{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:04:45Z","timestamp":1779264285254,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY027202-01A1"],"award-info":[{"award-number":["R01 EY027202-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","award":["HEK293"],"award-info":[{"award-number":["HEK293"]}],"id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006636","name":"University of Maryland, Baltimore County","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000770","name":"University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bpj.2025.11.006","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T16:50:58Z","timestamp":1762534258000},"page":"2298-2311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["RGS proteins: Potential regulators of mouse melanopsin\u2019s signaling phototransduction cascade across ipRGC subtypes"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8429-8240","authenticated-orcid":false,"given":"Lee H.","family":"Harkless","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grayson P.","family":"Ostermeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Hattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Lane","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-8826","authenticated-orcid":false,"given":"Phyllis R.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2025.11.006_bib1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1523\/JNEUROSCI.20-02-00600.2000","article-title":"A novel human opsin in the inner retina","volume":"20","author":"Provencio","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bpj.2025.11.006_bib2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bpj.2025.11.006_bib3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bpj.2025.11.006_bib4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.tins.2011.07.001","article-title":"Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions","volume":"34","author":"Schmidt","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bpj.2025.11.006_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature10567","article-title":"Melanopsin signalling in mammalian iris and retina","volume":"479","author":"Xue","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2025.11.006_bib6","article-title":"Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.neuron.2018.06.032","article-title":"Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits","volume":"99","author":"Sonoda","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2025.11.006_bib8","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2315282120","article-title":"Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs","volume":"120","author":"Li","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80749","article-title":"Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes","volume":"12","author":"Contreras","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.bpj.2025.11.006_bib10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.cell.2018.08.055","article-title":"Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells","volume":"175","author":"Jiang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bpj.2025.11.006_bib11","article-title":"Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib12","doi-asserted-by":"crossref","first-page":"12734","DOI":"10.1021\/bi035418z","article-title":"Melanopsin Forms a Functional Short-Wavelength Photopigment","volume":"42","author":"Newman","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bpj.2025.11.006_bib13","article-title":"Human melanopsin forms a pigment maximally sensitive to blue light (\u03bbmax \u2248 479 nm) supporting activation of Gq\/11 and Gi\/o signalling cascades","volume":"280","author":"Bailes","year":"2013","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib14","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258474","article-title":"Divergent G-protein selectivity across melanopsins from mice and humans","volume":"135","author":"McDowell","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.212910","article-title":"Melanopsin (Opn4) utilizes G\u03b1i and G\u03b2\u03b3 as major signal transducers","volume":"131","author":"Kankanamge","year":"2018","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib16","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0022-19.2019","article-title":"Transcriptomic Signatures of Postnatal and Adult Intrinsically Photosensitive Ganglion Cells","volume":"6","author":"Berg","year":"2019","journal-title":"eNeuro"},{"key":"10.1016\/j.bpj.2025.11.006_bib17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2019.11.006","article-title":"Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes","volume":"104","author":"Tran","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2025.11.006_bib18","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1073\/pnas.0912934107","article-title":"Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity","volume":"107","author":"Lambert","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib19","series-title":"International Review of Cell and Molecular Biology","first-page":"97","article-title":"Chapter Three - Regulators of G-Protein-Signaling Proteins: Negative Modulators of G-Protein-Coupled Receptor Signaling","author":"Woodard","year":"2015"},{"key":"10.1016\/j.bpj.2025.11.006_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/35000601","article-title":"Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1","volume":"403","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2025.11.006_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuron.2006.07.010","article-title":"RGS expression rate-limits recovery of rod photoresponses","volume":"51","author":"Krispel","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bpj.2025.11.006_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.visres.2015.02.011","article-title":"Speeding rod recovery improves temporal resolution in the retina","volume":"110","author":"Fortenbach","year":"2015","journal-title":"Vision Res."},{"key":"10.1016\/j.bpj.2025.11.006_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06358","article-title":"Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior","volume":"4","author":"Sarria","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.bpj.2025.11.006_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1085\/jgp.201611692","article-title":"Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9","volume":"149","author":"Peinado Allina","year":"2017","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bpj.2025.11.006_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aab4068","article-title":"Distinct profiles of functional discrimination among G proteins determine the actions of G protein\u2013coupled receptors","volume":"8","author":"Masuho","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bpj.2025.11.006_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2020.08.052","article-title":"A Global Map of G Protein Signaling Regulation by RGS Proteins","volume":"183","author":"Masuho","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bpj.2025.11.006_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12013-009-9052-9","article-title":"The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling","volume":"54","author":"Anderson","year":"2009","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bpj.2025.11.006_bib28","doi-asserted-by":"crossref","first-page":"10087","DOI":"10.1074\/jbc.M211382200","article-title":"RGS6, RGS7, RGS9, and RGS11 Stimulate GTPase Activity of Gi Family G-proteins with Differential Selectivity and Maximal Activity","volume":"278","author":"Hooks","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1167\/iovs.61.12.10","article-title":"Protein Phosphatase 2A and Clathrin-Mediated Endocytosis Facilitate Robust Melanopsin Light Responses and Resensitization","volume":"61","author":"Valdez-Lopez","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature10206","article-title":"Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs","volume":"476","author":"Chen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2025.11.006_bib31","article-title":"Defining spatial nonuniformities of all ipRGC types using an improved Opn4cre recombinase mouse line","volume":"4","author":"Dyer","year":"2024","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.bpj.2025.11.006_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.826590","article-title":"Adult Expression of Tbr2 Is Required for the Maintenance but Not Survival of Intrinsically Photosensitive Retinal Ganglion Cells","volume":"16","author":"Abed","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bpj.2025.11.006_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pharmthera.2007.09.005","article-title":"R4 RGS proteins: Regulation of G-protein signaling and beyond","volume":"116","author":"Bansal","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bpj.2025.11.006_bib34","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1038\/s41598-025-91045-5","article-title":"Spatial distribution and functional integration of displaced retinal ganglion cells","volume":"15","author":"Duda","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bpj.2025.11.006_bib35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/iovs.66.2.14","article-title":"Expression of Osteopontin in M2 and M4 Intrinsically Photosensitive Retinal Ganglion Cells in the Mouse Retina","volume":"66","author":"Kinder","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib36","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.cell.2019.04.044","article-title":"Illuminating G-Protein-Coupling Selectivity of GPCRs","volume":"177","author":"Inoue","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bpj.2025.11.006_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113173","article-title":"Rules and mechanisms governing G protein coupling selectivity of GPCRs","volume":"42","author":"Masuho","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bpj.2025.11.006_bib38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41467-017-02661-3","article-title":"Lack of beta-arrestin signaling in the absence of active G proteins","volume":"9","author":"Grundmann","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2025.11.006_bib39","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cellsig.2009.02.017","article-title":"The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers","volume":"21","author":"Hollins","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bpj.2025.11.006_bib40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nsmb.2068","article-title":"Integrating energy calculations with functional assays to decipher the specificity of G protein\u2013RGS protein interactions","volume":"18","author":"Kosloff","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bpj.2025.11.006_bib41","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/mol.62.3.654","article-title":"Characterization and Comparison of RGS2 and RGS4 as GTPase-Activating Proteins for m2 Muscarinic Receptor-Stimulated Gi","volume":"62","author":"Cladman","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bpj.2025.11.006_bib42","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cellsig.2005.07.003","article-title":"Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the \u03bc- and \u03b4-opioid receptors regulate opioid receptor signaling","volume":"18","author":"Georgoussi","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bpj.2025.11.006_bib43","doi-asserted-by":"crossref","first-page":"33497","DOI":"10.1074\/jbc.M005785200","article-title":"Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7","volume":"275","author":"Lan","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib44","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1073\/pnas.94.12.6159","article-title":"Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells","volume":"94","author":"Huang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095355","article-title":"Regulator of G Protein Signaling 2 (RGS2) and RGS4 Form Distinct G Protein-Dependent Complexes with Protease Activated-Receptor 1 (PAR1) in Live Cells","volume":"9","author":"Ghil","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2025.11.006_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan3677","article-title":"\u201cDisruptor\u201d residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of G\u03b1 subunits","volume":"11","author":"Asli","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bpj.2025.11.006_bib47","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.bbrc.2018.08.033","article-title":"Structural motifs in the RGS RZ subfamily combine to attenuate interactions with G\u03b1 subunits","volume":"503","author":"Salem-Mansour","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bpj.2025.11.006_bib48","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1016\/j.jmb.2019.05.037","article-title":"RGS6 and RGS7 Discriminate between the Highly Similar G\u03b1i and G\u03b1o Proteins Using a Two-Tiered Specificity Strategy","volume":"431","author":"Israeli","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bpj.2025.11.006_bib49","doi-asserted-by":"crossref","first-page":"18836","DOI":"10.1074\/jbc.274.26.18836","article-title":"Amino-terminal Cysteine Residues of RGS16 Are Required for Palmitoylation and Modulation of Gi- and Gq-mediated Signaling","volume":"274","author":"Druey","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib50","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0024-3205(01)00939-0","article-title":"Characterization of RGS5 in regulation of G protein-coupled receptor signaling","volume":"68","author":"Zhou","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib51","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3390\/cells10071748","article-title":"RGS5 Attenuates Baseline Activity of ERK1\/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells","volume":"10","author":"Demirel","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bpj.2025.11.006_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/ATVBAHA.115.305974","article-title":"Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation","volume":"36","author":"Daniel","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bpj.2025.11.006_bib53","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.bpj.2009.06.037","article-title":"RGS9 concentration matters in rod phototransduction","volume":"97","author":"Burns","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2025.11.006_bib54","doi-asserted-by":"crossref","first-page":"19799","DOI":"10.1074\/jbc.274.28.19799","article-title":"The Membrane Association Domain of RGS16 Contains Unique Amphipathic Features That Are Conserved in RGS4 and RGS5","volume":"274","author":"Chen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib55","doi-asserted-by":"crossref","first-page":"18520","DOI":"10.1074\/jbc.M000618200","article-title":"RGS4 Binds to Membranes through an Amphipathic \u03b1-Helix","volume":"275","author":"Bernstein","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib56","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1742-4658.2004.04516.x","article-title":"Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues","volume":"272","author":"Liang","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.bpj.2025.11.006_bib57","doi-asserted-by":"crossref","first-page":"38260","DOI":"10.1074\/jbc.274.53.38260","article-title":"Palmitoylation of a Conserved Cysteine in the Regulator of G Protein Signaling (RGS) Domain Modulates the GTPase-activating Activity of RGS4 and RGS10","volume":"274","author":"Tu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib58","doi-asserted-by":"crossref","first-page":"19309","DOI":"10.1074\/jbc.M210124200","article-title":"Palmitoylation Regulates Regulator of G-protein Signaling (RGS) 16 Function: II. Palmitoylation of a Cysteine Residue in the RGS Box is Critical for RGS16 GTPase Accelerating Activity and regulation of Gi-coupled Signaling","volume":"278","author":"Osterhout","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028557","article-title":"SUMO-SIM Interactions Regulate the Activity of RGSZ2 Proteins","volume":"6","author":"Garz\u00f3n","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2025.11.006_bib60","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/sj.npp.1301184","article-title":"Sumoylated RGS-Rz Proteins Act as Scaffolds for Mu-Opioid Receptors and G-Protein Complexes in Mouse Brain","volume":"32","author":"Rodr\u00edguez-Mu\u00f1oz","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bpj.2025.11.006_bib61","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1074\/jbc.RA118.006059","article-title":"High-resolution structure of RGS17 suggests a role for Ca 2+ in promoting the GTPase-activating protein activity by RZ subfamily members","volume":"294","author":"Sieng","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101757","article-title":"Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2","volume":"74","author":"Petersen","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bpj.2025.11.006_bib63","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41594-024-01263-0","article-title":"Structure of adenylyl cyclase 5 in complex with G\u03b2\u03b3 offers insights into ADCY5-related dyskinesia","volume":"31","author":"Yen","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bpj.2025.11.006_bib64","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1126\/science.7761832","article-title":"A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein \u03b2\u03b3 Subunits","volume":"268","author":"Chen","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bpj.2025.11.006_bib65","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1074\/jbc.M511045200","article-title":"G\u03b2\u03b3 Activation Site in Adenylyl Cyclase Type II: ADENYLYL CYCLASE TYPE III IS INHIBITED BY G\u03b2\u03b3","volume":"281","author":"Diel","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2025.11.006_bib66","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1073\/pnas.1918158117","article-title":"Gq\/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR","volume":"117","author":"White","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2025.11.006_bib67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1113\/jphysiol.2007.136150","article-title":"Properties of single two-pore domain TREK-2 channels expressed in mammalian cells","volume":"583","author":"Kang","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.bpj.2025.11.006_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098356","article-title":"Loss of Gq\/11 Genes Does Not Abolish Melanopsin Phototransduction","volume":"9","author":"Chew","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bpj.2025.11.006_bib69","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00018-014-1664-6","article-title":"Using siRNA to define functional interactions between melanopsin and multiple G Protein partners","volume":"72","author":"Hughes","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bpj.2025.11.006_bib70","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2017.09.005","article-title":"A Population Representation of Absolute Light Intensity in the Mammalian Retina","volume":"171","author":"Milner","year":"2017","journal-title":"Cell"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349525007416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349525007416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:38:22Z","timestamp":1779219502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349525007416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0006349525007416"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2025.11.006","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RGS proteins: Potential regulators of mouse melanopsin\u2019s signaling phototransduction cascade across ipRGC subtypes","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2025.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Biophysical Society.","name":"copyright","label":"Copyright"}]}}