{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:38:15Z","timestamp":1791175095993,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.bpg.2006.04.005","type":"journal-article","created":{"date-parts":[[2006,9,23]],"date-time":"2006-09-23T11:29:43Z","timestamp":1159010983000},"page":"709-719","source":"Crossref","is-referenced-by-count":22,"title":["Can gastric cancer be prevented by Helicobacter pylori eradication?"],"prefix":"10.1016","volume":"20","author":[{"given":"Peter","family":"Malfertheiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia C.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"M\u00f6nkem\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpg.2006.04.005_bib1","article-title":"Schistosomes, liver flukes and Helicobacter pylori: infection with Helicobacter pylori","volume":"vol. 61","year":"1994"},{"key":"10.1016\/j.bpg.2006.04.005_bib2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1053\/gast.2001.27999","article-title":"Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection","volume":"121","author":"Ekstr\u00f6m","year":"2001","journal-title":"Gastroenterololgy"},{"issue":"3","key":"10.1016\/j.bpg.2006.04.005_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/aje\/kwh039","article-title":"Is Helicobacter pylori infection a necessary condition for non-cardia gastric cancer?","volume":"159","author":"Brenner","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.bpg.2006.04.005_bib4","series-title":"Helicobacter pylori: Basic Mechanisms to Clinical Cure 1998","first-page":"354","article-title":"Lessons from ongoing intervention studies","author":"Forman","year":"1998"},{"key":"10.1016\/j.bpg.2006.04.005_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bpg.2006.04.005_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1349-7006.2005.00006.x","article-title":"Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence","volume":"96","author":"Tsugane","year":"2005","journal-title":"Cancer Sci"},{"key":"10.1016\/j.bpg.2006.04.005_bib7","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1111\/j.1572-0241.2005.41688.x","article-title":"Lejondal H. pylori-Gastric Cancer Task Force. Helicobacter pylori eradication has the potential to prevent gastric cancer: a state-of-the-art critique","volume":"100","author":"Malfertheiner","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1083\/jcb.200208039","article-title":"Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response","volume":"161","author":"Churin","year":"2003","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.bpg.2006.04.005_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1096\/fj.03-0055fje","article-title":"Helicobacter pylori stimulates host vascular endothelial growth factor-a (vegf-A) gene expression via MEK\/ERK-dependent activation of Sp1 and Sp3","volume":"18","author":"Strowski","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.bpg.2006.04.005_bib10","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1126\/science.1081919","article-title":"Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA","volume":"300","author":"Amieva","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bpg.2006.04.005_bib11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0006-291X(02)00740-4","article-title":"Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF","volume":"295","author":"Wallasch","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bpg.2006.04.005_bib12","doi-asserted-by":"crossref","first-page":"31059","DOI":"10.1074\/jbc.M104141200","article-title":"Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells","volume":"276","author":"Gupta","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bpg.2006.04.005_bib13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1046\/j.1462-5822.2003.00324.x","article-title":"Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK\/ERK-dependent activation of USF1\/-2 and CREB transcription factors","volume":"5","author":"J\u00fcttner","year":"2003","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.bpg.2006.04.005_bib14","series-title":"Gastrointestinal Cancers","first-page":"299","article-title":"The biology of gastric cancer","author":"Farrell","year":"2003"},{"key":"10.1016\/j.bpg.2006.04.005_bib15","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1111\/j.1572-0241.1999.01432.x","article-title":"Eradication of Helicobacter pylori normalizes elevated mucosal levels of epidermal growth factor and its receptor","volume":"94","author":"Coyle","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib16","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1093\/jnci\/92.23.1868","article-title":"Preventing cancer by disrupting progression of precancerous lesions","volume":"92","author":"Blot","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"10.1016\/j.bpg.2006.04.005_bib17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1046\/j.1365-2036.2002.01311.x","article-title":"Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis","volume":"16","author":"Ito","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2006.04.005_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/030098589703400308","article-title":"Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo)","volume":"34","author":"Fox","year":"1997","journal-title":"Vet Pathol"},{"key":"10.1016\/j.bpg.2006.04.005_bib19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0016-5085(98)70143-X","article-title":"Helicobacter pylori infection induces gastric cancer in Mongolian gerbils","volume":"115","author":"Watanabe","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2006.04.005_bib20","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s005350050295","article-title":"Development of poorly differentiated adenocarcinoma and carcinoid due to long-term Helicobacter pylori colonization in Mongolian gerbils","volume":"34","author":"Hirayama","year":"1999","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/carcin\/20.7.1261","article-title":"Effect of Helicobacter pylori infection on the N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Mongolian gerbils","volume":"20","author":"Tokieda","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bpg.2006.04.005_bib22","first-page":"696","article-title":"Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 pro-inflammatory responses","volume":"62","author":"Fox","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.bpg.2006.04.005_bib23","first-page":"1512","article-title":"Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils","volume":"60","author":"Shimizu","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.bpg.2006.04.005_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1349-7006.2003.tb01426.x","article-title":"Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils","volume":"94","author":"Nozaki","year":"2003","journal-title":"Cancer Sci"},{"key":"10.1016\/j.bpg.2006.04.005_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/cncr.10697","article-title":"Study of p53 immunostaining in the gastric epithelium of CagA-positive and CagA-negative Helicobacter pylori gastritis","volume":"95","author":"Teh","year":"2002","journal-title":"Cancer"},{"issue":"supplement 13","key":"10.1016\/j.bpg.2006.04.005_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02990091","article-title":"Analysis of p53 mutations and Helicobacter pylori infection in human and animal models","volume":"37","author":"Murakami","year":"2002","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib27","series-title":"Sleisenger & Fordtran's Gastrointestinal & Liver Disease","first-page":"829","article-title":"Tumors of the stomach","author":"Koh","year":"2002"},{"key":"10.1016\/j.bpg.2006.04.005_bib28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0002-9440(10)64586-5","article-title":"Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions","volume":"157","author":"Sung","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bpg.2006.04.005_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1023\/A:1021774029089","article-title":"Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy","volume":"48","author":"Konturek","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.bpg.2006.04.005_bib30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0016-5085(03)00899-0","article-title":"A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma","volume":"125","author":"Machado","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2006.04.005_bib31","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/003655202760230838","article-title":"Helicobacter pylori and CagA status, serum gastrin, interleukin-8 and gastric acid secretion in gastric cancer","volume":"37","author":"Konturek","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib32","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1128\/IAI.71.11.6573-6581.2003","article-title":"Correlation between Cag pathogenecity island status and Helicobacter pylori associated gastroduodenal disease","volume":"71","author":"Nilsson","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.bpg.2006.04.005_bib33","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1128\/JCM.35.6.1344-1347.1997","article-title":"Equally high prevalence of infection with CagA-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis-associated dyspepsia","volume":"35","author":"Pan","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bpg.2006.04.005_bib34","first-page":"1785","article-title":"Serological response to specific Helicobacter pylori antigens: antibody against CagA antigen is not predictive of gastric cancer in a developing country","volume":"91","author":"Mitchell","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2006.04.005_bib35","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1172\/JCI12672","article-title":"Helicobacter pylori genetic diversity and risk of human disease","volume":"107","author":"Blaser","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bpg.2006.04.005_bib36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/16495","article-title":"Genombbic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori","volume":"397","author":"Alm","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bpg.2006.04.005_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/315173","article-title":"Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart in the same host","volume":"181","author":"Kuipers","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bpg.2006.04.005_bib38","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1073\/pnas.97.26.14668","article-title":"A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains","volume":"19","author":"Salama","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpg.2006.04.005_bib39","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI11450","article-title":"Helicobacter pylori strain specific differences in genetic content, identified by microarray, influence host inflammatory responses","volume":"107","author":"Israel","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bpg.2006.04.005_bib40","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/jnci\/94.22.1680","article-title":"Helicobacter pylori and interleukin 1 genotypoing: an opportunity to identify high-risk individuals for gastric carcinoma","volume":"94","author":"Figueiredo","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bpg.2006.04.005_bib41","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/IAI.72.2.880-888.2004","article-title":"Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma","volume":"72","author":"Lehours","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.bpg.2006.04.005_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/gast.2001.28000","article-title":"Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma","volume":"121","author":"Machado","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2006.04.005_bib43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"124","author":"El-Omar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2006.04.005_bib44","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.49.3.347","article-title":"Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts","volume":"49","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2006.04.005_bib45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1046\/j.1365-2036.1999.00535.x","article-title":"The GU-MACH study: the effect of one-week omeprazole triple therapy on Helicobacter pylori infection. Eradication healing and relapse in patients with active gastric ulcer","volume":"14","author":"Malfertheiner","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2006.04.005_bib46","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1046\/j.1365-2036.2003.01560.x","article-title":"Helicobacter pylori eradication and gastric ulcer healing \u2013 comparison of three pantoprazole-based triple therapies","volume":"17","author":"Malfertheiner","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2006.04.005_bib47","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/92.23.1881","article-title":"Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and Helicobacter pylori therapy","volume":"92","author":"Correa","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bpg.2006.04.005_bib48","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1523-5378.2000.00032.x","article-title":"Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression","volume":"5","author":"Moayyedi","year":"2000","journal-title":"Helicobacter"},{"key":"10.1016\/j.bpg.2006.04.005_bib49","first-page":"2048","article-title":"The effect of eradication therapy on histological changes in the gastric mucosa in patients with non-ulcer dyspepsia and Helicobacter pylori infection. Prospective randomized intervention study","volume":"46","author":"Kyzekova","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.bpg.2006.04.005_bib50","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00042737-200104000-00012","article-title":"Gastric corpus atrophy following eradication of Helicobacter pylori","volume":"13","author":"Larkin","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2006.04.005_bib51","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/gut.46.5.615","article-title":"Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy","volume":"46","author":"Schenk","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2006.04.005_bib52","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1046\/j.1365-2036.2002.01300.x","article-title":"Review article: intestinal metaplasia and cancer carcinogenesis","volume":"16","author":"Leung","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2006.04.005_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/jama.291.2.187","article-title":"Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial","volume":"291","author":"Wong","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.bpg.2006.04.005_bib54","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpg.2006.04.005_bib55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1443-9573.2005.00204.x","article-title":"The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area","volume":"6","author":"Zhou","year":"2005","journal-title":"Chin J Dig Dis"},{"key":"10.1016\/j.bpg.2006.04.005_bib56","first-page":"639","article-title":"Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer","volume":"6","author":"Uemura","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.bpg.2006.04.005_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mge.2000.106112","article-title":"Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma","volume":"52","author":"Saito","year":"2000","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.bpg.2006.04.005_bib58","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1158\/1055-9965.EPI-03-0124","article-title":"Helicobacter pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial","volume":"13","author":"Ley","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.bpg.2006.04.005_bib59","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/gut.2005.072009","article-title":"Long term follow up of patients treated for Helicobacter pylori infection","volume":"54","author":"Mera","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2006.04.005_bib60","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2036.2002.01169.x","article-title":"Current concepts in the management of Helicobacter pylori infection\u2014the Maastricht 2-2000 Consensus Report","volume":"16","author":"Malfertheiner","year":"2002","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691806000461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691806000461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T09:24:11Z","timestamp":1587201851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691806000461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S1521691806000461"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2006.04.005","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}