{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:38:11Z","timestamp":1761561491056},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bpg.2010.09.002","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T09:49:35Z","timestamp":1291196975000},"page":"861-871","source":"Crossref","is-referenced-by-count":25,"title":["The refluxate: The impact of its magnitude, composition and distribution"],"prefix":"10.1016","volume":"24","author":[{"given":"Philip","family":"Woodland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sifrim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1572-0241.2000.01669.x","article-title":"Proximal migration of esophageal acid perfusions during waking and sleep","volume":"95","author":"Orr","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0002-9610(94)90068-X","article-title":"Alkaline gastroesophageal reflux: assessment by ambulatory esophageal aspiration and pH monitoring","volume":"167","author":"Stein","year":"1994","journal-title":"Am J Surg"},{"issue":"9","key":"10.1016\/j.bpg.2010.09.002_bib3","first-page":"1094","article-title":"Scintigraphy in gastroesophageal reflux disease: a comparison to endoscopy, LESp, and 24-h pH score, as well as to simultaneous pH monitoring","volume":"87","author":"Shay","year":"1992","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib4","doi-asserted-by":"crossref","first-page":"G469","DOI":"10.1152\/ajpgi.00019.2007","article-title":"Distension during gastroesophageal reflux: effects of acid inhibition and correlation with symptoms","volume":"293","author":"Tipnis","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4 Pt 1","key":"10.1016\/j.bpg.2010.09.002_bib5","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1542\/peds.111.4.e355","article-title":"Effects of thickened feeding on gastroesophageal reflux in infants: a placebo-controlled crossover study using intraluminal impedance","volume":"111","author":"Wenzl","year":"2003","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/gut.2004.043984","article-title":"Relevance of volume and proximal extent of reflux in gastro-oesophageal reflux disease","volume":"54","author":"Sifrim","year":"2005","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/gut.34.4.444","article-title":"Pressure events surrounding oesophageal acid reflux episodes and acid clearance in ambulant healthy volunteers","volume":"34","author":"Barham","year":"1993","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.bpg.2010.09.002_bib8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/00365520902718903","article-title":"Increased intragastric pressure gradients are involved in the occurrence of acid reflux in gastroesophageal reflux disease","volume":"44","author":"Frankhuisen","year":"2009","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib9","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0016-5085(03)01210-1","article-title":"Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects","volume":"125","author":"Pandolfino","year":"2003","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1365-2036.2006.02816.x","article-title":"Effect of hiatal hernia on proximal oesophageal acid clearance in gastro-oesophageal reflux disease patients","volume":"23","author":"Emerenziani","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib11","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1053\/gast.2001.24841","article-title":"Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings","volume":"120","author":"Sifrim","year":"2001","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/gut.2003.022160","article-title":"Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux","volume":"53","author":"Fletcher","year":"2004","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/gut.29.7.881","article-title":"Studies of the oesophageal clearance responses to intraluminal acid","volume":"29","author":"Thompson","year":"1988","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/bjs.1800820317","article-title":"Oesophageal acid clearance in patients with severe reflux oesophagitis","volume":"82","author":"Barham","year":"1995","journal-title":"Br J Surg"},{"issue":"5, Suppl. 1","key":"10.1016\/j.bpg.2010.09.002_bib15","doi-asserted-by":"crossref","first-page":"A-738","DOI":"10.1016\/S0016-5085(09)63404-1","article-title":"W1845 spread of gastro-esophageal reflux along the length of the esophagus is determined by vascular compressions on the esophagus","volume":"136","author":"Babaei","year":"2009","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jama.290.1.66","article-title":"Obesity and estrogen as risk factors for gastroesophageal reflux symptoms","volume":"290","author":"Nilsson","year":"2003","journal-title":"JAMA"},{"issue":"5, Suppl. 1","key":"10.1016\/j.bpg.2010.09.002_bib17","doi-asserted-by":"crossref","first-page":"A-426","DOI":"10.1016\/S0016-5085(09)61961-2","article-title":"M1826 the role of body mass index and waist circumference in determining reflux pattern and proximal extent of reflux events","volume":"136","author":"Scarpellini","year":"2009","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib18","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/0016-5085(95)90135-3","article-title":"Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics","volume":"108","author":"Weusten","year":"1995","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-2036.2003.01702.x","article-title":"Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease","volume":"18","author":"Cicala","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/gut.2005.074690","article-title":"Determinants of perception of heartburn and regurgitation","volume":"55","author":"Bredenoord","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1136\/gut.2007.133470","article-title":"Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors","volume":"57","author":"Zerbib","year":"2008","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib22","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00004836-200608000-00010","article-title":"Postprandial stomach contents have multiple acid layers","volume":"40","author":"Hila","year":"2006","journal-title":"J Clin Gastroenterol"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/gut.2006.109421","article-title":"Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket","volume":"57","author":"Clarke","year":"2008","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0016-5085(89)90890-1","article-title":"Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease","volume":"96","author":"Smith","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2010.09.002_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7326\/0003-4819-55-2-292","article-title":"The physiology of heartburn","volume":"55","author":"Tuttle","year":"1961","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1572-0241.2001.03598.x","article-title":"Composition of the postprandial refluxate in patients with gastroesophageal reflux disease","volume":"96","author":"Sifrim","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1365-2036.2003.01423.x","article-title":"Non-erosive reflux disease (NERD)-acid reflux and symptom patterns","volume":"17","author":"Martinez","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.bpg.2010.09.002_bib28","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1572-0241.2006.00711.x","article-title":"Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy","volume":"101","author":"Zerbib","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.2007.130104","article-title":"Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus","volume":"57","author":"Emerenziani","year":"2008","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.bpg.2010.09.002_bib30","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1365-2036.2003.01606.x","article-title":"Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study","volume":"17","author":"Jaspersen","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0091-6749(98)70087-9","article-title":"Extrathoracic airway dysfunction in cough associated with gastroesophageal reflux","volume":"102","author":"Rolla","year":"1998","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/ajrccm.149.1.8111576","article-title":"Pathogenesis of chronic persistent cough associated with gastroesophageal reflux","volume":"149","author":"Ing","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/gut.2004.055418","article-title":"Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring","volume":"54","author":"Sifrim","year":"2005","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0016-5085(69)80121-6","article-title":"Role of acid and pepsin in acute experimental esophagitis","volume":"56","author":"Goldberg","year":"1969","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.bpg.2010.09.002_bib35","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-5223(19)37879-1","article-title":"Technique, indications, and clinical use of 24 hour esophageal pH monitoring","volume":"79","author":"DeMeester","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"11","key":"10.1016\/j.bpg.2010.09.002_bib36","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1136\/gut.28.11.1484","article-title":"Patterns of acid reflux in complicated oesophagitis","volume":"28","author":"Robertson","year":"1987","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.bpg.2010.09.002_bib37","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/ajg.2009.670","article-title":"Characteristics of reflux episodes and symptom association in patients with erosive esophagitis and nonerosive reflux disease: study using combined impedance-pH off therapy","volume":"105","author":"Savarino","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0016-5085(92)91790-B","article-title":"Two doses of omeprazole versus placebo in symptomatic erosive esophagitis: the U.S. Multicenter Study","volume":"102","author":"Sontag","year":"1992","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.bpg.2010.09.002_bib39","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1056\/NEJM199903183401101","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma","volume":"340","author":"Lagergren","year":"1999","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1572-0241.2001.03515.x","article-title":"Increased acid and bile reflux in Barrett\u2019s esophagus compared to reflux esophagitis, and effect of proton pump inhibitor therapy","volume":"96","author":"Menges","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib41","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0039-6060(95)80015-8","article-title":"Synergism of acid and duodenogastroesophageal reflux in complicated Barrett\u2019s esophagus","volume":"117","author":"Vaezi","year":"1995","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1001\/jama.274.6.474","article-title":"The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia","volume":"274","author":"Chow","year":"1995","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/BF01296082","article-title":"Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique","volume":"38","author":"Bechi","year":"1993","journal-title":"Dig Dis Sci."},{"issue":"9","key":"10.1016\/j.bpg.2010.09.002_bib44","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/00365520701245645","article-title":"Biliary reflux and non-acid reflux are two distinct phenomena: a comparison between 24-hour multichannel intraesophageal impedance and bilirubin monitoring","volume":"42","author":"Pace","year":"2007","journal-title":"Scand J Gastroenterol"},{"issue":"10","key":"10.1016\/j.bpg.2010.09.002_bib45","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1136\/gut.2007.141804","article-title":"Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces","volume":"57","author":"Farre","year":"2008","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10620-005-1282-0","article-title":"Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects","volume":"50","author":"Siddiqui","year":"2005","journal-title":"Dig Dis Sci."},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/gut.40.2.182","article-title":"The relationship between acid and bile reflux and symptoms in gastro-oesophageal reflux disease","volume":"40","author":"Marshall","year":"1997","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib48","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1111\/j.1572-0241.2001.03863.x","article-title":"The role of acid and duodenal gastroesophageal reflux in symptomatic GERD","volume":"96","author":"Koek","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib49","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.41.3.297","article-title":"Contribution of acid and duodenogastro-oesophageal reflux to oesophageal mucosal injury and symptoms in partial gastrectomy patients [see comment]","volume":"41","author":"Vaezi","year":"1997","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib50","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1572-0241.2004.04171.x","article-title":"Gastroesophageal reflux disease poorly responsive to single-dose proton pump inhibitors in patients without Barrett\u2019s esophagus: acid reflux, bile reflux, or both?","volume":"99","author":"Tack","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.bpg.2010.09.002_bib51","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s10620-007-0186-6","article-title":"Yield of 24-hour esophageal pH and bilitec monitoring in patients with persisting symptoms on PPI therapy","volume":"53","author":"Karamanolis","year":"2008","journal-title":"Dig Dis Sci."},{"issue":"8","key":"10.1016\/j.bpg.2010.09.002_bib52","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/ajg.2009.240","article-title":"Comparison of the degree of duodenogastroesophageal reflux and acid reflux between patients who failed to respond and those who were successfully treated with a proton pump inhibitor once daily","volume":"104","author":"Gasiorowska","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib53","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archsurg.1965.01320180097021","article-title":"Bile esophagitis","volume":"91","author":"Moffat","year":"1965","journal-title":"Arch Surg"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib54","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1365-2168.1998.00533.x","article-title":"Assessment of combined bile acid and pH profiles using an automated sampling device in gastro-oesophageal reflux disease","volume":"85","author":"Nehra","year":"1998","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib55","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004836-199201000-00002","article-title":"Bile acids and trypsin are unimportant in alkaline esophageal reflux","volume":"14","author":"Gotley","year":"1992","journal-title":"J Clin Gastroenterol"},{"issue":"7","key":"10.1016\/j.bpg.2010.09.002_bib56","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/j.1572-0241.2002.05822.x","article-title":"Impact of esophageal bile exposure on the genesis of reflux esophagitis in the absence of gastric acid after total gastrectomy","volume":"97","author":"Yumiba","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib57","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF02303531","article-title":"Effect of gastroduodenal juice and dietary fat on the development of Barrett\u2019s esophagus and esophageal neoplasia: an experimental rat model","volume":"1","author":"Clark","year":"1994","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib58","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/(SICI)1097-0215(19960717)67:2<269::AID-IJC19>3.0.CO;2-6","article-title":"Reflux of duodenal or gastro-duodenal contents induces esophageal carcinoma in rats","volume":"67","author":"Miwa","year":"1996","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.bpg.2010.09.002_bib59","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3181\/00379727-197-43272","article-title":"Bile acid accumulation in gastric mucosal cells","volume":"197","author":"Batzri","year":"1991","journal-title":"Proc Soc Exp Biol Med"},{"issue":"3","key":"10.1016\/j.bpg.2010.09.002_bib60","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0016-5085(94)90123-6","article-title":"Duodenogastroesophageal reflux: relationship to pH and importance in Barrett\u2019s esophagus","volume":"107","author":"Champion","year":"1994","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib61","first-page":"276","article-title":"Role of the components of the gastroduodenal contents in experimental acid esophagitis","volume":"92","author":"Lillemoe","year":"1982","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.bpg.2010.09.002_bib62","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10620-006-3129-8","article-title":"Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats","volume":"51","author":"Nagahama","year":"2006","journal-title":"Dig Dis Sci."},{"issue":"1","key":"10.1016\/j.bpg.2010.09.002_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/gut.44.1.47","article-title":"Patterns of gas and liquid reflux during transient lower oesophageal sphincter relaxation: a study using intraluminal electrical impedance","volume":"44","author":"Sifrim","year":"1999","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.bpg.2010.09.002_bib64","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1111\/j.1572-0241.2006.00945.x","article-title":"Characteristics of gastroesophageal reflux in symptomatic patients with and without excessive esophageal acid exposure","volume":"101","author":"Bredenoord","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"10.1016\/j.bpg.2010.09.002_bib65","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/00042737-199610000-00008","article-title":"Mucosal acid exposure sensitizes a subset of normal subjects to intra-oesophageal balloon distension","volume":"8","author":"Peghini","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.bpg.2010.09.002_bib66","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0016-5085(98)70014-9","article-title":"Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans","volume":"115","author":"Fass","year":"1998","journal-title":"Gastroenterology"}],"container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691810001113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691810001113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T07:01:28Z","timestamp":1592118088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691810001113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1521691810001113"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2010.09.002","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}