{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:06:28Z","timestamp":1792613188515,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bpj.2019.11.008","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T19:56:57Z","timestamp":1573847817000},"page":"138-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Polymyxin B Loosens Lipopolysaccharide Bilayer but Stiffens Phospholipid Bilayer"],"prefix":"10.1016","volume":"118","author":[{"given":"Lei","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-3671","authenticated-orcid":false,"given":"Lianghui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihai","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2019.11.008_bib1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1345\/aph.18426","article-title":"Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria","volume":"33","author":"Evans","year":"1999","journal-title":"Ann. Pharmacother"},{"key":"10.1016\/j.bpj.2019.11.008_bib2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1086\/506571","article-title":"Old polymyxins are back: is resistance close?","volume":"43","author":"Li","year":"2006","journal-title":"Clin. Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijantimicag.2004.10.001","article-title":"Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria","volume":"25","author":"Li","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bpj.2019.11.008_bib4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1086\/520658","article-title":"Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains","volume":"45","author":"Li","year":"2007","journal-title":"Clin. Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1473-3099(06)70580-1","article-title":"Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections","volume":"6","author":"Li","year":"2006","journal-title":"Lancet Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib6","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1021\/jm900999h","article-title":"Structure--activity relationships of polymyxin antibiotics","volume":"53","author":"Velkov","year":"2010","journal-title":"J.\u00a0Med. Chem"},{"key":"10.1016\/j.bpj.2019.11.008_bib7","doi-asserted-by":"crossref","first-page":"742","DOI":"10.7164\/antibiotics.45.742","article-title":"Polymyxin B octapeptide and polymyxin B heptapeptide are potent outer membrane permeability-increasing agents","volume":"45","author":"Kimura","year":"1992","journal-title":"J.\u00a0Antibiot. (Tokyo)"},{"key":"10.1016\/j.bpj.2019.11.008_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1146\/annurev.bi.46.070177.003451","article-title":"Polymyxin and related peptide antibiotics","volume":"46","author":"Storm","year":"1977","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.bpj.2019.11.008_bib9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.7164\/antibiotics.30.1087","article-title":"Disruption of the Escherichia coli outer membrane permeability barrier by immobilized polymyxin B","volume":"30","author":"Rosenthal","year":"1977","journal-title":"J.\u00a0Antibiot. (Tokyo)"},{"key":"10.1016\/j.bpj.2019.11.008_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/acsinfecdis.5b00085","article-title":"Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: last-line antibiotics against multidrug-resistant gram-negative bacteria","volume":"1","author":"Roberts","year":"2015","journal-title":"ACS Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1021\/acs.jmedchem.5b01593","article-title":"Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B","volume":"59","author":"Gallardo-Godoy","year":"2016","journal-title":"J.\u00a0Med. Chem"},{"key":"10.1016\/j.bpj.2019.11.008_bib13","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/acsmedchemlett.9b00135","article-title":"Second-generation tryptamine derivatives potently sensitize colistin resistant bacteria to colistin","volume":"10","author":"Minrovic","year":"2019","journal-title":"ACS Med. Chem. Lett"},{"key":"10.1016\/j.bpj.2019.11.008_bib14","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1021\/acsinfecdis.8b00103","article-title":"New class of adjuvants enables lower dosing of colistin against Acinetobacter baumannii","volume":"4","author":"Minrovic","year":"2018","journal-title":"ACS Infect. Dis"},{"key":"10.1016\/j.bpj.2019.11.008_bib15","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1021\/acs.jmedchem.7b01367","article-title":"Synthesis and bioactivity investigation of the individual components of cyclic lipopeptide antibiotics","volume":"61","author":"Cui","year":"2018","journal-title":"J.\u00a0Med. Chem"},{"key":"10.1016\/j.bpj.2019.11.008_bib16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/jb.97.1.448-452.1969","article-title":"Electron microscopic studies on mode of action of polymyxin","volume":"97","author":"Koike","year":"1969","journal-title":"J.\u00a0Bacteriol"},{"key":"10.1016\/j.bpj.2019.11.008_bib17","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/AAC.44.12.3317-3321.2000","article-title":"Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa","volume":"44","author":"Zhang","year":"2000","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bpj.2019.11.008_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.mi.38.100184.001321","article-title":"Alterations in outer membrane permeability","volume":"38","author":"Hancock","year":"1984","journal-title":"Annu. Rev. Microbiol"},{"key":"10.1016\/j.bpj.2019.11.008_bib19","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/AAC.19.5.777","article-title":"Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa","volume":"19","author":"Hancock","year":"1981","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bpj.2019.11.008_bib20","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/AAC.43.6.1317","article-title":"Peptide antibiotics","volume":"43","author":"Hancock","year":"1999","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bpj.2019.11.008_bib21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0140-6736(97)80051-7","article-title":"Peptide antibiotics","volume":"349","author":"Hancock","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bpj.2019.11.008_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0065-2911(08)60145-9","article-title":"Cationic bactericidal peptides","volume":"37","author":"Hancock","year":"1995","journal-title":"Adv. Microb. Physiol"},{"key":"10.1016\/j.bpj.2019.11.008_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1021\/jp064757+","article-title":"Gram-negative outer and inner membrane models: insertion of cyclic cationic lipopeptides","volume":"111","author":"Clausell","year":"2007","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.bpj.2019.11.008_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1021\/bi9512408","article-title":"Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipids","volume":"35","author":"Cajal","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib25","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1021\/bi952703c","article-title":"Specificity for the exchange of phospholipids through polymyxin B mediated intermembrane molecular contacts","volume":"35","author":"Cajal","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bpj.2019.11.008_bib27","doi-asserted-by":"crossref","first-page":"e1004180","DOI":"10.1371\/journal.pcbi.1004180","article-title":"Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E.\u00a0coli: a molecular dynamics study","volume":"11","author":"Berglund","year":"2015","journal-title":"PLoS Comput. Biol"},{"key":"10.1016\/j.bpj.2019.11.008_bib28","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/acs.biochem.6b01063","article-title":"Through the lipopolysaccharide glass: a potent antimicrobial peptide induces phase changes in membranes","volume":"56","author":"Jefferies","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s42003-019-0297-6","article-title":"Membrane charge and lipid packing determine polymyxin-induced membrane damage","volume":"2","author":"Khondker","year":"2019","journal-title":"Commun Biol"},{"key":"10.1016\/j.bpj.2019.11.008_bib30","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/acs.jcim.7b00271","article-title":"Polymyxin binding to the bacterial outer membrane reveals cation displacement and increasing membrane curvature in susceptible but not in resistant lipopolysaccharide chemotypes","volume":"57","author":"Santos","year":"2017","journal-title":"J.\u00a0Chem. Inf. Model"},{"key":"10.1016\/j.bpj.2019.11.008_bib31","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1021\/jm991031b","article-title":"Solution structure of polymyxins B\u00a0and E and effect of binding to lipopolysaccharide: an NMR and molecular modeling study","volume":"42","author":"Pristovsek","year":"1999","journal-title":"J.\u00a0Med. Chem"},{"key":"10.1016\/j.bpj.2019.11.008_bib32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/ct300646g","article-title":"Improved parameters for the Martini coarse-grained protein force field","volume":"9","author":"de Jong","year":"2013","journal-title":"J.\u00a0Chem. Theory Comput"},{"key":"10.1016\/j.bpj.2019.11.008_bib33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1021\/ct700324x","article-title":"The MARTINI coarse-grained force field: extension to proteins","volume":"4","author":"Monticelli","year":"2008","journal-title":"J.\u00a0Chem. Theory Comput"},{"key":"10.1016\/j.bpj.2019.11.008_bib34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/jp036508g","article-title":"Coarse grained model for semiquantitative lipid simulations","volume":"108","author":"Marrink","year":"2004","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.bpj.2019.11.008_bib35","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1021\/ct900654e","article-title":"Mechanical properties of coarse-grained bilayers formed by cardiolipin and zwitterionic lipids","volume":"6","author":"Dahlberg","year":"2010","journal-title":"J.\u00a0Chem. Theory Comput"},{"key":"10.1016\/j.bpj.2019.11.008_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1128\/br.38.1.87-110.1974","article-title":"Structure and function of the cell envelope of gram-negative bacteria","volume":"38","author":"Costerton","year":"1974","journal-title":"Bacteriol. Rev"},{"key":"10.1016\/j.bpj.2019.11.008_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-4157(83)90014-X","article-title":"Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria","volume":"737","author":"Lugtenberg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2019.11.008_bib38","doi-asserted-by":"crossref","first-page":"11170","DOI":"10.1021\/acs.jpcb.6b06615","article-title":"Molecular dynamics simulations predict the pathways via which pristine fullerenes penetrate bacterial membranes","volume":"120","author":"Hsu","year":"2016","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.bpj.2019.11.008_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.bi.59.070190.001021","article-title":"Biochemistry of endotoxins","volume":"59","author":"Raetz","year":"1990","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.bpj.2019.11.008_bib40","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.bpj.2019.11.008_bib41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s008940100045","article-title":"GROMACS 3.0: a package for molecular simulation and trajectory analysis","volume":"7","author":"Lindahl","year":"2001","journal-title":"J.\u00a0Mol. Model"},{"key":"10.1016\/j.bpj.2019.11.008_bib42","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J.\u00a0Comput. Chem"},{"key":"10.1016\/j.bpj.2019.11.008_bib43","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J.\u00a0Chem. Theory Comput"},{"key":"10.1016\/j.bpj.2019.11.008_bib44","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","article-title":"GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bpj.2019.11.008_bib45","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J.\u00a0Appl. Phys"},{"key":"10.1016\/j.bpj.2019.11.008_bib46","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/00268978300102851","article-title":"Constant pressure molecular dynamics for molecular systems","volume":"50","author":"Nos\u00e9","year":"1983","journal-title":"Mol. Phys"},{"key":"10.1016\/j.bpj.2019.11.008_bib47","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1063\/1.449071","article-title":"The Nose-Hoover thermostat","volume":"83","author":"Evans","year":"1985","journal-title":"J.\u00a0Chem. Phys"},{"key":"10.1016\/j.bpj.2019.11.008_bib48","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.bpj.2012.11.3837","article-title":"Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues","volume":"104","author":"Vanni","year":"2013","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib49","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bpj.2012.11.3836","article-title":"Conical lipids in flat bilayers induce packing defects similar to that induced by positive curvature","volume":"104","author":"Vamparys","year":"2013","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib50","doi-asserted-by":"crossref","first-page":"13381","DOI":"10.1021\/jp207013v","article-title":"Electroporation of the E.\u00a0coli and S. Aureus membranes: molecular dynamics simulations of complex bacterial membranes","volume":"115","author":"Piggot","year":"2011","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.bpj.2019.11.008_bib51","doi-asserted-by":"crossref","first-page":"e1003911","DOI":"10.1371\/journal.pcbi.1003911","article-title":"Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers","volume":"10","author":"Kolds\u00f8","year":"2014","journal-title":"PLoS Comput. Biol"},{"key":"10.1016\/j.bpj.2019.11.008_bib52","doi-asserted-by":"crossref","first-page":"028102","DOI":"10.1103\/PhysRevLett.109.028102","article-title":"Determining biomembrane bending rigidities from simulations of modest size","volume":"109","author":"Watson","year":"2012","journal-title":"Phys. Rev. Lett"},{"key":"10.1016\/j.bpj.2019.11.008_bib53","doi-asserted-by":"crossref","first-page":"13582","DOI":"10.1021\/ja507910r","article-title":"Determination of biomembrane bending moduli in fully atomistic simulations","volume":"136","author":"Levine","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc"},{"key":"10.1016\/j.bpj.2019.11.008_bib54","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.bpj.2018.08.040","article-title":"Peptide-lipid interaction sites affect vesicles\u2019 responses to antimicrobial peptides","volume":"115","author":"Shi","year":"2018","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib55","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/039139880602900210","article-title":"Multi-scale analysis of the toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins","volume":"29","author":"Vesentini","year":"2006","journal-title":"Int. J. Artif. Organs"},{"key":"10.1016\/j.bpj.2019.11.008_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583500000123","article-title":"Electrically gated ionic channels in lipid bilayers","volume":"10","author":"Ehrenstein","year":"1977","journal-title":"Q.\u00a0Rev. Biophys"},{"key":"10.1016\/j.bpj.2019.11.008_bib57","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0006-3495(00)76448-4","article-title":"Crystallization of antimicrobial pores in membranes: magainin and protegrin","volume":"79","author":"Yang","year":"2000","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib58","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbamem.2012.11.033","article-title":"Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV","volume":"1828","author":"Bobone","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2019.11.008_bib59","doi-asserted-by":"crossref","first-page":"12416","DOI":"10.1021\/bi00164a017","article-title":"Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes","volume":"31","author":"Pouny","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib60","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/pro.5560021208","article-title":"Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy","volume":"2","author":"Bechinger","year":"1993","journal-title":"Protein Sci"},{"key":"10.1016\/j.bpj.2019.11.008_bib61","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1021\/bi00177a027","article-title":"Orientational and aggregational states of magainin 2 in phospholipid bilayers","volume":"33","author":"Matsuzaki","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib62","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1128\/AAC.00209-09","article-title":"Peptide-lipid huge toroidal pore, a new antimicrobial mechanism mediated by a lactococcal bacteriocin, lacticin Q","volume":"53","author":"Yoneyama","year":"2009","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.bpj.2019.11.008_bib63","doi-asserted-by":"crossref","first-page":"11361","DOI":"10.1021\/bi960016v","article-title":"An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation","volume":"35","author":"Matsuzaki","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2019.11.008_bib64","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1021\/acsomega.8b00483","article-title":"Insights into membrane translocation of protegrin antimicrobial peptides by multistep molecular dynamics simulations","volume":"3","author":"Lai","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.bpj.2019.11.008_bib65","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-3495(92)81763-0","article-title":"Structure and interactions of magainin antibiotic peptides in lipid bilayers: a solid-state nuclear magnetic resonance investigation","volume":"62","author":"Bechinger","year":"1992","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib66","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1021\/la803898g","article-title":"Effects of colistin on surface ultrastructure and nanomechanics of Pseudomonas aeruginosa cells","volume":"25","author":"Mortensen","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.bpj.2019.11.008_bib67","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ijantimicag.2011.07.014","article-title":"Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy","volume":"38","author":"Soon","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bpj.2019.11.008_bib68","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bpj.2017.12.027","article-title":"Selective interaction of colistin with lipid model membranes","volume":"114","author":"Dupuy","year":"2018","journal-title":"Biophys. J"},{"key":"10.1016\/j.bpj.2019.11.008_bib69","series-title":"Biochemistry","author":"Berg","year":"2015"},{"key":"10.1016\/j.bpj.2019.11.008_bib70","doi-asserted-by":"crossref","first-page":"e0187936","DOI":"10.1371\/journal.pone.0187936","article-title":"Excessive aggregation of membrane proteins in the Martini model","volume":"12","author":"Javanainen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2019.11.008_bib71","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1006\/bbrc.1995.1722","article-title":"Direct vesicle-vesicle exchange of phospholipids mediated by polymyxin B","volume":"210","author":"Cajal","year":"1995","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.bpj.2019.11.008_bib72","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/bip.20165","article-title":"Polymyxin B-lipid interactions in Langmuir-Blodgett monolayers of Escherichia coli lipids: a thermodynamic and atomic force microscopy study","volume":"75","author":"Clausell","year":"2004","journal-title":"Biopolymers"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349519309312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349519309312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:40:41Z","timestamp":1757781641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349519309312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0006349519309312"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2019.11.008","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymyxin B Loosens Lipopolysaccharide Bilayer but Stiffens Phospholipid Bilayer","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2019.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Biophysical Society.","name":"copyright","label":"Copyright"}]}}