{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:55:58Z","timestamp":1791665758438,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","content-domain":{"domain":["bestpracticeobgyn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.bpobgyn.2014.01.010","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T18:01:52Z","timestamp":1391191312000},"page":"379-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Facial cleft detected: Is the palate normal?"],"prefix":"10.1016","volume":"28","author":[{"given":"Wassim A.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph C.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2014.01.010_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1597\/04-101R.1","article-title":"Antenatal transabdominal ultrasound detection of cleft lip and palate in Western Australia from 1996 to 2003","volume":"43","author":"Hanikeri","year":"2006","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1259\/bjr.75.895.750584","article-title":"Sensitivity and accuracy of routine antenatal ultrasound screening for isolated facial clefts","volume":"75","author":"Wayne","year":"2002","journal-title":"Br J Radiol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/1097-0223(200011)20:11<870::AID-PD940>3.0.CO;2-J","article-title":"Evaluation of prenatal diagnosis of cleft lip with or without cleft palate and cleft palate by ultrasound: experience from 20 European registries","volume":"20","author":"Clementi","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/uog.5280","article-title":"Prenatal ultrasound detection of facial clefts: a prospective study of 49,314 deliveries in a non- selected population in Norway","volume":"31","author":"Offerdal","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/2000656X.2012.668773","article-title":"Prenatal ultrasound detection of cleft lip, or cleft palate, or both, in southern Sweden, 2006\u20132010","volume":"46","author":"Berggren","year":"2012","journal-title":"J\u00a0Plast Surg Hand Surg"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1258\/jms.2011.010139","article-title":"Monitoring the prenatal detection of structural fetal congenital anomalies in England and Wales: register-based study","volume":"18","author":"Boyd","year":"2011","journal-title":"J\u00a0Med Screen"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib7","unstructured":"NHS Fetal Anomaly Screening Programme. Standards and policies; http:\/\/fetalanomaly.screening.nhs.uk\/standardsandpolicies [last accessed 22.01.14]."},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib8","first-page":"147","article-title":"A\u00a0morphometric analysis of human embryonic craniofacial growth in the median plane during primary palate formation","volume":"13","author":"Diewert","year":"1993","journal-title":"J\u00a0Craniofac Genet Dev Biol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<126::AID-AJMG2>3.0.CO;2-R","article-title":"Classification and birth prevalence of orofacial clefts","volume":"75","author":"Tolerova","year":"1998","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib10","first-page":"603","article-title":"Segregation analysis of cleft lip with or without cleft palate: a comparison of Danish and Japanese data","volume":"39","author":"Chung","year":"1986","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib11","series-title":"Advances in the management of cleft palate","first-page":"43","article-title":"Incidence and aetiology","author":"Fog-Andersen","year":"1980"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/ajmg.1320060108","article-title":"Cleft lip +\/\u2013 cleft palate: an overview of the literature and an analysis of Danish cases born between 1941 and 1968","volume":"6","author":"Melnick","year":"1980","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0266-4356(96)90242-9","article-title":"The incidence of oral clefts: a review","volume":"34","author":"Derijcke","year":"1996","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/jmg.31.2.126","article-title":"Facial clefts in the West of Scotland in the period 1980\u20131984: epidemiology and genetic diagnosis","volume":"31","author":"Fitzpatrick","year":"1994","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1179\/bjo.21.4.387","article-title":"The incidence of cleft lip and palate in Northern Ireland from 1980\u20131990","volume":"21","author":"Gregg","year":"1994","journal-title":"Br J Orthod"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1597\/1545-1569(1998)035<0040:IOCLAP>2.3.CO;2","article-title":"Incidence of cleft lip and palate and risks of additional malformations","volume":"35","author":"Hagberg","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00006534-195811000-00001","article-title":"A\u00a0new classification for cleft lip and palate","volume":"22","author":"Kernahan","year":"1958","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00006534-197105000-00010","article-title":"The striped Y \u2013 a symbolic classification for cleft lips and palates","volume":"47","author":"Kernohan","year":"1971","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib19","first-page":"247","article-title":"The modified striped Y-a systematic classification for the cleft lip and palate","volume":"10","author":"Elsahy","year":"1973","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1597\/1545-1569(1991)028<0252:SROCLA>2.3.CO;2","article-title":"Symbolic representation of cleft lip and palate","volume":"28","author":"Friedman","year":"1991","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib21","first-page":"258","article-title":"Cleft lip and palate in Denmark 1976\u20131981: epidemiology, variability and early somatic development","volume":"25","author":"Jensen","year":"1988","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib22","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ng.2360","article-title":"Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci","volume":"44","author":"Ludwig","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib23","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/ajmg.a.35257","article-title":"Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts","volume":"158A","author":"Shi","year":"2012","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00439-013-1283-6","article-title":"Confirming genes influencing risk to cleft lip with\/without cleft palate in a case-parent trio study","volume":"132","author":"Beaty","year":"2013","journal-title":"Hum Genet"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/uog.7704","article-title":"The \u2018equals sign\u2019: a novel marker in the diagnosis of fetal isolated cleft palate","volume":"36","author":"Wilhelm","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1469-0705.2002.00721.x","article-title":"Two-dimensional ultrasound is accurate in the diagnosis of fetal craniofacial malformation","volume":"19","author":"Ghi","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/uog.918","article-title":"The three-dimensional reverse face (3D view for the diagnosis of cleft palate)","volume":"22","author":"Campbell","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/uog.1819","article-title":"Ultrasound antenatal diagnosis of cleft palate by a new technique: the 3D \u2018reverse face\u2019 view","volume":"25","author":"Campbell","year":"2005","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/uog.7739","article-title":"Detection of lip, alveolar ridge and hard palate abnormalities using two-dimensional ultrasound enhanced with the three-dimensional reverse-face view","volume":"36","author":"Sommerlad","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib30","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.7863\/jum.2006.25.11.1423","article-title":"Improving cleft palate\/cleft lip antenatal diagnosis by 3-dimensional sonography: the \u2018flipped face\u2019 view","volume":"25","author":"Platt","year":"2006","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/uog.3877","article-title":"A\u00a0novel technique for visualization of the normal and cleft fetal secondary palate: angled insonation and three-dimensional ultrasound","volume":"29","author":"Pilu","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.01.010_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/uog.7484","article-title":"Retronasal triangle: a sonographic landmark for the screening of cleft palate in the first trimester","volume":"35","author":"Sepulveda","year":"2010","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169341400011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169341400011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T01:58:58Z","timestamp":1565143138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152169341400011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S152169341400011X"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.01.010","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Facial cleft detected: Is the palate normal?","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Obstetrics & Gynaecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}