{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:32:25Z","timestamp":1790728345255,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.bpobgyn.2010.10.012","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T04:35:49Z","timestamp":1290659749000},"page":"301-311","source":"Crossref","is-referenced-by-count":137,"title":["Defective deep placentation"],"prefix":"10.1016","volume":"25","author":[{"given":"Yee","family":"Khong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Brosens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2010.10.012_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0002-9378(64)90057-2","article-title":"Effect of uterine contractions on the human uteroplacental blood circulation. An\u00a0arteriographic study","volume":"89","author":"Borell","year":"1964","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib2","series-title":"The human placenta","author":"Boyd","year":"1970"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9378(53)90560-2","article-title":"Measurement of uterine blood flow and uterine metabolism. I. Critical review of methods","volume":"66","author":"Assali","year":"1953","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1471-0528.1953.tb07668.x","article-title":"The maternal placental blood flow in normotensive and hypertensive women","volume":"60","author":"Browne","year":"1953","journal-title":"J Obstet Gynaec Brit Emp"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1471-0528.1958.tb08876.x","article-title":"A study of the vessels of the placental bed in normotensive and hypertensive women","volume":"65","author":"Dixon","year":"1958","journal-title":"J Obstet Gynaecol Br Emp"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib6","first-page":"103","article-title":"Spiral arterioles in the decidua basalis in hypertensive complications of pregnancy","volume":"63","author":"Renaer","year":"1963","journal-title":"Ned Tijdschr Verloskd Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/path.1700930218","article-title":"The physiological response of the vessels of the placental bed to normal pregnancy","volume":"93","author":"Brosens","year":"1967","journal-title":"J\u00a0Pathol Bacteriol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib8","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"Brosens","year":"1972","journal-title":"Obstet Gynecol Annu"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"Khong","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib10","series-title":"Fetal and neonatal pathology","article-title":"The placenta","author":"Khong","year":"2007"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1471-0528.1991.tb13450.x","article-title":"Placental bed spiral arteries in the hypertensive disorders of pregnancy","volume":"98","author":"Pijnenborg","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib12","first-page":"404","article-title":"Pathological changes in placentas from pregnancies with preeclampsia and eclampsia with emphasis on persistence of endovascular trophoblastic plugs","volume":"46","author":"Kos","year":"2005","journal-title":"Croat Med J"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/jcp.45.10.925","article-title":"Alternative method of sampling placentas for the assessment of uteroplacental vasculature","volume":"45","author":"Khong","year":"1992","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib14","first-page":"722","article-title":"Acute atherosis in pregnancies complicated by hypertension, small-for-gestational-age infants, and diabetes mellitus","volume":"115","author":"Khong","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1471-0528.1964.tb04270.x","article-title":"A study of the spiral arteries of the decidua basalis in normotensive and hypertensive pregnancies","volume":"71","author":"Brosens","year":"1964","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0002-9378(81)90703-1","article-title":"Decidual arteriopathy in hypertension and diabetes in pregnancy: immunofluorescent studies","volume":"141","author":"Kitzmiller","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1471-0528.1980.tb04601.x","article-title":"Fetal growth retardation and the maternal arterial supply of the human placenta in the absence of sustained hypertension","volume":"87","author":"De Wolf","year":"1980","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0143-4004(85)80056-4","article-title":"Maternal vascular lesions in placentae of small-for-gestational-age infants","volume":"6","author":"Althabe","year":"1985","journal-title":"Placenta"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib19","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/j.1471-0528.1976.tb00781.x","article-title":"The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation","volume":"83","author":"Sheppard","year":"1976","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib20","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1471-0528.1981.tb01268.x","article-title":"An ultrastructural study of utero-placental spiral arteries in hypertensive and normotensive pregnancy and fetal growth retardation","volume":"88","author":"Sheppard","year":"1981","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib21","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJM198009183031204","article-title":"Decidual vasculopathy of the placenta in lupus erythematosus","volume":"303","author":"Abramowsky","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib22","first-page":"489","article-title":"Maternal vascular lesions in pre-eclampsia and intrauterine growth retardation: light microscopy and immunofluorescence","volume":"4","author":"Hustin","year":"1983","journal-title":"Placenta"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib23","first-page":"38","article-title":"Morphology of myometrial and decidual arteries in normal pregnancy, in toxemia of pregnancy, and in maternal diabetes","volume":"43","author":"Emmrich","year":"1975","journal-title":"Pathol Microbiol (Basel)"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0025-7125(16)33295-3","article-title":"The pathology of pregnancy complicated by diabetes mellitus","volume":"49","author":"Driscoll","year":"1965","journal-title":"Med Clin N Am"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0002-9378(75)90522-0","article-title":"The ultrastructure of acute atherosis in hypertensive pregnancy","volume":"123","author":"De Wolf","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0028-2243(93)90034-A","article-title":"Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia","volume":"51","author":"Khong","year":"1993","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0002-9378(87)80172-2","article-title":"Acute atherosis in preeclampsia: maternal determinants and fetal outcome in the presence of the lesion","volume":"157","author":"Khong","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1471-0528.1986.tb07933.x","article-title":"The relation of birthweight to histological appearances in vessels of the placental bed","volume":"93","author":"McFadyen","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00006250-196409000-00004","article-title":"Placental pathology in eclampsia and preeclampsia","volume":"24","author":"Maqueo","year":"1964","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0002-9378(11)91583-X","article-title":"An immunohistologic study of endothelialization of uteroplacental vessels in human pregnancy: evidence that endothelium is focally disrupted by trophoblast in preeclampsia","volume":"167","author":"Khong","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9440(10)63803-5","article-title":"Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies","volume":"162","author":"Jauniaux","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib32","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/j.1471-0528.1972.tb12922.x","article-title":"On the pathogenesis of placental infarcts in pre-eclampsia","volume":"79","author":"Brosens","year":"1972","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0002-9378(73)91018-1","article-title":"The pathogenesis of placental infarction. I. A morphologic study in the human placenta","volume":"116","author":"Wallenburg","year":"1973","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib34","series-title":"Pathology of the placenta","author":"Fox","year":"2007"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib35","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1471-0528.1994.tb13041.x","article-title":"Chorionic villous haemorrhage is associated with retroplacental haemorrhage","volume":"101","author":"Mooney","year":"1994","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib36","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1471-0528.1992.tb13848.x","article-title":"Placental bed biopsies in placental abruption","volume":"99","author":"Dommisse","year":"1992","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib37","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1067\/mob.2002.127720","article-title":"Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes","volume":"187","author":"Kim","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib38","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1067\/S0002-9378(03)00838-X","article-title":"Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes","volume":"189","author":"Kim","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/JPM.2006.089","article-title":"Normal and abnormal transformation of the spiral arteries during pregnancy","volume":"34","author":"Espinoza","year":"2006","journal-title":"J Perinat Med"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib40","series-title":"Placental bed disorders","article-title":"Defective spiral artery remodeling","author":"Brosens","year":"2010"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib41","doi-asserted-by":"crossref","unstructured":"Brosens I, Pijnenborg R, Vercruysse L, et al. The \u201cGreat Obstetrical Syndromes\u201d are associated with disorders of deep placentation. Am J Obstet Gynecol, in press, doi:10.1016\/j.ajog.2010.08.009.","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib42","doi-asserted-by":"crossref","first-page":"615.e1","DOI":"10.1016\/j.ajog.2008.11.037","article-title":"A role for menstruation in preconditioning the uterus for successful pregnancy","volume":"200","author":"Brosens","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib43","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJM199504273321701","article-title":"Association of young maternal age with adverse reproductive outcomes","volume":"332","author":"Fraser","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1053\/plac.2002.0922","article-title":"On an anatomical basis for the increase in birth weight in second and subsequent born children","volume":"24","author":"Khong","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib45","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.fertnstert.2005.09.055","article-title":"Influence of parity on first trimester endovascular trophoblast invasion","volume":"85","author":"Prefumo","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1472-6483(10)60578-0","article-title":"NK cells and pre-eclampsia","volume":"16","author":"Goldman-Wohl","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1471-0528.2006.01186.x","article-title":"Adenomyosis and risk of preterm delivery","volume":"114","author":"Juang","year":"2007","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib48","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.fertnstert.2008.01.096","article-title":"Preterm birth, ovarian endometriomata, and assisted reproduction technologies","volume":"91","author":"Fernando","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib49","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1093\/humrep\/dep186","article-title":"Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome","volume":"24","author":"Stephansson","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2010.10.012_bib50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/humrep\/dep474","article-title":"The enigmatic uterine junctional zone: the missing link between reproductive disorders and major obstetrical disorders?","volume":"25","author":"Brosens","year":"2010","journal-title":"Hum Reprod"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693410001355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693410001355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T10:48:13Z","timestamp":1559818093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693410001355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1521693410001355"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2010.10.012","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}