{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:16:21Z","timestamp":1793920581741,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","bestpracticeobgyn.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bpobgyn.2014.12.001","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T12:02:12Z","timestamp":1419422532000},"page":"489-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Recurrent pregnancy loss and obesity"],"prefix":"10.1016","volume":"29","author":[{"given":"Mayumi","family":"Sugiura-Ogasawara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bpobgyn.2014.12.001_bib1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1542\/peds.2009-3081","article-title":"Marriage and cohabitation outcomes after pregnancy loss","volume":"125","author":"Gold","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib2","first-page":"1483","article-title":"Incidence of early pregnancy loss of pregnancy","volume":"319","author":"Herz-Picciotto","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1447-0756.2012.01973.x","article-title":"Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: the Okazaki Cohort Study in Japan","volume":"39","author":"Sugiura-Ogasawara","year":"2013","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(84)90517-8","article-title":"Lupus anticoagulant and pregnancy management","volume":"28","author":"Farquharson","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib5","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.fertnstert.2008.12.097","article-title":"Midline uterine defect size correlated with miscarriage of euploid embryos in recurrent cases","volume":"93","author":"Sugiura-Ogasawara","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fertnstert.2003.07.014","article-title":"Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocation","volume":"81","author":"Sugiura-Ogasawara","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib7","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0015-0282(99)00495-1","article-title":"Embryonic karyotype of abortuses in relation to the number of previous miscarriages","volume":"73","author":"Ogasawara","year":"2000","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib8","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMcp1005330","article-title":"Clinical practice: recurrent miscarriage","volume":"363","author":"Branch","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib9","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/humrep\/des179","article-title":"Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage","volume":"27","author":"Sugiura-Ogasawara","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib10","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/humrep\/deg309","article-title":"Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies","volume":"18","author":"Philipp","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib11","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1093\/humrep\/deq202","article-title":"Identification of copy number variants in miscarriages from couples with idiopathic recurrent pregnancy loss","volume":"25","author":"Rajcan-Separovic","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement of an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-0031-1293204","article-title":"Does obesity increase the risk of miscarriage in spontaneous conception: a systematic review","volume":"29","author":"Boots","year":"2011","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib14","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/humrep\/deh277","article-title":"Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study","volume":"19","author":"Lashen","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.fertnstert.2009.03.021","article-title":"Body mass index and risk of miscarriage in women with recurrent miscarriage","volume":"94","author":"Metwally","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib16","first-page":"167","article-title":"The effect of body mass index on the outcome of pregnancy in women with recurrent miscarriage","volume":"19","author":"Lo","year":"2012","journal-title":"J\u00a0Fam Community Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.fertnstert.2014.05.005","article-title":"Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss","volume":"102","author":"Boots","year":"2014","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.bpobgyn.2014.12.001_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/humrep\/15.3.612","article-title":"Polycystic ovaries and recurrent miscarriage\u2013a reappraisal","volume":"15","author":"Rai","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00404-003-0537-2","article-title":"The effect of obesity on the outcome of infertility management in women with polycystic ovary syndrome","volume":"270","author":"Al-Azemi","year":"2004","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1471-0528.1992.tb14470.x","article-title":"Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin","volume":"99","author":"Hamilton-Fairly","year":"1992","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib21","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1093\/humrep\/17.11.2858","article-title":"Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin","volume":"17","author":"Glueck","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0897.2008.00662.x","article-title":"The polycystic ovary syndrome does not predict further miscarriage in Japanese couples experiencing recurrent miscarriages","volume":"61","author":"Sugiura-Ogasawara","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib24","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/0002-9378(92)91596-3","article-title":"Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment","volume":"166","author":"Cowchock","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/bmj.314.7076.253","article-title":"Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)","volume":"314","author":"Rai","year":"1997","journal-title":"BMJ"},{"issue":"9032","key":"10.1016\/j.bpobgyn.2014.12.001_bib26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(96)04125-6","article-title":"Increased fetal loss in women with heritable thrombophilia","volume":"348","author":"Preston","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1056\/NEJM199901073400102","article-title":"Increased frequency of genetic thrombophilia in women with complications of pregnancy","volume":"340","author":"Kupferminc","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/14767058.2010.511331","article-title":"Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XII genes in patients with recurrent spontaneous abortion","volume":"24","author":"Aarabi","year":"2011","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib29","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.fertnstert.2007.07.1376","article-title":"Association of the protein Z F G79A gene polymorphism with recurrent pregnancy loss","volume":"90","author":"Dossenbach-Glaninger","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib30","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/ard.2005.045237","article-title":"Annexin A5 polymorphism (-1Col) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome","volume":"65","author":"Laat","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib31","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.fertnstert.2013.06.020","article-title":"Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss","volume":"100","author":"Hayashi","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib32","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.338.6110.1016","article-title":"Human genetics. Genetic influences on disease remain hidden","volume":"338","author":"Kaiser","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib33","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2014.05.050","article-title":"Recurrent pregnancy loss: a risk factor for long-term maternal atherosclerotic morbidity?","volume":"211","author":"Kessous","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/humupd\/dmu007","article-title":"Celiac disease and reproductive disorders: meta-analysis of epidemiologic associations and potential pathogenic mechanisms","volume":"20","author":"Tersigni","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.bpobgyn.2014.12.001_bib35","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/oxfordjournals.humrep.a135772","article-title":"Weight loss results in significantly improvement in pregnancy and ovulation rates in anovulatory obese women","volume":"10","author":"Clark","year":"1995","journal-title":"Hum Reprod"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693414002570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693414002570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T14:51:53Z","timestamp":1537973513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693414002570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S1521693414002570"],"URL":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.12.001","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recurrent pregnancy loss and obesity","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Obstetrics & Gynaecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}