{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:11:42Z","timestamp":1790752302453,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":927,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.bpj.2010.10.050","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T04:13:10Z","timestamp":1294200790000},"page":"215-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["In Vivo NMR Metabolic Profiling of Fabrea salina Reveals Sequential Defense Mechanisms against Ultraviolet Radiation"],"prefix":"10.1016","volume":"100","author":[{"given":"Roberto","family":"Marangoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Paris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Melck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Fulgentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Colombetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2010.10.050_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1011-1344(98)00184-5","article-title":"Effects of increased solar ultraviolet radiation on terrestrial ecosystems","volume":"46","author":"Caldwell","year":"1998","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0168-9525(97)01246-8","article-title":"Sunlight and the onset of skin cancer","volume":"13","author":"Brash","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/j.bpj.2010.10.050_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0176-1617(96)80298-7","article-title":"Effect of UV-B on enzymes of nitrogen metabolism in the cyanobacterium Nostoc calcicola","volume":"148","author":"Kumar","year":"1996","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/1011-1344(95)07205-5","article-title":"Effects of UV irradiation on certain physiological and biochemical processes in cyanobacteria","volume":"32","author":"Sinha","year":"1996","journal-title":"J.\u00a0Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1011-1344(98)00198-5","article-title":"Ultraviolet-absorbing\/screening substances in cyanobacteria, phytoplankton and macroalgae","volume":"47","author":"Sinha","year":"1998","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.es.26.110195.003343","article-title":"Antarctic terrestrial ecosystem response to global environmental change","volume":"26","author":"Kennedy","year":"1995","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"10.1016\/j.bpj.2010.10.050_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1011-1344(98)00185-7","article-title":"Effects on aquatic ecosystems","volume":"46","author":"H\u00e4der","year":"1998","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib8","first-page":"78","article-title":"Effects of UV-B irradiation on a marine microecosystem","volume":"80","author":"Marangoni","year":"2004","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1009718604610","article-title":"Penetration and effects of solar UV-B on phytoplankton and macroalgae","volume":"128","author":"H\u00e4der","year":"2004","journal-title":"Plant Ecol."},{"key":"10.1016\/j.bpj.2010.10.050_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1012986500543","article-title":"Responses of aquatic algae and cyanobacteria to solar UV-B","volume":"154","author":"Sinha","year":"2004","journal-title":"Plant Ecol."},{"key":"10.1016\/j.bpj.2010.10.050_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0167-4838(92)90487-X","article-title":"Damage to functional components and partial degradation of Photosystem II reaction center proteins upon chloroplast exposure to ultraviolet-B radiation","volume":"1100","author":"Melis","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2010.10.050_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/b700020k","article-title":"Effects of solar UV radiation on aquatic ecosystems and interactions with climate change","volume":"6","author":"H\u00e4der","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.bpj.2010.10.050_bib13","first-page":"101","article-title":"UV-B induces DNA damage and DNA synthesis delay in the marine diatom Cyclotella sp","volume":"60","author":"Buma","year":"1996","journal-title":"Scientia Marina"},{"key":"10.1016\/j.bpj.2010.10.050_bib14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1104\/pp.103.3.741","article-title":"The role of flavonol glycosides and carotenoids in protecting soybean from ultraviolet-B damage","volume":"103","author":"Middleton","year":"1993","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1011-1344(99)00103-7","article-title":"Induction of a mycosporine-like amino acid (MAA) in the rice-field cyanobacterium Anabaena sp. by UV irradiation","volume":"52","author":"Sinha","year":"1999","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1751-1097.1996.tb02435.x","article-title":"Mycosporine-like amino acids provide protection against ultraviolet radiation in eggs of the green sea urchin Strongylocentrotus droebachiensis","volume":"64","author":"Adams","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib17","series-title":"Animal Models in Eye Research","first-page":"6","article-title":"The simplest eyes: rhodopsin-mediated phototaxis reception in microorganisms","author":"Spudich","year":"2008"},{"key":"10.1016\/j.bpj.2010.10.050_bib18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/mben.2001.0212","article-title":"Functional genomics: high-throughput mRNA, protein, and metabolite analyses","volume":"4","author":"Oliver","year":"2002","journal-title":"Metab. Eng."},{"key":"10.1016\/j.bpj.2010.10.050_bib19","series-title":"Metabolomics, Metabonomics and Metabolites Profiling","author":"Griffiths","year":"2007"},{"key":"10.1016\/j.bpj.2010.10.050_bib20","series-title":"Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis","author":"Harrigan","year":"2003"},{"key":"10.1016\/j.bpj.2010.10.050_bib21","series-title":"The Handbook of Metabonomics and Metabolomics","author":"Lindon","year":"2006"},{"key":"10.1016\/j.bpj.2010.10.050_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-008-0152-0","article-title":"Environmental metabolomics: a critical review and future perspectives","volume":"5","author":"Bundy","year":"2009","journal-title":"Metabolomics"},{"key":"10.1016\/j.bpj.2010.10.050_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1011-1344(01)00161-0","article-title":"Influence of solar ultraviolet-B radiation on Antarctic terrestrial plants: results from a 4-year field study","volume":"62","author":"Day","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/BF00714462","article-title":"Accumulation of UV-absorbing flavonoids induced by UV-B radiation in Arabidopsis thaliana. 1. Mechanisms of UV-resistance in Arabidopsis","volume":"194","author":"Lois","year":"1994","journal-title":"Planta"},{"key":"10.1016\/j.bpj.2010.10.050_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/jxb\/eri058","article-title":"Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism","volume":"56","author":"Broeckling","year":"2005","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.bpj.2010.10.050_bib26","first-page":"471","article-title":"On the nature of stentorin","volume":"32","author":"Moeller","year":"1962","journal-title":"Compt. Rend. Lab. Carlsberg"},{"key":"10.1016\/j.bpj.2010.10.050_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1011-1344(96)07474-X","article-title":"Effect of UV-B irradiation on motility and photomotility of the marine ciliate Fabrea salina","volume":"39","author":"Martini","year":"1997","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bpj.2010.10.050_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:JOBB.0000019594.43450.c5","article-title":"Transport of compatible solutes in extremophiles","volume":"36","author":"Pfl\u00fcger","year":"2004","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bpj.2010.10.050_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmra.1995.1047","article-title":"Water suppression that works: excitation sculpting using arbitrary waveforms and pulse field gradients","volume":"112","author":"Hwang","year":"1995","journal-title":"J. Magn. Reson"},{"key":"10.1016\/j.bpj.2010.10.050_bib30","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.1021\/ja00231a044","article-title":"Clean TOCSY for proton spin system identification in macromolecules","volume":"110","author":"Griesinger","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bpj.2010.10.050_bib31","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1021\/ja00052a088","article-title":"Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity","volume":"114","author":"Kay","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bpj.2010.10.050_bib32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/nbm.775","article-title":"High-resolution magic angle spinning MRS of breast cancer tissue","volume":"15","author":"Sitter","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bpj.2010.10.050_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0079-6565(88)80010-4","article-title":"13C labelling in studies of metabolic regulation","volume":"20","author":"London","year":"1988","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.bpj.2010.10.050_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0079-6565(95)01017-3","article-title":"Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures","volume":"28","author":"Fan","year":"1996","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.bpj.2010.10.050_bib35","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"Human Metabolome Database","volume":"35","author":"Whishart","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bpj.2010.10.050_bib36","first-page":"204","article-title":"Extrusion of a protein-pigment complex from Blepharisma undulans","volume":"10","author":"Prabhakara Rao","year":"1963","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib37","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.7112124","article-title":"Living with water stress: evolution of osmolyte systems","volume":"217","author":"Yancey","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.bpj.2010.10.050_bib38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1104\/pp.120.4.945","article-title":"Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance","volume":"120","author":"McNeil","year":"1999","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib39","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0161-813X(03)00059-7","article-title":"Formate, the toxic metabolite of methanol, in cultured ocular cells","volume":"24","author":"Treichel","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bpj.2010.10.050_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0005-2728(76)90218-8","article-title":"The effect of formate on cytochrome aa3 and on electron transport in the intact respiratory chain","volume":"430","author":"Nicholls","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2010.10.050_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.mi.43.100189.001533","article-title":"Genetics and regulation of bacterial lipid metabolism","volume":"43","author":"Vanden Boom","year":"1989","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bpj.2010.10.050_bib42","first-page":"117","article-title":"An overview of the role and diversity of compatible solutes in bacteria and archaea","volume":"61","author":"Da Costa","year":"1998","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.bpj.2010.10.050_bib43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/BF00025092","article-title":"Proline in relation to free radical production in seedlings of Brassica juncea raised under sodium chloride stress","volume":"155\/156","author":"Alia","year":"1993","journal-title":"Plant Soil."},{"key":"10.1016\/j.bpj.2010.10.050_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1365-313X.1993.04020215.x","article-title":"Proline biosynthesis and osmoregulation in plants","volume":"4","author":"Delauney","year":"1993","journal-title":"Plant J."},{"key":"10.1016\/j.bpj.2010.10.050_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1023\/A:1001005031886","article-title":"Role of abscitic acid in regulation of wheat seedling growth under salinity stress","volume":"39","author":"Naqvi","year":"1997","journal-title":"Biol. Plant."},{"key":"10.1016\/j.bpj.2010.10.050_bib46","first-page":"915","article-title":"Molecular biology of salt tolerance in the context of whole-plant physiology","volume":"49","author":"Yeo","year":"1998","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.bpj.2010.10.050_bib47","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.3390\/ijms10093793","article-title":"Trehalose metabolism: from osmoprotection to signaling","volume":"10","author":"Iturriaga","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bpj.2010.10.050_bib48","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0300-9084(91)90003-J","article-title":"Characterization of an osmoregulated periplasmic glycine betaine-binding protein in Azospirillum brasilense sp7","volume":"73","author":"Riou","year":"1991","journal-title":"Biochimie"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349510013780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349510013780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:12:01Z","timestamp":1757779921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349510013780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0006349510013780"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2010.10.050","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Vivo NMR Metabolic Profiling of Fabrea salina Reveals Sequential Defense Mechanisms against Ultraviolet Radiation","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2010.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}