{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T09:40:46Z","timestamp":1712223646128},"reference-count":110,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.bpg.2010.07.009","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T17:40:39Z","timestamp":1298050839000},"page":"709-723","source":"Crossref","is-referenced-by-count":14,"title":["Viral hepatitis: Human genes that limit infection"],"prefix":"10.1016","volume":"24","author":[{"given":"Frank","family":"Gr\u00fcnhage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpg.2010.07.009_bib1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance","volume":"461","author":"Ge","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bpg.2010.07.009_bib2","unstructured":"McCarthy JJ, Li JH, Thompson A, et\u00a0al. Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. Gastroenterology."},{"key":"10.1016\/j.bpg.2010.07.009_bib3","unstructured":"Rauch A, Kutalik Z, Descombes P, et\u00a0al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology."},{"key":"10.1016\/j.bpg.2010.07.009_bib4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","article-title":"IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy","volume":"41","author":"Suppiah","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpg.2010.07.009_bib5","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C","volume":"41","author":"Tanaka","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpg.2010.07.009_bib6","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nature08463","article-title":"Genetic variation in IL28B and spontaneous clearance of hepatitis C virus","volume":"461","author":"Thomas","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bpg.2010.07.009_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex","volume":"4","author":"Kotenko","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL-28, IL-29 and their class II cytokine receptor IL-28R","volume":"4","author":"Sheppard","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib9","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1053\/j.gastro.2006.09.052","article-title":"Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics","volume":"131","author":"Marcello","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2010.07.009_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-2007-1007106","article-title":"Cytokines and the hepatic acute-phase response","volume":"19","author":"Ramadori","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.bpg.2010.07.009_bib11","first-page":"92","article-title":"STATs and liver disease","volume":"2","author":"Cytokines","year":"2005","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib12","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bpg.2010.07.009_bib13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/jmv.10472","article-title":"Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection","volume":"71","author":"Barrett","year":"2003","journal-title":"J Med Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.humimm.2004.11.001","article-title":"Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, -6, or -10 genes","volume":"66","author":"Minton","year":"2005","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0198-8859(03)00080-6","article-title":"IL-10 and TNF-alpha polymorphisms and the recovery from HCV infection","volume":"64","author":"Lio","year":"2003","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib16","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.1128\/JVI.00339-06","article-title":"Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism","volume":"80","author":"Paladino","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.gene.6364188","article-title":"Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance","volume":"6","author":"Oleksyk","year":"2005","journal-title":"Genes Immun"},{"key":"10.1016\/j.bpg.2010.07.009_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2006.03.011","article-title":"Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan","volume":"34","author":"Kusumoto","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.bpg.2010.07.009_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cyto.2003.10.005","article-title":"IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection","volume":"25","author":"Mangia","year":"2004","journal-title":"Cytokine"},{"key":"10.1016\/j.bpg.2010.07.009_bib20","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1440-1746.2006.04304.x","article-title":"Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-alpha gene promoter polymorphisms","volume":"21","author":"Cheong","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib21","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1073\/pnas.0602800103","article-title":"Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence","volume":"103","author":"Frodsham","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bpg.2010.07.009_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/jir.2005.25.271","article-title":"Polymorphisms in the IL-12B gene and outcome of HCV infection","volume":"25","author":"Houldsworth","year":"2005","journal-title":"J Interferon Cytokine Res."},{"key":"10.1016\/j.bpg.2010.07.009_bib23","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jhep.2004.06.021","article-title":"Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection","volume":"41","author":"Mueller","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib24","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3748\/wjg.v10.i16.2330","article-title":"Association of interleukin-12 p40 gene 3\u2032-untranslated region polymorphism and outcome of HCV infection","volume":"10","author":"Yin","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib25","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1086\/592047","article-title":"Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C\u00a0virus clearance","volume":"198","author":"An","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bpg.2010.07.009_bib26","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1478-3231.2007.01518.x","article-title":"Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection","volume":"27","author":"Hennig","year":"2007","journal-title":"Liver Int"},{"key":"10.1016\/j.bpg.2010.07.009_bib27","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1086\/503436","article-title":"Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus","volume":"193","author":"Kimura","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bpg.2010.07.009_bib28","first-page":"210","article-title":"Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C","volume":"23","author":"Larrea","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib29","first-page":"150","article-title":"A polymorphic variation in a putative regulation box of the TNFA promoter region","volume":"39","author":"D\u2019Alfonso","year":"1994","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bpg.2010.07.009_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1084\/jem.177.2.557","article-title":"An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles","volume":"177","author":"Wilson","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.bpg.2010.07.009_bib31","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpg.2010.07.009_bib32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2249.1998.00534.x","article-title":"A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection","volume":"111","author":"Hohler","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1086\/498244","article-title":"Tumor necrosis factor-alpha promoter polymorphism at position \u2013308 predicts response to combination therapy in hepatitis C virus infection","volume":"193","author":"Dai","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bpg.2010.07.009_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.gene.6363696","article-title":"Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection","volume":"1","author":"Yee","year":"2000","journal-title":"Genes Immun"},{"key":"10.1016\/j.bpg.2010.07.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000073218","article-title":"Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism","volume":"68","author":"Schiemann","year":"2003","journal-title":"Digestion"},{"key":"10.1016\/j.bpg.2010.07.009_bib36","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/hmg\/ddg262","article-title":"Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection","volume":"12","author":"Kim","year":"2003","journal-title":"Hum Mol Genet."},{"key":"10.1016\/j.bpg.2010.07.009_bib37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2005.01166.x","article-title":"Tumor necrosis factor gene polymorphisms and clearance or progression of hepatitis B virus infection","volume":"25","author":"Niro","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.bpg.2010.07.009_bib38","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2893.2006.00731.x","article-title":"Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population","volume":"13","author":"Du","year":"2006","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib39","first-page":"14","article-title":"Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B","volume":"25","author":"Somi","year":"2006","journal-title":"Indian J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s002510050008","article-title":"Polymorphisms of the human IFNG gene noncoding regions","volume":"51","author":"Bream","year":"2000","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bpg.2010.07.009_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2370.1999.00122.x","article-title":"In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene","volume":"26","author":"Pravica","year":"1999","journal-title":"Eur J Immunogenet"},{"key":"10.1016\/j.bpg.2010.07.009_bib42","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1073\/pnas.0609954104","article-title":"A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection","volume":"104","author":"Huang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bpg.2010.07.009_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00251-006-0161-y","article-title":"Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection","volume":"58","author":"Liu","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bpg.2010.07.009_bib44","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/jmv.20739","article-title":"Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea","volume":"78","author":"Ahn","year":"2006","journal-title":"J Med Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib45","first-page":"116","article-title":"[Association between CCR5 promoter polymorphisms and hepatitis B virus infection]","volume":"11","author":"Chang","year":"2005","journal-title":"Korean J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jcv.2004.05.008","article-title":"T cell response in hepatitis C virus infection","volume":"32","author":"Neumann-Haefelin","year":"2005","journal-title":"J Clin Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib47","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3748\/wjg.v13.i12.1770","article-title":"A comparative review of HLA associations with hepatitis B and C viral infections across global populations","volume":"13","author":"Singh","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1034\/j.1399-0039.2000.560207.x","article-title":"Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearance","volume":"56","author":"Alric","year":"2000","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.bpg.2010.07.009_bib49","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0140-6736(99)91443-5","article-title":"Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research","volume":"354","author":"Thursz","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bpg.2010.07.009_bib50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.20261","article-title":"Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source","volume":"40","author":"McKiernan","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib51","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/jmv.20848","article-title":"Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population","volume":"79","author":"Chuang","year":"2007","journal-title":"J Med Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib52","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1128\/JVI.76.10.4792-4797.2002","article-title":"HLA-Cw*04 and hepatitis C virus persistence","volume":"76","author":"Thio","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib53","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/hep.21889","article-title":"Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection","volume":"46","author":"Hraber","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib54","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.3748\/wjg.v11.i46.7302","article-title":"Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis","volume":"11","author":"Hong","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib55","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2893.2007.00880.x","article-title":"Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population","volume":"14","author":"Kummee","year":"2007","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJM199504203321604","article-title":"Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia","volume":"332","author":"Thursz","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpg.2010.07.009_bib57","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1046\/j.1365-2249.1998.00665.x","article-title":"A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B","volume":"113","author":"Diepolder","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib58","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1097670","article-title":"HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection","volume":"305","author":"Khakoo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bpg.2010.07.009_bib59","article-title":"Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus","author":"Knapp","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib60","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/cmi.2008.57","article-title":"Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population","volume":"5","author":"Lu","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib61","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.molimm.2009.05.014","article-title":"Protective KIR-HLA interactions for HCV infection in intravenous drug users","volume":"46","author":"Zuniga","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1744-313X.2007.00739.x","article-title":"Killer cell immunoglobulin-like receptors on NK cells: the how, where and why","volume":"35","author":"Gardiner","year":"2008","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.bpg.2010.07.009_bib63","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3325\/cmj.2007.6.800","article-title":"Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population","volume":"48","author":"Zhi-ming","year":"2007","journal-title":"Croat Med J"},{"key":"10.1016\/j.bpg.2010.07.009_bib64","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/j.1478-3231.2007.01553.x","article-title":"Recipient cytotoxic T lymphocyte antigen-4 +49 G\/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients","volume":"27","author":"Jiang","year":"2007","journal-title":"Liver Int"},{"key":"10.1016\/j.bpg.2010.07.009_bib65","doi-asserted-by":"crossref","first-page":"11258","DOI":"10.1128\/JVI.78.20.11258-11262.2004","article-title":"Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection","volume":"78","author":"Thio","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.bpg.2010.07.009_bib66","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cca.2008.12.001","article-title":"Association of functional polymorphism of ApoB promoter with hepatitis C virus infection","volume":"401","author":"Zhu","year":"2009","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.bpg.2010.07.009_bib67","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/ije\/dym093","article-title":"SPP1 polymorphisms associated with HBV clearance and HCC occurrence","volume":"36","author":"Shin","year":"2007","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.bpg.2010.07.009_bib68","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/emm.2006.82","article-title":"Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance","volume":"38","author":"Park","year":"2006","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.bpg.2010.07.009_bib69","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3346\/jkms.2007.22.3.529","article-title":"RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated with the outcome of hepatitis B virus infection: results from a large scale single ethnic population","volume":"22","author":"Cheong","year":"2007","journal-title":"J Korean Med Sci."},{"key":"10.1016\/j.bpg.2010.07.009_bib70","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s10528-006-9029-y","article-title":"Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection","volume":"44","author":"Cheong","year":"2006","journal-title":"Biochem Genet"},{"key":"10.1016\/j.bpg.2010.07.009_bib71","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00251-009-0377-8","article-title":"A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection","volume":"61","author":"Zhou","year":"2009","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bpg.2010.07.009_bib72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbrc.2006.05.080","article-title":"IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma","volume":"346","author":"Kim","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bpg.2010.07.009_bib73","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0028-1110008","article-title":"Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection","volume":"48","author":"Sarrazin","year":"2010","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib74","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hep.22877","article-title":"Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial","volume":"49","author":"Welzel","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib75","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jhep.2008.04.011","article-title":"Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C","volume":"49","author":"Su","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib76","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000025035","article-title":"Identification of a single nucleotide polymorphism in the MxA gene promoter (G\/T at nt \u201388) correlated with the response of hepatitis C patients to interferon","volume":"43","author":"Hijikata","year":"2000","journal-title":"Intervirology"},{"key":"10.1016\/j.bpg.2010.07.009_bib77","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/sj.gene.6363984","article-title":"Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR","volume":"4","author":"Knapp","year":"2003","journal-title":"Genes Immun"},{"key":"10.1016\/j.bpg.2010.07.009_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2893.2004.00509.x","article-title":"Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection","volume":"11","author":"Suzuki","year":"2004","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib79","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/gut.2007.129478","article-title":"Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C","volume":"57","author":"Persico","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2010.07.009_bib80","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0014-5793(01)02339-0","article-title":"The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response","volume":"495","author":"Lindemann","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bpg.2010.07.009_bib81","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2005.03.020","article-title":"GNB3 C825T polymorphism and response to interferon-alfa\/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection","volume":"43","author":"Sarrazin","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib82","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jhep.2007.04.008","article-title":"The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV\/HIV co-infected but not in HCV mono-infected patients","volume":"47","author":"Ahlenstiel","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib83","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1034\/j.1600-0676.2002.01553.x","article-title":"Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy","volume":"22","author":"Constantini","year":"2002","journal-title":"Liver"},{"key":"10.1016\/j.bpg.2010.07.009_bib84","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/hep.510300207","article-title":"Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa","volume":"30","author":"Edwards-Smith","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib85","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-8278(01)00243-4","article-title":"Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin","volume":"36","author":"Vidigal","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.bpg.2010.07.009_bib86","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0602313","article-title":"Interleukin-18","volume":"73","author":"Gracie","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.bpg.2010.07.009_bib87","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","article-title":"Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu","volume":"12","author":"Nakanishi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bpg.2010.07.009_bib88","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2174\/1566524033479618","article-title":"Cytokine-induced inflammatory liver injuries","volume":"3","author":"Tsutsui","year":"2003","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.bpg.2010.07.009_bib89","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s10875-009-9302-z","article-title":"Interleukin 18 promoter variants (\u2013137G>C and \u2013607C>A) in patients with chronic hepatitis C: association with treatment response","volume":"29","author":"Haas","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib90","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-5728(00)00407-0","article-title":"Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation","volume":"112","author":"Giedraitis","year":"2001","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib91","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0009-9120(99)00053-3","article-title":"Predictors of sustained response to alpha interferon therapy in chronic hepatitis C","volume":"32","author":"Neuman","year":"1999","journal-title":"Clin Biochem"},{"key":"10.1016\/j.bpg.2010.07.009_bib92","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1572-0241.2002.05552.x","article-title":"Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C","volume":"97","author":"Rosen","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib93","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hep.20322","article-title":"Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C","volume":"40","author":"Wasmuth","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib94","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0198-8859(98)00010-X","article-title":"Interferon-alpha therapy in HCV hepatitis: HLA phenotype and cirrhosis are independent predictors of clinical outcome","volume":"59","author":"Almarri","year":"1998","journal-title":"Hum Immunol"},{"key":"10.1016\/j.bpg.2010.07.009_bib95","first-page":"80","article-title":"Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-alpha and ribavirin in patients with chronic hepatitis C","volume":"4","author":"Jiao","year":"2005","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.bpg.2010.07.009_bib96","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1572-0241.2003.07537.x","article-title":"HLA class I B44 is associated with sustained response to interferon+ribavirin therapy in patients with chronic hepatitis C","volume":"98","author":"Romero-Gomez","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2010.07.009_bib97","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2893.2007.00898.x","article-title":"Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy","volume":"15","author":"Schott","year":"2008","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib98","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1365-2893.2003.00488.x","article-title":"Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C","volume":"11","author":"Lebray","year":"2004","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib99","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1086\/374561","article-title":"Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection","volume":"187","author":"Yee","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bpg.2010.07.009_bib100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08825","article-title":"ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C","volume":"464","author":"Fellay","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bpg.2010.07.009_bib101","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2893.2009.01095.x","article-title":"Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients","volume":"16","author":"Wada","year":"2009","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1176\/appi.psy.45.1.49","article-title":"Association between apolipoprotein E epsilon4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C","volume":"45","author":"Gochee","year":"2004","journal-title":"Psychosomatics"},{"key":"10.1016\/j.bpg.2010.07.009_bib103","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0197-4580(00)00097-X","article-title":"The role of apolipoprotein E in Alzheimer\u2019s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models","volume":"21","author":"Horsburgh","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.bpg.2010.07.009_bib104","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2893.2009.01130.x","article-title":"Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection","volume":"16","author":"Gong","year":"2009","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.bpg.2010.07.009_bib105","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/j.1365-2036.2006.02948.x","article-title":"Genetic polymorphisms of interleukin-1-beta in association with sustained response to anti-viral treatment in chronic hepatitis B in Chinese","volume":"23","author":"Chan","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2010.07.009_bib106","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.antiviral.2009.06.003","article-title":"A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients","volume":"83","author":"Wu","year":"2009","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bpg.2010.07.009_bib107","first-page":"187","article-title":"Genetic polymorphisms of MxA protein and eIF-2a-reg2 and their responses to interferon treatment in patients with chronic hepatitis B","volume":"15","author":"Huang","year":"2007","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.bpg.2010.07.009_bib108","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1053\/jhep.2002.37198","article-title":"Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: a pilot study","volume":"36","author":"King","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.bpg.2010.07.009_bib109","article-title":"Association between polymorphism of tumor necrosis factor-alpha promoter and response to lamivudine treatment in patients with chronic hepatitis B","author":"Park","year":"2009","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.bpg.2010.07.009_bib110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jhep.2006.09.011","article-title":"Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection","volume":"46","author":"Schott","year":"2007","journal-title":"J Hepatol"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691810000880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691810000880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T09:01:29Z","timestamp":1712221289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691810000880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":110,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1521691810000880"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2010.07.009","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}