{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:49:42Z","timestamp":1781088582090,"version":"3.54.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Science Foundation","award":["CBET-1530884"],"award-info":[{"award-number":["CBET-1530884"]}]},{"name":"National Science Foundation","award":["ECCS-1611083"],"award-info":[{"award-number":["ECCS-1611083"]}]},{"name":"National Science Foundation","award":["CAREER-1651385"],"award-info":[{"award-number":["CAREER-1651385"]}]}],"content-domain":{"domain":["biophysj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.bpj.2018.08.050","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T22:40:50Z","timestamp":1538520050000},"page":"1966-1980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Substrate Stiffness on Mechanical Coupling and Force Propagation at the Infarct Boundary"],"prefix":"10.1016","volume":"115","author":[{"given":"Dung Trung","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerajha","family":"Nagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Zorlutuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2018.08.050_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ije\/dyq165","article-title":"World Health Organization definition of myocardial infarction: 2008-09 revision","volume":"40","author":"Mendis","year":"2011","journal-title":"Int. J. Epidemiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/FJC.0b013e31821823d9","article-title":"Biomarkers of myocardial fibrosis","volume":"57","author":"de Jong","year":"2011","journal-title":"J.\u00a0Cardiovasc. Pharmacol"},{"key":"10.1016\/j.bpj.2018.08.050_bib3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/FJC.0b013e318207a35f","article-title":"Fibrosis and cardiac arrhythmias","volume":"57","author":"de Jong","year":"2011","journal-title":"J.\u00a0Cardiovasc. Pharmacol"},{"key":"10.1016\/j.bpj.2018.08.050_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.yjmcc.2015.06.006","article-title":"Building a better infarct: modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction","volume":"85","author":"Voorhees","year":"2015","journal-title":"J.\u00a0Mol. Cell. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib5","doi-asserted-by":"crossref","first-page":"H221","DOI":"10.1152\/ajpheart.00495.2009","article-title":"Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat","volume":"298","author":"Fomovsky","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15476278.2015.1019687","article-title":"Tissue stiffness dictates development, homeostasis, and disease progression","volume":"11","author":"Handorf","year":"2015","journal-title":"Organogenesis"},{"key":"10.1016\/j.bpj.2018.08.050_bib7","first-page":"41","article-title":"Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution","volume":"28","author":"Nag","year":"1980","journal-title":"Cytobios"},{"key":"10.1016\/j.bpj.2018.08.050_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cardiores.2004.08.020","article-title":"Structural and functional characterisation of cardiac fibroblasts","volume":"65","author":"Camelliti","year":"2005","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.bpj.2018.08.050_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2015.11.025","article-title":"Mechanical control of cardiac myofibroblasts","volume":"93","author":"van Putten","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"van den Borne","year":"2010","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","article-title":"Redefining the identity of cardiac fibroblasts","volume":"14","author":"Tallquist","year":"2017","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.bpj.2018.08.050_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","article-title":"Myofibroblast-mediated mechanisms of pathological remodelling of the heart","volume":"10","author":"Weber","year":"2013","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib14","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1021\/ac3022532","article-title":"Characterization of the mechanodynamic response of cardiomyocytes with atomic force microscopy","volume":"85","author":"Chang","year":"2013","journal-title":"Anal. Chem"},{"key":"10.1016\/j.bpj.2018.08.050_bib15","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1529\/biophysj.107.124545","article-title":"Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes","volume":"95","author":"Jacot","year":"2008","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.08.050_bib16","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.bpj.2011.09.057","article-title":"Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium","volume":"101","author":"Rodriguez","year":"2011","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.08.050_bib17","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1021\/acsbiomaterials.6b00576","article-title":"Fibroblasts slow conduction velocity in a reconstituted tissue model of fibrotic cardiomyopathy","volume":"3","author":"Spencer","year":"2016","journal-title":"ACS Biomater. Sci. Eng"},{"key":"10.1016\/j.bpj.2018.08.050_bib18","doi-asserted-by":"crossref","first-page":"150038","DOI":"10.1098\/rsob.150038","article-title":"Crosstalk of cardiomyocytes and fibroblasts in co-cultures","volume":"5","author":"Rother","year":"2015","journal-title":"Open Biol"},{"key":"10.1016\/j.bpj.2018.08.050_bib19","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1161\/CIRCULATIONAHA.110.015057","article-title":"Mechanical coupling between myofibroblasts and cardiomyocytes slows electric conduction in fibrotic cell monolayers","volume":"123","author":"Thompson","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2018.08.050_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.hrthm.2011.10.002","article-title":"Fibroblast-myocyte connections in the heart","volume":"9","author":"Kohl","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2018.08.050_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.lfs.2011.12.009","article-title":"Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias?","volume":"90","author":"Mezzano","year":"2012","journal-title":"Life Sci"},{"key":"10.1016\/j.bpj.2018.08.050_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yjmcc.2013.12.025","article-title":"Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin","volume":"68","author":"Thompson","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib23","article-title":"Modulation of the contractility of micropatterned myocardial cells with nanoscale forces using atomic force microscopy","volume":"3","author":"Nagarajan","year":"2016","journal-title":"Nanobiomedicine (Rij)"},{"key":"10.1016\/j.bpj.2018.08.050_bib24","doi-asserted-by":"crossref","first-page":"e37559","DOI":"10.1371\/journal.pone.0037559","article-title":"Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2018.08.050_bib25","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1016\/j.jbiomech.2016.09.020","article-title":"Guidelines for an optimized indentation protocol for measurement of cartilage stiffness: the effects of spatial variation and indentation parameters","volume":"49","author":"Moshtagh","year":"2016","journal-title":"J.\u00a0Biomech"},{"key":"10.1016\/j.bpj.2018.08.050_bib26","doi-asserted-by":"crossref","first-page":"025009","DOI":"10.1088\/1748-605X\/aa5d5c","article-title":"3D hydrogel-based microwell arrays as a tumor microenvironment model to study breast cancer growth","volume":"12","author":"Casey","year":"2017","journal-title":"Biomed. Mater"},{"key":"10.1016\/j.bpj.2018.08.050_bib27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jmbbm.2015.05.003","article-title":"Microscale consolidation analysis of relaxation behavior of single living chondrocytes subjected to varying strain-rates","volume":"49","author":"Nguyen","year":"2015","journal-title":"J.\u00a0Mech. Behav. Biomed. Mater"},{"key":"10.1016\/j.bpj.2018.08.050_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4939-7113-8_9","article-title":"Modeling cardiac fibrosis in mice: (myo)fibroblast phenotype after ischemia","volume":"1627","author":"Fraccarollo","year":"2017","journal-title":"Methods Mol. Biol"},{"key":"10.1016\/j.bpj.2018.08.050_bib29","doi-asserted-by":"crossref","first-page":"1600035","DOI":"10.1002\/adbi.201600035","article-title":"Muscle-cell-based \u201cliving diodes\u201d","volume":"1","author":"Can","year":"2017","journal-title":"Adv. Biosyst"},{"key":"10.1016\/j.bpj.2018.08.050_bib30","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1039\/C6LC00681G","article-title":"Development and characterization of muscle-based actuators for self-stabilizing swimming biorobots","volume":"16","author":"Holley","year":"2016","journal-title":"Lab Chip"},{"key":"10.1016\/j.bpj.2018.08.050_bib31","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1073\/pnas.93.9.4219","article-title":"Myofibroblasts differentiate from fibroblasts when plated at low density","volume":"93","author":"Masur","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2018.08.050_bib32","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/dvdy.22280","article-title":"Cardiac fibroblast to myofibroblast differentiation in\u00a0vivo and in\u00a0vitro: expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts","volume":"239","author":"Santiago","year":"2010","journal-title":"Dev. Dyn"},{"key":"10.1016\/j.bpj.2018.08.050_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1063\/1.4876056","article-title":"Exploration of mechanisms underlying the strain-rate-dependent mechanical property of single chondrocytes","volume":"104","author":"Nguyen","year":"2014","journal-title":"Appl. Phys. Lett"},{"key":"10.1016\/j.bpj.2018.08.050_bib34","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jbiomech.2007.06.019","article-title":"Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes","volume":"41","author":"Darling","year":"2008","journal-title":"J.\u00a0Biomech"},{"key":"10.1016\/j.bpj.2018.08.050_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/2004\/482680","article-title":"Single-cell elastography: probing for disease with the atomic force microscope","volume":"19","author":"Costa","year":"2003","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bpj.2018.08.050_bib36","series-title":"Atomic Force Microscopy Indentation of Living Cells, Microscopy: Science, Technology, Applications and Education","first-page":"433","author":"Sirghi","year":"2010"},{"key":"10.1016\/j.bpj.2018.08.050_bib37","doi-asserted-by":"crossref","first-page":"38059","DOI":"10.1038\/srep38059","article-title":"Investigation of cell-substrate adhesion properties of living chondrocyte by measuring adhesive shear force and detachment using AFM and inverse FEA","volume":"6","author":"Nguyen","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1016\/j.bpj.2018.08.050_bib38","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1039\/c2sm26348c","article-title":"Influence of cell spreading and contractility on stiffness measurements using AFM","volume":"8","author":"Vichare","year":"2012","journal-title":"Soft Matter"},{"issue":"Suppl. 1","key":"10.1016\/j.bpj.2018.08.050_bib39","first-page":"1","article-title":"Analysis of strain-rate dependent mechanical behavior of single chondrocyte: a finite element study","volume":"11","author":"Nguyen","year":"2014","journal-title":"Int. J. Comput. Methods"},{"key":"10.1016\/j.bpj.2018.08.050_bib40","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/10255842.2014.996875","article-title":"A poroviscohyperelastic model for numerical analysis of mechanical behavior of single chondrocyte","volume":"19","author":"Nguyen","year":"2016","journal-title":"Comput. Methods Biomech. Biomed. Engin"},{"key":"10.1016\/j.bpj.2018.08.050_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12013-016-0721-1","article-title":"Investigation of the effects of extracellular osmotic pressure on morphology and mechanical properties of individual chondrocyte","volume":"74","author":"Nguyen","year":"2016","journal-title":"Cell Biochem. Biophys"},{"key":"10.1016\/j.bpj.2018.08.050_bib42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jmbbm.2015.07.018","article-title":"Investigation of the mechanical behavior of kangaroo humeral head cartilage tissue by a porohyperelastic model based on the strain-rate-dependent permeability","volume":"51","author":"Thibbotuwawa","year":"2015","journal-title":"J.\u00a0Mech. Behav. Biomed. Mater"},{"key":"10.1016\/j.bpj.2018.08.050_bib43","series-title":"1989 Advances in Bioengineering","first-page":"97","article-title":"Total Lagrangian \u201cporohyperelastic\u201d finite element models of soft tissue undergoing finite strain.pdf","author":"Simon","year":"1989"},{"key":"10.1016\/j.bpj.2018.08.050_bib44","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1529\/biophysj.106.101386","article-title":"Fibroblast adaptation and stiffness matching to soft elastic substrates","volume":"93","author":"Solon","year":"2007","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.08.050_bib45","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/03008209209006997","article-title":"The dramatic influence of loading velocity on the compressive response of articular cartilage","volume":"27","author":"Oloyede","year":"1992","journal-title":"Connective Tissue Research"},{"key":"10.1016\/j.bpj.2018.08.050_bib46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s10237-012-0413-8","article-title":"Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics","volume":"11","author":"Majkut","year":"2012","journal-title":"Biomech. Model. Mechanobiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib47","doi-asserted-by":"crossref","first-page":"051005","DOI":"10.1115\/1.4027145","article-title":"Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts","volume":"136","author":"Rodriguez","year":"2014","journal-title":"J.\u00a0Biomech. Eng"},{"key":"10.1016\/j.bpj.2018.08.050_bib48","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/s41467-017-02032-y","article-title":"Broad modulus range nanomechanical mapping by magnetic-drive soft probes","volume":"8","author":"Meng","year":"2017","journal-title":"Nat. Commun"},{"key":"10.1016\/j.bpj.2018.08.050_bib49","doi-asserted-by":"crossref","first-page":"054001","DOI":"10.1063\/2.1405401","article-title":"Stress relaxation analysis of single chondrocytes using porohyperelastic model based on AFM experiments","volume":"4","author":"Nguyen","year":"2014","journal-title":"Theoretical and Applied Mechanics Letters"},{"key":"10.1016\/j.bpj.2018.08.050_bib50","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.1073\/pnas.1203007109","article-title":"Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle","volume":"109","author":"McCain","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2018.08.050_bib51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/ten.teb.2014.0383","article-title":"Effect of substrate mechanics on cardiomyocyte maturation and growth","volume":"21","author":"Tallawi","year":"2015","journal-title":"Tissue Eng. Part B Rev"},{"key":"10.1016\/j.bpj.2018.08.050_bib52","doi-asserted-by":"crossref","first-page":"e0175324","DOI":"10.1371\/journal.pone.0175324","article-title":"Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behavior","volume":"12","author":"Omachi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2018.08.050_bib53","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00424-011-0931-8","article-title":"Micromechanical regulation in cardiac myocytes and fibroblasts: implications for tissue remodeling","volume":"462","author":"Curtis","year":"2011","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.bpj.2018.08.050_bib54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.carpath.2012.10.003","article-title":"Substrate stiffness affects sarcomere and costamere structure and electrophysiological function of isolated adult cardiomyocytes","volume":"22","author":"Galie","year":"2013","journal-title":"Cardiovasc. Pathol"},{"key":"10.1016\/j.bpj.2018.08.050_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cm.20041","article-title":"Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion","volume":"60","author":"Yeung","year":"2005","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.bpj.2018.08.050_bib56","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bpj.2012.07.023","article-title":"Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions","volume":"103","author":"Han","year":"2012","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2018.08.050_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2013.12.020","article-title":"Influence of mechanical stress on fibroblast-myocyte interactions in mammalian heart","volume":"70","author":"Abramochkin","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib58","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/jbm.b.33244","article-title":"Fibroblast extracellular matrix and adhesion on microtextured polydimethylsiloxane scaffolds","volume":"103","author":"Stanton","year":"2015","journal-title":"J.\u00a0Biomed. Mater. Res. B Appl. Biomater"},{"key":"10.1016\/j.bpj.2018.08.050_bib59","doi-asserted-by":"crossref","first-page":"1601434","DOI":"10.1002\/adhm.201601434","article-title":"Engineered 3D cardiac fibrotic tissue to study fibrotic remodeling","volume":"6","author":"Sadeghi","year":"2017","journal-title":"Adv. Healthc. Mater"},{"key":"10.1016\/j.bpj.2018.08.050_bib60","doi-asserted-by":"crossref","first-page":"508294","DOI":"10.1155\/2012\/508294","article-title":"Effects of substrate mechanics on contractility of cardiomyocytes generated from human pluripotent stem cells","volume":"2012","author":"Hazeltine","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.bpj.2018.08.050_bib61","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2170\/jjphysiol.35.831","article-title":"Anisotropic elasticity of bovine pericardial tissues","volume":"35","author":"Radjeman","year":"1985","journal-title":"Jpn. J. Physiol"},{"key":"10.1016\/j.bpj.2018.08.050_bib62","doi-asserted-by":"crossref","first-page":"101004","DOI":"10.1115\/1.4028098","article-title":"Determination of strain-rate-dependent mechanical behavior of living and fixed osteocytes and chondrocytes using atomic force microscopy and inverse finite element analysis","volume":"136","author":"Nguyen","year":"2014","journal-title":"J.\u00a0Biomech. Eng"},{"key":"10.1016\/j.bpj.2018.08.050_bib63","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.1073\/pnas.1520428113","article-title":"Mechanical signaling coordinates the embryonic heartbeat","volume":"113","author":"Chiou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2018.08.050_bib64","series-title":"The 15th International Conference on Biomedical Engineering","first-page":"56","article-title":"Porohyperelastic analysis of single osteocyte using AFM and inverse FEA","author":"Nguyen","year":"2014"},{"key":"10.1016\/j.bpj.2018.08.050_bib65","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1115\/1.2798315","article-title":"Porohyperelastic finite element analysis of large arteries using ABAQUS","volume":"120","author":"Simon","year":"1998","journal-title":"J.\u00a0Biomech. Eng"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349518311081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349518311081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T05:36:38Z","timestamp":1589952998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349518311081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0006349518311081"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2018.08.050","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Substrate Stiffness on Mechanical Coupling and Force Propagation at the Infarct Boundary","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2018.08.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Biophysical Society.","name":"copyright","label":"Copyright"}]}}