{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T12:28:59Z","timestamp":1776515339307,"version":"3.51.2"},"reference-count":112,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.bpobgyn.2006.09.011","type":"journal-article","created":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T01:31:26Z","timestamp":1162344686000},"page":"129-143","source":"Crossref","is-referenced-by-count":13,"title":["ART: iatrogenic multiple pregnancy?"],"prefix":"10.1016","volume":"21","author":[{"given":"M.F.G.","family":"Verberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.S.","family":"Macklon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.M.E.W.","family":"Heijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.C.J.M.","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2006.09.011_bib1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1136\/bmj.291.6510.1693","article-title":"Population study of causes, treatment, and outcome of infertility","volume":"291","author":"Hull","year":"1985","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/humrep\/12.7.1582","article-title":"The spontaneous pregnancy prognosis in untreated subfertile couples: the Walcheren primary care study","volume":"12","author":"Snick","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib3","author":"Human Fertilisation and Embryology Authority"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0950-3552(98)80045-X","article-title":"Multifetal pregnancy reduction","volume":"12","author":"Evans","year":"1998","journal-title":"Bailliere's Clin Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib5","author":"Martin","year":"1999","journal-title":"Trends in twin and triplet births: 1980\u201397"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib6","series-title":"Recent demographic developments in Europe, 2001","author":"Council of Europe","year":"2002"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1203\/00006450-200211000-00011","article-title":"The risk of mortality or cerebral palsy in twins: a collaborative population-based study","volume":"52","author":"Scher","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib8","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1093\/humrep\/11.suppl_4.110","article-title":"The outcome of multiple pregnancy","volume":"11","author":"Doyle","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib9","first-page":"499","article-title":"French national register on in vitro fertilization","volume":"25","author":"FIVNAT 1996 Report","year":"1997","journal-title":"Contracept Fertil Sex"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib10","first-page":"661","article-title":"The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States","volume":"37","author":"Luke","year":"1992","journal-title":"J Reprod Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib11","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/humrep\/15.8.1856","article-title":"The ESHRE Capri Workshop Group. Multiple gestation pregnancy","volume":"15","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib12","series-title":"Assisted reproduction technologies. Quality and safety","first-page":"23","article-title":"Obstetric risks and neonatal complications of twin pregnancy and higher-order multiple pregnancy","author":"Wennerholm","year":"2004"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib13","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1136\/bmj.307.6914.1239","article-title":"Twins, triplets, and cerebral palsy in births in Western Australia in the 1980s","volume":"307","author":"Petterson","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib14","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1111\/j.1471-0528.2004.00345.x","article-title":"Adverse maternal outcomes in multifetal pregnancies","volume":"111","author":"Walker","year":"2004","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0002-9378(96)70605-1","article-title":"The maternal and neonatal outcome of triplet gestations","volume":"174","author":"Albrecht","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib16","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/0002-9378(90)90896-F","article-title":"Seventy-one quadruplet pregnancies: management and outcome","volume":"162","author":"Collins","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00003081-199803000-00013","article-title":"How does multiple pregnancy affect maternal mortality and morbidity?","volume":"41","author":"Senat","year":"1998","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJM199407283310407","article-title":"The economic impact of multiple-gestation pregnancies and the contribution of assisted-reproduction techniques to their incidence","volume":"331","author":"Callahan","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib19","series-title":"Multiple pregnancy","first-page":"334","article-title":"Resource implications of multiple births","author":"Mugford","year":"1995"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/1464727002000199131","article-title":"The economic consequences of multiple gestation pregnancy in assisted conception cycles","volume":"3","author":"Collins","year":"2000","journal-title":"Hum Fertil (Camb)"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib21","doi-asserted-by":"crossref","first-page":"F114","DOI":"10.1136\/fn.74.2.F114","article-title":"Cost of care for a geographically determined population of low birthweight infants to age 8\u20139 years. 1. Children without disability","volume":"74","author":"Stevenson","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib22","doi-asserted-by":"crossref","first-page":"F542","DOI":"10.1136\/adc.2003.043851","article-title":"Economic implications of multiple births: inpatient hospital costs in the first 5 years of life","volume":"89","author":"Henderson","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib23","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0015-0282(02)04197-3","article-title":"Progress we can be proud of: U.S. trends in assisted reproduction over the first 20 years","volume":"78","author":"Toner","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib24","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/0002-9378(95)91407-2","article-title":"Evolving patterns of iatrogenic multifetal pregnancy generation: implications for aggressiveness of infertility treatments","volume":"172","author":"Evans","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib25","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1093\/humrep\/deg357","article-title":"The ESHRE task force on ethics and law. Ethical issues related to multiple pregnancies in medically assisted procreation","volume":"18","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib26","first-page":"1","article-title":"Assisted reproductive technology surveillance \u2013 United States, 2002","volume":"54","author":"Wright","year":"2005","journal-title":"MMWR. Surveill Summ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib27","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1210\/jc.83.7.2361","article-title":"Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility","volume":"83","author":"Imani","year":"1998","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib28","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1093\/humrep\/dei128","article-title":"Ovulation induction: a mini review","volume":"20","author":"Messinis","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0015-0282(16)45308-2","article-title":"Multiple pregnancies following induction of ovulation","volume":"35","author":"Schenker","year":"1981","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1479-828X.1994.tb01040.x","article-title":"Clomiphene citrate and pregnancy outcome","volume":"34","author":"Venn","year":"1994","journal-title":"Aust NZ J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1477-7827-3-54","article-title":"The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment","volume":"3","author":"Mitwally","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/er.18.1.71","article-title":"Manipulation of human ovarian function: physiological concepts and clinical consequences","volume":"18","author":"Fauser","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib33","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(05)66478-1","article-title":"Multiple birth resulting from ovarian stimulation for subfertility treatment","volume":"365","author":"Fauser","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib34","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/oxfordjournals.humrep.a136248","article-title":"Cryopreservation: the problem of evaluation","volume":"10","author":"Jones","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib35","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.fertnstert.2004.01.017","article-title":"Assisted reproductive technology in the United States: 2000 results generated from the American Society for reproductive medicine\/society for assisted reproductive technology registry","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib36","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/humrep\/deh755","article-title":"Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE","volume":"20","author":"Andersen","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib37","series-title":"Obstetrie en Gynaecologie, de voortplanting van de mens","first-page":"435","article-title":"Vruchtbaarheidsstoornissen","author":"Evers","year":"2001"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0015-0282(16)56451-6","article-title":"The prediction of the chance to conceive in subfertile couples","volume":"61","author":"Eimers","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib39","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/humrep\/deh821","article-title":"Prospective validation of two models predicting pregnancy leading to live birth among untreated subfertile couples","volume":"20","author":"Hunault","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1365-2265.1992.tb02909.x","article-title":"Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome","volume":"36","author":"Kiddy","year":"1992","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0889-8545(05)70187-X","article-title":"Obesity and weight loss in polycystic ovary syndrome","volume":"28","author":"Hoeger","year":"2001","journal-title":"Obstet Gynecol Clin North Am"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/humupd\/dmh018","article-title":"Improving reproductive performance in overweight\/obese women with effective weight management","volume":"10","author":"Norman","year":"2004","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib43","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/humrep\/13.6.1502","article-title":"Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment","volume":"13","author":"Clark","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib44","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1034\/j.1600-0412.2003.00164.x","article-title":"Alcohol use as predictor for infertility in a representative population of Danish women","volume":"82","author":"Tolstrup","year":"2003","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib45","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/humrep\/deh898","article-title":"Effects of subfertility cause, smoking and body weight on the success rate of IVF","volume":"20","author":"Lintsen","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib46","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00001648-199011000-00010","article-title":"Cigarette smoking and the risk of natural menopause","volume":"1","author":"Midgette","year":"1990","journal-title":"Epidemiology"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib47","series-title":"NICE guideline, second draft for consultation","article-title":"Fertility: assessment and treatment for people with fertility problems","author":"National Institute for Clinical Excellence","year":"2003"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib48","series-title":"Yen and Jaffe's reproductive endocrinology","first-page":"965","article-title":"Medical approaches to ovarian stimulation for infertility","author":"Fauser","year":"2004"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib49","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1472-6483(10)62069-X","article-title":"Infertility therapy-associated multiple pregnancies (births): an ongoing epidemic","volume":"7","author":"Adashi","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib50","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/bmj.327.7421.951","article-title":"Metformin in polycystic ovary syndrome: systematic review and meta-analysis","volume":"327","author":"Lord","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib51","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/bmj.38867.631551.55","article-title":"Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial","volume":"332","author":"Moll","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/humrep\/deg105","article-title":"Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial","volume":"18","author":"George","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib53","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/jc.2005-1923","article-title":"Review: aromatase inhibitors for ovulation induction","volume":"91","author":"Casper","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib54","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.fertnstert.2005.07.230","article-title":"The outcome of 150 babies following the treatment with letrozole or letrozole and gonadotropins","volume":"84","author":"Biljan","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib55","first-page":"CD001122","article-title":"Laparoscopic \u201cdrilling\u201d by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome","volume":"3","author":"Farquhar","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/bmj.328.7433.192","article-title":"Using an electrocautery strategy or recombinant follicle stimulating hormone to induce ovulation in polycystic ovary syndrome: randomised controlled trial","volume":"328","author":"Bayram","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib57","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/humrep\/12.9.1865","article-title":"The effectiveness of ovulation induction and intrauterine insemination in the treatment of persistent infertility: a meta-analysis","volume":"12","author":"Hughes","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000080492","article-title":"Should we continue performing intrauterine inseminations in the year 2004?","volume":"59","author":"Cohlen","year":"2005","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib59","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/oxfordjournals.humrep.a019486","article-title":"The ESHRE Capri workshop. Infertility revisited: the state of the art today and tomorrow.","volume":"11","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1056\/NEJM200007063430101","article-title":"Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins","volume":"343","author":"Gleicher","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib61","first-page":"CD000360","article-title":"Timed intercourse versus intra-uterine insemination with or without ovarian hyperstimulation for subfertility in men","volume":"2","author":"Cohlen","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib62","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(05)67057-2","article-title":"Multiple pregnancy after assisted reproduction. Authors' reply","volume":"366","author":"Macklon","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib63","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/humrep\/deg170","article-title":"Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility. Current best evidence for the advanced treatment of unexplained subfertility","volume":"18","author":"Collins","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0140-6736(99)04002-7","article-title":"Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis","volume":"355","author":"Goverde","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib65","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM199808273390901","article-title":"Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization","volume":"339","author":"Templeton","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib66","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/humrep\/deh672","article-title":"Two cycles with single embryo transfer versus one cycle with double embryo transfer: a randomized controlled trial","volume":"20","author":"Lukassen","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib67","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa041032","article-title":"Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization","volume":"351","author":"Thurin","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib68","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/humrep\/deg081","article-title":"Risks and complications in assisted reproduction techniques. Report of an ESHRE consensus meeting","volume":"18","author":"Land","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib69","unstructured":"Heijnen EM, Eijkemans MJ, de Klerk C, et\u00a0al. A randomized trial comparing a standard treatment strategy and a mild treatment strategy, considering term live birth, cost and patient discomfort during one year of treatment. Abstract ESHRE annual meeting, in press."},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib70","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/humupd\/8.2.129","article-title":"Efficacy of natural cycle IVF: a review of the literature","volume":"8","author":"Pelinck","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib71","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.ejogrb.2003.11.007","article-title":"Cryopreservation of IVF embryos: which stage?","volume":"113","author":"Menezo","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib72","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.fertnstert.2003.07.023","article-title":"Single blastocyst transfer: a prospective randomized trial","volume":"81","author":"Gardner","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib73","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/oxfordjournals.humrep.a019596","article-title":"The neglected human blastocyst revisited","volume":"12","author":"Bavister","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib74","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1006\/cbir.1994.1044","article-title":"Blastocyst transfer in human in vitro fertilization: the use of embryo co-culture","volume":"18","author":"Bongso","year":"1994","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib75","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jemt.1070320105","article-title":"Co-culture of the early human embryo: factors affecting human blastocyst formation in vitro","volume":"32","author":"Menezo","year":"1995","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib76","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1093\/humrep\/dei217","article-title":"Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study","volume":"20","author":"Papanikolaou","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib77","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa053524","article-title":"In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos","volume":"354","author":"Papanikolaou","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib78","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/humrep\/deg394","article-title":"Similar delivery rates in a selected group of patients, for day 2 and day 5 embryos both cultured in sequential medium: a randomized study","volume":"18","author":"Emiliani","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib79","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.fertnstert.2003.07.016","article-title":"Comparison of embryo transfer on day 2, day 3, and day 6: a prospective randomized study","volume":"81","author":"Pantos","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib80","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1023\/A:1009461213139","article-title":"Blastocyst-ET and monozygotic twinning","volume":"17","author":"Behr","year":"2000","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib81","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0015-0282(97)00438-X","article-title":"Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers","volume":"69","author":"Gardner","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humrep\/deh579","article-title":"ESHRE PGD Consortium \u2018Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)\u2019","volume":"20","author":"Thornhill","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib83","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/humrep\/dei291","article-title":"Preimplantation genetic screening reveals a high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF","volume":"21","author":"Baart","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib84","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/S0303-7207(01)00574-3","article-title":"Chromosomal abnormalities in embryos","volume":"183","author":"Magli","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib85","first-page":"CD005291","article-title":"Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injection","volume":"1","author":"Twisk","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib86","doi-asserted-by":"crossref","first-page":"S249","DOI":"10.1016\/j.fertnstert.2004.07.664","article-title":"Is aneuploidy screening for patients aged 35 or over beneficial? A prospective randomized trial","volume":"82","author":"Stevens","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib87","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/humrep\/deh536","article-title":"Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial","volume":"19","author":"Staessen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib88","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2004.06.071","article-title":"Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages","volume":"83","author":"Platteau","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib89","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0002-9378(96)80017-2","article-title":"Selective reduction of multifetal pregnancies to twins improves outcome over nonreduced triplet gestations","volume":"175","author":"Smith-Levitin","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib90","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.ajog.2004.05.003","article-title":"First-trimester fetal reduction to a singleton infant or twins: outcome in relation to the final number and karyotyping before reduction by transabdominal chorionic villus sampling","volume":"191","author":"Brambati","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib91","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bpobgyn.2004.04.019","article-title":"Do reduced multiples do better?","volume":"18","author":"Evans","year":"2004","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib92","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1469-0705.1992.02020084.x","article-title":"Selective termination to a singleton pregnancy is ethically justified","volume":"2","author":"Chervenak","year":"1992","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib93","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/BF02212916","article-title":"Three ethically justified indications for selective termination in multifetal pregnancy: a practical and comprehensive management strategy","volume":"12","author":"Chervenak","year":"1995","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib94","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0095-5108(02)00091-X","article-title":"Selective reduction","volume":"30","author":"Evans","year":"2003","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib95","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1053\/j.semperi.2005.10.004","article-title":"Fetal reduction","volume":"29","author":"Evans","year":"2005","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib96","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.fertnstert.2003.05.035","article-title":"The desire of infertile patients for multiple births","volume":"81","author":"Ryan","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib97","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1067\/mob.2001.117305","article-title":"Patient perceptions of multiple gestations: an assessment of knowledge and risk aversion","volume":"185","author":"Grobman","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib98","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/humrep\/deh097","article-title":"The desire for multiple pregnancy in male and female infertility patients","volume":"19","author":"Child","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib99","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fertnstert.2003.10.022","article-title":"Infertility and the desire for multiple births","volume":"81","author":"D'Alton","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib100","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/humrep\/deh202","article-title":"What is the most relevant standard of success in assisted reproduction? Assessing the BESST index for reproduction treatment","volume":"19","author":"Davies","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib101","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humrep\/deh028","article-title":"What is the most relevant standard of success in assisted reproduction? The singleton, term gestation, live birth rate per cycle initiated: the BESST endpoint for assisted reproduction","volume":"19","author":"Min","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib102","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1093\/humrep\/deh368","article-title":"What is the most relevant standard of success in assisted reproduction? The next step to improving outcomes of IVF: consider the whole treatment","volume":"19","author":"Heijnen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib103","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/humrep\/deh228","article-title":"What is the most relevant standard of success in assisted reproduction? Is there a single \u2018parameter of excellence\u2019?","volume":"19","author":"Pinborg","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib104","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/humrep\/deh237","article-title":"What is the most relevant standard of success in assisted reproduction? Is BESST (birth emphasizing a successful singleton at term) truly the best?","volume":"19","author":"Griesinger","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib105","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/humrep\/deh215","article-title":"What is the most relevant standard of success in assisted reproduction? Defining outcome in ART: a Gordian knot of safety, efficacy and quality","volume":"19","author":"Land","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib106","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1093\/humrep\/deh501","article-title":"What is the most relevant standard of success in assisted reproduction? The cumulated singleton\/twin delivery rates per oocyte pick-up: the CUSIDERA and CUTWIDERA","volume":"19","author":"Germond","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib107","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/dmh048","article-title":"Multiple gestation and infertility treatment: registration, reflection and reaction \u2013 the Belgian project","volume":"11","author":"Ombelet","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib108","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.fertnstert.2005.01.087","volume":"83","author":"Debrock","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib109","series-title":"The biology of twinning in man","author":"Bulmer","year":"1970"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib110","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1093\/humrep\/14.10.2581","article-title":"Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial","volume":"14","author":"Gerris","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib111","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/humrep\/16.9.1900","article-title":"One versus two embryo transfer after IVF and ICSI: a randomized study","volume":"16","author":"Martikainen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2006.09.011_bib112","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/humrep\/dei359","article-title":"In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial","volume":"21","author":"van Montfoort","year":"2006","journal-title":"Hum Reprod"}],"container-title":["Best Practice & Research Clinical Obstetrics & Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693406001295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693406001295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T03:43:29Z","timestamp":1555904609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693406001295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1521693406001295"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2006.09.011","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}