{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:20:49Z","timestamp":1791429649534,"version":"4.3.3"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM073791"],"award-info":[{"award-number":["R01 GM073791"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM110352"],"award-info":[{"award-number":["GM110352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.bpj.2017.07.007","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T12:00:54Z","timestamp":1503403254000},"page":"889-899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination"],"prefix":"10.1016","volume":"113","author":[{"given":"Malgorzata","family":"Boczkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Yurtsever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Rebowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Eck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2017.07.007_bib1","doi-asserted-by":"crossref","first-page":"a018226","DOI":"10.1101\/cshperspect.a018226","article-title":"Actin and actin-binding proteins","volume":"8","author":"Pollard","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bpj.2017.07.007_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tibs.2016.03.004","article-title":"The WH2 domain and actin nucleation: necessary but insufficient","volume":"41","author":"Dominguez","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bpj.2017.07.007_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.1155313","article-title":"Leiomodin is an actin filament nucleator in muscle cells","volume":"320","author":"Chereau","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bpj.2017.07.007_bib4","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.bpj.2017.03.034","article-title":"Tropomodulins and leiomodins: actin pointed end caps and nucleators in muscles","volume":"112","author":"Fowler","year":"2017","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2017.07.007_bib5","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1016\/S0006-3495(02)75281-8","article-title":"Crystal structure of the C-terminal half of tropomodulin and structural basis of actin filament pointed-end capping","volume":"83","author":"Krieger","year":"2002","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2017.07.007_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1126\/science.1256159","article-title":"Mechanism of actin filament pointed-end capping by tropomodulin","volume":"345","author":"Rao","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bpj.2017.07.007_bib7","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1038\/ncomms9314","article-title":"How leiomodin and tropomodulin use a common fold for different actin assembly functions","volume":"6","author":"Boczkowska","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2017.07.007_bib8","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1073\/pnas.1512464112","article-title":"Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2017.07.007_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-biophys-083012-130253","article-title":"Advances, interactions, and future developments in the CNS, Phenix, and Rosetta structural biology software systems","volume":"42","author":"Adams","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.bpj.2017.07.007_bib10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.bpj.2017.07.007_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-biophys-042910-155359","article-title":"Actin structure and function","volume":"40","author":"Dominguez","year":"2011","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.bpj.2017.07.007_bib12","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.str.2015.05.015","article-title":"Structure of a Bud6\/Actin complex reveals a novel WH2-like actin monomer recruitment motif","volume":"23","author":"Park","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.bpj.2017.07.007_bib13","doi-asserted-by":"crossref","first-page":"16644","DOI":"10.1073\/pnas.0507021102","article-title":"Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly","volume":"102","author":"Chereau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2017.07.007_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jmb.2010.08.040","article-title":"Structure of a longitudinal actin dimer assembled by tandem W domains: implications for actin filament nucleation","volume":"403","author":"Rebowski","year":"2010","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bpj.2017.07.007_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature14033","article-title":"Structure of the F-actin-tropomyosin complex","volume":"519","author":"von der Ecken","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2017.07.007_bib16","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1091\/mbc.e10-02-0109","article-title":"Different localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeres","volume":"21","author":"Skwarek-Maruszewska","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bpj.2017.07.007_bib17","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1242\/jcs.071837","article-title":"Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle","volume":"123","author":"Tsukada","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bpj.2017.07.007_bib18","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1172\/JCI75199","article-title":"Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy","volume":"124","author":"Yuen","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bpj.2017.07.007_bib19","first-page":"4351","article-title":"Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle","volume":"142","author":"Gokhin","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bpj.2017.07.007_bib20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.tibs.2004.09.004","article-title":"Actin-binding proteins\u2014a unifying hypothesis","volume":"29","author":"Dominguez","year":"2004","journal-title":"Trends Biochem. Sci."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349517308044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349517308044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:29:45Z","timestamp":1757780985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349517308044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0006349517308044"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2017.07.007","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2017.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2017.07.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Biophysical Society.","name":"copyright","label":"Copyright"}]}}