{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:04:13Z","timestamp":1792015453965,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1445,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.bpj.2009.04.059","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T12:01:10Z","timestamp":1249041670000},"page":"857-865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils"],"prefix":"10.1016","volume":"97","author":[{"given":"Alfonso","family":"Gautieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Uzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Vesentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2009.04.059_bib1","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1073\/pnas.77.10.6179","article-title":"A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide","volume":"77","author":"Peltonen","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2009.04.059_bib2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.bpj.2009.04.059_bib3","first-page":"393","article-title":"Osteogenesis imperfecta at the beginning of bone and joint decade","volume":"42","author":"Primorac","year":"2001","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.bpj.2009.04.059_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bpj.2009.04.059_bib5","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1359\/JBMR.040111","article-title":"Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength","volume":"19","author":"Kozloff","year":"2004","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bpj.2009.04.059_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/nar\/25.1.181","article-title":"The human type I collagen mutation database","volume":"25","author":"Dalgleish","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bpj.2009.04.059_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.22203\/eCM.v005a04","article-title":"Osteogenesis imperfecta\u2014clinical and molecular diversity","volume":"5","author":"Roughley","year":"2003","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bpj.2009.04.059_bib8","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1073\/pnas.070050097","article-title":"Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine","volume":"97","author":"Beck","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2009.04.059_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1098\/rstb.2000.0760","article-title":"Folding defects in fibrillar collagens","volume":"356","author":"Byers","year":"2001","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bpj.2009.04.059_bib10","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1021\/bi970051h","article-title":"Amino acid environment modulates the disruption by osteogenesis imperfecta glycine substitutions in collagen-like peptides","volume":"36","author":"Yang","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2009.04.059_bib11","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1110\/ps.0218502","article-title":"A statistically derived parameterization for the collagen triple-helix","volume":"13","author":"Rainey","year":"2002","journal-title":"Protein Sci."},{"key":"10.1016\/j.bpj.2009.04.059_bib12","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1093\/bioinformatics\/bth247","article-title":"An interactive triple-helical collagen builder","volume":"20","author":"Rainey","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bpj.2009.04.059_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/pro.21","article-title":"Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains","volume":"18","author":"Gautieri","year":"2009","journal-title":"Protein Sci."},{"key":"10.1016\/j.bpj.2009.04.059_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","article-title":"GROMACS\u2014a message-passing parallel molecular-dynamics implementation","volume":"91","author":"Berendsen","year":"1995","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.bpj.2009.04.059_bib15","first-page":"49","article-title":"GROMACS\u2014a software package and a parallel computer for molecular-dynamics","volume":"209","author":"Vandrunen","year":"1995","journal-title":"Abstr. Paper. Am. Chem. Soc. Natl. Meet."},{"key":"10.1016\/j.bpj.2009.04.059_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/jmbi.1997.1449","article-title":"Molecular packing of type I collagen in tendon","volume":"275","author":"Wess","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bpj.2009.04.059_bib17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0969-2126(01)00669-4","article-title":"The In Situ Supramolecular Structure of Type I Collagen","volume":"9","author":"Orgel","year":"2001","journal-title":"Structure"},{"key":"10.1016\/j.bpj.2009.04.059_bib18","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2009.04.059_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.bbamem.2008.12.007","article-title":"Prediction of the most favorable configuration in the ACBP-membrane interaction based on electrostatic calculations","volume":"1788","author":"Vallejo","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2009.04.059_bib20","doi-asserted-by":"crossref","first-page":"W665","DOI":"10.1093\/nar\/gkh381","article-title":"PDB2PQR: an automated pipeline for the setup, execution, and analysis of Poisson-Boltzmann electrostatics calculations","volume":"32","author":"Dolinsky","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bpj.2009.04.059_bib21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0022-2836(02)00703-9","article-title":"The role of alpha2 chain in the stabilization of the collagen type I heterotrimer: a study of the type I homotrimer in oim mouse tissues","volume":"321","author":"Miles","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bpj.2009.04.059_bib22","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1073\/pnas.0603216103","article-title":"Nature designs tough collagen: Explaining the nanostructure of collagen fibrils","volume":"103","author":"Buehler","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2009.04.059_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jmbbm.2007.04.001","article-title":"Nanomechanics of collagen fibrils under varying cross-link densities: atomistic and continuum studies","volume":"1","author":"Buehler","year":"2008","journal-title":"J. Mech. Behav. Biomed. Mat."},{"key":"10.1016\/j.bpj.2009.04.059_bib24","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.jbiomech.2004.02.028","article-title":"Stretching type II collagen with optical tweezers","volume":"37","author":"Sun","year":"2004","journal-title":"J. Biomech."},{"key":"10.1016\/j.bpj.2009.04.059_bib25","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0021-9290(95)00110-7","article-title":"Stress-strain curve and Young's modulus of a collagen molecule as determined by the x-ray diffraction technique","volume":"29","author":"Sasaki","year":"1996","journal-title":"J. Biomech."},{"key":"10.1016\/j.bpj.2009.04.059_bib26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.pmatsci.2007.06.001","article-title":"Nature's hierarchical materials","volume":"52","author":"Fratzl","year":"2007","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.bpj.2009.04.059_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1006\/jmbi.2001.4682","article-title":"Osteogenesis imperfecta murine: interaction between type I collagen homotrimers","volume":"309","author":"Kuznetsova","year":"2001","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bpj.2009.04.059_bib28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00223-007-9045-x","article-title":"Abnormal mineral-matrix interactions are a significant contributor to fragility in oim\/oim bone","volume":"81","author":"Miller","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bpj.2009.04.059_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/03008200390181663","article-title":"Properties of collagen in OIM mouse tissues","volume":"44","author":"Sims","year":"2003","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bpj.2009.04.059_bib30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0047-6374(01)00225-1","article-title":"Molecular mechanisms of ageing in connective tissues","volume":"122","author":"Bailey","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bpj.2009.04.059_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1172\/JCI119519","article-title":"Collagen from the osteogenesis imperfecta mouse model (oim) shows reduced resistance against tensile stress","volume":"100","author":"Misof","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bpj.2009.04.059_bib32","series-title":"Cracks and Fracture","author":"Broberg","year":"1990"},{"key":"10.1016\/j.bpj.2009.04.059_bib33","series-title":"Atomistic Modeling of Materials Failure","author":"Buehler","year":"2008"},{"key":"10.1016\/j.bpj.2009.04.059_bib34","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1529\/biophysj.107.124602","article-title":"Stress-strain experiments on individual collagen fibrils","volume":"95","author":"Shen","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2009.04.059_bib35","doi-asserted-by":"crossref","first-page":"15528","DOI":"10.1021\/bi981147u","article-title":"Nuclear magnetic resonance shows asymmetric loss of triple helix in peptides modeling a collagen mutation in brittle bone disease","volume":"37","author":"Liu","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2009.04.059_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmbi.1997.1106","article-title":"Altered collagen structure in mouse tail tendon lacking the alpha2(I) chain","volume":"270","author":"McBride","year":"1997","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bpj.2009.04.059_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S8756-3282(01)00594-4","article-title":"Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)","volume":"29","author":"Grabner","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.bpj.2009.04.059_bib38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1359\/jbmr.1999.14.2.264","article-title":"The material basis for reduced mechanical properties in oim bones","volume":"14","author":"Camacho","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bpj.2009.04.059_bib39","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI118428","article-title":"Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering","volume":"97","author":"Fratzl","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bpj.2009.04.059_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nmat2387","article-title":"Deformation and failure of protein materials in physiologically extreme conditions and disease","volume":"8","author":"Buehler","year":"2009","journal-title":"Nat. Mater."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349509010261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349509010261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:06:44Z","timestamp":1757779604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349509010261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0006349509010261"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2009.04.059","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and Mesoscale Mechanisms of Osteogenesis Imperfecta Disease in Collagen Fibrils","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2009.04.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Biophysical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}