{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:37:46Z","timestamp":1788327466937,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010263","name":"DuPont Pioneer","doi-asserted-by":"publisher","award":["U01 HL141074"],"award-info":[{"award-number":["U01 HL141074"]}],"id":[{"id":"10.13039\/100010263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010263","name":"DuPont Pioneer","doi-asserted-by":"publisher","award":["R01 HL126802"],"award-info":[{"award-number":["R01 HL126802"]}],"id":[{"id":"10.13039\/100010263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010263","name":"DuPont Pioneer","doi-asserted-by":"publisher","award":["DP1-HL123271"],"award-info":[{"award-number":["DP1-HL123271"]}],"id":[{"id":"10.13039\/100010263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL126802"],"award-info":[{"award-number":["R01 HL126802"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP1-HL123271"],"award-info":[{"award-number":["DP1-HL123271"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL141074"],"award-info":[{"award-number":["U01 HL141074"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002980","name":"Dalian University of Technology","doi-asserted-by":"publisher","award":["DUT18RC(3)068"],"award-info":[{"award-number":["DUT18RC(3)068"]}],"id":[{"id":"10.13039\/501100002980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bpj.2019.07.024","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T19:28:45Z","timestamp":1563823725000},"page":"2287-2294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Characterizing Conduction Channels in Postinfarction Patients Using a Personalized Virtual\u00a0Heart"],"prefix":"10.1016","volume":"117","author":[{"given":"Dongdong","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adityo","family":"Prakosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Shade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Plamen","family":"Nikolov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Trayanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2019.07.024_bib1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/CIRCEP.113.000264","article-title":"Three-dimensional architecture of scar and conducting channels based on high resolution ce-CMR: insights for ventricular tachycardia ablation","volume":"6","author":"Fern\u00e1ndsez-Armenta","year":"2013","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCULATIONAHA.116.021955","article-title":"High-resolution mapping of postinfarction reentrant ventricular tachycardia: electrophysiological\u00a0characterization of the circuit","volume":"134","author":"Anter","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2019.07.024_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jacc.2010.07.043","article-title":"Noninvasive identification of ventricular tachycardia-related conducting channels using contrast-enhanced magnetic resonance imaging in patients with chronic myocardial infarction: comparison of signal intensity scar mapping and endocardial voltage mapping","volume":"57","author":"Perez-David","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib4","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.hrthm.2011.07.027","article-title":"The critical isthmus sites of ischemic ventricular tachycardia are in zones of tissue\u00a0heterogeneity, visualized by magnetic resonance imaging","volume":"8","author":"Estner","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib5","doi-asserted-by":"crossref","first-page":"e006569","DOI":"10.1161\/CIRCEP.118.006569","article-title":"Characteristics of scar-related ventricular tachycardia circuits using ultra-high-density mapping","volume":"11","author":"Martin","year":"2018","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.hrthm.2007.01.033","article-title":"On the accuracy of CartoMerge for guiding posterior left atrial ablation in man","volume":"4","author":"Zhong","year":"2007","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib7","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0735-1097(03)00398-X","article-title":"Nonsurgical transthoracic epicardial radiofrequency ablation: an alternative in incessant ventricular tachycardia","volume":"41","author":"Brugada","year":"2003","journal-title":"J.\u00a0Am. Coll. Cardiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib8","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/S0735-1097(00)00606-9","article-title":"Nonsurgical transthoracic epicardial catheter ablation to treat recurrent ventricular tachycardia occurring late after myocardial infarction","volume":"35","author":"Sosa","year":"2000","journal-title":"J.\u00a0Am. Coll. Cardiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/j.1540-8167.2007.00956.x","article-title":"Impact of heart rhythm status on registration accuracy of the left atrium for catheter ablation of atrial fibrillation","volume":"18","author":"Dong","year":"2007","journal-title":"J.\u00a0Cardiovasc. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib10","doi-asserted-by":"crossref","first-page":"e006131","DOI":"10.1161\/CIRCEP.117.006131","article-title":"Role of 3-dimensional architecture of scar and surviving tissue in ventricular tachycardia: insights from high-resolution ex\u00a0vivo porcine models","volume":"11","author":"Pashakhanloo","year":"2018","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.CIR.77.3.589","article-title":"Reentry as a\u00a0cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation","volume":"77","author":"de Bakker","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2019.07.024_bib12","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1161\/01.CIR.97.17.1746","article-title":"Myocardial architecture and ventricular arrhythmogenesis","volume":"97","author":"Peters","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2019.07.024_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/CIRCRESAHA.107.158980","article-title":"Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation","volume":"101","author":"Ashikaga","year":"2007","journal-title":"Circ. Res"},{"key":"10.1016\/j.bpj.2019.07.024_bib14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.hrthm.2011.02.029","article-title":"Characterization of myocardial scars: electrophysiological imaging correlates in a porcine infarct model","volume":"8","author":"Nakahara","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCEP.111.961946","article-title":"Integration of 3D electroanatomic maps and magnetic resonance scar characterization into the navigation system to guide ventricular tachycardia ablation","volume":"4","author":"Andreu","year":"2011","journal-title":"Circ. Arrhythm. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib16","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/europace\/euu310","article-title":"3D delayed-enhanced magnetic resonance sequences improve conducting channel delineation prior to ventricular tachycardia ablation","volume":"17","author":"Andreu","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.bpj.2019.07.024_bib17","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1038\/ncomms11437","article-title":"Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models","volume":"7","author":"Arevalo","year":"2016","journal-title":"Nat. Commun"},{"key":"10.1016\/j.bpj.2019.07.024_bib18","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.hrthm.2014.05.018","article-title":"Image-based left ventricular shape analysis for sudden cardiac death risk stratification","volume":"11","author":"Vadakkumpadan","year":"2014","journal-title":"Heart Rhythm"},{"issue":"Suppl 4","key":"10.1016\/j.bpj.2019.07.024_bib19","doi-asserted-by":"crossref","first-page":"iv60","DOI":"10.1093\/europace\/euw351","article-title":"A feasibility study of arrhythmia risk prediction in patients with myocardial infarction and preserved ejection fraction","volume":"18","author":"Deng","year":"2016","journal-title":"Europace"},{"key":"10.1016\/j.bpj.2019.07.024_bib20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fphys.2015.00282","article-title":"Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI","volume":"6","author":"Deng","year":"2015","journal-title":"Front. Physiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.hrthm.2013.04.015","article-title":"Feasibility of image-based simulation to estimate ablation target in human ventricular arrhythmia","volume":"10","author":"Ashikaga","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cvr\/cvw073","article-title":"Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern","volume":"110","author":"Zahid","year":"2016","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.bpj.2019.07.024_bib23","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.hrthm.2016.04.009","article-title":"Feasibility of using patient-specific models and the \u201cminimum cut\u201d algorithm to predict optimal ablation targets for left atrial flutter","volume":"13","author":"Zahid","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib24","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41551-018-0282-2","article-title":"Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia","volume":"2","author":"Prakosa","year":"2018","journal-title":"Nat. Biomed. Eng"},{"key":"10.1016\/j.bpj.2019.07.024_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pbiomolbio.2014.08.009","article-title":"Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology","volume":"115","author":"Prakosa","year":"2014","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/j.bpj.2019.07.024_bib26","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1109\/TBME.2009.2014243","article-title":"Automatically generated, anatomically accurate meshes for cardiac electrophysiology problems","volume":"56","author":"Prassl","year":"2009","journal-title":"IEEE Trans. Biomed. Eng"},{"key":"10.1016\/j.bpj.2019.07.024_bib27","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s10439-012-0593-5","article-title":"A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models","volume":"40","author":"Bayer","year":"2012","journal-title":"Ann. Biomed. Eng"},{"key":"10.1016\/j.bpj.2019.07.024_bib28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jacc.2012.05.022","article-title":"Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial","volume":"60","author":"Narayan","year":"2012","journal-title":"J.\u00a0Am. Coll. Cardiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib29","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jacep.2018.04.007","article-title":"Infarct-related ventricular tachycardia: redefining the electrophysiological substrate of the isthmus during sinus rhythm","volume":"4","author":"Anter","year":"2018","journal-title":"JACC Clin. Electrophysiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib30","doi-asserted-by":"crossref","first-page":"e68872","DOI":"10.1371\/journal.pone.0068872","article-title":"Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models","volume":"8","author":"Arevalo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2019.07.024_bib31","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41551-018-0282-2","article-title":"Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia","volume":"2","author":"Prakosa","year":"2018","journal-title":"Nat. Biomed. Eng"},{"key":"10.1016\/j.bpj.2019.07.024_bib32","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.hrthm.2007.04.015","article-title":"Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping","volume":"4","author":"Ciaccio","year":"2007","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2019.07.024_bib33","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3389\/fphys.2019.00628","article-title":"Sensitivity of ablation\u00a0targets prediction to electrophysiological parameter variability in image-based computational models of ventricular tachycardia in post-infarction patients","volume":"10","author":"Deng","year":"2019","journal-title":"Front. Physiol"},{"key":"10.1016\/j.bpj.2019.07.024_bib34","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.CIR.88.3.915","article-title":"Slow conduction in the infarcted human heart. \u2018Zigzag\u2019 course of activation","volume":"88","author":"de Bakker","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2019.07.024_bib35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.hrthm.2015.07.030","article-title":"A swine model of infarct-related reentrant ventricular tachycardia: electroanatomic, magnetic resonance, and histopathological characterization","volume":"13","author":"Tschabrunn","year":"2016","journal-title":"Heart Rhythm"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349519305922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349519305922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:05:46Z","timestamp":1777403146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349519305922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0006349519305922"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2019.07.024","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing Conduction Channels in Postinfarction Patients Using a Personalized Virtual\u00a0Heart","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2019.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Biophysical Society.","name":"copyright","label":"Copyright"}]}}