{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:44:33Z","timestamp":1790660673021,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":380,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["biophysj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bpj.2013.05.049","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T18:00:29Z","timestamp":1373997629000},"page":"502-511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Platelet Transport Rates and Binding Kinetics at High Shear over a\u00a0Thrombus"],"prefix":"10.1016","volume":"105","author":[{"suffix":"Jr.","given":"David\u00a0L.","family":"Bark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0N.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2013.05.049_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1440-1827.1999.00861.x","article-title":"Coronary atherosclerosis and interventions: pathological sequences and restenosis","volume":"49","author":"Yutani","year":"1999","journal-title":"Pathol. Int."},{"key":"10.1016\/j.bpj.2013.05.049_bib2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.ehj.2004.03.011","article-title":"Atherothrombosis: a widespread disease with unpredictable and life-threatening consequences","volume":"25","author":"Viles-Gonzalez","year":"2004","journal-title":"Eur. Heart\u00a0J."},{"key":"10.1016\/j.bpj.2013.05.049_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1056\/NEJM198405033101801","article-title":"Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death","volume":"310","author":"Davies","year":"1984","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bpj.2013.05.049_bib4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0002-9149(74)90703-6","article-title":"Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction","volume":"34","author":"Chandler","year":"1974","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bpj.2013.05.049_bib5","first-page":"555","article-title":"The role of high wall shear rate on thrombus formation in stenoses","volume":"26","author":"Markou","year":"1993","journal-title":"Adv. Bioeng"},{"key":"10.1016\/j.bpj.2013.05.049_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1114\/1.1359449","article-title":"A mechanistic model of acute platelet accumulation in thrombogenic stenoses","volume":"29","author":"Wootton","year":"2001","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib7","unstructured":"Flannery, C. J. 2005. Thrombus formation under high shear in arterial stenotic flow. MS thesis, Georgia Tech, Atlanta, GA."},{"key":"10.1016\/j.bpj.2013.05.049_bib8","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1172\/JCI114277","article-title":"Mechanisms of arterial thrombosis in nonparallel streamlines: platelet thrombi grow on the apex of stenotic severely injured vessel wall. Experimental study in the pig model","volume":"84","author":"Badimon","year":"1989","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bpj.2013.05.049_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.CIR.54.3.365","article-title":"Platelet aggregation in partially obstructed vessels and its elimination with aspirin","volume":"54","author":"Folts","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2013.05.049_bib10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/01.ATV.10.2.306","article-title":"Dynamic monitoring of platelet deposition on severely damaged vessel wall in flowing blood. Effects of different stenoses on thrombus growth","volume":"10","author":"Lassila","year":"1990","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bpj.2013.05.049_bib11","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s10439-011-0296-3","article-title":"Rapid platelet accumulation leading to thrombotic occlusion","volume":"39","author":"Para","year":"2011","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib12","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1182\/blood.V81.5.1263.1263","article-title":"Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets","volume":"81","author":"Alevriadou","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.bpj.2013.05.049_bib13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.ATV.6.3.312","article-title":"Influence of arterial damage and wall shear rate on platelet deposition. Ex\u00a0vivo study in a swine model","volume":"6","author":"Badimon","year":"1986","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bpj.2013.05.049_bib14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1055\/s-0038-1650343","article-title":"Collagen induced thrombus formation at the apex of eccentric stenoses\u2014a time course study with non-anticoagulated human blood","volume":"75","author":"Barstad","year":"1996","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bpj.2013.05.049_bib15","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1161\/01.ATV.14.12.1984","article-title":"A perfusion chamber developed to investigate thrombus formation and shear profiles in flowing native human blood at the apex of well-defined stenoses","volume":"14","author":"Barstad","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.bpj.2013.05.049_bib16","first-page":"220","article-title":"Effects of blocking the platelet GPIb interaction with von Willebrand factor under a range of shearing forces","volume":"21","author":"Markou","year":"1993","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.ATV.10.2.276","article-title":"Collagen type III induced ex\u00a0vivo thrombogenesis in humans. Role of platelets and leukocytes in deposition of fibrin","volume":"10","author":"Sakariassen","year":"1990","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bpj.2013.05.049_bib18","first-page":"1591","article-title":"Effect of fluid shear on mass transport in flowing blood","volume":"30","author":"Keller","year":"1971","journal-title":"Fed. Proc."},{"key":"10.1016\/j.bpj.2013.05.049_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0021-9797(79)90248-0","article-title":"Flow behavior of erythrocytes. II. Particle motions in concentrated suspensions of ghost cells","volume":"71","author":"Goldsmith","year":"1979","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.bpj.2013.05.049_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S0022112077000111","article-title":"Self-diffusion of particles in shear flow of a suspension","volume":"79","author":"Eckstein","year":"1977","journal-title":"J.\u00a0Fluid Mech."},{"key":"10.1016\/j.bpj.2013.05.049_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1017\/S0022112087002155","article-title":"The shear-induced migration of particles in concentrated suspensions","volume":"181","author":"Leighton","year":"1987","journal-title":"J.\u00a0Fluid Mech."},{"key":"10.1016\/j.bpj.2013.05.049_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0022112087000880","article-title":"Measurement of shear-induced self-diffusion in concentrated suspensions of spheres","volume":"177","author":"Leighton","year":"1987","journal-title":"J.\u00a0Fluid Mech."},{"key":"10.1016\/j.bpj.2013.05.049_bib23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1098\/rspa.1964.0252","article-title":"The flow of suspensions through tubes. III. Collisions of small uniform spheres","volume":"282","author":"Goldsmith","year":"1964","journal-title":"Proc. Roy. Soc. Lond. A. Mat."},{"key":"10.1016\/j.bpj.2013.05.049_bib24","first-page":"77","article-title":"Augmented solute transport in the shear flow of a concentrated suspension","volume":"10","author":"Zydney","year":"1988","journal-title":"PhysicoChem. Hydrodyn."},{"key":"10.1016\/j.bpj.2013.05.049_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0021-9797(85)90093-1","article-title":"Augmented transport of extracellular solutes in concentrated erythrocyte suspensions in Couette flow","volume":"103","author":"Wang","year":"1985","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.bpj.2013.05.049_bib26","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1161\/01.ATV.8.6.819","article-title":"Blood platelets are concentrated near the wall and red blood cells, in the center in flowing blood","volume":"8","author":"Aarts","year":"1988","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.bpj.2013.05.049_bib27","first-page":"161","article-title":"Investigation of platelet margination phenomena at elevated shear stress","volume":"44","author":"Zhao","year":"2007","journal-title":"Biorheology"},{"key":"10.1016\/j.bpj.2013.05.049_bib28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/BIR-1989-26606","article-title":"A freeze-capture method for the study of platelet-sized particle distributions","volume":"26","author":"Bilsker","year":"1989","journal-title":"Biorheology"},{"key":"10.1016\/j.bpj.2013.05.049_bib29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0022112008004011","article-title":"Simulating deformable particle suspensions using a coupled lattice-Boltzmann and finite-element method","volume":"618","author":"MacMeccan","year":"2009","journal-title":"J.\u00a0Fluid Mech."},{"key":"10.1016\/j.bpj.2013.05.049_bib30","doi-asserted-by":"crossref","first-page":"204502","DOI":"10.1103\/PhysRevLett.96.204502","article-title":"Cluster size distribution and scaling for spherical particles and red blood cells in pressure-driven flows at small Reynolds number","volume":"96","author":"Ding","year":"2006","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.bpj.2013.05.049_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jcp.2006.05.010","article-title":"Rheology of red blood cell aggregation by computer simulation","volume":"220","author":"Liu","year":"2006","journal-title":"J.\u00a0Comput. Phys."},{"key":"10.1016\/j.bpj.2013.05.049_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10439-005-9017-0","article-title":"Hemodynamic computation using multiphase flow dynamics in a right coronary artery","volume":"34","author":"Jung","year":"2006","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib33","doi-asserted-by":"crossref","unstructured":"Fiechter, J. 1998. Numerical study of platelet transport in flowing blood. MS thesis, Georgia Institute of Technology, Atlanta, GA.","DOI":"10.1115\/IMECE1998-0006"},{"key":"10.1016\/j.bpj.2013.05.049_bib34","unstructured":"Bark, D. L., Jr. 2007. Mechanistic numerical study of thrombus growth. MS thesis, Georgia Institute of Technology, Atlanta, GA."},{"key":"10.1016\/j.bpj.2013.05.049_bib35","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1088\/0031-9155\/54\/20\/024","article-title":"An extended convection diffusion model for red blood cell-enhanced transport of thrombocytes and leukocytes","volume":"54","author":"Hund","year":"2009","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.bpj.2013.05.049_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-3495(91)82030-6","article-title":"Model of platelet transport in flowing blood with drift and diffusion terms","volume":"60","author":"Eckstein","year":"1991","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2013.05.049_bib37","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/jbm.820231108","article-title":"Embolization: critical thrombus height, shear rates, and pulsatility. Patency of blood vessels","volume":"23","author":"Basmadjian","year":"1989","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.bpj.2013.05.049_bib38","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/bit.24537","article-title":"Correlation of thrombosis growth rate to pathological wall shear rate during platelet accumulation","volume":"109","author":"Bark","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bpj.2013.05.049_bib39","first-page":"273","article-title":"Development of a flow-through system to create occluding thrombus","volume":"44","author":"Ku","year":"2007","journal-title":"Biorheology"},{"key":"10.1016\/j.bpj.2013.05.049_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1098\/rspb.1972.0084","article-title":"Flow behavior of erythrocytes. I. Rotation and deformation in dilute suspensions","volume":"182","author":"Goldsmith","year":"1972","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bpj.2013.05.049_bib41","unstructured":"Wootton, D. M. 1998. Mechanistic modeling of occlusive arterial thrombosis. PhD, Mechanical Engineering thesis. Georgia Institute of Technology, Atlanta, GA."},{"key":"10.1016\/j.bpj.2013.05.049_bib42","first-page":"593","article-title":"Platelet deposition on subendothelium exposed to flowing blood: mathematical analysis of physical parameters","volume":"21","author":"Turitto","year":"1975","journal-title":"Trans. Am. Soc. Artif. Intern. Organs"},{"key":"10.1016\/j.bpj.2013.05.049_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0002-9149(74)90743-7","article-title":"Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve","volume":"33","author":"Gould","year":"1974","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bpj.2013.05.049_bib44","unstructured":"Reasor, D. A. 2011. Numerical simulation of cellular blood flow. PhD thesis, Georgia Institute of Technology, Atlanta, GA."},{"key":"10.1016\/j.bpj.2013.05.049_bib45","first-page":"113","article-title":"Platelet near-wall excess in porcine whole blood in artery-sized tubes under steady and pulsatile flow conditions","volume":"41","author":"Xu","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.bpj.2013.05.049_bib46","first-page":"641","article-title":"The effects of margination and red cell augmented platelet diffusivity on platelet adhesion in complex flow","volume":"41","author":"Jordan","year":"2004","journal-title":"Biorheology"},{"key":"10.1016\/j.bpj.2013.05.049_bib47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1114\/1.201","article-title":"Computational simulation of platelet deposition and activation: II. Results for Poiseuille flow over collagen","volume":"27","author":"Sorensen","year":"1999","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib48","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s10439-005-2951-z","article-title":"Computational model of device-induced thrombosis and thromboembolism","volume":"33","author":"Goodman","year":"2005","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.05.049_bib49","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1016\/j.jbiomech.2010.07.011","article-title":"Wall shear over high degree stenoses pertinent to atherothrombosis","volume":"43","author":"Bark","year":"2010","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.bpj.2013.05.049_bib50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s13239-012-0086-6","article-title":"Mechanisms of platelet capture under very high shear","volume":"3","author":"Wellings","year":"2012","journal-title":"Cardiovasc. Eng. Technol."},{"key":"10.1016\/j.bpj.2013.05.049_bib51","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1182\/blood-2009-08-238238","article-title":"Role for ADAP in shear flow-induced platelet mechanotransduction","volume":"115","author":"Kasirer-Friede","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bpj.2013.05.049_bib52","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1073\/pnas.0608422104","article-title":"Shear-induced unfolding triggers adhesion of von Willebrand factor fibers","volume":"104","author":"Schneider","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2013.05.049_bib53","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/0017-9310(94)90389-1","article-title":"Heat and mass transfer in a separated flow region for high Prandtl and Schmidt numbers under pulsatile conditions","volume":"37","author":"Ma","year":"1994","journal-title":"Int. J. Heat Mass Tran."},{"key":"10.1016\/j.bpj.2013.05.049_bib54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1115\/1.3426241","article-title":"Fluid mechanics of arterial stenoses","volume":"101","author":"Young","year":"1979","journal-title":"J.\u00a0Biomech. Eng-T. ASME"},{"key":"10.1016\/j.bpj.2013.05.049_bib55","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0045-7949(02)00111-6","article-title":"Simulating cyclic artery compression using a 3D unsteady model with fluid-structure interactions","volume":"80","author":"Tang","year":"2002","journal-title":"Comput. Struc."},{"key":"10.1016\/j.bpj.2013.05.049_bib56","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1115\/1.2796096","article-title":"Effects of frictional losses and pulsatile flow on the collapse of stenotic arteries","volume":"119","author":"Downing","year":"1997","journal-title":"J.\u00a0Biomech. Eng."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634951300636X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634951300636X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:30:22Z","timestamp":1646130622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000634951300636X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S000634951300636X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2013.05.049","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet Transport Rates and Binding Kinetics at High Shear over a\u00a0Thrombus","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2013.05.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}