamic nuclear polarization magic-angle spinning solid-state nuclear magnetic resonance by solubilizing traditional ionic salts","volume":"14","author":"Ferrer","year":"2023","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.bpc.2024.107303_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymertesting.2019.106316","article-title":"Amphiphilic nature of polyethylene glycols and their role in medical research","volume":"82","author":"Parray","year":"2020","journal-title":"Polym. Test."},{"issue":"3","key":"10.1016\/j.bpc.2024.107303_bb0310","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrd1033","article-title":"Effect of pegylation on pharmaceuticals","volume":"2","author":"Harris","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"20","key":"10.1016\/j.bpc.2024.107303_bb0315","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1039\/c4tb00253a","article-title":"Binding characteristics between polyethylene glycol (peg) and proteins in aqueous solution","volume":"2","author":"Wu","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"3\u20134","key":"10.1016\/j.bpc.2024.107303_bb0320","first-page":"249","article-title":"The uses and properties of peg-linked proteins","volume":"9","author":"Delgado","year":"1992","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.bpc.2024.107303_bb0325","series-title":"PEGylated Protein Drugs: Basic Science and Clinical Applications","first-page":"127","article-title":"Peg and peg conjugates toxicity: towards an understanding of the toxicity of peg and its relevance to pegylated biologicals","author":"Webster","year":"2009"},{"issue":"3","key":"10.1016\/j.bpc.2024.107303_bb0330","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajps.2015.08.011","article-title":"Pegylation in anti-cancer therapy: an overview","volume":"11","author":"Mishra","year":"2016","journal-title":"Asian J. Pharm. Sci."},{"issue":"18","key":"10.1016\/j.bpc.2024.107303_bb0335","doi-asserted-by":"crossref","DOI":"10.1063\/1.4874341","article-title":"Perturbation of nuclear spin polarizations in solid state nmr of nitroxide-doped samples by magic-angle spinning without microwaves","volume":"140","author":"Thurber","year":"2014","journal-title":"J. Chem. Phys."},{"issue":"34","key":"10.1016\/j.bpc.2024.107303_bb0340","doi-asserted-by":"crossref","first-page":"21,824","DOI":"10.1039\/C5CP03457D","article-title":"Nuclear depolarization and absolute sensitivity in magic-angle spinning cross effect dynamic nuclear polarization","volume":"17","author":"Mentink-Vigier","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"37","key":"10.1016\/j.bpc.2024.107303_bb0345","doi-asserted-by":"crossref","first-page":"23,976","DOI":"10.1039\/C8CP04167A","article-title":"Tuning nuclear depolarization under mas by electron t 1e","volume":"20","author":"Lund","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"9","key":"10.1016\/j.bpc.2024.107303_bb0350","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1039\/C4CP05735J","article-title":"Rotation-induced recovery and bleaching in magnetic resonance","volume":"17","author":"Linde","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bpc.2024.107303_bb0355","series-title":"Direct Sensing of Remote Nuclei: Expanding the Reach of Cross-Effect Dynamic Nuclear Polarization","author":"Javed","year":"2023"},{"issue":"8","key":"10.1016\/j.bpc.2024.107303_bb0360","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1021\/acs.jpclett.3c03472","article-title":"Role of protons in and around strongly coupled nitroxide biradicals for cross-effect dynamic nuclear polarization","volume":"15","author":"Chatterjee","year":"2024","journal-title":"J. Phys. Chem. Lett."},{"issue":"43","key":"10.1016\/j.bpc.2024.107303_bb0365","doi-asserted-by":"crossref","first-page":"27,646","DOI":"10.1039\/C8CP04909B","article-title":"Maximizing NMR signal per unit time by facilitating the e\u2013e\u2013n cross effect dnp rate","volume":"20","author":"Leavesley","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bpc.2024.107303_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnmrs.2021.05.003","article-title":"Role of electron spin dynamics and coupling network in designing dynamic nuclear polarization","volume":"126","author":"Equbal","year":"2021","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0375","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1039\/C1SC00550B","article-title":"One hundred fold overall sensitivity enhancements for silicon-29 NMR spectroscopy of surfaces by dynamic nuclear polarization with cpmg acquisition","volume":"3","author":"Rossini","year":"2012","journal-title":"Chem. Sci."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0380","first-page":"27","article-title":"Carbon-13 chemical shift parameters for amines, carboxylic acids, and amino acids","volume":"24","author":"Rabenstein","year":"1976","journal-title":"J. Magn. Reson."},{"issue":"1","key":"10.1016\/j.bpc.2024.107303_bb0385","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.physchem.53.082201.124235","article-title":"Chemical shifts in amino acids, peptides, and proteins: from quantum chemistry to drug design","volume":"53","author":"Oldfield","year":"2002","journal-title":"Annu. Rev. Phys. Chem."},{"issue":"2","key":"10.1016\/j.bpc.2024.107303_bb0390","first-page":"231","article-title":"Carbon-13 NMR studies of amino acids: chemical shifts, protonation shifts, microscopic protonation behavior","volume":"40","author":"Surprenant","year":"1980","journal-title":"J. Magn. Reson."},{"issue":"7","key":"10.1016\/j.bpc.2024.107303_bb0395","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/acs.jpclett.9b00306","article-title":"A strategy for probing the evolution of crystallization processes by low-temperature solid-state nmr and dynamic nuclear polarization","volume":"10","author":"Vioglio","year":"2019","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.bpc.2024.107303_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.ssnmr.2022.101836","article-title":"Monitoring the influence of additives on the crystallization processes of glycine with dynamic nuclear polarization solid-state NMR","volume":"122","author":"Juramy","year":"2022","journal-title":"Solid State Nucl. Magn. Reson."},{"issue":"8","key":"10.1016\/j.bpc.2024.107303_bb0405","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41557-020-0465-9","article-title":"Synuclein aggregation nucleates through liquid\u2013liquid phase separation","volume":"12","author":"Ray","year":"2020","journal-title":"Nat. Chem."},{"key":"10.1016\/j.bpc.2024.107303_bb0410","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jmr.2022.107144","article-title":"Dynamic nuclear polarization-enhanced, double-quantum filtered 13c-13c dipolar correlation spectroscopy of natural 13c abundant bone-tissue biomaterial","volume":"335","author":"Wi","year":"2022","journal-title":"J. Magn. Reson."},{"issue":"12","key":"10.1016\/j.bpc.2024.107303_bb0415","doi-asserted-by":"crossref","DOI":"10.1002\/ange.202114103","article-title":"Highly efficient polarizing agents for mas-dnp of proton-dense molecular solids","volume":"134","author":"Harrabi","year":"2022","journal-title":"Angew. Chem."},{"key":"10.1016\/j.bpc.2024.107303_bb0420","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cplett.2015.07.008","article-title":"Improving spectral resolution in biological solid-state nmr using phase-alternated rcw heteronuclear decoupling","volume":"635","author":"Equbal","year":"2015","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.bpc.2024.107303_bb0425","series-title":"Improved Proton Decoupling in NMR Spectroscopy of Crystalline Solids Using the SPINAL-64 Sequence","author":"Br\u00e4uniger","year":"2003"}],"container-title":["Biophysical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462224001327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462224001327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:43:45Z","timestamp":1725270225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301462224001327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":85,"alternative-id":["S0301462224001327"],"URL":"https:\/\/doi.org\/10.1016\/j.bpc.2024.107303","relation":{},"ISSN":["0301-4622"],"issn-type":[{"value":"0301-4622","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tailoring solid-state DNP methods to the study of -synuclein LLPS","name":"articletitle","label":"Article Title"},{"value":"Biophysical Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpc.2024.107303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107303"}}