{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:50:19Z","timestamp":1791834619183,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Re1435\/25\\u20131"],"award-info":[{"award-number":["Re1435\/25\\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015655","name":"Bose Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR29978\/MED\/30\/2037\/2018"],"award-info":[{"award-number":["BT\/PR29978\/MED\/30\/2037\/2018"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Chemistry"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bpc.2026.107720","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:48:24Z","timestamp":1790981304000},"page":"107720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Inhibition of hIAPP amyloid aggregation by the polyherbal formulation NAMIG-5: a bench-to-bedside translational study"],"prefix":"10.1016","volume":"340","author":[{"given":"Pradyut","family":"Nama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanwita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prantick Kumar","family":"Bhunia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karishma","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Suladze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Mroue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiman","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaravadhi","family":"Harikishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Taraphdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Bhunia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpc.2026.107720_bb0005","series-title":"Diabetes Atlas","year":"2003"},{"issue":"3","key":"10.1016\/j.bpc.2026.107720_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ecl.2021.06.004","article-title":"Definition and classification of diabetes and prediabetes and emerging data on phenotypes","volume":"50","author":"Colagiuri","year":"2021","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.bpc.2026.107720_bb0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"\u0392-Cell deficit and increased \u03b2-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bpc.2026.107720_bb0020","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCRESAHA.111.258285","article-title":"Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats","volume":"110","author":"Despa","year":"2012","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bpc.2026.107720_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01516-6","article-title":"Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management","volume":"21","author":"Ma","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"issue":"8","key":"10.1016\/j.bpc.2026.107720_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11082131","article-title":"Premature mortality in type 2 diabetes mellitus associated with heart failure and chronic kidney disease: 20 years of real-world data","volume":"11","author":"Gavina","year":"2022","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.bpc.2026.107720_bb0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ab.2005.11.029","article-title":"Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide","volume":"351","author":"Abedini","year":"2006","journal-title":"Anal. Biochem."},{"issue":"13","key":"10.1016\/j.bpc.2026.107720_bb0040","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1021\/acs.biochem.5b00061","article-title":"Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP","volume":"54","author":"Ghosh","year":"2015","journal-title":"Biochemistry"},{"issue":"23","key":"10.1016\/j.bpc.2026.107720_bb0045","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"48","key":"10.1016\/j.bpc.2026.107720_bb0050","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1073\/pnas.1305517110","article-title":"Islet amyloid polypeptide toxicity and membrane interactions","volume":"110","author":"Cao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"48","key":"10.1016\/j.bpc.2026.107720_bb0055","doi-asserted-by":"crossref","first-page":"19285","DOI":"10.1073\/pnas.1314481110","article-title":"Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient \u03b2-sheet","volume":"110","author":"Buchanan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.bpc.2026.107720_bb0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0925-4439(01)00078-3","article-title":"Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology","volume":"1537","author":"Jaikaran","year":"2001","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.bpc.2026.107720_bb0065","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211297","article-title":"Linking hIAPP misfolding and aggregation with type 2 diabetes mellitus: a structural perspective","volume":"42","author":"Hassan","year":"2022","journal-title":"Biosci. Rep."},{"issue":"2","key":"10.1016\/j.bpc.2026.107720_bb0070","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0079-6107(84)90007-5","article-title":"Hydrogen bonding in globular proteins","volume":"44","author":"Baker","year":"1984","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"5","key":"10.1016\/j.bpc.2026.107720_bb0075","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1039\/C5CC07792C","article-title":"Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes","volume":"52","author":"Pithadia","year":"2016","journal-title":"Chem. Commun."},{"issue":"46","key":"10.1016\/j.bpc.2026.107720_bb0080","doi-asserted-by":"crossref","first-page":"16748","DOI":"10.1021\/jacs.7b08830","article-title":"A free energy barrier caused by the refolding of an oligomeric intermediate controls the lag time of amyloid formation by hIAPP","volume":"139","author":"Serrano","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bpc.2026.107720_bb0085","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijbiomac.2016.06.053","article-title":"Understanding curcumin-induced modulation of protein aggregation","volume":"100","author":"Ahmad","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"7376","key":"10.1016\/j.bpc.2026.107720_bb0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature10577","article-title":"Atomic-resolution dynamics on the surface of amyloid-\u03b2 protofibrils probed by solution NMR","volume":"480","author":"Fawzi","year":"2011","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bpc.2026.107720_bb0095","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1021\/jp511758w","article-title":"Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP","volume":"119","author":"Brender","year":"2015","journal-title":"J. Phys. Chem. B"},{"issue":"4","key":"10.1016\/j.bpc.2026.107720_bb0100","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s13410-025-01502-0","article-title":"RSSDI 2025 nutrition guidelines for individuals with type 2 diabetes (supported by ICMR - National Institute of Nutrition)","volume":"45","year":"2025","journal-title":"Int. J. Diabetes Dev. Ctries."},{"issue":"1","key":"10.1016\/j.bpc.2026.107720_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010058","article-title":"Antidiabetic properties of curcumin part II: evidence from in vivo studies","volume":"12","author":"Den Hartogh","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bpc.2026.107720_bb0110","first-page":"27","article-title":"Herbal versus synthetic drugs; beliefs and facts","volume":"4","author":"Karimi","year":"2015","journal-title":"J. Nephropharmacol."},{"key":"10.1016\/j.bpc.2026.107720_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00006","article-title":"Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management","volume":"8","author":"Chaudhury","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bpc.2026.107720_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/8507453","article-title":"Antidiabetic effect of fenugreek seed powder solution (Trigonella foenum-graecum L.) on hyperlipidemia in diabetic patients","volume":"2019","author":"Geberemeskel","year":"2019","journal-title":"J. Diabetes Res."},{"issue":"6","key":"10.1016\/j.bpc.2026.107720_bb0125","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jsps.2023.04.009","article-title":"The antidiabetic effect of methanolic extract of Holarrhena pubescens seeds is mediated through multiple mechanisms of action","volume":"31","author":"Alyahya","year":"2023","journal-title":"Saudi Pharm. J."},{"issue":"4","key":"10.1016\/j.bpc.2026.107720_bb0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4103\/0974-8520.127731","article-title":"Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters","volume":"34","author":"Patel","year":"2013","journal-title":"AYU"},{"issue":"7","key":"10.1016\/j.bpc.2026.107720_bb0135","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.18203\/2319-2003.ijbcp20182686","article-title":"Evaluation of antidiabetic activity of Tinospora cardifolia in alloxan induced diabetes in albino wistar rats","volume":"7","author":"Abhijith","year":"2018","journal-title":"Int. J. Basic Clin. Pharmacol."},{"issue":"Suppl. 2","key":"10.1016\/j.bpc.2026.107720_bb0140","first-page":"497","article-title":"Acute oral toxicity","volume":"106","author":"Walum","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bpc.2026.107720_bb0145","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.toxrep.2020.08.028","article-title":"Acute and sub-chronic toxicity evaluation of the crude methanolic extract of Diospyros mespiliformis hochst ex a. dc (ebenaceae) and its fractions","volume":"7","author":"Ebbo","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.bpc.2026.107720_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/854267","article-title":"Antidiabetic activity of benzopyrone analogues in nicotinamide-streptozotocin induced type 2 diabetes in rats","volume":"2014","author":"Nayak","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.bpc.2026.107720_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijbiomac.2019.06.050","article-title":"Human islet amyloid polypeptide (hIAPP) aggregation in type 2 diabetes: correlation between intrinsic physicochemical properties of hIAPP aggregates and their cytotoxicity","volume":"136","author":"Chaari","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.bpc.2026.107720_bb0160","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.bpc.2026.107720_bb0165","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bpc.2026.107720_bb0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pep.2014.10.012","article-title":"Cloning, expression and purification of the human islet amyloid polypeptide (hIAPP) from Escherichia coli","volume":"106","author":"Camargo","year":"2015","journal-title":"Protein Expr. Purif."},{"issue":"20","key":"10.1016\/j.bpc.2026.107720_bb0175","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.1111\/j.1742-4658.2009.07307.x","article-title":"The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds","volume":"276","author":"Hudson","year":"2009","journal-title":"FEBS J."}],"container-title":["Biophysical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462226001535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301462226001535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:32:40Z","timestamp":1791833560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301462226001535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":35,"alternative-id":["S0301462226001535"],"URL":"https:\/\/doi.org\/10.1016\/j.bpc.2026.107720","relation":{},"ISSN":["0301-4622"],"issn-type":[{"value":"0301-4622","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of hIAPP amyloid aggregation by the polyherbal formulation NAMIG-5: a bench-to-bedside translational study","name":"articletitle","label":"Article Title"},{"value":"Biophysical Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpc.2026.107720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107720"}}