{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:28:33Z","timestamp":1792625313632,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"am","delay-in-days":414,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bpg.2022.101788","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T15:37:17Z","timestamp":1645717037000},"page":"101788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Digestive outcomes in Cystic fibrosis"],"prefix":"10.1016","volume":"56-57","author":[{"given":"Delphine","family":"Ley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Turck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpg.2022.101788_bib1","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0140-6736(20)32542-3","article-title":"Cystic fibrosis","volume":"397","author":"Shteinberg","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bpg.2022.101788_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/genes11060589","article-title":"The changing epidemiology of cystic fibrosis: incidence, survival and impact of the CFTR gene discovery","volume":"11","author":"Scotet","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.bpg.2022.101788_bib3","doi-asserted-by":"crossref","first-page":"eS4","DOI":"10.1016\/S0929-693X(20)30043-9","article-title":"Genetics of cystic fibrosis: Basics","volume":"27","author":"F\u00e9rec","year":"2020","journal-title":"Arch Pediatr"},{"issue":"21","key":"10.1016\/j.bpg.2022.101788_bib4","article-title":"Pregnancy in cystic fibrosis: review of the literature and expert recommendations","volume":"S1569\u20131993","author":"Jain","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s10995-016-2181-z","article-title":"Attitudes and decision making related to pregnancy among young women with cystic fibrosis","volume":"21","author":"Kazmerski","year":"2017","journal-title":"Matern child health"},{"key":"10.1016\/j.bpg.2022.101788_bib6","article-title":"Increasing life expectancy in cystic fibrosis: advances and challenges","author":"McBennett","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bpg.2022.101788_bib7","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.jcf.2017.06.009","article-title":"Approach to chronic abdominal pain in cystic fibrosis","volume":"16","author":"Lusman","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib8","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.jcf.2017.07.014","article-title":"Bacterial overgrowth, dysbiosis, inflammation and dysmotility in the cystic fibrosis intestine","volume":"16","author":"Dorsey","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.608821","article-title":"Early diagnosis and intervention in cystic fibrosis: imagining the unimaginable","volume":"8","author":"Coverstone","year":"2021","journal-title":"Front Pediatr"},{"key":"10.1016\/j.bpg.2022.101788_bib10","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jcf.2017.06.007","article-title":"Meconium ileus in cystic fibrosis","volume":"16","author":"Sathe","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jcf.2018.02.006","article-title":"ECFS best practice guidelines: the 2018 revision","volume":"17","author":"Castellani","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1001\/archpedi.1938.01980140114013","article-title":"Cystic fibrosis of the pancreas and its relation to celiac disease: a clinical and pathological study","volume":"56","author":"Andersen","year":"1938","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.bpg.2022.101788_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/flgastro-2020-101610","article-title":"Cystic fibrosis and the gut","volume":"12","author":"Slae","year":"2021","journal-title":"Frontline Gastroenterol"},{"key":"10.1016\/j.bpg.2022.101788_bib14","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s10620-015-3546-7","article-title":"Gastrointestinal manifestations of cystic fibrosis","volume":"60","author":"Kelly","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.bpg.2022.101788_bib15","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.jcf.2017.06.011","article-title":"Pancreatic insufficiency in cystic fibrosis","volume":"16","author":"Singh","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib16","first-page":"CD008227","article-title":"Pancreatic enzyme replacement therapy for people with cystic fibrosis","volume":"8","author":"Somaraju","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpg.2022.101788_bib17","first-page":"CD013488","article-title":"Timing of pancreatic enzyme replacement therapy (PERT) in cystic fibrosis","volume":"8","author":"Ng","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpg.2022.101788_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.clnu.2016.03.004","article-title":"ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis","volume":"35","author":"Turck","year":"2016","journal-title":"Clin Nutr"},{"key":"10.1016\/j.bpg.2022.101788_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/archdischild-2019-316882","article-title":"NICE guidance on diagnosis and management of cystic fibrosis","volume":"106","author":"Dayasiri","year":"2021","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"10.1016\/j.bpg.2022.101788_bib21","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jcf.2017.07.007","article-title":"Cystic fibrosis and gastroesophageal reflux","volume":"16","author":"Maqbool","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jcf.2021.05.016","article-title":"Review of gastrointestinal motility in cystic fibrosis","volume":"20","author":"Henen","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jcf.2018.11.005","article-title":"Cystic fibrosis is associated with an increased risk of Barrett's esophagus","volume":"18","author":"Knotts","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MPG.0b013e3181a6e01d","article-title":"Defining DIOS and constipation in cystic fibrosis with a multicentre study on the incidence, characteristics, and treatment of DIOS","volume":"50","author":"Houwen","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.bpg.2022.101788_bib25","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.jcf.2017.06.013","article-title":"Cystic fibrosis & disorders of the large intestine: DIOS, constipation, and colorectal cancer","volume":"16","author":"Abraham","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jcf.2016.02.002","article-title":"International prospective study of distal intestinal obstruction syndrome in cystic fibrosis: associated factors and outcome","volume":"15","author":"Munck","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib27","first-page":"CD012798","article-title":"Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis","volume":"12","author":"Gilchrist","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpg.2022.101788_bib28","first-page":"CD012619","article-title":"Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis","volume":"12","author":"Carroll","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl2","key":"10.1016\/j.bpg.2022.101788_bib29","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/S1569-1993(11)60005-2","article-title":"Guidelines for the diagnosis and management of distal intestinal obstruction syndrome in cystic fibrosis patients","volume":"10","author":"Colombo","year":"2011","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib30","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1053\/gast.2002.37042","article-title":"Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis","volume":"123","author":"Durno","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2022.101788_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1053\/j.gastro.2010.09.046","article-title":"Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis","volume":"140","author":"Ooi","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2022.101788_bib32","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.jcf.2017.07.004","article-title":"Pancreatitis and pancreatic cystosis in cystic fibrosis","volume":"16","author":"Freeman","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib33","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1053\/j.gastro.2018.12.043","article-title":"Pancreatitis in children","volume":"156","author":"Uc","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bpg.2022.101788_bib34","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jcf.2016.01.002","article-title":"Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis","volume":"15","author":"Niccum","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib35","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1470-2045(18)30188-8","article-title":"Risk of gastrointestinal cancers in patients with cystic fibrosis: a systematic review and meta-analysis","volume":"19","author":"Yamada","year":"2018","journal-title":"Lancet Oncol"},{"issue":"21","key":"10.1016\/j.bpg.2022.101788_bib36","article-title":"Cancer in cystic fibrosis. A narrative review of prevalence, risk factors, screening, and treatment challenges","volume":"S0012\u20133692","author":"Maisonneuve","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.bpg.2022.101788_bib37","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4251\/wjgo.v13.i9.1121","article-title":"Screening strategy for gastrointestinal and hepatopancreatobiliary cancers in cystic fibrosis","volume":"13","author":"Hoskins","year":"2021","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.bpg.2022.101788_bib38","first-page":"307","article-title":"Appendicitis in cystic fibrosis","volume":"65","author":"Shields","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.bpg.2022.101788_bib39","article-title":"Motor dysfunction of the gut in cystic fibrosis","volume":"32","author":"Malagelada","year":"2020","journal-title":"Neuro Gastroenterol Motil"},{"key":"10.1016\/j.bpg.2022.101788_bib40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jcf.2020.06.004","article-title":"Postprandial changes in gastrointestinal function and transit in cystic fibrosis assessed by Magnetic Resonance Imaging","volume":"20","author":"Ng","year":"2021","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bpg.2022.101788_bib41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00535-018-1509-4","article-title":"The role of small intestinal bacterial overgrowth in cystic fibrosis: a randomized case-controlled clinical trial with rifaximin","volume":"54","author":"Furnari","year":"2019","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.bpg.2022.101788_bib42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/BF02087437","article-title":"Crohn's disease and cystic fibrosis","volume":"39","author":"Lloyd-Still","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.bpg.2022.101788_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/jpm11090859","article-title":"Increased prevalence of celiac disease in patients with cystic fibrosis: a systematic review and meta-analysis","volume":"11","author":"Imrei","year":"2021","journal-title":"J Personalized Med"},{"key":"10.1016\/j.bpg.2022.101788_bib44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/archdischild-2020-320680","article-title":"Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?","volume":"106","author":"Edmonson","year":"2021","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.bpg.2022.101788_bib45","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1007\/s00431-021-04168-y","article-title":"A new era for people with cystic fibrosis","volume":"180","author":"Bierlaagh","year":"2021","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.bpg.2022.101788_bib46","article-title":"Clinical effectiveness of elexacaftor\/tezacaftor\/ivacaftor in people with cystic fibrosis","author":"Nichols","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bpg.2022.101788_bib47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1513\/AnnalsATS.201909-671CME","article-title":"The extrapulmonary effects of cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis","volume":"17","author":"Sergeev","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.bpg.2022.101788_bib48","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1002\/ppul.25627","article-title":"Review of CFTR modulators 2020","volume":"56","author":"Goetz","year":"2021","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bpg.2022.101788_bib49","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/MPG.0000000000001788","article-title":"Reduction of recurrence risk of pancreatitis in cystic fibrosis with ivacaftor: case series","volume":"66","author":"Carrion","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169182200004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169182200004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:02:53Z","timestamp":1761498173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152169182200004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":48,"alternative-id":["S152169182200004X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2022.101788","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Digestive outcomes in Cystic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpg.2022.101788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101788"}}