{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:12:41Z","timestamp":1761513161598},"reference-count":61,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.bpobgyn.2012.05.011","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T22:26:50Z","timestamp":1342218410000},"page":"829-840","source":"Crossref","is-referenced-by-count":13,"title":["Prevention of multiple pregnancies in infertility treatment"],"prefix":"10.1016","volume":"26","author":[{"given":"Aila","family":"Tiitinen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2012.05.011_bib1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3109\/00016349.2010.498495","article-title":"Origin of multiple pregnancies in a subfertile population","volume":"89","author":"Brandes","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib2","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(05)66478-1","article-title":"Multiple birth resulting from ovarian stimulation for subfertility","volume":"365","author":"Fauser","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib3","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/humrep\/des023","article-title":"Assisted reproductive technology in Europe, 2007: results generated from European registers by ESHRE","volume":"27","author":"de Mouzon","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib4","series-title":"European perinatal health report","year":"2004"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib5","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.fertnstert.2007.01.112","volume":"88","author":"Dickey","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib6","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.fertnstert.2010.12.018","article-title":"Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer","volume":"95","author":"Kawachiya","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/bmj.37957.560278.EE","article-title":"Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies","volume":"328","author":"Helmerhorst","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib8","first-page":"1","article-title":"Centers for Disease Control and Prevention. Assisted reproductive technology surveillance \u2013 United States, 2004","volume":"56","author":"Wright","year":"2007","journal-title":"MMWR Surveill Summ"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0029-7844(99)00640-7","article-title":"Maternal morbidity and mortality associated with multiple gestations","volume":"95","author":"Conde-Agudelo","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/bmj.322.7294.1089","article-title":"Incidence and predictors of severe obstetric morbidity; case-control study","volume":"332","author":"Waterstone","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib11","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fertnstert.2006.11.008","article-title":"Contemporary risks of maternal morbidity and adverse outcomes with increasing maternal age and plurality","volume":"88","author":"Luke","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ajog.2003.12.003","article-title":"Maternal morbidity and obstetric complications in triplet pregnancies and quadruplet and higher-order multiple pregnancies","volume":"191","author":"Wen","year":"2004","journal-title":"Am J Obstet and Gynecol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib13","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/humrep\/17.5.1391","article-title":"Neonatal outcome and congenital malformations in children born after in-vitro fertilization","volume":"17","author":"Koivurova","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib14","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJM199407283310407","article-title":"The economic impact of multiple-gestation pregnancies and the contribution of assisted-reproduction techniques to their incidence","volume":"331","author":"Callahan","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib15","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1093\/humrep\/17.11.2897","article-title":"The course of pregnancy and delivery and the use of maternal healthcare services after standard IVF in Northern Finland 1990\u20131995","volume":"17","author":"Koivurova","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmi027","article-title":"IVF\/ICSI twin pregnancies: risks and prevention","volume":"11","author":"Pinborg","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib17","series-title":"Iatrogenic multiple pregnancy","first-page":"199","article-title":"Long term health and psychosocial outcomes","author":"Alin Akerman","year":"2001"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1375\/136905203322686509","article-title":"Maternal perinatal mental health and multiple births: implications for practice","volume":"6","author":"Fisher","year":"2003","journal-title":"Twin Res"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00003081-199003000-00014","article-title":"Twins: family adjustment, parenting, and infant feeding in the fourth trimester","volume":"33","author":"Neifert","year":"1990","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humrep\/den427","article-title":"Mental health of mothers and fathers of twins conceived via assisted reproduction treatment: a 1-year prospective study","volume":"24","author":"Vilska","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib21","unstructured":"Centers for Disease Control and Prevention. National Center for Health Statistics. Public-use data files and documentation. National vital statistics system. Natality (births). Available at: http:\/\/www.cdc.gov\/nchs\/data_access\/ftp_data.htm [last accessed 13.05.12]."},{"issue":"1","key":"10.1016\/j.bpobgyn.2012.05.011_bib22","first-page":"CD000057","article-title":"Clomiphene citrate for unexplained subfertility in women","author":"Hughes","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3109\/01443615.2011.596956","article-title":"Is ultrasound monitoring of the ovaries during ovulation induction by clomiphene essential? A systematic review","volume":"31","author":"Galazis","year":"2011","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.rbmo.2009.06.008","article-title":"Aromatase inhibitors for female infertility: a systematic review of the literature","volume":"19","author":"Polyzos","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/01443615.2010.497873","article-title":"Clomiphene citrate or aromatase inhibitors combined with gonadotropins for superovulation in women undergoing intrauterine insemination: a prospective randomised trial","volume":"30","author":"Badawy","year":"2010","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1701-2163(16)32551-8","article-title":"Fetal safety of letrozole and clomiphene citrate for ovulation induction","volume":"29","author":"Forman","year":"2007","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib27","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.fertnstert.2012.02.031","article-title":"Ovarian stimulation and intrauterine insemination at the quarter centennial: implications for the multiple births epidemic","volume":"97","author":"McClamrock","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.fertnstert.2011.11.048","article-title":"Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine Practice Committee opinion","volume":"97","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib29","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/aje\/kwp281","article-title":"Estimation of the contribution of non-assisted reproductive technology ovulation stimulation fertility treatments to US singleton and multiple births","volume":"170","author":"Schieve","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib30","first-page":"CD000057","article-title":"Ovarian stimulation protocols (anti-oestrogens, gonadotrophins with and without GnRH agonists\/antagonists) for intrauterine insemination (IUI) in women with subfertility","volume":"6","author":"Cantineau","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib31","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cct.2011.07.009","article-title":"Estimating rates of multiple gestation pregnancies: sample size calculation from the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) trial","volume":"32","author":"Diamond","year":"2011","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib32","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.fertnstert.2009.04.003","article-title":"The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysis","volume":"94","author":"Gelbaya","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib33","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1093\/humrep\/14.9.2392","article-title":"Elective transfer of one embryo results in an acceptable pregnancy rate and eliminates the risk of multiple birth","volume":"14","author":"Vilska","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib34","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/humrep\/deh188","article-title":"A real-life prospective health economic study of elective single embryo transfer versus two-embryo transfer in first IVF\/ICSI cycles","volume":"19","author":"Gerris","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deh744","article-title":"Single embryo transfer: a mini review","volume":"20","author":"Bergh","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib36","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa041032","article-title":"Elective single-embryo transfer versus double-embryo transfer in in\u00a0vitro fertilization","volume":"351","author":"Thurin","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib37","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/humrep\/deh446","article-title":"What is the most relevant standard of success in assisted reproduction? The value of cryopreservation on cumulative pregnancy rates per single oocyte retrieval should not be forgotten","volume":"19","author":"Tiitinen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib38","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/humrep\/del484","article-title":"Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial","volume":"22","author":"Baart","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib39","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/humrep\/16.2.326","article-title":"Calculating the implantation potential of day 3 embryos in women younger than 38 years of agea new model","volume":"16","author":"Van Royen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/humrep\/deg184","article-title":"Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures","volume":"18","author":"Salumets","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib41","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.fertnstert.2005.05.064","article-title":"Elective transfer of single fresh blastocysts and later transfer of cryostored blastocysts reduces the twin pregnancy rate and can improve the in\u00a0vitro fertilization live birth rate in younger women","volume":"84","author":"Henman","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib42","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1093\/humrep\/dei133","article-title":"Single embryo transfer is an option in frozen embryo transfer","volume":"20","author":"Hyd\u00e9n-Granskog","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/humrep\/15.1.175","article-title":"A quantitative analysis of the impact of cryopreservation on the implantation potential of human early cleavage stage embryos","volume":"15","author":"Edgar","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/humupd\/dmq013","article-title":"The costs and consequences of assisted reproductive technology: an economic perspective","volume":"16","author":"Connolly","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/humupd\/dml053","article-title":"Economic evaluations of single versus double embryo transfer in IVF","volume":"13","author":"Fiddelers","year":"2007","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib46","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1472-6483(10)60695-5","article-title":"Cumulative impact of adding frozen-thawed cycles to single versus double fresh embryo transfers","volume":"15","author":"Lundin","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/humupd\/dmh049","article-title":"Single embryo transfer and IVF\/ICSI outcome: a balanced appraisal","volume":"11","author":"Gerris","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib48","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.fertnstert.2005.01.087","volume":"83","author":"Debrock","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib49","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.fertnstert.2011.11.033","article-title":"Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis","volume":"97","author":"Grady","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/humupd\/dmq028","article-title":"Global variations in the uptake of single embryo transfer","volume":"17","author":"Maheshwari","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib51","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/humrep\/16.9.1900","article-title":"One versus two-embryo transfer after IVF and ICSI: a randomized study","volume":"16","author":"Martikainen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib52","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/humrep\/dep042","article-title":"Elective single embryo transfer with cryopreservation improves the outcome and diminishes the costs of IVF\/ICSI","volume":"24","author":"Veleva","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib53","unstructured":"National Institute for Health and Welfare (Finland). Statistics and registers: assisted fertility treatments; http:\/\/www.stakes.fi\/EN\/tilastot\/statisticsbytopic\/reproduction\/IVFtreatments.htm [last accessed 19.05.12]."},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib54","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/humrep\/16.6.1140","article-title":"Elective single embryo transfer. The value of cryopreservation","volume":"16","author":"Tiitinen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib55","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/humrep\/deg301","article-title":"Impact of elective single embryo transfer on the twin pregnancy rate","volume":"18","author":"Tiitinen","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib56","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1600-0412.2011.01145.x","article-title":"Assisted reproductive technology registers for infant and maternal health monitoring. Structure and feasibility of combining data","volume":"90","author":"Henningsen","year":"2011","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib57","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/humrep\/deh215","article-title":"What is the most relevant standard of success in assisted reproduction? Defining outcome in ART: a Gordian knot of safety, efficacy and quality","volume":"19","author":"Land","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib58","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/humrep\/deh228","article-title":"What is the most relevant standard of success in assisted reproduction? Is there a single \u2018parameter of excellence\u2019?","volume":"19","author":"Pinborg","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib59","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/humrep\/deh097","article-title":"The desire for multiple pregnancy in male and female infertility patients","volume":"19","author":"Child","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib60","doi-asserted-by":"crossref","first-page":"c6945","DOI":"10.1136\/bmj.c6945","article-title":"Clinical effectiveness of elective single versus double embryo transfer: results from an individual patient data meta-analysis of randomised trials","volume":"341","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.bpobgyn.2012.05.011_bib61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.fertnstert.2011.11.050","article-title":"Elective single embryo transfer","volume":"97","year":"2012","journal-title":"Fertil Steril"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693412001034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693412001034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T05:21:21Z","timestamp":1542864081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693412001034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1521693412001034"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2012.05.011","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}