{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:58:57Z","timestamp":1790200737234,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017636","name":"Cancer Centre Amsterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bpg.2024.101925","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T09:19:47Z","timestamp":1717751987000},"page":"101925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Considerations in case of suspected anastomotic leakage in the lower GI tract"],"prefix":"10.1016","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7955-5291","authenticated-orcid":false,"given":"A.","family":"de Wit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Daams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bpg.2024.101925_bib1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s11605-014-2625-y","article-title":"Endoscopy in the early postoperative setting after primary gastrointestinal anastomosis","volume":"18","author":"Amr","year":"2014","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11605-022-05473-z","article-title":"C-reactive protein and procalcitonin levels to predict anastomotic leak after colorectal surgery: systematic review and meta-analysis","volume":"27","author":"Bona","year":"2022","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.bpg.2024.101925_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.suronc.2022.101708","article-title":"Anastomotic leakage in colorectal cancer surgery","volume":"40","author":"Chiarello","year":"2022","journal-title":"Surg Oncol"},{"issue":"7","key":"10.1016\/j.bpg.2024.101925_bib4","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/codi.16591","article-title":"Diagnostic accuracy of water\u2010soluble contrast enema, contrast\u2010enema computed tomography and endoscopy in detecting anastomotic leakage after (CoLo) proctectomy: a Meta\u2010analysis","volume":"25","author":"Chierici","year":"2023","journal-title":"Colorectal Dis"},{"issue":"3","key":"10.1016\/j.bpg.2024.101925_bib5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00423-019-01776-z","article-title":"\u201cVirtual ileostomy\u201d combined with early endoscopy to avoid a diversion ileostomy in low or ultralow colorectal anastomoses. a preliminary report","volume":"404","author":"Flor-Lorente","year":"2019","journal-title":"Langenbeck's Arch Surg"},{"issue":"4","key":"10.1016\/j.bpg.2024.101925_bib6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00384-016-2744-x","article-title":"Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery","volume":"32","author":"Gessler","year":"2017","journal-title":"Int J Colorectal Dis"},{"issue":"suppl_4","key":"10.1016\/j.bpg.2024.101925_bib7","doi-asserted-by":"crossref","first-page":"S346","DOI":"10.1093\/cid\/cir050","article-title":"Procalcitonin as a biomarker in respiratory tract infection","volume":"52","author":"Gilbert","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1016\/j.bpg.2024.101925_bib8","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1111\/codi.15845","article-title":"Diagnostic accuracy of C\u2010reactive protein, procalcitonin and neutrophils for the early detection of anastomotic leakage after colorectal resection: a multicentric, prospective study","volume":"23","author":"Hern\u00e1ndez","year":"2021","journal-title":"Colorectal Dis"},{"issue":"11","key":"10.1016\/j.bpg.2024.101925_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10151-023-02808-z","article-title":"Comparison of proactive and conventional treatment of anastomotic leakage in rectal cancer surgery: a multicentre retrospective cohort series","volume":"27","author":"Talboom","year":"2023","journal-title":"Tech Coloproctol"},{"issue":"6","key":"10.1016\/j.bpg.2024.101925_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-0041-1735270","article-title":"Diagnosis of anastomotic leak","volume":"34","author":"Hernandez","year":"2021","journal-title":"Clin Colon Rectal Surg"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jviscsurg.2016.07.003","article-title":"Should CT scan be performed when CRP is elevated after colorectal surgery? Results from the inflammatory markers after colorectal surgery study","volume":"154","author":"H\u00f6ll","year":"2017","journal-title":"Journal of Visceral Surgery"},{"issue":"2","key":"10.1016\/j.bpg.2024.101925_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jamcollsurg.2008.10.015","article-title":"Colonic anastomotic leak: risk factors, diagnosis, and treatment","volume":"208","author":"Kingham","year":"2009","journal-title":"J Am Coll Surg"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/DCR.0b013e3181fd2948","article-title":"What is the risk for a permanent stoma after low anterior resection of the rectum for cancer? A Six-Year Follow-Up of a multicenter trial","volume":"54","author":"Lindgren","year":"2011","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.bpg.2024.101925_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.suronc.2021.101621","article-title":"C Reactive protein to albumin ratio (CAR) as predictor of anastomotic leakage in colorectal surgery","volume":"38","author":"Paliogiannis","year":"2021","journal-title":"Surg Oncol"},{"issue":"11","key":"10.1016\/j.bpg.2024.101925_bib15","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s00384-021-03963-1","article-title":"Less is More\u2014the best test for anastomotic leaks in rectal cancer patients prior to ileostomy reversal","volume":"36","author":"Lindner","year":"2021","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"10.1016\/j.bpg.2024.101925_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00384-020-03766-w","article-title":"Flexible endoscopy is enough diagnostic prior to loop ileostomy reversal","volume":"36","author":"Lindner","year":"2020","journal-title":"Int J Colorectal Dis"},{"issue":"10","key":"10.1016\/j.bpg.2024.101925_bib17","doi-asserted-by":"crossref","first-page":"e719","DOI":"10.1016\/j.crad.2022.05.013","article-title":"Routine postoperative CT to detect anastomotic leakage after low anterior resection for rectal cancer has a low sensitivity and specificity and a poor interobserver agreement","volume":"77","author":"Lynglund","year":"2022","journal-title":"Clin Radiol"},{"issue":"9","key":"10.1016\/j.bpg.2024.101925_bib18","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1111\/codi.15764","article-title":"The importance of rectal contrast in CT assessment to detect anastomotic leakage after colorectal surgery","volume":"23","author":"Marres","year":"2021","journal-title":"Colorectal Dis"},{"issue":"5","key":"10.1016\/j.bpg.2024.101925_bib19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/SLA.0b013e3182128929","article-title":"Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak","volume":"253","author":"Mirnezami","year":"2011","journal-title":"Ann Surg"},{"issue":"8","key":"10.1016\/j.bpg.2024.101925_bib20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10151-022-02716-8","article-title":"CT scan for early diagnosis of anastomotic leak after colorectal surgery: is rectal contrast useful?","volume":"27","author":"Moreno-Lopez","year":"2022","journal-title":"Tech Coloproctol"},{"issue":"2","key":"10.1016\/j.bpg.2024.101925_bib21","first-page":"645","article-title":"Early predictive factors and risk assessment for anastomotic leakage in patients undergoing low anterior resection for rectal cancer","volume":"28","author":"Ozgul","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib22","doi-asserted-by":"crossref","DOI":"10.1007\/s00384-023-04571-x","article-title":"Is early CT in cases of elevated postoperative CRP the best option for the diagnosis of colorectal anastomotic leakage?","volume":"38","author":"L\u00e9ourier","year":"2023","journal-title":"Int J Colorectal Dis"},{"issue":"12","key":"10.1016\/j.bpg.2024.101925_bib23","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.bpg.2024.101925_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.21614\/sgo-488","article-title":"The Usefulness of inflammatory biomarkers to predict anastomotic leakage after colorectal Surgery: systematic Review and Meta-Analysis","volume":"27","author":"Rama","year":"2022","journal-title":"Surg Gastroenterol Oncol"},{"issue":"4","key":"10.1016\/j.bpg.2024.101925_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/bjs.9354","article-title":"Systematic review and meta-analysis of use of serum C-reactive protein levels to predict anastomotic leak after colorectal surgery","volume":"101","author":"Singh","year":"2013","journal-title":"Br J Surg"},{"issue":"13","key":"10.1016\/j.bpg.2024.101925_bib26","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1002\/bjs.11812","article-title":"C-reactive protein trajectory to predict Colorectal anastomotic leak: PREDICT study","volume":"107","author":"Stephensen","year":"2020","journal-title":"Br J Surg"},{"issue":"5","key":"10.1016\/j.bpg.2024.101925_bib27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/bjs.10487","article-title":"Systematic review of the role of biomarkers in diagnosing anastomotic leakage following colorectal surgery","volume":"104","author":"Su\u2019a","year":"2017","journal-title":"Br J Surg"},{"issue":"5","key":"10.1016\/j.bpg.2024.101925_bib28","first-page":"675","article-title":"Diagnostic accuracy of procalcitonin for the early diagnosis of anastomotic leakage after colorectal surgery: a Meta\u2010analysis","volume":"90","author":"Su\u2019a","year":"2019","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.bpg.2024.101925_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/codi.16864","article-title":"Is proctoscopy sufficient for the evaluation of colorectal anastomosis prior to ileostomy reversal? A nationwide retrospective analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative group (SICO\u2010CCN)","author":"Manigrasso","year":"2024","journal-title":"Colorectal Dis"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/s40560-017-0246-8","article-title":"Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy","volume":"5","author":"Vijayan","year":"2017","journal-title":"J Intensive Care"},{"issue":"7","key":"10.1016\/j.bpg.2024.101925_bib31","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/codi.15688","article-title":"MRI\u2010EnEMa for the assessment of pelvic intestinal anastomotic integrity","volume":"23","author":"Worley","year":"2021","journal-title":"Colorectal Dis"},{"issue":"7","key":"10.1016\/j.bpg.2024.101925_bib32","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00384-020-03608-9","article-title":"Late anastomotic leakage after anal sphincter saving surgery for rectal cancer: is it different from early anastomotic leakage?","volume":"35","author":"Yang","year":"2020","journal-title":"Int J Colorectal Dis"},{"issue":"6","key":"10.1016\/j.bpg.2024.101925_bib33","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00384-021-03854-5","article-title":"C-reactive protein can predict anastomotic leak in colorectal Surgery: a systematic review and meta-analysis","volume":"36","author":"Yeung","year":"2021","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"10.1016\/j.bpg.2024.101925_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12893-022-01872-w","article-title":"MRI Diagnose post-operative anastomotic leak in patients with rectal cancer: preliminary experience","volume":"22","author":"Yu","year":"2022","journal-title":"BMC Surg"},{"issue":"2","key":"10.1016\/j.bpg.2024.101925_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00384-021-04066-7","article-title":"Endoscopic vacuum therapy for the treatment of colorectal leaks \u2014 a systematic review and meta-analysis","volume":"37","author":"K\u00fchn","year":"2021","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"10.1016\/j.bpg.2024.101925_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/bjs5.50124","article-title":"Systematic review of endoluminal vacuum\u2010assisted therapy as salvage treatment for rectal anastomotic leakage","volume":"3","author":"Shalaby","year":"2018","journal-title":"BJS Open"},{"issue":"8","key":"10.1016\/j.bpg.2024.101925_bib37","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1007\/s00464-007-9706-x","article-title":"Endoscopic vacuum-assisted closure of anastomotic leakage following anterior resection of the rectum: a new method","volume":"22","author":"Weidenhagen","year":"2007","journal-title":"Surgical Endoscopy\/Surgical Endoscopy And Other Interventional Techniques"},{"issue":"S 01","key":"10.1016\/j.bpg.2024.101925_bib38","article-title":"Stent with vacuum therapy for treatment of colonic anastomotic leakage","volume":"56","author":"Basiliya","year":"2024","journal-title":"Endoscopy"}],"container-title":["Best Practice &amp; Research Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691824000507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521691824000507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T11:20:23Z","timestamp":1750677623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521691824000507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S1521691824000507"],"URL":"https:\/\/doi.org\/10.1016\/j.bpg.2024.101925","relation":{},"ISSN":["1521-6918"],"issn-type":[{"value":"1521-6918","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Considerations in case of suspected anastomotic leakage in the lower GI tract","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpg.2024.101925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101925"}}