{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:03:55Z","timestamp":1788577435624,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL105239"],"award-info":[{"award-number":["R01HL105239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.bpj.2023.09.001","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T20:00:24Z","timestamp":1694548824000},"page":"4042-4056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Estimating the probability of early afterdepolarizations and predicting arrhythmic risk associated with long QT syndrome type 1 mutations"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-1805","authenticated-orcid":false,"given":"Qingchu","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Greenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimond L.","family":"Winslow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2023.09.001_bib1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/wsbm.122","article-title":"Integrative modeling of the cardiac ventricular myocyte","volume":"3","author":"Winslow","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.bpj.2023.09.001_bib2","doi-asserted-by":"crossref","first-page":"H921","DOI":"10.1152\/ajpheart.01055.2010","article-title":"Ca(2)(+)-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2(2)(+) affirming that increasing SERCA reduces aftercontractions","volume":"301","author":"Fink","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib3","doi-asserted-by":"crossref","first-page":"76ra28","DOI":"10.1126\/scitranslmed.3001551","article-title":"Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients","volume":"3","author":"Jons","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bpj.2023.09.001_bib4","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.102.258103","article-title":"Bifurcation and chaos in a model of cardiac early afterdepolarizations","volume":"102","author":"Tran","year":"2009","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.bpj.2023.09.001_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151178","article-title":"Early afterdepolarizations with growing amplitudes via delayed subcritical Hopf bifurcations and unstable manifolds of saddle foci in cardiac action potential dynamics","volume":"11","author":"K\u00fcgler","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2023.09.001_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1161\/01.RES.64.5.977","article-title":"Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current","volume":"64","author":"January","year":"1989","journal-title":"Circ. Res."},{"key":"10.1016\/j.bpj.2023.09.001_bib7","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.hrthm.2010.09.017","article-title":"Early afterdepolarizations and cardiac arrhythmias","volume":"7","author":"Weiss","year":"2010","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bpj.2023.09.001_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1529\/biophysj.104.051508","article-title":"The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations","volume":"88","author":"Tanskanen","year":"2005","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib9","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.1918649117","article-title":"Arrhythmogenic late Ca2+ sparks in failing heart cells and their control by action potential configuration","volume":"117","author":"Fowler","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2023.09.001_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005783","article-title":"Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue","volume":"13","author":"Walker","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bpj.2023.09.001_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009536","article-title":"Estimating ectopic beat probability with simplified statistical models that account for experimental uncertainty","volume":"17","author":"Jin","year":"2021","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bpj.2023.09.001_bib12","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2013"},{"key":"10.1016\/j.bpj.2023.09.001_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.joa.2015.12.006","article-title":"Molecular pathogenesis of long QT syndrome type 1","volume":"32","author":"Wu","year":"2016","journal-title":"J.\u00a0Arrhythm."},{"key":"10.1016\/j.bpj.2023.09.001_bib14","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1161\/01.CIR.98.21.2314","article-title":"Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of \u03b2-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes","volume":"98","author":"Shimizu","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2023.09.001_bib15","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bbagen.2011.07.018","article-title":"Partial restoration of the long QT syndrome associated KCNQ1 A341V mutant by the KCNE1 \u03b2-subunit","volume":"1810","author":"Mikuni","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bpj.2023.09.001_bib16","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.jacc.2018.01.078","article-title":"Interplay between genetic substrate, QTc duration, and arrhythmia risk in patients with long QT syndrome","volume":"71","author":"Mazzanti","year":"2018","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/europace\/euab238","article-title":"Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk)","volume":"24","author":"Mazzanti","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.bpj.2023.09.001_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jacc.2005.07.068","article-title":"Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT syndrome types 1 and 2","volume":"47","author":"Viitasalo","year":"2006","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib19","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1016\/j.jacc.2020.10.024","article-title":"Echocardiography-guided risk stratification for long QT syndrome","volume":"76","author":"Sugrue","year":"2020","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2019.01.098","article-title":"Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1","volume":"286","author":"Ter Bekke","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib21","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","article-title":"Long-QT syndrome: from genetics to management","volume":"5","author":"Schwartz","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib22","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.jacc.2012.07.053","article-title":"In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models","volume":"60","author":"Hoefen","year":"2012","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib23","series-title":"The Non-clinical Evaluation of the Potential for Delayed Ventricular Repolarization (Qt Interval Prolongation) by Human Pharmaceuticals","author":"Guideline","year":"2005"},{"key":"10.1016\/j.bpj.2023.09.001_bib24","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.celrep.2018.08.079","article-title":"International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment","volume":"24","author":"Blinova","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bpj.2023.09.001_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/sj.bjp.0706070","article-title":"Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres","volume":"144","author":"Champeroux","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bpj.2023.09.001_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004628","article-title":"Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-a-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology","volume":"10","author":"Li","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cpt.367","article-title":"Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms","volume":"100","author":"Lancaster","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bpj.2023.09.001_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008109","article-title":"A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants","volume":"16","author":"Kernik","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bpj.2023.09.001_bib29","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/S0006-3495(02)75301-0","article-title":"An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release","volume":"83","author":"Greenstein","year":"2002","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib30","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1113\/JP277724","article-title":"A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources","volume":"597","author":"Kernik","year":"2019","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/01.RES.78.4.689","article-title":"Evidence for two components of delayed rectifier K+ current in human ventricular myocytes","volume":"78","author":"Li","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.bpj.2023.09.001_bib32","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/heartjnl-2020-318259","article-title":"Diagnosis, management and therapeutic strategies for congenital long QT syndrome","volume":"108","author":"Wilde","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.bpj.2023.09.001_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1161\/01.CIR.103.1.89","article-title":"Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias","volume":"103","author":"Schwartz","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2023.09.001_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02294361","article-title":"Model selection and Akaike's information criterion (AIC): The general theory and its analytical extensions","volume":"52","author":"Bozdogan","year":"1987","journal-title":"Psychometrika"},{"key":"10.1016\/j.bpj.2023.09.001_bib35","doi-asserted-by":"crossref","first-page":"H2617","DOI":"10.1152\/ajpheart.00350.2006","article-title":"Contributions of sustained I Na and I Kv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes","volume":"291","author":"Flaim","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib36","series-title":"The Elements of Statistical Learning: Data Mining, Inference, and Prediction","author":"Hastie","year":"2009"},{"key":"10.1016\/j.bpj.2023.09.001_bib37","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.patcog.2015.03.009","article-title":"Performance evaluation of classification algorithms by k-fold and leave-one-out cross validation","volume":"48","author":"Wong","year":"2015","journal-title":"Pattern Recogn."},{"key":"10.1016\/j.bpj.2023.09.001_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0196-17","article-title":"Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias","volume":"12","author":"Wang","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bpj.2023.09.001_bib39","series-title":"Excitation-contraction Coupling and Cardiac Contractile Force","author":"Bers","year":"2001"},{"key":"10.1016\/j.bpj.2023.09.001_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCULATIONAHA.105.570200","article-title":"Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism","volume":"113","author":"Anderson","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2023.09.001_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1124\/jpet.107.128405","article-title":"Alfuzosin delays cardiac repolarization by a novel mechanism","volume":"324","author":"Lacerda","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bpj.2023.09.001_bib42","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehab588","article-title":"Deep learning analysis of electrocardiogram for risk prediction of drug-induced arrhythmias and diagnosis of long QT syndrome","volume":"42","author":"Prifti","year":"2021","journal-title":"Eur. Heart\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00232-008-9113-9","article-title":"Contribution of L-type Ca 2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes","volume":"222","author":"Yamada","year":"2008","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.bpj.2023.09.001_bib44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0735-1097(03)00554-0","article-title":"International Long QT Syndrome Registry. Modulating effects of age and gender on the clinical course of long QT syndrome by genotype","volume":"42","author":"Zareba","year":"2003","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcm.2017.07.012","article-title":"Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome","volume":"28","author":"Vink","year":"2018","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bpj.2023.09.001_bib46","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/eurheartj\/ehaa769","article-title":"1970\u20132020: 50 years of research on the long QT syndrome\u2014from almost zero knowledge to precision medicine","volume":"42","author":"Schwartz","year":"2021","journal-title":"Eur. Heart\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCRESAHA.111.249482","article-title":"Dominant-negative control of cAMP-dependent IKs upregulation in human long-QT syndrome type 1","volume":"110","author":"Heijman","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bpj.2023.09.001_bib48","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1161\/CIRCULATIONAHA.111.048041","article-title":"Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to \u03b2-blocker therapy in type 1 long-QT syndrome","volume":"125","author":"Barsheshet","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.bpj.2023.09.001_bib49","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1093\/eurheartj\/ehab582","article-title":"Mutation location and I Ks regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region","volume":"42","author":"Schwartz","year":"2021","journal-title":"Eur. Heart\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib50","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bpj.2010.06.042","article-title":"So little source, so much sink: requirements for afterdepolarizations to propagate in tissue","volume":"99","author":"Xie","year":"2010","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2023.09.001_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004400","article-title":"Revealing the concealed nature of long-QT type 3 syndrome","volume":"10","author":"Greer-Short","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib52","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1080\/15513815.2021.2002988","article-title":"Histopathology of the Conduction System in Long QT Syndrome","volume":"41","author":"Rogers","year":"2022","journal-title":"Fetal Pediatr. Pathol."},{"key":"10.1016\/j.bpj.2023.09.001_bib53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-neuro-092920-121538","article-title":"Ion channel degeneracy, variability, and covariation in neuron and circuit resilience","volume":"44","author":"Goaillard","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bpj.2023.09.001_bib54","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1113\/jphysiol.2006.126714","article-title":"Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart","volume":"582","author":"Gaborit","year":"2007","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib55","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nn1639","article-title":"Variable channel expression in identified single and electrically coupled neurons in different animals","volume":"9","author":"Schulz","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bpj.2023.09.001_bib56","first-page":"2203","article-title":"From in\u00a0vivo plasma composition to in\u00a0vitro cardiac electrophysiology and in\u00a0silico virtual heart: the extracellular calcium enigma","volume":"367","author":"Severi","year":"2009","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.bpj.2023.09.001_bib57","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1113\/jphysiol.2011.223313","article-title":"Exploiting mathematical models to illuminate electrophysiological variability between individuals","volume":"590","author":"Sarkar","year":"2012","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bpj.2023.09.001_bib58","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1093\/cvr\/cvab375","article-title":"Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes","volume":"118","author":"Lachaud","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bpj.2023.09.001_bib59","doi-asserted-by":"crossref","first-page":"E2098","DOI":"10.1073\/pnas.1304382110","article-title":"Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology","volume":"110","author":"Britton","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2023.09.001_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mex.2016.12.002","article-title":"Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk","volume":"4","author":"Morotti","year":"2017","journal-title":"MethodsX"},{"key":"10.1016\/j.bpj.2023.09.001_bib61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pbiomolbio.2015.11.003","article-title":"The link between abnormal calcium handling and electrical instability in acquired long QT syndrome\u2013does calcium precipitate arrhythmic storms?","volume":"120","author":"N\u011bmec","year":"2016","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bpj.2023.09.001_bib62","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2017.0660","article-title":"Mechanistic models versus machine learning, a fight worth fighting for the biological community?","volume":"14","author":"Baker","year":"2018","journal-title":"Biol. Lett."},{"key":"10.1016\/j.bpj.2023.09.001_bib63","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cpt.367","article-title":"Improved prediction of drug-induced Torsades de Pointes through simulations of dynamics and machine learning algorithms","volume":"100","author":"Lancaster","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bpj.2023.09.001_bib64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cels.2017.08.014","article-title":"Gene regulatory network inference from single-cell data using multivariate information measures","volume":"5","author":"Chan","year":"2017","journal-title":"Cell Syst."},{"key":"10.1016\/j.bpj.2023.09.001_bib65","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2104019118","article-title":"Prediction of arrhythmia susceptibility through mathematical modeling and machine learning","volume":"118","author":"Varshneya","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2023.09.001_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1196\/annals.1302.002","article-title":"Modeling the actions of \u03b2-adrenergic signaling on excitation\u2013contraction coupling processes","volume":"1015","author":"Greenstein","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bpj.2023.09.001_bib67","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1152\/physrev.1998.78.4.921","article-title":"Phospholamban: protein structure, mechanism of action, and role in cardiac function","volume":"78","author":"Simmerman","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bpj.2023.09.001_bib68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/cvr\/cvu201","article-title":"Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during \u03b2-adrenergic stimulation in cardiac myocytes","volume":"104","author":"Briston","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bpj.2023.09.001_bib69","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0006-3495(93)81199-8","article-title":"Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gating","volume":"65","author":"Herzig","year":"1993","journal-title":"Biophys.\u00a0J."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634952300557X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634952300557X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T17:08:49Z","timestamp":1757783329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000634952300557X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":69,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S000634952300557X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2023.09.001","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estimating the probability of early afterdepolarizations and predicting arrhythmic risk associated with long QT syndrome type 1 mutations","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2023.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Biophysical Society.","name":"copyright","label":"Copyright"}]}}