{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:01:09Z","timestamp":1781236869469,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1567,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.bpj.2008.12.3948","type":"journal-article","created":{"date-parts":[[2009,4,17]],"date-time":"2009-04-17T08:30:12Z","timestamp":1239957012000},"page":"3179-3186","source":"Crossref","is-referenced-by-count":74,"title":["Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent"],"prefix":"10.1016","volume":"96","author":[{"given":"Jun-Ping","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Surguchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Santos-Sacchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhasakumar","family":"Navaratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2008.12.3948_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/35012009","article-title":"Prestin is the motor protein of cochlear outer hair cells","volume":"405","author":"Zheng","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2008.12.3948_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1469-7793.2001.0661h.x","article-title":"Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein","volume":"531","author":"Santos-Sacchi","year":"2001","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.bpj.2008.12.3948_bib3","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1073\/pnas.071613498","article-title":"Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells","volume":"98","author":"Ludwig","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2008.12.3948_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature01059","article-title":"Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier","volume":"419","author":"Liberman","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2008.12.3948_bib5","unstructured":"Reference deleted in proof."},{"key":"10.1016\/j.bpj.2008.12.3948_bib6","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1073\/pnas.0608583104","article-title":"Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent\/chloride anion exchangers","volume":"104","author":"Schaechinger","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2008.12.3948_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nrm730","article-title":"Prestin, a new type of motor protein","volume":"3","author":"Dallos","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib8","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1126\/science.1060939","article-title":"Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein","volume":"292","author":"Oliver","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bpj.2008.12.3948_bib9","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1529\/biophysj.108.134197","article-title":"Anion control of voltage sensing by the motor protein prestin in outer hair cells","volume":"95","author":"Rybalchenko","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1113\/jphysiol.2002.036434","article-title":"Cl\u2212 flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig","volume":"547","author":"Rybalchenko","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib11","series-title":"Biophysics of the Cochlea: From Molecules to Models","first-page":"116","article-title":"Allosteric modulation of the outer hair cell motor protein prestin by chloride","author":"Rybalchenko","year":"2003"},{"key":"10.1016\/j.bpj.2008.12.3948_bib12","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1529\/biophysj.104.053579","article-title":"On membrane motor activity and chloride flux in the outer hair cell: lessons learned from the environmental toxin tributyltin","volume":"88","author":"Song","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib13","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1529\/biophysj.105.068759","article-title":"N-terminal-mediated homomultimerization of prestin, the outer hair cell motor protein","volume":"89","author":"Navaratnam","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib14","doi-asserted-by":"crossref","first-page":"33963","DOI":"10.1074\/jbc.M202660200","article-title":"Specificity of anion exchange mediated by mouse Slc26a6","volume":"277","author":"Jiang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2008.12.3948_bib15","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1529\/biophysj.103.033993","article-title":"Determination of cell capacitance using the exact empirical solution of dY\/dCm and its phase angle","volume":"87","author":"Santos-Sacchi","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1469-7793.1998.225bz.x","article-title":"Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pig","volume":"510","author":"Santos-Sacchi","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib17","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1523\/JNEUROSCI.11-10-03096.1991","article-title":"Reversible inhibition of voltage-dependent outer hair cell motility and capacitance","volume":"11","author":"Santos-Sacchi","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bpj.2008.12.3948_bib18","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/S0006-3495(93)81247-5","article-title":"Harmonics of outer hair cell motility","volume":"65","author":"Santos-Sacchi","year":"1993","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib19","doi-asserted-by":"crossref","first-page":"L27","DOI":"10.1529\/biophysj.105.059782","article-title":"How many states can the motor molecule, prestin, assume in an electric field?","volume":"88","author":"Scherer","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/ng1762","article-title":"Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6","volume":"38","author":"Jiang","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bpj.2008.12.3948_bib21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.1995.sp020765","article-title":"Action of salicylate on membrane capacitance of outer hair cells from the guinea-pig cochlea","volume":"485","author":"Tunstall","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib22","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1523\/JNEUROSCI.16-16-04881.1996","article-title":"Effects of salicylate and lanthanides on outer hair cell motility and associated gating charge","volume":"16","author":"Kakehata","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bpj.2008.12.3948_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.physiol.69.040705.141319","article-title":"Specificity and regulation of renal sulfate transporters","volume":"69","author":"Markovich","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib24","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00424-003-1090-3","article-title":"The SLC26 gene family of multifunctional anion exchangers","volume":"447","author":"Mount","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bpj.2008.12.3948_bib25","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1529\/biophysj.105.073254","article-title":"An anion antiporter model of prestin, the outer hair cell motor protein","volume":"90","author":"Muallem","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib26","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1523\/JNEUROSCI.3808-05.2006","article-title":"Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms","volume":"26","author":"Kennedy","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bpj.2008.12.3948_bib27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0959-440X(02)00358-5","article-title":"CLC chloride channels: correlating structure with function","volume":"12","author":"Estevez","year":"2002","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib28","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1242\/jcs.02431","article-title":"The C-terminus of prestin influences nonlinear capacitance and plasma membrane targeting","volume":"118","author":"Zheng","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bpj.2008.12.3948_bib29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neulet.2006.05.062","article-title":"En bloc C-terminal charge cluster reversals in prestin (SLC26A5): effects on voltage-dependent electromechanical activity","volume":"404","author":"Bai","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bpj.2008.12.3948_bib30","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0896-6273(00)80143-9","article-title":"Contribution of the S4 segment to gating charge in the Shaker K+ channel","volume":"16","author":"Aggarwal","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2008.12.3948_bib31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0896-6273(00)80142-7","article-title":"Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel","volume":"16","author":"Seoh","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2008.12.3948_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0896-6273(00)80028-8","article-title":"Molecular basis of charge movement in voltage-gated sodium channels","volume":"16","author":"Yang","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2008.12.3948_bib33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1085\/jgp.114.2.277","article-title":"Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)","volume":"114","author":"Horrigan","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1085\/jgp.114.5.723","article-title":"Voltage sensitivity and gating charge in Shaker and Shab family potassium channels","volume":"114","author":"Islas","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1085\/jgp.200509421","article-title":"Role of charged residues in\u00a0the S1\u2013S4 voltage sensor of BK channels","volume":"127","author":"Ma","year":"2006","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00232-002-1024-6","article-title":"Presteady-state and steady-state kinetics and turnover rate of the mouse gamma-aminobutyric acid transporter (mGAT3)","volume":"190","author":"Sacher","year":"2002","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s002329900169","article-title":"Presteady-state currents of the rabbit Na+\/glucose cotransporter (SGLT1)","volume":"155","author":"Hazama","year":"1997","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1085\/jgp.200409150","article-title":"Perturbation analysis of the voltage-sensitive conformational changes of the Na+\/glucose cotransporter","volume":"125","author":"Loo","year":"2005","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01870395","article-title":"Energy-dependence of phlorizin binding to isolated renal microvillus membranes. Evidence concerning the mechanism of coupling between the electrochemical Na+ gradient the sugar transport","volume":"42","author":"Aronson","year":"1978","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.1082708","article-title":"Gating the selectivity filter in ClC chloride channels","volume":"300","author":"Dutzler","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bpj.2008.12.3948_bib41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrm2376","article-title":"How membrane proteins sense voltage","volume":"9","author":"Bezanilla","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bpj.2008.12.3948_bib42","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/S0006-3495(93)81248-7","article-title":"Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation","volume":"65","author":"Huang","year":"1993","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2008.12.3948_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s004240050395","article-title":"The outer hair cell motor in membrane patches","volume":"434","author":"Gale","year":"1997","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bpj.2008.12.3948_bib44","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1523\/JNEUROSCI.4548-05.2006","article-title":"Control of mammalian cochlear amplification by chloride anions","volume":"26","author":"Santos-Sacchi","year":"2006","journal-title":"J. Neurosci."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349509004706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349509004706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T14:10:16Z","timestamp":1558275016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349509004706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0006349509004706"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2008.12.3948","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}