{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:20:59Z","timestamp":1788956459108,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bpg.2018.05.011","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T16:17:54Z","timestamp":1526487474000},"page":"11-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Geoepidemiology and (epi-)genetics in primary biliary cholangitis"],"prefix":"10.1016","volume":"34-35","author":[{"given":"Rosa","family":"Roberto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristoferi","family":"Laura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaka","family":"Atsushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Invernizzi","family":"Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"Hirschfield","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/gut.15.6.473","article-title":"The epidemiology of primary biliary cirrhosis: a survey of mortality in England and Wales","volume":"15","author":"Hamlyn","year":"1974","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/hep.510300213","article-title":"Primary biliary cirrhosis once rare, now common in the United Kingdom?","volume":"30","author":"James","year":"1999","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.bpg.2018.05.011_bib4","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/MEG.0b013e328353753d","article-title":"The epidemiology and natural history of primary biliary cirrhosis: a nationwide population-based study","volume":"24","author":"Baldursdottir","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1478-3231.2010.02366.x","article-title":"A\u00a035-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre","volume":"31","author":"Floreani","year":"2011","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.bpg.2018.05.011_bib6","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/MEG.0b013e328277594a","article-title":"Incidence, prevalence and clinical course of primary biliary cirrhosis in a Spanish community","volume":"19","author":"Pla","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/liv.12434","article-title":"Rising incidence and prevalence of primary biliary cirrhosis: a large population-based study","volume":"34","author":"Boonstra","year":"2014","journal-title":"Liver Int"},{"issue":"7","key":"10.1016\/j.bpg.2018.05.011_bib8","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1111\/liv.12479","article-title":"Geoepidemiology and space-time analysis of Primary biliary cirrhosis in Crete, Greece","volume":"34","author":"Koulentaki","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.bpg.2018.05.011_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejim.2017.05.006","article-title":"Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece","volume":"42","author":"Gatselis","year":"2017","journal-title":"Eur J Intern Med"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib10","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1136\/gut.36.6.927","article-title":"Low prevalence of primary biliary cirrhosis in Victoria, Australia. Melbourne Liver Group","volume":"36","author":"Watson","year":"1995","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1053\/j.gastro.2004.04.064","article-title":"Epidemiology of primary biliary cirrhosis in Victoria, Australia: high prevalence in migrant populations","volume":"127","author":"Sood","year":"2004","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib12","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/hep.23210","article-title":"Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: a population-based study","volume":"50","author":"Myers","year":"2009","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib13","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1053\/gast.2000.20197","article-title":"Epidemiology and natural history of primary biliary cirrhosis in a US community","volume":"119","author":"Kim","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2018.05.011_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1471-230X-10-100","article-title":"Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China","volume":"10","author":"Liu","year":"2010","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"10.1016\/j.bpg.2018.05.011_bib15","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1038\/ctg.2017.43","article-title":"Epidemiology and natural history of primary primary biliary cholangitis in the Chinese: a territory-based study in Hong Kong between 2000 and 2015","volume":"8","author":"Cheung","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/apt.13448","article-title":"Population-based epidemiology of primary biliary cirrhosis in South Korea","volume":"43","author":"Kim","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.bpg.2018.05.011_bib17","first-page":"6","article-title":"Evolving trends in female to male incidence and male mortality of primary biliary cholangitis","author":"Lleo","year":"2016","journal-title":"Sci Rep"},{"issue":"3\u20134","key":"10.1016\/j.bpg.2018.05.011_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jaut.2009.07.008","article-title":"The genetics of human autoimmune disease","volume":"33","author":"Invernizzi","year":"2009","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.bpg.2018.05.011_bib19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1542-3565(04)00678-0","article-title":"From bases to basis: linking genetics to causation in primary biliary cirrhosis","volume":"3","author":"Invernizzi","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/hep.29504","article-title":"Gene-disease associations identify a connectome with shared molecular pathways in human cholangiopathies","volume":"67","author":"Luo","year":"2017","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.bpg.2018.05.011_bib21","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/hep.20907","article-title":"Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients","volume":"42","author":"Gershwin","year":"2005","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0168-8278(00)80213-5","article-title":"CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis","volume":"32","author":"Agarwal","year":"2000","journal-title":"J\u00a0Hepatol"},{"issue":"9","key":"10.1016\/j.bpg.2018.05.011_bib23","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1046\/j.1440-1746.2003.03091.x","article-title":"Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis","volume":"18","author":"Bittencourt","year":"2003","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cgh.2007.02.012","article-title":"Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis","volume":"5","author":"Donaldson","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"20","key":"10.1016\/j.bpg.2018.05.011_bib25","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3748\/wjg.v10.i20.3056","article-title":"Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population","volume":"10","author":"Fan","year":"2004","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib26","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/j.gastro.2008.06.077","article-title":"Primary biliary cirrhosis is associated with a genetic variant in the 3\u2032 flanking region of the CTLA4 gene","volume":"135","author":"Juran","year":"2008","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/hep.22048","article-title":"Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis","volume":"47","author":"Juran","year":"2008","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/17402520500317859","article-title":"SNP analysis of genes implicated in T cell proliferation in primary biliary cirrhosis","volume":"12","author":"Oertelt","year":"2005","journal-title":"Clin Dev Immunol"},{"issue":"11","key":"10.1016\/j.bpg.2018.05.011_bib29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/MEG.0b013e3282efa240","article-title":"Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease","volume":"19","author":"Schott","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/gut.26.6.625","article-title":"HLA-DR antigens in primary biliary cirrhosis: lack of association","volume":"26","author":"Bassendine","year":"1985","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1399-0039.1987.tb01566.x","article-title":"A\u00a0major histocompatibility complex Class III allotype (C4B 2) associated with Primary Biliary Cirrhosis (PBC)","volume":"29","author":"Briggs","year":"1987","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1016\/j.bpg.2018.05.011_bib32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1399-0039.1979.tb00874.x","article-title":"Primary biliary cirrhosis associated with HLA\u2014DRw3","volume":"14","author":"Ercilla","year":"1979","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1016\/j.bpg.2018.05.011_bib33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/0016-5085(91)90090-8","article-title":"HLA DRw8 and complement C4 deficiency as risk factors in primary biliary cirrhosis","volume":"101","author":"Manns","year":"1991","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000198892","article-title":"HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis","volume":"26","author":"Miyamori","year":"1983","journal-title":"Digestion"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF00189520","article-title":"DNA polymorphism of HLA class II genes in primary biliary cirrhosis","volume":"35","author":"Morling","year":"1992","journal-title":"Immunogenetics"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib36","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0168-8278(05)80617-8","article-title":"DNA typing of HLA class II genes; DRB1*0803 increases the susceptibility of Japanese to primary biliary cirrhosis","volume":"21","author":"Onishi","year":"1994","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0168-8278(02)00440-3","article-title":"Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis","volume":"38","author":"Invernizzi","year":"2003","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib38","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/hep.21316","article-title":"HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study","volume":"44","author":"Donaldson","year":"2006","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib39","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1002\/hep.22567","article-title":"Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls","volume":"48","author":"Invernizzi","year":"2008","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib40","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/2050640616665030","article-title":"Distinctive HLA-II association with primary biliary cholangitis on the Island of Sardinia","volume":"5","author":"Clemente","year":"2017","journal-title":"United Eur Gastroenterol J"},{"issue":"5","key":"10.1016\/j.bpg.2018.05.011_bib41","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1872-034X.2010.00631.x","article-title":"Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): the HLA-DRB1polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC","volume":"40","author":"Nakamura","year":"2010","journal-title":"Hepatol Res"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib42","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.24705","article-title":"Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis","volume":"55","author":"Umemura","year":"2012","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib43","doi-asserted-by":"crossref","first-page":"11093","DOI":"10.1038\/s41598-017-11148-6","article-title":"Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population","volume":"7","author":"Yasunami","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/liv.12236","article-title":"Human leucocyte antigen alleles and haplotypes and their associations with antinuclear antibodies features in Chinese patients with primary biliary cirrhosis","volume":"34","author":"Zhao","year":"2014","journal-title":"Liver Int"},{"issue":"24","key":"10.1016\/j.bpg.2018.05.011_bib45","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.bpg.2018.05.011_bib46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ng.627","article-title":"Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis","volume":"42","author":"Liu","year":"2010","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.bpg.2018.05.011_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/ng1111-1164b","article-title":"Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis","volume":"43","author":"Mells","year":"2011","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/gene.2013.1","article-title":"Pathway-based analysis of primary biliary cirrhosis genome-wide association studies","volume":"14","author":"Kar","year":"2013","journal-title":"Gene Immun"},{"issue":"4","key":"10.1016\/j.bpg.2018.05.011_bib49","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/eji.201344270","article-title":"Implications of genome-wide association studies in novel therapeutics in primary biliary cirrhosis","volume":"44","author":"Carbone","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.bpg.2018.05.011_bib50","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.tcb.2014.08.010","article-title":"Epigenetics reloaded: the single-cell revolution","volume":"24","author":"Bheda","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1099800417742967","article-title":"Primer in genetics and genomics, article 6: basics of epigenetic control","volume":"20","author":"Fessele","year":"2018","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.bpg.2018.05.011_bib52","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrg2540","article-title":"Linking DNA methylation and histone modification: patterns and paradigms","volume":"10","author":"Cedar","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib53","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10875-010-9492-4","article-title":"\u03b2-arrestin 1 modulates functions of autoimmune T cells from primary biliary cirrhosis patients","volume":"31","author":"Hu","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/hep.24630","article-title":"Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis","volume":"55","author":"Lleo","year":"2012","journal-title":"Hepatology"},{"issue":"9408","key":"10.1016\/j.bpg.2018.05.011_bib55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(04)15541-4","article-title":"Frequency of monosomy X in women with primary biliary cirrhosis","volume":"363","author":"Invernizzi","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib56","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/hep.21696","article-title":"Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis","volume":"46","author":"Miozzo","year":"2007","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib57","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4161\/epi.6.1.13405","article-title":"Epigenetic investigation of variably X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis","volume":"6","author":"Mitchell","year":"2011","journal-title":"Epigenetics"},{"issue":"MAR","key":"10.1016\/j.bpg.2018.05.011_bib58","article-title":"Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis","volume":"5","author":"Selmi","year":"2014","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib59","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1053\/j.gastro.2004.05.005","article-title":"Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment","volume":"127","author":"Selmi","year":"2004","journal-title":"Gastroenterology"},{"issue":"3\u20134","key":"10.1016\/j.bpg.2018.05.011_bib60","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaut.2009.02.022","article-title":"Primary biliary cirrhosis is associated with altered hepatic microRNA expression","volume":"32","author":"Padgett","year":"2009","journal-title":"J\u00a0Autoimmun"},{"issue":"3","key":"10.1016\/j.bpg.2018.05.011_bib61","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/jgh.12040","article-title":"Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis","volume":"28","author":"Qin","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.bpg.2018.05.011_bib62","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/hep.25691","article-title":"Up-regulation of microRNA 506 leads to decreased Cl-\/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis","volume":"56","author":"Banales","year":"2012","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bpg.2018.05.011_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066086","article-title":"Distinct MicroRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers","volume":"8","author":"Ninomiya","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bpg.2018.05.011_bib64","first-page":"533","article-title":"Abnormal expression of miR-let-7b in primary biliary cirrhosis and its clinical significance","volume":"21","author":"Qian","year":"2013","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"1","key":"10.1016\/j.bpg.2018.05.011_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0098-9","article-title":"DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis","volume":"7","author":"Lleo","year":"2015","journal-title":"Clin Epigenet"}],"container-title":["Best Practice & Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691818300519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691818300519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T13:14:28Z","timestamp":1541855668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691818300519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":65,"alternative-id":["S1521691818300519"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2018.05.011","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geoepidemiology and (epi-)genetics in primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpg.2018.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}