{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:58:21Z","timestamp":1786640301922,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.bpg.2015.09.005","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T11:10:39Z","timestamp":1442056239000},"page":"739-748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Clinical features of Eosinophilic esophagitis in children and adults"],"prefix":"10.1016","volume":"29","author":[{"given":"Stephan","family":"Miehlke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpg.2015.09.005_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cgh.2009.06.023","article-title":"Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota","volume":"7","author":"Prasad","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib3","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1053\/j.gastro.2008.02.016","article-title":"Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups","volume":"134","author":"Kapel","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaci.2011.09.013","article-title":"Swiss EoE study group escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County","volume":"128","author":"Hruz","year":"2011","journal-title":"Switz J Allergy Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib5","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/apt.12053","article-title":"The rising incidence of eosinophilic oesophagitis is associated with increasing biopsy rates: a population-based study","volume":"36","author":"Syed","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2015.09.005_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/apt.13129","article-title":"The increasing incidence and prevalence of eosinophilic oesophagitis outpaces changes in endoscopic and biopsy practice: national population-based estimates from Denmark","volume":"41","author":"Dellon","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2015.09.005_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1398-9995.2012.02787.x","article-title":"Pediatric and adult eosinophilic esophagitis: similarities and differences","volume":"67","author":"Straumann","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.bpg.2015.09.005_bib8","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1586\/eci.12.68","article-title":"Adult versus pediatric eosinophilic esophagitis: important differences and similarities for the clinician to understand","volume":"8","author":"Lucendo","year":"2012","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.cgh.2009.08.030","article-title":"Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease","volume":"7","author":"Dellon","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cgh.2008.10.009","article-title":"Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study","volume":"7","author":"Veerappan","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib11","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1111\/j.1572-0241.2007.01512.x","article-title":"Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study","volume":"102","author":"Prasad","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2015.09.005_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.giec.2007.09.005","article-title":"Demographic data and symptoms of eosinophilic esophagitis in adults","volume":"18","author":"Katzka","year":"2008","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"10.1016\/j.bpg.2015.09.005_bib13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.gie.2011.06.029","article-title":"Esophageal foreign-body impactions: epidemiology, time trends, and the impact of the increasing prevalence of eosinophilic esophagitis","volume":"74","author":"Sperry","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.bpg.2015.09.005_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000355161","article-title":"Induction of eosinophilic esophagitis by sublingual pollen immunotherapy","volume":"7","author":"Miehlke","year":"2013","journal-title":"Case Rep Gastroenterol"},{"key":"10.1016\/j.bpg.2015.09.005_bib15","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","article-title":"Eosinophilic esophagitis: a 10-year experience in 381 children","volume":"3","author":"Liacouras","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib16","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2012.03.001","article-title":"Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors","volume":"142","author":"Gonsalves","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib17","article-title":"A\u00a0randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis","author":"Miehlke","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2015.09.005_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1053\/j.gastro.2014.08.028","article-title":"Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis","volume":"147","author":"Schoepfer","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib19","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cgh.2012.04.019","article-title":"The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis","volume":"10","author":"Kim","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib20","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/gutjnl-2011-301817","article-title":"Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system","volume":"62","author":"Hirano","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.bpg.2015.09.005_bib21","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1055\/s-0034-1377781","article-title":"Evaluating the endoscopic reference score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability","volume":"46","author":"van Rhijn","year":"2014","journal-title":"Endoscopy"},{"key":"10.1016\/j.bpg.2015.09.005_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2013.463","article-title":"The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinophilic esophagitis","author":"Nielsen","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.bpg.2015.09.005_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cgh.2009.03.022","article-title":"A\u00a0novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis","volume":"7","author":"Protheroe","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2559.2008.03187.x","article-title":"Comparison of histological para-meters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material","volume":"53","author":"Mueller","year":"2008","journal-title":"Histopathology"},{"issue":"1\u20132","key":"10.1016\/j.bpg.2015.09.005_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000357009","article-title":"Diagnostics of eosinophilic esophagitis: clinical, endoscopic, and histologic pitfalls","volume":"32","author":"Dellon","year":"2014","journal-title":"Dig Dis"},{"key":"10.1016\/j.bpg.2015.09.005_bib26","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1053\/j.gastro.2003.09.024","article-title":"Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years","volume":"125","author":"Straumann","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib27","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2013.08.015","article-title":"Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation, in a time-dependent manner","volume":"145","author":"Schoepfer","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.gastro.2010.09.037","article-title":"Mechanical properties of the esophagus in eosinophilic esophagitis","volume":"140","author":"Kwiatek","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2015.09.005_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1365-2982.2010.01633.x","article-title":"Manometric features of eosinophilic esophagitis in esophageal pressure topography","volume":"23","author":"Roman","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.bpg.2015.09.005_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cgh.2010.09.019","article-title":"Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults","volume":"9","author":"Molina-Infante","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib31","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/apt.12914","article-title":"Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression","volume":"40","author":"Molina-Infante","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2015.09.005_bib32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MOG.0000000000000080","article-title":"Proton-pump inhibitor-responsive esophageal eosinophilia","volume":"30","author":"Molina-Infante","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.bpg.2015.09.005_bib33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/apt.12636","article-title":"Eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia have similar clinical, endoscopic and histological findings","volume":"39","author":"Moawad","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2015.09.005_bib34","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/MEG.0000000000000331","article-title":"PPI-responsive esophageal eosinophilia cannot be distinguished from eosinophilic esophagitis by endoscopic signs","volume":"27","author":"Warners","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib35","first-page":"187","article-title":"Transcriptome analysis of proton pump inhibitor\u2013responsive esophageal eosinophilia reveals proton pump inhibitor\u2013reversible allergic inflammation","volume":"135","author":"Wen","year":"2015","journal-title":"JACI"},{"key":"10.1016\/j.bpg.2015.09.005_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cgh.2007.12.045","article-title":"Atopic characteristics of adult patients with eosinophilic esophagitis","volume":"6","author":"Roy-Ghanta","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.bpg.2015.09.005_bib37","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jaci.2005.01.017","article-title":"Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases","volume":"115","author":"Simon","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib38","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jaci.2012.12.664","article-title":"Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease","volume":"131","author":"Lucendo","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaci.2011.05.006","article-title":"Long-term outcomes in pediatric onset esophageal eosinophilia","volume":"128","author":"DeBrosse","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.bpg.2015.09.005_bib40","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1365-2036.2011.04791.x","article-title":"The adult eosinophilic oesophagitis quality of life questionnaire: a new measure of health-related quality of life","volume":"34","author":"Taft","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2015.09.005_bib41","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/MPG.0b013e31829ce5ad","article-title":"Psychosocial dysfunction in children and adolescents with eosinophilic esophagitis","volume":"57","author":"Harris","year":"2013","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691815001183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691815001183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T13:26:44Z","timestamp":1537363604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691815001183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1521691815001183"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2015.09.005","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features of Eosinophilic esophagitis in children and adults","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpg.2015.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}