{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:22:23Z","timestamp":1780363343071,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.bpobgyn.2008.12.007","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T05:48:15Z","timestamp":1237528095000},"page":"509-518","source":"Crossref","is-referenced-by-count":20,"title":["Conservative management of tubal ectopic pregnancy"],"prefix":"10.1016","volume":"23","author":[{"given":"N.M.","family":"van Mello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.W.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Hajenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2008.12.007_bib1","first-page":"525","article-title":"Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone","volume":"40","author":"Ankum","year":"1995","journal-title":"J Reprod Med"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib2","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/humrep\/deh341","article-title":"The use of a new logistic regression model for prediciting the outcome of pregnancies of unknown location","volume":"19","author":"Condous","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib3","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1093\/humrep\/14.11.2855","article-title":"Implementation of probabilistic decision rules improves the predictive values of algorithms in the diagnostic management of ectopic pregnancy","volume":"14","author":"Mol","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0015-0282(98)00278-7","article-title":"Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive","volume":"70","author":"Mol","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib5","first-page":"70","article-title":"Early ectopic pregnancy -comments on conservative treatment","volume":"62","author":"Lund","year":"1955","journal-title":"J Obstet Gynaecol of the British Empire"},{"issue":"6","key":"10.1016\/j.bpobgyn.2008.12.007_bib6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/j.1879-3479.1980.tb00215.x","article-title":"Complete abortion of early ectopic pregnancy","volume":"17","author":"Ohel","year":"1980","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib7","first-page":"127","article-title":"Non operative management of ectopic pregnancy: a preliminary report","volume":"27","author":"Mashiach","year":"1982","journal-title":"J Reprod Med"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0015-0282(16)56638-2","article-title":"Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy","volume":"61","author":"Korhonen","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib9","first-page":"258","article-title":"Suspected ectopic pregnancy: expectant management in patients with negative sonographic findings and low serum hCG concentrations","volume":"1","author":"Hajenius","year":"1995","journal-title":"Early Pregnancy: Biol Med"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/uog.1061","article-title":"Expectant mangement of tubal ectopic pregnancy: prediction of succesful outcome using decision tree analysis","volume":"23","author":"Elson","year":"2004","journal-title":"Ultrasound in Obstet Gynaecol"},{"issue":"8","key":"10.1016\/j.bpobgyn.2008.12.007_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3109\/00016349709024350","article-title":"Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG < or = 2500mIU\/mL","volume":"76","author":"Lang","year":"1997","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0952-3278(91)90154-W","article-title":"Prostaglandin versus expectant management in early tubal pregnancy","volume":"42","author":"Egarter","year":"1991","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0029-7844(96)00293-1","article-title":"Low-dose oral methotrexate with expectant management of ectopic pregnancy","volume":"88","author":"Korhonen","year":"1996","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2008.12.007_bib14","first-page":"321","article-title":"Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms","volume":"48","author":"Goldstein","year":"1976","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.bpobgyn.2008.12.007_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1471-0528.1989.tb03318.x","article-title":"The role of low-dose methotrexate and folinic acid in gestational trophoblastic tumours (GTT)","volume":"96","author":"Bagshawe","year":"1989","journal-title":"Br J Obstet Gynaecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2008.12.007_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1517\/14656566.2.3.409","article-title":"The pharmacology of methotrexate","volume":"2","author":"Barnhart","year":"2001","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib17","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0015-0282(16)57055-1","article-title":"Treatment of unruptured tubal pregnancy with methotrexate: pharmacokinetic analysis of local versus intramuscular administration","volume":"62","author":"Fernandez","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0140-6736(97)05487-1","article-title":"Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy","volume":"350","author":"Hajenius","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejogrb.2004.04.017","article-title":"Pre and post treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy","volume":"117","author":"Natale","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0029-7844(98)00324-X","article-title":"Resolution of hormonal markers of ectopic gestation: a randomized trial comparing single dose intramuscular methotrexate with salpingostomy","volume":"92","author":"Saraj","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib21","first-page":"740","article-title":"Nonsurgical management of ectopic pregnancy associated with severe hyperstimulation syndrome","volume":"66","author":"Chotiner","year":"1985","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0015-0282(16)46349-1","article-title":"Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case","volume":"37","author":"Tanaka","year":"1982","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0002-9378(86)90716-7","article-title":"Conservative treatment of ectopic pregnancy with methotrexate","volume":"154","author":"Ory","year":"1986","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.bpobgyn.2008.12.007_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0015-0282(16)60549-6","article-title":"Outpatient chemotherapy of unruptured ectopic pregnancy","volume":"51","author":"Stovall","year":"1989","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib25","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9378(99)70330-3","article-title":"The treatment of tubal pregnancy in The Netherlands: an economic evaluation of systemic methotrexate and laparoscopic salpingostomy","volume":"181","author":"Mol","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0015-0282(98)00212-X","article-title":"Systemic methotrexate therapy versus laparoscopic salpingostomy in patients with tubal pregnancy. Part I. Impact on patients' health related quality of life","volume":"70","author":"Nieuwkerk","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0015-0282(98)00213-1","article-title":"Systemic methotrexate therapy versus laparoscopic salpingostomy in tubal pregnancy. Part II patient preferences for systemic methotrexate","volume":"7","author":"Nieuwkerk","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib28","first-page":"256","article-title":"Methotrexate verus laparoscopic surgery for the management of unruptured tubal pregnancy","volume":"8","author":"El-Sherbiny","year":"2003","journal-title":"Middle East Fertil Soc J"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib29","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/humrep\/13.11.3239","article-title":"Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility","volume":"13","author":"Fernandez","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0306-5456(00)00038-3","article-title":"A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy","volume":"108","author":"Sowter","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0306-5456(00)00037-1","article-title":"An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy","volume":"108","author":"Sowter","year":"2001","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib32","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.fertnstert.2005.11.055","article-title":"Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial","volume":"85","author":"Alleyassin","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib33","first-page":"64S","article-title":"Methotrexate for ectopic pregnancy: a randomized single dose compared with multiple dose","volume":"105","author":"Klauser","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib34","first-page":"179A","article-title":"A comparison of 25mg\/m2 vs 50mg\/m2 dose of methotrexate (MTX) for the treatment of ectopic pregnancy (EP)","volume":"7","author":"Yalcinkaya","year":"2000","journal-title":"J Soc Gynecol Invest"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib35","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/humrep\/13.7.1987","article-title":"Mifepristone in combination with methotrexate for the medical mangement of tubal pregnancy: a randomized controlled trial","volume":"13","author":"Gazvani","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib36","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1093\/humrep\/deg344","article-title":"Medical treatment of ectopic pregnancies: a randomized clinical trial comparing methotrexate-mifepristone and methotrexate-placebo","volume":"18","author":"Rozenberg","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.fertnstert.2006.07.1481","article-title":"Medical treatment of ectopic pregnancy","volume":"86","author":"The practice committee of the American Society for Reproductive Medicine","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib38","unstructured":"Jurkovic D. Randomised double blind placebo controlled trial of single dose methotrexate versus expectant management in women with tubal ectopic pregnancy. Ongoing study. Controlled trials registration ISRCTN95698259 2005 Sep 1."},{"key":"10.1016\/j.bpobgyn.2008.12.007_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6874-8-10","article-title":"The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial","volume":"8","author":"van Mello","year":"2008","journal-title":"BMC Womens Health"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169340900011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169340900011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T20:25:15Z","timestamp":1558211115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152169340900011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S152169340900011X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2008.12.007","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}