{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:20:56Z","timestamp":1789806056368,"version":"4.0.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M004643\/1"],"award-info":[{"award-number":["MR\/M004643\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bpj.2018.04.026","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T17:41:12Z","timestamp":1528393272000},"page":"2679-2690","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions"],"prefix":"10.1016","volume":"114","author":[{"given":"Linda","family":"Irons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben D.","family":"O\u2019Dea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindi S.","family":"Brook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2018.04.026_bib1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1164\/ajrccm.161.5.9903102","article-title":"Asthma. From bronchoconstriction to airways inflammation and remodeling","volume":"161","author":"Bousquet","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.bpj.2018.04.026_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1569-9048(03)00144-7","article-title":"Cytoskeletal remodeling of the airway smooth muscle cell: a mechanism for adaptation to mechanical forces in the lung","volume":"137","author":"Gunst","year":"2003","journal-title":"Respir. Physiol. Neurobiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1513\/pats.200704-048VS","article-title":"Interactions of airway smooth muscle cells with their tissue matrix: implications for contraction","volume":"5","author":"Zhang","year":"2008","journal-title":"Proc. Am. Thorac. Soc"},{"key":"10.1016\/j.bpj.2018.04.026_bib4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bpj.2018.04.026_bib5","doi-asserted-by":"crossref","first-page":"a005066","DOI":"10.1101\/cshperspect.a005066","article-title":"Integrins and extracellular matrix in mechanotransduction","volume":"2","author":"Schwartz","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol"},{"key":"10.1016\/j.bpj.2018.04.026_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature10316","article-title":"Dynamic molecular processes mediate cellular mechanotransduction","volume":"475","author":"Hoffman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2018.04.026_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.201609037","article-title":"Integrin-mediated mechanotransduction","volume":"215","author":"Sun","year":"2016","journal-title":"J.\u00a0Cell Biol"},{"key":"10.1016\/j.bpj.2018.04.026_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.devcel.2013.02.012","article-title":"Dynamic regulation of\u00a0the structure and functions of integrin adhesions","volume":"24","author":"Wolfenson","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bpj.2018.04.026_bib9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1152\/jappl.2000.89.2.711","article-title":"Potent bronchoprotective effect of deep inspiration and its absence in asthma","volume":"89","author":"Kapsali","year":"2000","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib10","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1152\/japplphysiol.00209.2002","article-title":"Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects","volume":"93","author":"Crimi","year":"2002","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib11","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/ajrccm.162.3.9907048","article-title":"Deep inspiration-induced bronchoprotection is stronger than bronchodilation","volume":"162","author":"Scichilone","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.bpj.2018.04.026_bib12","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1152\/jappl.1983.55.3.759","article-title":"Contractile force of canine airway smooth muscle during cyclical length changes","volume":"55","author":"Gunst","year":"1983","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib13","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1152\/japplphysiol.01090.2000","article-title":"Dynamic equilibration of airway smooth muscle contraction during physiological loading","volume":"92","author":"Latourelle","year":"2002","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1152\/japplphysiol.00107.2010","article-title":"Tidal stretches do not modulate responsiveness of intact airways in\u00a0vitro","volume":"109","author":"LaPrad","year":"2010","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib15","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1152\/japplphysiol.00938.2014","article-title":"Modeling the impairment of airway smooth muscle force by stretch","volume":"118","author":"Bates","year":"2015","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tibs.2004.06.005","article-title":"The talin-tail interaction places integrin activation on FERM ground","volume":"29","author":"Campbell","year":"2004","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.bpj.2018.04.026_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/BST0360229","article-title":"Integrin activation","volume":"36","author":"Banno","year":"2008","journal-title":"Biochem. Soc. Trans"},{"key":"10.1016\/j.bpj.2018.04.026_bib18","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1103\/PhysRevLett.84.2750","article-title":"Rupture of multiple parallel molecular bonds under dynamic loading","volume":"84","author":"Seifert","year":"2000","journal-title":"Phys. Rev. Lett"},{"key":"10.1016\/j.bpj.2018.04.026_bib19","doi-asserted-by":"crossref","first-page":"108102","DOI":"10.1103\/PhysRevLett.92.108102","article-title":"Stability of adhesion clusters under constant force","volume":"92","author":"Erdmann","year":"2004","journal-title":"Phys. Rev. Lett"},{"key":"10.1016\/j.bpj.2018.04.026_bib20","doi-asserted-by":"crossref","first-page":"L60","DOI":"10.1529\/biophysj.106.090209","article-title":"Bistability of cell-matrix adhesions resulting from nonlinear receptor-ligand dynamics","volume":"91","author":"Erdmann","year":"2006","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib21","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.bpj.2009.08.027","article-title":"Lifetime and strength of periodic bond clusters between elastic media under inclined loading","volume":"97","author":"Qian","year":"2009","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib22","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1529\/biophysj.108.131342","article-title":"Stability of adhesion clusters and cell reorientation under lateral cyclic tension","volume":"95","author":"Kong","year":"2008","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib23","doi-asserted-by":"crossref","first-page":"e1000604","DOI":"10.1371\/journal.pcbi.1000604","article-title":"Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate","volume":"5","author":"Paszek","year":"2009","journal-title":"PLoS Comput. Biol"},{"key":"10.1016\/j.bpj.2018.04.026_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-3495(92)81577-1","article-title":"Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion","volume":"63","author":"Hammer","year":"1992","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib25","doi-asserted-by":"crossref","first-page":"021006","DOI":"10.1115\/1.4026402","article-title":"Adhesive dynamics","volume":"136","author":"Hammer","year":"2014","journal-title":"J.\u00a0Biomech. Eng"},{"key":"10.1016\/j.bpj.2018.04.026_bib26","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1126\/science.1163595","article-title":"Traction dynamics of filopodia on compliant substrates","volume":"322","author":"Chan","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bpj.2018.04.026_bib27","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.bpj.2011.11.010","article-title":"Nucleation and decay initiation are the stiffness-sensitive phases of focal adhesion maturation","volume":"101","author":"Walcott","year":"2011","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib28","doi-asserted-by":"crossref","first-page":"135503","DOI":"10.1103\/PhysRevLett.92.135503","article-title":"Friction through dynamical formation and rupture of molecular bonds","volume":"92","author":"Filippov","year":"2004","journal-title":"Phys. Rev. Lett"},{"key":"10.1016\/j.bpj.2018.04.026_bib29","doi-asserted-by":"crossref","first-page":"046124","DOI":"10.1103\/PhysRevE.80.046124","article-title":"Binding site models of friction due to the formation and rupture of bonds: state-function formalism, force-velocity relations, response to slip velocity transients, and slip stability","volume":"80","author":"Srinivasan","year":"2009","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys"},{"key":"10.1016\/j.bpj.2018.04.026_bib30","unstructured":"Lacker, H. M., and C. S. Peskin. 1986. A mathematical method for unique determination of crossbridge properties from steady-state mechanical and energetic experiments on macroscopic muscle. In Some Mathematical Questions in Biology\u2013Muscle Physiology, (The American Mathematical Society), Volume 16, pp. 121\u2013153."},{"key":"10.1016\/j.bpj.2018.04.026_bib31","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1242\/jcs.01416","article-title":"Spatial mapping of integrin interactions and dynamics during cell migration by image correlation microscopy","volume":"117","author":"Wiseman","year":"2004","journal-title":"J.\u00a0Cell Sci"},{"key":"10.1016\/j.bpj.2018.04.026_bib32","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.bpj.2012.08.021","article-title":"A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding","volume":"103","author":"Welf","year":"2012","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib33","doi-asserted-by":"crossref","first-page":"042704","DOI":"10.1103\/PhysRevE.92.042704","article-title":"Integrin-mediated adhesion as self-sustained waves of enzymatic activation","volume":"92","author":"Block","year":"2015","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys"},{"key":"10.1016\/j.bpj.2018.04.026_bib34","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bpj.2015.08.048","article-title":"A chemomechanical model of matrix and nuclear rigidity regulation of focal adhesion size","volume":"109","author":"Cao","year":"2015","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib35","doi-asserted-by":"crossref","first-page":"E4549","DOI":"10.1073\/pnas.1620486114","article-title":"Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices","volume":"114","author":"Cao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2018.04.026_bib36","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.bpj.2014.03.027","article-title":"A computational study of stress fiber-focal adhesion dynamics governing cell contractility","volume":"106","author":"Maraldi","year":"2014","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib37","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.jmps.2007.08.006","article-title":"A bio-mechanical model for coupling cell contractility with focal adhesion formation","volume":"56","author":"Deshpande","year":"2008","journal-title":"J.\u00a0Mech. Phys. Solids"},{"key":"10.1016\/j.bpj.2018.04.026_bib38","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1073\/pnas.0403539101","article-title":"Cell mechanosensitivity controls the anisotropy of focal adhesions","volume":"101","author":"Nicolas","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2018.04.026_bib39","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1098\/rsif.2011.0157","article-title":"Probing mechanical principles of focal contacts in cell-matrix adhesion with a coupled stochastic-elastic modelling framework","volume":"8","author":"Gao","year":"2011","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.bpj.2018.04.026_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0096-4174(18)30128-8","article-title":"Muscle structure and theories of contraction","volume":"7","author":"Huxley","year":"1957","journal-title":"Prog. Biophys. Biophys. Chem"},{"key":"10.1016\/j.bpj.2018.04.026_bib41","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions","volume":"81","author":"Gillespie","year":"1977","journal-title":"J.\u00a0Phys. Chem"},{"key":"10.1016\/j.bpj.2018.04.026_bib42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0079-6107(74)90020-0","article-title":"Theoretical formalism for the sliding filament model of contraction of striated muscle. Part I","volume":"28","author":"Hill","year":"1974","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/j.bpj.2018.04.026_bib43","doi-asserted-by":"crossref","first-page":"L362","DOI":"10.1152\/ajplung.00095.2009","article-title":"Transient oscillatory force-length behavior of activated airway smooth muscle","volume":"297","author":"Bates","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib44","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1152\/japplphysiol.00009.2013","article-title":"Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?","volume":"115","author":"Harvey","year":"2013","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.resp.2017.04.013","article-title":"An in\u00a0vitro study examining the duration between deep inspirations on the rate of renarrowing","volume":"243","author":"Mailhot-Larouche","year":"2017","journal-title":"Respir. Physiol. Neurobiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib46","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1152\/japplphysiol.00676.2010","article-title":"Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscle","volume":"109","author":"Raqeeb","year":"2010","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib47","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1016\/j.bpj.2014.10.067","article-title":"Nonlinear compliance modulates dynamic bronchoconstriction in a multiscale airway model","volume":"107","author":"Hiorns","year":"2014","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib48","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1529\/biophysj.108.139584","article-title":"Cooperativity in adhesion cluster formation during initial cell adhesion","volume":"95","author":"Selhuber-Unkel","year":"2008","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10439-008-9438-7","article-title":"Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch","volume":"36","author":"Na","year":"2008","journal-title":"Ann. Biomed. Eng"},{"key":"10.1016\/j.bpj.2018.04.026_bib50","doi-asserted-by":"crossref","first-page":"H2526","DOI":"10.1152\/ajpheart.00658.2004","article-title":"Mechanical properties of the interaction between fibronectin and \u03b15\u03b21-integrin on vascular smooth muscle cells studied using atomic force microscopy","volume":"289","author":"Sun","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib51","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.4049\/jimmunol.1003507","article-title":"Integrin \u03b1v\u03b25-mediated TGF-\u03b2 activation by airway smooth muscle cells in asthma","volume":"187","author":"Tatler","year":"2011","journal-title":"J.\u00a0Immunol"},{"key":"10.1016\/j.bpj.2018.04.026_bib52","doi-asserted-by":"crossref","first-page":"e65580","DOI":"10.1371\/journal.pone.0065580","article-title":"Bronchoconstriction induces TGF-\u03b2 release and airway remodelling in guinea pig lung slices","volume":"8","author":"Oenema","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2018.04.026_bib53","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1172\/JCI8124","article-title":"Airway remodeling in asthma","volume":"104","author":"Elias","year":"1999","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.bpj.2018.04.026_bib54","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1183\/09031936.00146905","article-title":"Clinical relevance of airway remodelling in airway diseases","volume":"30","author":"James","year":"2007","journal-title":"Eur. Respir. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib55","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jaci.2005.07.011","article-title":"Airway remodeling contributes to the progressive loss of lung function in asthma: an overview","volume":"116","author":"Pascual","year":"2005","journal-title":"J.\u00a0Allergy Clin. Immunol"},{"key":"10.1016\/j.bpj.2018.04.026_bib56","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1152\/japplphysiol.01209.2013","article-title":"Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways","volume":"116","author":"Brook","year":"2014","journal-title":"J.\u00a0Appl. Physiol"},{"key":"10.1016\/j.bpj.2018.04.026_bib57","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.347575","article-title":"Models for the specific adhesion of cells to cells","volume":"200","author":"Bell","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.bpj.2018.04.026_bib58","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0006-3495(91)82296-2","article-title":"Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments","volume":"59","author":"Evans","year":"1991","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib59","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0006-3495(97)78802-7","article-title":"Dynamic strength of molecular adhesion bonds","volume":"72","author":"Evans","year":"1997","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib60","doi-asserted-by":"crossref","first-page":"pl5","DOI":"10.1126\/stke.4062007pl5","article-title":"Studying integrin-mediated cell adhesion at the single-molecule level using AFM force spectroscopy","volume":"2007","author":"Franz","year":"2007","journal-title":"Sci. STKE"},{"issue":"Suppl 1","key":"10.1016\/j.bpj.2018.04.026_bib61","first-page":"S30","article-title":"Extracellular matrix and integrin composition of the normal bladder wall","volume":"14","author":"Wilson","year":"1996","journal-title":"World J. Urol"},{"key":"10.1016\/j.bpj.2018.04.026_bib62","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1095\/biolreprod.104.035626","article-title":"Expression of \u03b15 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labor: implications for development of a mechanical syncytium","volume":"72","author":"Williams","year":"2005","journal-title":"Biol. Reprod"},{"key":"10.1016\/j.bpj.2018.04.026_bib63","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0006-3495(03)74940-6","article-title":"Force measurements of the \u03b15\u03b21 integrin-fibronectin interaction","volume":"84","author":"Li","year":"2003","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib64","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bpj.2009.11.001","article-title":"Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors","volume":"98","author":"Selhuber-Unkel","year":"2010","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.04.026_bib65","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1002\/j.1460-2075.1988.tb03303.x","article-title":"Electron microscopy and structural model of human fibronectin receptor","volume":"7","author":"Nermut","year":"1988","journal-title":"EMBO J"},{"key":"10.1016\/j.bpj.2018.04.026_bib66","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1021\/la203725a","article-title":"Integrin clustering in two and three dimensions","volume":"28","author":"Lepzelter","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.bpj.2018.04.026_bib67","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.jbiomech.2010.05.019","article-title":"Stabilizing to disruptive transition of focal adhesion response to mechanical forces","volume":"43","author":"Kong","year":"2010","journal-title":"J.\u00a0Biomech"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349518305204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349518305204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:35:06Z","timestamp":1757781306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349518305204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0006349518305204"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2018.04.026","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2018.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Biophysical Society.","name":"copyright","label":"Copyright"}]}}