{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:08:48Z","timestamp":1778544528581,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007855","name":"Central Leather Research Institute","doi-asserted-by":"publisher","award":["MMP 035201"],"award-info":[{"award-number":["MMP 035201"]}],"id":[{"id":"10.13039\/501100007855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007855","name":"Central Leather Research Institute","doi-asserted-by":"publisher","award":["2155"],"award-info":[{"award-number":["2155"]}],"id":[{"id":"10.13039\/501100007855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bpc.2026.107600","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:48:09Z","timestamp":1772095689000},"page":"107600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synergistic effects of glycerol on the hydration dynamics and rheological properties of collagen"],"prefix":"10.1016","volume":"333","author":[{"given":"Anjali C.","family":"Venkitesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhini P.","family":"Muthulakshmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin P.","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanda Kumar","family":"Raja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanagasabai","family":"Balamurugan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Nishad","family":"Fathima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpc.2026.107600_bb0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cbpa.2019.08.001","article-title":"Mechanics and structural stability of the collagen triple helix","volume":"53","author":"Kirkness","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bpc.2026.107600_bb0010","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1006\/jmbi.1996.0673","article-title":"Crystallographic evidence for c\u03b1\u2013H\u00b7\u00b7\u00b7O=C hydrogen bonds in a collagen triple helix","volume":"264","author":"Bella","year":"1996","journal-title":"J. Mol. Biol."},{"issue":"1994","key":"10.1016\/j.bpc.2026.107600_bb0015","first-page":"75","article-title":"Crystal and molecular structure of a collagen-like peptide at 1.9 \u00c5 resolution","volume":"266","author":"Bella","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bpc.2026.107600_bb0020","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0308-8146(99)00097-7","article-title":"Stabilizing effect of glycerol on collagen type I isolated from different species","volume":"66","author":"Penkova","year":"1999","journal-title":"Food Chem."},{"key":"10.1016\/j.bpc.2026.107600_bb0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1023\/A:1020632424142","article-title":"Stability of collagen during denaturation","volume":"18","author":"Penkova","year":"1999","journal-title":"J. Protein Chem."},{"key":"10.1016\/j.bpc.2026.107600_bb0030","doi-asserted-by":"crossref","first-page":"11888","DOI":"10.1021\/bi980089+","article-title":"Sugars and polyols inhibit fibrillogenesis of type I collagen by disrupting hydrogen-bonded water bridges between the helices","volume":"37","author":"Kuznetsova","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpc.2026.107600_bb0035","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.ijbiomac.2014.10.032","article-title":"The effect of glycerol and 2-propanol on the molecular aggregation of collagen in solution","volume":"72","author":"Li","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bpc.2026.107600_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1140\/epje\/i2017-11545-1","article-title":"Preferential hydration fully controls the renaturation dynamics of collagen in water-glycerol solvents","volume":"40","author":"Ronsin","year":"2017","journal-title":"Eur. Phys. J. E"},{"key":"10.1016\/j.bpc.2026.107600_bb0045","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/S0006-3495(99)77424-2","article-title":"Effect of glycerol on the interactions and solubility of bovine pancreatic trypsin inhibitor","volume":"76","author":"Farnum","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpc.2026.107600_bb0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cplett.2017.01.012","article-title":"Influence of protein crowder size on hydration structure and dynamics in macromolecular crowding","volume":"671","author":"Wang","year":"2017","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.bpc.2026.107600_bb0055","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bpj.2018.07.019","article-title":"Direct evidence for the effect of glycerol on protein hydration and thermal structural transition","volume":"115","author":"Hirai","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpc.2026.107600_bb0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2306\/scienceasia1513-1874.2009.35.247","article-title":"Properties of \u03b2-glycerol phosphate\/collagen\/chitosan blend scaffolds for application in skin tissue engineering","volume":"35","author":"Faikrua","year":"2009","journal-title":"ScienceAsia"},{"key":"10.1016\/j.bpc.2026.107600_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2024.110447","article-title":"pH-responsive collagen nanocomposite films reinforced by curcumin-loaded laponite nanoplatelets for dynamic visualization of shrimp freshness","volume":"157","author":"Shi","year":"2024","journal-title":"Food Hydrocoll."},{"issue":"9","key":"10.1016\/j.bpc.2026.107600_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202517075","article-title":"Stimuli-responsive multicolor nacre-mimetic phosphorescent bionanocomposite thin films via network-confinement coupling","volume":"38","author":"Shi","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bpc.2026.107600_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.164809","article-title":"Biodegradable, fire-safe, and wearable triboelectric nanogenerator enabled by polyphenol-mediated 1D\/2D interface architecture","volume":"519","author":"Shi","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bpc.2026.107600_bb0080","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","article-title":"The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bpc.2026.107600_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2020.112654","article-title":"Are aqueous solutions of choline-based ionic liquid biocompatible cross-linkers for collagen?","volume":"303","author":"Tarannum","year":"2020","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bpc.2026.107600_bb0090","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1038\/ncomms6942","article-title":"Osmotic pressure induced tensile forces in tendon collagen","volume":"6","author":"Masic","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpc.2026.107600_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/jrs.5088","article-title":"Raman spectroscopic investigation on pure D2O\/H2O from 303 to 573 K: interpretation and implications for water structure: Raman spectroscopic investigation on pure D2O\/H2O","volume":"48","author":"Hu","year":"2017","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.bpc.2026.107600_bb0100","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1093\/bioinformatics\/bth247","article-title":"An interactive triple-helical collagen builder","volume":"20","author":"Rainey","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bpc.2026.107600_bb0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.bpc.2026.107600_bb0110","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"10.1016\/j.bpc.2026.107600_bb0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"key":"10.1016\/j.bpc.2026.107600_bb0120","series-title":"The PyMOL Molecular Graphics System, Version1.8","author":"Scr\u00f6dinger","year":"2015"},{"key":"10.1016\/j.bpc.2026.107600_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2024.107192","article-title":"Structural and mechanical behavior of type-I collagen fibrils in presence of induced electrostatic interactions through ionic liquids","volume":"307","author":"Banerjee","year":"2024","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bpc.2026.107600_bb0130","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12039-009-0061-4","article-title":"Collagen-curcumin interaction \u2014 a physico-chemical study","volume":"121","author":"Fathima","year":"2009","journal-title":"J. Chem. Sci."},{"key":"10.1016\/j.bpc.2026.107600_bb0135","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.saa.2019.01.029","article-title":"Stability of collagen in ionic liquids: ion specific Hofmeister series effect","volume":"212","author":"Tarannum","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bpc.2026.107600_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.118006","article-title":"FTIR investigation of the secondary structure of type I collagen: new insight into the amide III band","volume":"229","author":"Stani","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bpc.2026.107600_bb0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/05704928.2018.1426595","article-title":"FTIR analysis of natural and synthetic collagen","volume":"53","author":"Riaz","year":"2018","journal-title":"Appl. Spectrosc. Rev."},{"key":"10.1016\/j.bpc.2026.107600_bb0150","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijbiomac.2010.12.013","article-title":"The thermal behavior of collagen in solution: effect of glycerol and 2-propanol","volume":"48","author":"Li","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bpc.2026.107600_bb0155","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1021\/acs.jpcb.7b09626","article-title":"Impact of ionic liquids on the structure and dynamics of collagen","volume":"122","author":"Tarannum","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bpc.2026.107600_bb0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cellbi.2005.09.009","article-title":"An NMR method to characterize multiple water compartments on mammalian collagen","volume":"30","author":"Fullerton","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bpc.2026.107600_bb0165","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/(SICI)1097-0282(200005)53:6<476::AID-BIP4>3.0.CO;2-8","article-title":"1H-NMR study of water dynamics in hydrated collagen: transverse relaxation-time and diffusion analysis","volume":"53","author":"Traore","year":"2000","journal-title":"Biopolymers"},{"key":"10.1016\/j.bpc.2026.107600_bb0170","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jrs.1016","article-title":"Hydration of glutaraldehyde-fixed pericardium tissue: Raman spectroscopic study","volume":"34","author":"Jastrzebska","year":"2003","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.bpc.2026.107600_bb0175","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1073\/pnas.94.21.11312","article-title":"Raman spectral evidence for hydration forces between collagen triplehelices","volume":"94","author":"Leikin","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bpc.2026.107600_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.142972","article-title":"Physicochemical studies of asarylaldehyde crosslinked type-I collagen fibrils","volume":"1344","author":"Banerjee","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bpc.2026.107600_bb0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijbiomac.2007.12.010","article-title":"Effect of concentration and temperature on the rheological behavior of collagen solution","volume":"42","author":"Lai","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bpc.2026.107600_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/app.50840","article-title":"Rheological behavior of collagen\/chitosan blended solutions","volume":"138","author":"Zheng","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.bpc.2026.107600_bb0195","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1177\/0003702817693855","article-title":"Adsorption of water to collagen as studied using infrared (IR) microspectroscopy combined with relative humidity control system and quartz crystal microbalance","volume":"71","author":"Kudo","year":"2017","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.bpc.2026.107600_bb0200","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.ijbiomac.2017.09.066","article-title":"AFM analysis of collagen fibrils in expanded scalp tissue after anisotropic tissue expansion","volume":"107","author":"Aziz","year":"2018","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biophysical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462226000335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462226000335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:13:02Z","timestamp":1778541182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301462226000335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"alternative-id":["S0301462226000335"],"URL":"https:\/\/doi.org\/10.1016\/j.bpc.2026.107600","relation":{},"ISSN":["0301-4622"],"issn-type":[{"value":"0301-4622","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effects of glycerol on the hydration dynamics and rheological properties of collagen","name":"articletitle","label":"Article Title"},{"value":"Biophysical Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpc.2026.107600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107600"}}