{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:40:25Z","timestamp":1772120425564,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness (Ministerio de Econom\u00eda, Industria y Competitividad (MINECO))"},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["FIS2015-66503-C3-1-P"],"award-info":[{"award-number":["FIS2015-66503-C3-1-P"]}]},{"name":"Fondo Europeo de Desarrollo Regional (FEDER)","award":["SAF2013-49063-C2-1-R"],"award-info":[{"award-number":["SAF2013-49063-C2-1-R"]}]},{"name":"Center for Models of Life, Niels Bohr Institute, Copenhagen University"},{"DOI":"10.13039\/501100007747","name":"Red Espa\u00f1ola de Esclerosis M\u00faltiple","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007747","name":"REEM","doi-asserted-by":"crossref","award":["RD12\/0032\/0005"],"award-info":[{"award-number":["RD12\/0032\/0005"]}],"id":[{"id":"10.13039\/501100007747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007747","name":"REEM","doi-asserted-by":"crossref","award":["RD16\/0015\/0017"],"award-info":[{"award-number":["RD16\/0015\/0017"]}],"id":[{"id":"10.13039\/501100007747","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007747","name":"REEM","doi-asserted-by":"crossref","award":["ISCIII-MINECO"],"award-info":[{"award-number":["ISCIII-MINECO"]}],"id":[{"id":"10.13039\/501100007747","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Academia programme of the Catalan Institution for Research and Advanced Studies\u00a0(ICREA), the Generalitat de Catalunya","award":["2014SGR0947"],"award-info":[{"award-number":["2014SGR0947"]}]},{"name":"\u201cMar\u00eda de Maeztu\u201d Programme for Units of Excellence in R&D"},{"name":"MINECO","award":["MDM-2014-0370"],"award-info":[{"award-number":["MDM-2014-0370"]}]},{"name":"EU FP7-MINECO Infect-ERA program","award":["PCIN-2015-191-C02-01"],"award-info":[{"award-number":["PCIN-2015-191-C02-01"]}]}],"content-domain":{"domain":["biophysj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.bpj.2017.05.010","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T14:31:13Z","timestamp":1499783473000},"page":"148-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Zygosity on Bimodal Phenotype Distributions"],"prefix":"10.1016","volume":"113","author":[{"given":"Thomas","family":"Holst-Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Abad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aura","family":"Muntasell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"L\u00f3pez-Botet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens H.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Trusina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Garcia-Ojalvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2017.05.010_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2567.2003.01738.x","article-title":"The MHC class I antigen presentation pathway: strategies for viral immune evasion","volume":"110","author":"Hewitt","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/j.bpj.2017.05.010_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature07665","article-title":"Adaptive immune features of natural killer cells","volume":"457","author":"Sun","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2017.05.010_bib5","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood-2004-05-2058","article-title":"Imprint of human cytomegalovirus infection on the NK cell receptor repertoire","volume":"104","author":"Gum\u00e1","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bpj.2017.05.010_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1086\/504719","article-title":"Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94\/NKG2C receptor in aviremic HIV-1-positive patients","volume":"194","author":"Gum\u00e1","year":"2006","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.bpj.2017.05.010_bib7","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1073\/pnas.1110900108","article-title":"Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection","volume":"108","author":"Lopez-Verg\u00e8s","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2017.05.010_bib8","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.4049\/jimmunol.1402281","article-title":"Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus","volume":"194","author":"Costa-Garcia","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib9","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1002\/eji.201343773","article-title":"NKG2C zygosity influences CD94\/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus","volume":"43","author":"Muntasell","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib10","first-page":"409","article-title":"Feedback loops, stability and multistationarity in dynamical systems","volume":"03","author":"Plante","year":"1995","journal-title":"J.\u00a0Biol. Syst."},{"key":"10.1016\/j.bpj.2017.05.010_bib11","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/emboj\/20.10.2528","article-title":"Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion","volume":"20","author":"Becskei","year":"2001","journal-title":"EMBO\u00a0J."},{"key":"10.1016\/j.bpj.2017.05.010_bib12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0960-9822(01)00330-X","article-title":"Bistability in the JNK cascade","volume":"11","author":"Bagowski","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bpj.2017.05.010_bib13","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cub.2007.03.016","article-title":"Positive-feedback loops as a flexible biological module","volume":"17","author":"Ingolia","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bpj.2017.05.010_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/ard.2007.075028","article-title":"Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis","volume":"67","author":"McKinney","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bpj.2017.05.010_bib15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/humu.20074","article-title":"Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers","volume":"24","author":"Brasch-Andersen","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bpj.2017.05.010_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1126\/science.1101160","article-title":"The influence of CCL3L1 gene-containing segmental duplications on HIV-1\/AIDS susceptibility","volume":"307","author":"Gonzalez","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bpj.2017.05.010_bib17","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/genetics\/165.3.1355","article-title":"A theoretical model for the\u00a0regulation of Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila melanogaster","volume":"165","author":"Louis","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.bpj.2017.05.010_bib18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nature04678","article-title":"NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21","volume":"441","author":"Arron","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2017.05.010_bib19","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1073\/pnas.1216091110","article-title":"Circuit-level input integration in bacterial gene regulation","volume":"110","author":"Espinar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2017.05.010_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/biomet\/76.2.297","article-title":"Regression and time series model selection in small samples","volume":"76","author":"Hurvich","year":"1989","journal-title":"Biometrika"},{"key":"10.1016\/j.bpj.2017.05.010_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3758\/BF03206482","article-title":"AIC model selection using Akaike weights","volume":"11","author":"Wagenmakers","year":"2004","journal-title":"Psychon. Bull. Rev."},{"key":"10.1016\/j.bpj.2017.05.010_bib22","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/clinchem\/46.8.1221","article-title":"Flow cytometry: principles and clinical applications in hematology","volume":"46","author":"Brown","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bpj.2017.05.010_bib23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1084\/jem.20100479","article-title":"Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection","volume":"208","author":"Sun","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bpj.2017.05.010_bib24","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1182\/blood-2012-10-459545","article-title":"NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs","volume":"121","author":"B\u00e9ziat","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bpj.2017.05.010_bib25","doi-asserted-by":"crossref","first-page":"e1002140","DOI":"10.1371\/journal.pcbi.1002140","article-title":"Bistability versus bimodal distributions in gene regulatory processes from population balance","volume":"7","author":"Shu","year":"2011","journal-title":"PLOS Comput. Biol."},{"key":"10.1016\/j.bpj.2017.05.010_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04599","article-title":"Stochastic protein expression in individual cells at the single molecule level","volume":"440","author":"Cai","year":"2006","journal-title":"Nature"},{"issue":"R1","key":"10.1016\/j.bpj.2017.05.010_bib27","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1093\/hmg\/ddp011","article-title":"Copy number variants, diseases and gene expression","volume":"18","author":"Henrichsen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bpj.2017.05.010_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ygeno.2008.08.012","article-title":"Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis","volume":"93","author":"Ionita-Laza","year":"2009","journal-title":"Genomics"},{"key":"10.1016\/j.bpj.2017.05.010_bib29","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1002\/eji.1830250904","article-title":"Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily","volume":"25","author":"Chang","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib30","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1002\/eji.200425210","article-title":"Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR \u03b1\u03b2 lymphocytes","volume":"34","author":"Arlettaz","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jri.2005.12.008","article-title":"Expression patterns of lectin-like natural killer receptors, inhibitory CD94\/NKG2A, and activating CD94\/NKG2C on decidual CD56bright natural killer cells differ from those on peripheral CD56dim natural killer cells","volume":"70","author":"Kusumi","year":"2006","journal-title":"J.\u00a0Reprod. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib32","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.4049\/jimmunol.1102989","article-title":"Two-compartment model of NK cell proliferation: insights from population response to IL-15 stimulation","volume":"188","author":"Zhao","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1023\/A:1014204519468","article-title":"HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells","volume":"22","author":"Husain","year":"2002","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.bpj.2017.05.010_bib34","doi-asserted-by":"crossref","first-page":"e1001208","DOI":"10.1371\/journal.pbio.1001208","article-title":"Copy number variation of KIR genes influences HIV-1 control","volume":"9","author":"Pelak","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bpj.2017.05.010_bib35","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1182\/blood-2012-10-461442","article-title":"Influence of KIR gene copy number on natural killer cell education","volume":"121","author":"B\u00e9ziat","year":"2013","journal-title":"Blood"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349517305179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349517305179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T08:27:24Z","timestamp":1655886444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349517305179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0006349517305179"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2017.05.010","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/086215","asserted-by":"object"}]},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Zygosity on Bimodal Phenotype Distributions","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2017.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Biophysical Society.","name":"copyright","label":"Copyright"}]}}