{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:10:46Z","timestamp":1788930646807,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bpj.2024.02.016","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T14:35:26Z","timestamp":1708612526000},"page":"2085-2096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["GABAA receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation"],"prefix":"10.1016","volume":"123","author":[{"given":"Joseph W.","family":"Nors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Endres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel P.","family":"Goldschen-Ohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2024.02.016_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/2398212819858249","article-title":"A half century of \u03b3-aminobutyric acid","volume":"3","author":"Smart","year":"2019","journal-title":"Brain Neurosci. Adv."},{"key":"10.1016\/j.bpj.2024.02.016_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cophys.2017.12.012","article-title":"A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins","volume":"2","author":"Pless","year":"2019","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.bpj.2024.02.016_bib3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neuron.2015.03.042","article-title":"The GABAA receptor as a therapeutic target for neurodevelopmental disorders","volume":"86","author":"Braat","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2024.02.016_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8423420","article-title":"Impaired GABA neural circuits are critical for fragile X syndrome","volume":"2018","author":"Gao","year":"2018","journal-title":"Neural Plast."},{"key":"10.1016\/j.bpj.2024.02.016_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s43141-021-00224-0","article-title":"GABAA receptors: structure, function, pharmacology, and related disorders","volume":"19","author":"Ghit","year":"2021","journal-title":"J.\u00a0Genet. Eng. Biotechnol."},{"key":"10.1016\/j.bpj.2024.02.016_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.brainres.2019.03.004","article-title":"A structural look at GABAA receptor mutations linked to epilepsy syndromes","volume":"1714","author":"Hernandez","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.bpj.2024.02.016_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-018-1073-7","article-title":"Meta-Analysis of the Association between GABA Receptor Polymorphisms and Autism Spectrum Disorder (ASD)","volume":"65","author":"Mahdavi","year":"2018","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.bpj.2024.02.016_bib8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.molmed.2011.03.003","article-title":"The contribution of GABAergic dysfunction to neurodevelopmental disorders","volume":"17","author":"Ramamoorthi","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bpj.2024.02.016_bib9","first-page":"529","article-title":"[Autism, chromosome 15 and the GAbaergic dysfunction hypothesis]","volume":"48","author":"Sol\u00eds-A\u00f1ez","year":"2007","journal-title":"Invest. Clin."},{"key":"10.1016\/j.bpj.2024.02.016_bib10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.7399","article-title":"Patterns in outpatient benzodiazepine prescribing in the United States","volume":"2","author":"Agarwal","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bpj.2024.02.016_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.300.1.2","article-title":"A new benzodiazepine pharmacology","volume":"300","author":"M\u00f6hler","year":"2002","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bpj.2024.02.016_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121784","article-title":"Benzodiazepine modulation of GABAA receptors: A mechanistic perspective","volume":"12","author":"Goldschen-Ohm","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bpj.2024.02.016_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bpj.2024.02.016_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2174\/1568026023393507","article-title":"Subunit composition, distribution and function of GABA(A) receptor subtypes","volume":"2","author":"Sieghart","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bpj.2024.02.016_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1085\/jgp.200709856","article-title":"Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker","volume":"130","author":"Jha","year":"2007","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.bpj.2024.02.016_bib16","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1021\/acschemneuro.2c00401","article-title":"\u03b11 Proline 277 Residues Regulate GABAAR Gating through M2-M3 Loop Interaction in the Interface Region","volume":"13","author":"Kaczor","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bpj.2024.02.016_bib17","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature01280","article-title":"Coupling of agonist binding to channel gating in the GABA(A) receptor","volume":"421","author":"Kash","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib18","doi-asserted-by":"crossref","first-page":"22764","DOI":"10.1074\/jbc.M001299200","article-title":"Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency","volume":"275","author":"O\u2019Shea","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bpj.2024.02.016_bib19","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1046\/j.1471-4159.1999.731758.x","article-title":"Role of the conserved lysine residue in the middle of the predicted extracellular loop between M2 and M3 in the GABA(A) receptor","volume":"73","author":"Sigel","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bpj.2024.02.016_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2654-5","article-title":"Shared structural mechanisms of general anaesthetics and benzodiazepines","volume":"585","author":"Kim","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib21","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0832-5","article-title":"GABAA receptor signalling mechanisms revealed by structural pharmacology","volume":"565","author":"Masiulis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neuron.2016.03.032","article-title":"Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels","volume":"90","author":"Nemecz","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2024.02.016_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64400","article-title":"A critical residue in the \u03b11M2-M3 linker regulating mammalian GABAA receptor pore gating by diazepam","volume":"10","author":"Nors","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.bpj.2024.02.016_bib24","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/mol.104.008151","article-title":"Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site","volume":"67","author":"Baur","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1124\/mol.109.058289","article-title":"An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites","volume":"77","author":"Goldschen-Ohm","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib26","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.neuropharm.2010.11.009","article-title":"Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor","volume":"60","author":"Sancar","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpj.2024.02.016_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1124\/mol.108.044891","article-title":"Individually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces","volume":"74","author":"Sharkey","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib28","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1074\/jbc.M111.316836","article-title":"Structural link between \u03b3-aminobutyric acid type A (GABAA) receptor agonist binding site and inner \u03b2-sheet governs channel activation and allosteric drug modulation","volume":"287","author":"Venkatachalan","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bpj.2024.02.016_bib29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0026-895X(24)12487-X","article-title":"Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment","volume":"58","author":"Williams","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib30","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1038\/s41467-022-32212-4","article-title":"Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities","volume":"13","author":"Zhu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2024.02.016_bib31","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/81800","article-title":"Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms","volume":"3","author":"Walters","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bpj.2024.02.016_bib32","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0006-3495(99)77089-X","article-title":"Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine","volume":"77","author":"Chang","year":"1999","journal-title":"Biophys.\u00a0J."},{"key":"10.1016\/j.bpj.2024.02.016_bib33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/00000542-200504000-00014","article-title":"Classic benzodiazepines modulate the open-close equilibrium in alpha1beta2gamma2L gamma-aminobutyric acid type A receptors","volume":"102","author":"R\u00fcsch","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bpj.2024.02.016_bib34","doi-asserted-by":"crossref","first-page":"8411","DOI":"10.1523\/JNEUROSCI.22-19-08411.2002","article-title":"Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors","volume":"22","author":"Scheller","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bpj.2024.02.016_bib35","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0028-3908(01)00132-0","article-title":"Mutation of the 9\u2019 leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states","volume":"41","author":"Bianchi","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpj.2024.02.016_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1073\/pnas.0809272106","article-title":"Unliganded gating of acetylcholine receptor channels","volume":"106","author":"Purohit","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2024.02.016_bib37","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.bjp.0702164","article-title":"Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors","volume":"125","author":"Colquhoun","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0028-3908(02)00036-9","article-title":"The relative amount of cRNA coding for gamma2 subunits affects stimulation by benzodiazepines in GABA(A) receptors expressed in Xenopus oocytes","volume":"43","author":"Boileau","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpj.2024.02.016_bib39","series-title":"Biothermodynamics, Part A","first-page":"193","article-title":"Chapter 7 the hill coefficient","volume":"455","author":"Holt","year":"2009"},{"key":"10.1016\/j.bpj.2024.02.016_bib40","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12154-009-0029-3","article-title":"Hill coefficients, dose-response curves and allosteric mechanisms","volume":"3","author":"Prinz","year":"2010","journal-title":"J.\u00a0Chem. Biol."},{"key":"10.1016\/j.bpj.2024.02.016_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41586-022-04517-3","article-title":"Differential assembly diversifies GABAA receptor structures and signalling","volume":"604","author":"Sente","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1085\/jgp.201411183","article-title":"A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors","volume":"144","author":"Goldschen-Ohm","year":"2014","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.bpj.2024.02.016_bib43","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.bjp.0706796","article-title":"Mechanism of action of benzodiazepines on GABAA receptors","volume":"148","author":"Campo-Soria","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib44","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1097\/ALN.0b013e318289bcd3","article-title":"The benzodiazepine diazepam potentiates responses of \u03b11\u03b22\u03b32L \u03b3-aminobutyric acid type A receptors activated by either \u03b3-aminobutyric acid or allosteric agonists","volume":"118","author":"Li","year":"2013","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bpj.2024.02.016_bib45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1085\/jgp.200910317","article-title":"The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors","volume":"135","author":"Keramidas","year":"2010","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.bpj.2024.02.016_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-2999(03)02125-3","article-title":"Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity","volume":"476","author":"Mortensen","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bpj.2024.02.016_bib47","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/s41467-023-37106-7","article-title":"Conformational transitions and allosteric modulation in a heteromeric glycine receptor","volume":"14","author":"Gibbs","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2024.02.016_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2023.09.014","article-title":"Potentiation of the GABAAR reveals variable energetic contributions by etiocholanolone and propofol","volume":"123","author":"Pierce","year":"2024","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2024.02.016_bib49","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0028-3908(96)00077-9","article-title":"Direct evidence for diazepam modulation of GABAA receptor microscopic affinity","volume":"35","author":"Lavoie","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bpj.2024.02.016_bib50","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1523\/JNEUROSCI.19-02-00578.1999","article-title":"Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses","volume":"19","author":"Perrais","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bpj.2024.02.016_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1113\/jphysiol.1994.sp020050","article-title":"Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture","volume":"475","author":"Rogers","year":"1994","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bpj.2024.02.016_bib52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ana.410250302","article-title":"Differential regulation of gamma-aminobutyric acid receptor channels by diazepam and phenobarbital","volume":"25","author":"Twyman","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bpj.2024.02.016_bib53","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0022-3565(25)39288-8","article-title":"Actions of benzodiazepine and beta-carboline derivatives on gamma-aminobutyric acid-activated Cl- channels recorded from membrane patches of neonatal rat cortical neurons in culture","volume":"243","author":"Vicini","year":"1987","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.bpj.2024.02.016_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-023-06556-w","article-title":"Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib55","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature14853","article-title":"Glycine receptor mechanism elucidated by electron cryo-microscopy","volume":"526","author":"Du","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2024.02.016_bib56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.bpj.2024.02.016_bib57","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1074\/jbc.M410881200","article-title":"Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments","volume":"280","author":"Horenstein","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bpj.2024.02.016_bib58","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ng0501-46","article-title":"First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene","volume":"28","author":"Baulac","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bpj.2024.02.016_bib59","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1074\/jbc.M603599200","article-title":"An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits","volume":"281","author":"Hales","year":"2006","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634952400136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000634952400136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:01:02Z","timestamp":1750406462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000634952400136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":59,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S000634952400136X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2024.02.016","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.30.564751","asserted-by":"object"}]},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GABAA receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2024.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Biophysical Society.","name":"copyright","label":"Copyright"}]}}