{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:09:53Z","timestamp":1791490193827,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020397","name":"University of Vermont Cardiovascular Research Institute of Vermont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"The Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bpj.2026.07.003","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:00:41Z","timestamp":1783119641000},"page":"3793-3799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells"],"prefix":"10.1016","volume":"125","author":[{"given":"Trevor","family":"Harriman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-1100","authenticated-orcid":false,"given":"Osama F.","family":"Harraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpj.2026.07.003_bib1","article-title":"2025 Alzheimer\u2019s disease facts and figures","volume":"21","year":"2025","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"10.1016\/j.bpj.2026.07.003_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: a systematic review","volume":"7","author":"Biffi","year":"2011","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.bpj.2026.07.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000369101","article-title":"Amyloid-beta: a crucial factor in Alzheimer\u2019s disease","volume":"24","author":"Sadigh-Eteghad","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.bpj.2026.07.003_bib4","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1038\/399a023","article-title":"Translating cell biology into therapeutic advances in Alzheimer\u2019s disease","volume":"399","author":"Selkoe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bpj.2026.07.003_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12881","article-title":"Vascular Function and Ion Channels in Alzheimer\u2019s Disease","volume":"31","author":"Taylor","year":"2024","journal-title":"Microcirculation"},{"key":"10.1016\/j.bpj.2026.07.003_bib6","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41580-024-00753-9","article-title":"Cellular and pathological functions of tau","volume":"25","author":"Parra Bravo","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bpj.2026.07.003_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37840-y","article-title":"Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy","volume":"14","author":"Hussong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2026.07.003_bib8","doi-asserted-by":"crossref","first-page":"15317","DOI":"10.1074\/jbc.M110.209296","article-title":"Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles","volume":"286","author":"Guo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bpj.2026.07.003_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.14336\/AD.2017.0112","article-title":"Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer\u2019s Disease and Related Tauopathies","volume":"8","author":"Castillo-Carranza","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.bpj.2026.07.003_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jalz.2017.02.007","article-title":"Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer\u2019s disease","volume":"13","author":"Nielsen","year":"2017","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bpj.2026.07.003_bib11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nn.4533","article-title":"Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow","volume":"20","author":"Longden","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bpj.2026.07.003_bib12","doi-asserted-by":"crossref","first-page":"E3569","DOI":"10.1073\/pnas.1800201115","article-title":"Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion","volume":"115","author":"Harraz","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2026.07.003_bib13","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/CIRCRESAHA.122.320827","article-title":"Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries","volume":"130","author":"Harraz","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bpj.2026.07.003_bib14","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1038\/s41467-024-52969-0","article-title":"Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow","volume":"15","author":"Lim","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bpj.2026.07.003_bib15","doi-asserted-by":"crossref","first-page":"zqab010","DOI":"10.1093\/function\/zqab010","article-title":"PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer\u2019s Disease","volume":"2","author":"Mughal","year":"2021","journal-title":"Function"},{"key":"10.1016\/j.bpj.2026.07.003_bib16","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1111\/bph.15751","article-title":"Alzheimer\u2019s disease and cerebrovascular pathology alter inward rectifier potassium (KIR2.1) channels in endothelium of mouse cerebral arteries","volume":"179","author":"Lacalle-Aurioles","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bpj.2026.07.003_bib17","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3233\/JAD-200085","article-title":"Development of Alzheimer\u2019s Disease Progressively Alters Sex-Dependent KCa and Sex-Independent KIR Channel Function in Cerebrovascular Endothelium","volume":"76","author":"Hakim","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bpj.2026.07.003_bib18","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025998118","article-title":"PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity","volume":"118","author":"Dabertrand","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2026.07.003_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149029","article-title":"Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease","volume":"131","author":"Koide","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bpj.2026.07.003_bib20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2522750122","article-title":"PIP2 corrects an endothelial Piezo1 channelopathy","volume":"122","author":"Hashad","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2026.07.003_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204581119","article-title":"Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer\u2019s disease","volume":"119","author":"Taylor","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bpj.2026.07.003_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13041-025-01208-8","article-title":"Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo","volume":"18","author":"Yang","year":"2025","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bpj.2026.07.003_bib23","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1016\/j.bpj.2024.12.025","article-title":"Amyloid beta A\u03b21-40 activates Piezo1 channels in brain capillary endothelial cells","volume":"124","author":"Lim","year":"2025","journal-title":"Biophys. J."},{"key":"10.1016\/j.bpj.2026.07.003_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/151979","article-title":"Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?","volume":"2015","author":"Alavi Naini","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bpj.2026.07.003_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/alz.12394","article-title":"Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia","volume":"18","author":"Esteras","year":"2022","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.bpj.2026.07.003_bib26","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.celrep.2018.07.072","article-title":"Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia","volume":"24","author":"Brelstaff","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bpj.2026.07.003_bib27","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1007\/s11357-023-00841-2","article-title":"Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling","volume":"45","author":"Fang","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.bpj.2026.07.003_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/biof.2024","article-title":"Melatonin protects Kir2.1 function in an oxidative stress-related model of aging neuroglia","volume":"50","author":"Remigante","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.bpj.2026.07.003_bib29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/0271678X241235790","article-title":"Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature","volume":"44","author":"Mughal","year":"2024","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bpj.2026.07.003_bib30","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1021\/acschemneuro.7b00275","article-title":"Novel Cell Model for Tauopathy Induced by a Cell-Permeable Tau-Related Peptide","volume":"8","author":"Veloria","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bpj.2026.07.003_bib31","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/srep00700","article-title":"Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau","volume":"2","author":"Lasagna-Reeves","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bpj.2026.07.003_bib32","first-page":"1","article-title":"The role of wild-type tau in Alzheimer\u2019s disease and related tauopathies","volume":"2","author":"Lo","year":"2020","journal-title":"J. Life Sci."},{"key":"10.1016\/j.bpj.2026.07.003_bib33","article-title":"Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bpj.2026.07.003_bib34","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cub.2023.02.060","article-title":"Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis","volume":"33","author":"Hirata","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bpj.2026.07.003_bib35","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41593-020-0686-7","article-title":"Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration","volume":"23","author":"Park","year":"2020","journal-title":"Nat. Neurosci."}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349526004844?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349526004844?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:09:42Z","timestamp":1787832582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349526004844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0006349526004844"],"URL":"https:\/\/doi.org\/10.1016\/j.bpj.2026.07.003","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpj.2026.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Biophysical Society.","name":"copyright","label":"Copyright"}]}}