{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:46:41Z","timestamp":1774068401441,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":431,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["biophysj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bpj.2013.12.017","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T18:47:41Z","timestamp":1391539661000},"page":"763-768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Spatiotemporal Evolution of Erythema Migrans, the Hallmark Rash of Lyme Disease"],"prefix":"10.1016","volume":"106","author":[{"given":"Dhruv\u00a0K.","family":"Vig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles\u00a0W.","family":"Wolgemuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2013.12.017_bib1","first-page":"2","article-title":"Summary of notifiable disease\u2014United States","volume":"59","author":"Hall-Baker","year":"2010","journal-title":"Morb. Mortal. Wkly Rep"},{"key":"10.1016\/j.bpj.2013.12.017_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochetes","volume":"10","author":"Radolf","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bpj.2013.12.017_bib3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.idc.2007.12.012","article-title":"Erythema migrans","volume":"22","author":"Dandache","year":"2008","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.bpj.2013.12.017_bib4","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.1114362109","article-title":"The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue","volume":"109","author":"Harman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2013.12.017_bib5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1365-2958.2005.04759.x","article-title":"Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete","volume":"57","author":"Coburn","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bpj.2013.12.017_bib6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease","volume":"113","author":"Steere","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bpj.2013.12.017_bib7","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.4049\/jimmunol.171.5.2660","article-title":"Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans","volume":"171","author":"Salazar","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bpj.2013.12.017_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1182\/blood-2002-04-1164","article-title":"Interferon-\u03b3 switches monocyte differentiation from dendritic cells to macrophages","volume":"101","author":"Delneste","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bpj.2013.12.017_bib9","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.4049\/jimmunol.0804111","article-title":"Local production of IFN-\u03b3 by invariant NKT cells modulates acute Lyme carditis","volume":"182","author":"Olson","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bpj.2013.12.017_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1098\/rsif.2008.0363","article-title":"Constraint-based network model of pathogen-immune system interactions","volume":"6","author":"Thakar","year":"2009","journal-title":"J.\u00a0Roy. Soc. Interface"},{"key":"10.1016\/j.bpj.2013.12.017_bib11","doi-asserted-by":"crossref","first-page":"031929","DOI":"10.1103\/PhysRevE.84.031929","article-title":"Network analysis reveals cross-links of the immune pathways activated by bacteria and allergen","volume":"84","author":"Campbell","year":"2011","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"10.1016\/j.bpj.2013.12.017_bib12","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1086\/340826","article-title":"Human phagocytic cells in the early innate immune response to Borrelia burgdorferi","volume":"185","author":"Montgomery","year":"2002","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.bpj.2013.12.017_bib13","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1128\/IAI.01666-06","article-title":"Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production","volume":"75","author":"Moore","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bpj.2013.12.017_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0022-5193(71)90050-6","article-title":"Model for chemotaxis","volume":"30","author":"Keller","year":"1971","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.bpj.2013.12.017_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2672.1989.tb04952.x","article-title":"Rapid flow cytometric studies of Borrelia burgdorferi phagocytosis by human polymorphonuclear leukocytes","volume":"67","author":"Banfi","year":"1989","journal-title":"J.\u00a0Appl. Bacteriol."},{"key":"10.1016\/j.bpj.2013.12.017_bib16","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-3-642-76977-1_22","article-title":"Rash theory","volume":"66","author":"Segel","year":"1992","journal-title":"Theor. Exp. Insights Immunol"},{"key":"10.1016\/j.bpj.2013.12.017_bib17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1137\/110834081","article-title":"Pattern formation in a model of acute inflammation","volume":"11","author":"Penner","year":"2012","journal-title":"J.\u00a0App. Dyn. Sys."},{"key":"10.1016\/j.bpj.2013.12.017_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/JB.01956-12","article-title":"Changes in bacterial growth rate govern expression of the Borrelia burgdorferi OspC and Erp infection-associated surface proteins","volume":"195","author":"Jutras","year":"2013","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.bpj.2013.12.017_bib19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.4049\/jimmunol.109.5.1109","article-title":"Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. 3. The turnover of macrophages and its relation to their activation and antimicrobial immunity in primary BCG lesions and those of reinfection","volume":"109","author":"Dannenberg","year":"1972","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bpj.2013.12.017_bib20","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1128\/JCM.37.6.1958-1963.1999","article-title":"Quantitative detection of Borrelia burgdorferi by real-time PCR","volume":"37","author":"Pahl","year":"1999","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.bpj.2013.12.017_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/JCM.30.2.359-361.1992","article-title":"Cultivation of Borrelia burgdorferi from erythema migrans lesions and perilesional skin","volume":"30","author":"Berger","year":"1992","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.bpj.2013.12.017_bib22","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1001\/jama.297.23.2617","article-title":"Does this patient have erythema migrans?","volume":"297","author":"Tibbles","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bpj.2013.12.017_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s10439-009-9652-y","article-title":"The transport profile of cytokines in epidermal equivalents subjected to mechanical loading","volume":"37","author":"Cornelissen","year":"2009","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.bpj.2013.12.017_bib24","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bpj.2013.12.017_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/cid\/cis402","article-title":"Treatment of erythema migrans with doxycycline for 10\u00a0days versus 15\u00a0days","volume":"55","author":"Stupica","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bpj.2013.12.017_bib26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-138-9-200305060-00005","article-title":"Duration of antibiotic therapy for early Lyme disease. A randomized, double-blind, placebo-controlled trial","volume":"138","author":"Wormser","year":"2003","journal-title":"Ann. Intern. Med."},{"issue":"Suppl 6","key":"10.1016\/j.bpj.2013.12.017_bib27","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1186\/1471-2164-13-S6-S21","article-title":"Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction","volume":"13","author":"Wang","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bpj.2013.12.017_bib28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fmicb.2012.00104","article-title":"Population dynamics of Borrelia burgdorferi in Lyme disease","volume":"3","author":"Binder","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bpj.2013.12.017_bib29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/387188a0","article-title":"Decay characteristics of HIV-1-infected compartments during combination therapy","volume":"387","author":"Perelson","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2013.12.017_bib30","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/nm.2892","article-title":"Antiretroviral dynamics determines HIV evolution and predicts therapy outcome","volume":"18","author":"Rosenbloom","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bpj.2013.12.017_bib31","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0002-9343(99)80040-0","article-title":"Erythema migrans and early Lyme disease","volume":"98","author":"Nadelman","year":"1995","journal-title":"Am. J. Med"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349513058098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349513058098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T07:06:11Z","timestamp":1688972771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349513058098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0006349513058098"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2013.12.017","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal Evolution of Erythema Migrans, the Hallmark Rash of Lyme Disease","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2013.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}